Psychosocial treatment and interventions for bipolar disorder: A systematic review

Annals of General Psychiatry

Volumn 14, Issue 1, 2015, Pages

  Miziou, Stella ^a   Tsitsipa, Eirini ^a   Moysidou, Stefania ^a   Karavelas, Vangelis ^a   Dimelis, Dimos ^a   Polyzoidou, Vagia ^b   Fountoulakis, Konstantinos N ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b School of Medicine ^*  (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

BIPOLAR DISORDER; CLINICAL EFFECTIVENESS; COGNITIVE REMEDIATION; COGNITIVE THERAPY; DISEASE SEVERITY; EXECUTIVE FUNCTION; FAMILY THERAPY; FUNCTIONAL REMEDIATION; HUMAN; INTERPERSONAL AND SOCIAL RHYTHM THERAPY; MINDFULNESS; OUTCOME ASSESSMENT; PSYCHOEDUCATION; PSYCHOSOCIAL CARE; PSYCHOTHERAPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RELAPSE; REVIEW; SYSTEMATIC REVIEW; THERAPY EFFECT;

EID: 84935430461     PISSN: None     EISSN: 1744859X     Source Type: Journal    
DOI: 10.1186/s12991-015-0057-z     Document Type: Review

References (108)

1. Fountoulakis KN, Kasper S, Andreassen O, Blier P, Okasha A, Severus E et al (2012) Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry. Eur Arch Psychiatry Clin Neurosci 262(Suppl 1):1-48
2. Grunze H, Vieta E, Goodwin GM, Bowden C, Licht RW, Moller HJ et al (2013) The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: update 2012 on the long-term treatment of bipolar disorder. World J Biol Psychiatry 14(3):154-219
3. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C et al (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2197-2223
4. Rosa AR, Reinares M, Michalak EE, Bonnin CM, Sole B, Franco C et al (2010) Functional impairment and disability across mood states in bipolar disorder. Value Health 13(8):984-988
5. Tohen M, Hennen J, Zarate CM Jr, Baldessarini RJ, Strakowski SM, Stoll AL et al (2000) Two-year syndromal and functional recovery in 219 cases of first-episode major affective disorder with psychotic features. Am J Psychiatry 157(2):220-228
6. Rosa AR, Reinares M, Amann B, Popovic D, Franco C, Comes M et al (2011) Six-month functional outcome of a bipolar disorder cohort in the context of a specialized-care program. Bipolar Disord 13(7-8):679-686
7. Reinares M, Papachristou E, Harvey P, Mar BC, Sanchez-Moreno J, Torrent C et al (2013) Towards a clinical staging for bipolar disorder: defining patient subtypes based on functional outcome. J Affect Disord 144(1-2):65-71
8. Catala-Lopez F, Genova-Maleras R, Vieta E, Tabares-Seisdedos R (2013) The increasing burden of mental and neurological disorders. Eur Neuropsychopharmacol 23(11):1337-1339
9. De DC, Ezquiaga E, Agud JL, Vieta E, Soler B, Garcia-Lopez A (2012) Subthreshold symptoms and time to relapse/recurrence in a community cohort of bipolar disorder outpatients. J Affect Disord 143(1-3):160-165
10. Berk L, Hallam KT, Colom F, Vieta E, Hasty M, Macneil C et al (2010) Enhancing medication adherence in patients with bipolar disorder. Hum Psychopharmacol 25(1):1-16
11. Fountoulakis K (2015) Bipolar disorder: an evidence-based guide to manic depression. Springer, New York
12. Geddes JR, Miklowitz DJ (2013) Treatment of bipolar disorder. Lancet 381(9878):1672-1682
13. Scott J, Paykel E, Morriss R, Bentall R, Kinderman P, Johnson T et al (2006) Cognitive-behavioural therapy for severe and recurrent bipolar disorders: randomised controlled trial. Br J Psychiatry 188:313-320
14. Miller IW, Solomon DA, Ryan CE, Keitner GI (2004) Does adjunctive family therapy enhance recovery from bipolar I mood episodes? J Affect Disord 82(3):431-436
