Pyruvate modifies metabolic flux and nutrient sensing during extracorporeal membrane oxygenation in an immature swine model

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 309, Issue 1, 2015, Pages H137-H146

  Ledee, Dolena R ^a   Kajimoto, Masaki ^a   Priddy, Colleen M O’Kelly ^b   Olson, Aaron K ^a,b   Isern, Nancy ^c   Robillard Frayne, Isabelle ^d   Rosiers, Christine Des ^d   Portman, Michael A ^a,b  

^a SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^d MONTREAL HEART INSTITUTE   (Canada)

Author keywords

Extracorporeal membrane oxygenation; Leucine; Metabolism; Pyruvate

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; AMINO ACID; HEXOSAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LACTIC ACID; LEUCINE; PYRUVIC ACID; CARBON; FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CARBOXYLATION; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EXTRACORPOREAL OXYGENATION; FATTY ACID OXIDATION; IN VIVO STUDY; MALE; METABOLIC FLUX ANALYSIS; NONHUMAN; NUTRIENT; NUTRITIONAL SUPPORT; PIGLET; PORCINE MODEL; PRIORITY JOURNAL; PROTEIN SYNTHESIS; YORKSHIRE PIG; ANIMAL; CARDIAC MUSCLE; DRUG EFFECTS; ENERGY METABOLISM; HEART; METABOLISM; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; PIG; PROTON NUCLEAR MAGNETIC RESONANCE;

ACETYL-COA CARBOXYLASE; AMINO ACIDS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CARBON RADIOISOTOPES; ENERGY METABOLISM; EXTRACORPOREAL MEMBRANE OXYGENATION; FATTY ACIDS; HEART; LEUCINE; MYOCARDIUM; OXIDATION-REDUCTION; PHOSPHORYLATION; PROTON MAGNETIC RESONANCE SPECTROSCOPY; PYRUVIC ACID; SWINE;

EID: 84935510930     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00011.2015     Document Type: Article

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