15. Meyer TD, Hautzinger M (2012) Cognitive behaviour therapy and supportive therapy for bipolar disorders: relapse rates for treatment period and 2-year follow-up. Psychol Med 42(7):1429-1439
16. de Barros PK, de O Costa L, Silval KI, Dias VV, Roso MC, Bandeira M et al (2013) Efficacy of psychoeducation on symptomatic and functional recovery in bipolar disorder. Acta Psychiatr Scand 127(2):153-158
17. Gomes BC, Abreu LN, Brietzke E, Caetano SC, Kleinman A, Nery FG et al (2011) A randomized controlled trial of cognitive behavioral group therapy for bipolar disorder. Psychother Psychosom 80(3):144-150
18. Reinares M, Sanchez-Moreno J, Fountoulakis KN (2014) Psychosocial interventions in bipolar disorder: what, for whom, and when. J Affect Disord 156:46-55
19. Fountoulakis KN, Siamouli M (2009) Re: how well do psychosocial interventions work in bipolar disorder? Can J Psychiatry (Revue canadienne de psychiatrie) 54(8):578
20. Moher D, Liberati A, Tetzlaff J, Altman DG (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8(5):336-341
21. Lam DH, Watkins ER, Hayward P, Bright J, Wright K, Kerr N et al (2003) A randomized controlled study of cognitive therapy for relapse prevention for bipolar affective disorder: outcome of the first year. Arch Gen Psychiatry 60(2):145-152
22. Lam DH, McCrone P, Wright K, Kerr N (2005) Cost-effectiveness of relapse-prevention cognitive therapy for bipolar disorder: 30-month study. Br J Psychiatry 186:500-506
23. Ball JR, Mitchell PB, Corry JC, Skillecorn A, Smith M, Malhi GS (2006) A randomized controlled trial of cognitive therapy for bipolar disorder: focus on long-term change. J Clin Psychiatry 67(2):277-286
24. Gonzalez IA, Echeburua E, Liminana JM, Gonzalez-Pinto A (2014) Psychoeducation and cognitive-behavioral therapy for patients with refractory bipolar disorder: a 5-year controlled clinical trial. Eur Psychiatry 29(3):134-141
25. Zaretsky A, Lancee W, Miller C, Harris A, Parikh SV (2008) Is cognitive-behavioural therapy more effective than psychoeducation in bipolar disorder? Can J Psychiatry 53(7):441-448
26. Costa RT, Cheniaux E, Rosaes PA, Carvalho MR, Freire RC, Versiani M et al (2011) The effectiveness of cognitive behavioral group therapy in treating bipolar disorder: a randomized controlled study. Rev Bras Psiquiatr 33(2):144-149
27. Gonzalez Isasi A, Echeburua E, Liminana JM, Gonzalez-Pinto A (2014) Psychoeducation and cognitive-behavioral therapy for patients with refractory bipolar disorder: a 5-year controlled clinical trial. Eur Psychiatry 29(3):134-141
28. Fracalanza K, McCabe RE, Taylor VH, Antony MM (2014) The effect of comorbid major depressive disorder or bipolar disorder on cognitive behavioral therapy for social anxiety disorder. J Affect Disord 162:61-66
29. Hollandare F, Eriksson A, Lovgren L, Humble MB, Boersma K (2015) Internet-based cognitive behavioral therapy for residual symptoms in bipolar disorder type II: a single-subject design pilot study. JMIR Res Protoc 4(2):e44
30. Jones SH, Smith G, Mulligan LD, Lobban F, Law H, Dunn G et al (2015) Recovery-focused cognitive-behavioural therapy for recent-onset bipolar disorder: randomised controlled pilot trial. Br J Psychiatry 206(1):58-66
31. Steinan MK, Krane-Gartiser K, Langsrud K, Sand T, Kallestad H, Morken G (2014) Cognitive behavioral therapy for insomnia in euthymic bipolar disorder: study protocol for a randomized controlled trial. Trials 15:24
32. Peet M, Harvey NS (1991) Lithium maintenance: 1. A standard education programme for patients. Br J Psychiatry 158:197-200
33. Harvey NS, Peet M (1991) Lithium maintenance: 2. Effects of personality and attitude on health information acquisition and compliance. Br J Psychiatry 158:200-204
34. Dogan S, Sabanciogullari S (2003) The effects of patient education in lithium therapy on quality of life and compliance. Arch Psychiatr Nurs 17(6):270-275
35. Perry A, Tarrier N, Morriss R, McCarthy E, Limb K (1999) Randomised controlled trial of efficacy of teaching patients with bipolar disorder to identify early symptoms of relapse and obtain treatment. BMJ 318(7177):149-153
36. Colom F, Vieta E, Sanchez-Moreno J, Palomino-Otiniano R, Reinares M, Goikolea JM et al (2009) Group psychoeducation for stabilised bipolar disorders: 5-year outcome of a randomised clinical trial. Br J Psychiatry 194(3):260-265
37. Colom F, Vieta E, Martinez-Aran A, Reinares M, Goikolea JM, Benabarre A et al (2003) A randomized trial on the efficacy of group psychoeducation in the prophylaxis of recurrences in bipolar patients whose disease is in remission. Arch Gen Psychiatry 60(4):402-407
38. Colom F, Vieta E, Reinares M, Martinez-Aran A, Torrent C, Goikolea JM et al (2003) Psychoeducation efficacy in bipolar disorders: beyond compliance enhancement. J Clin Psychiatry 64(9):1101-1105
39. Lobban F, Taylor L, Chandler C, Tyler E, Kinderman P, Kolamunnage-Dona R et al (2010) Enhanced relapse prevention for bipolar disorder by community mental health teams: cluster feasibility randomised trial. Br J Psychiatry 196(1):59-63
40. Colom F, Reinares M, Pacchiarotti I, Popovic D, Mazzarini L, Martinez AA et al (2010) Has number of previous episodes any effect on response to group psychoeducation in bipolar patients? Acta Neuropsychiatrica 22:50-53
41. Javadpour A, Hedayati A, Dehbozorgi GR, Azizi A (2013) The impact of a simple individual psycho-education program on quality of life, rate of relapse and medication adherence in bipolar disorder patients. Asian J Psychiatry 6(3):208-213
42. Kurdal E, Tanriverdi D, Savas HA (2014) The effect of psychoeducation on the functioning level of patients with bipolar disorder. West J Nurs Res 36(3):312-328
43. Scott J, Colom F, Popova E, Benabarre A, Cruz N, Valenti M et al (2009) Long-term mental health resource utilization and cost of care following group psychoeducation or unstructured group support for bipolar disorders: a cost-benefit analysis. J Clin Psychiatry 70(3):378-386
44. Parikh SV, Zaretsky A, Beaulieu S, Yatham LN, Young LT, Patelis-Siotis I et al (2012) A randomized controlled trial of psychoeducation or cognitive-behavioral therapy in bipolar disorder: a Canadian Network for Mood and Anxiety treatments (CANMAT) study [CME]. J Clin Psychiatry 73(6):803-810
45. Smith DJ, Griffiths E, Poole R, di Florio A, Barnes E, Kelly MJ et al (2011) Beating bipolar: exploratory trial of a novel Internet-based psychoeducational treatment for bipolar disorder. Bipolar Disord 13(5-6):571-577
46. Proudfoot J, Parker G, Manicavasagar V, Hadzi-Pavlovic D, Whitton A, Nicholas J et al (2012) Effects of adjunctive peer support on perceptions of illness control and understanding in an online psychoeducation program for bipolar disorder: a randomised controlled trial. J Affect Disord 142(1-3):98-105
47. Castle D, White C, Chamberlain J, Berk M, Berk L, Lauder S et al (2010) Group-based psychosocial intervention for bipolar disorder: randomised controlled trial. Br J Psychiatry 196(5):383-388
48. van der Voort TY, van Meijel B, Goossens PJ, Hoogendoorn AW, Draisma S, Beekman A et al (2015) Collaborative care for patients with bipolar disorder: randomised controlled trial. Br J Psychiatry 206(5):393-400
49. Fiorillo A, Del Vecchio V, Luciano M, Sampogna G, De Rosa C, Malangone C et al (2014) Efficacy of psychoeducational family intervention for bipolar I disorder: a controlled, multicentric, real-world study. J Affect Disord 172C:291-299
50. Bauer MS, McBride L, Williford WO, Glick H, Kinosian B, Altshuler L et al (2006) Collaborative care for bipolar disorder: part II. Impact on clinical outcome, function, and costs. Psychiatr Serv 57(7):937-945
51. Simon GE, Ludman EJ, Bauer MS, Unutzer J, Operskalski B (2006) Long-term effectiveness and cost of a systematic care program for bipolar disorder. Arch Gen Psychiatry 63(5):500-508
52. Eker F, Harkin S (2012) Effectiveness of six-week psychoeducation program on adherence of patients with bipolar affective disorder. J Affect Disord 138(3):409-416
53. Faria AD, de Mattos Souza LD, de Azevedo Cardoso T, Pinheiro KA, Pinheiro RT, da Silva RA et al (2014) The influence of psychoeducation on regulating biological rhythm in a sample of patients with bipolar II disorder: a randomized clinical trial. Psychol Res Behav Manag 7:167-174
54. de Cardoso TA, de Farias CA, Mondin TC, da Silva GDG, Souza LD, da Silva RA et al (2014) Brief psychoeducation for bipolar disorder: impact on quality of life in young adults in a 6-month follow-up of a randomized controlled trial. Psychiatry Res 220(3):896-902
55. Cuhadar D, Cam MO (2014) Effectiveness of psychoeducation in reducing internalized stigmatization in patients with bipolar disorder. Arch Psychiatr Nurs 28(1):62-66
56. Todd NJ, Jones SH, Hart A, Lobban FA (2014) A web-based self-management intervention for bipolar disorder 'living with bipolar': a feasibility randomised controlled trial. J Affect Disord 169:21-29
57. Barnes CW, Hadzi-Pavlovic D, Wilhelm K, Mitchell PB (2015) A web-based preventive intervention program for bipolar disorder: outcome of a 12-months randomized controlled trial. J Affect Disord 174:485-492
58. Depp CA, Ceglowski J, Wang VC, Yaghouti F, Mausbach BT, Thompson WK et al (2015) Augmenting psychoeducation with a mobile intervention for bipolar disorder: a randomized controlled trial. J Affect Disord 174:23-30
59. Bond K, Anderson IM (2015) Psychoeducation for relapse prevention in bipolar disorder: a systematic review of efficacy in randomized controlled trials. Bipolar Disord 17(4):349-362
60. Frank E, Kupfer DJ, Thase ME, Mallinger AG, Swartz HA, Fagiolini AM et al (2005) Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder. Arch Gen Psychiatry 62(9):996-1004
61. Frank E, Soreca I, Swartz HA, Fagiolini AM, Mallinger AG, Thase ME et al (2008) The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder. Am J Psychiatry 165(12):1559-1565
62. Swartz HA, Frank E, Cheng Y (2012) A randomized pilot study of psychotherapy and quetiapine for the acute treatment of bipolar II depression. Bipolar Disord 14(2):211-216
63. Inder ML, Crowe MT, Luty SE, Carter JD, Moor S, Frampton CM et al (2015) Randomized, controlled trial of Interpersonal and Social Rhythm Therapy for young people with bipolar disorder. Bipolar Disord 17(2):128-138
64. van Gent EM, Zwart FM (1991) Psychoeducation of partners of bipolar-manic patients. J Affect Disord 21(1):15-18
65. Miklowitz DJ, Simoneau TL, George EL, Richards JA, Kalbag A, Sachs-Ericsson N et al (2000) Family-focused treatment of bipolar disorder: 1-year effects of a psychoeducational program in conjunction with pharmacotherapy. Biol Psychiatry 48(6):582-592
66. Miklowitz DJ, George EL, Richards JA, Simoneau TL, Suddath RL (2003) A randomized study of family-focused psychoeducation and pharmacotherapy in the outpatient management of bipolar disorder. Arch Gen Psychiatry 60(9):904-912
67. Rea MM, Tompson MC, Miklowitz DJ, Goldstein MJ, Hwang S, Mintz J (2003) Family-focused treatment versus individual treatment for bipolar disorder: results of a randomized clinical trial. J Consult Clin Psychol 71(3):482-492
68. Scott J, Colom F, Pope M, Reinares M, Vieta E (2012) The prognostic role of perceived criticism, medication adherence and family knowledge in bipolar disorders. J Affect Disord 142(1-3):72-76
69. Clarkin JF, Carpenter D, Hull J, Wilner P, Glick I (1998) Effects of psychoeducational intervention for married patients with bipolar disorder and their spouses. Psychiatr Serv 49(4):531-533
70. Miller IW, Keitner GI, Ryan CE, Uebelacker LA, Johnson SL, Solomon DA (2008) Family treatment for bipolar disorder: family impairment by treatment interactions. J Clin Psychiatry 69(5):732-740
71. Solomon DA, Keitner GI, Ryan CE, Kelley J, Miller IW (2008) Preventing recurrence of bipolar I mood episodes and hospitalizations: family psychotherapy plus pharmacotherapy versus pharmacotherapy alone. Bipolar Disord 10(7):798-805
72. Reinares M, Colom F, Sanchez-Moreno J, Torrent C, Martinez-Aran A, Comes M et al (2008) Impact of caregiver group psychoeducation on the course and outcome of bipolar patients in remission: a randomized controlled trial. Bipolar Disord 10(4):511-519
73. Reinares M, Vieta E, Colom F, Martinez-Aran A, Torrent C, Comes M et al (2004) Impact of a psychoeducational family intervention on caregivers of stabilized bipolar patients. Psychother Psychosom 73(5):312-319
74. Madigan K, Egan P, Brennan D, Hill S, Maguire B, Horgan F et al (2012) A randomised controlled trial of carer-focussed multi-family group psychoeducation in bipolar disorder. Eur Psychiatry 27(4):281-284
75. Perlick DA, Miklowitz DJ, Lopez N, Chou J, Kalvin C, Adzhiashvili V et al (2010) Family-focused treatment for caregivers of patients with bipolar disorder. Bipolar Disord 12(6):627-637
76. D'Souza R, Piskulic D, Sundram S (2010) A brief dyadic group based psychoeducation program improves relapse rates in recently remitted bipolar disorder: a pilot randomised controlled trial. J Affect Disord 120(1-3):272-276
77. Fredman SJ, Baucom DH, Boeding SE, Miklowitz DJ (2015) Relatives' emotional involvement moderates the effects of family therapy for bipolar disorder. J Consult Clin Psychol 83(1):81-91
78. Miklowitz DJ, Otto MW, Frank E, Reilly-Harrington NA, Wisniewski SR, Kogan JN et al (2007) Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program. Arch Gen Psychiatry 64(4):419-426
79. Miklowitz DJ, Otto MW, Frank E, Reilly-Harrington NA, Kogan JN, Sachs GS et al (2007) Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial. Am J Psychiatry 164(9):1340-1347
80. Deckersbach T, Nierenberg AA, Kessler R, Lund HG, Ametrano RM, Sachs G et al (2010) RESEARCH: cognitive rehabilitation for bipolar disorder: an open trial for employed patients with residual depressive symptoms. CNS Neurosci Ther 16(5):298-307
81. Martinez-Aran A, Torrent C, Sole B, Bonnin CM, Rosa AR, Sanchez-Moreno J et al (2011) Functional remediation for bipolar disorder. Clin Pract Epidemiol Ment Health 7:112-116
82. Torrent C, Bonnin CM, Martinez-Aran A, Valle J, Amann BL, Gonzalez-Pinto A et al (2013) Efficacy of functional remediation in bipolar disorder: a multicenter randomized controlled study. Am J Psychiatry 170(8):852-859
83. Lahera G, Benito A, Montes JM, Fernandez-Liria A, Olbert CM, Penn DL (2013) Social cognition and interaction training (SCIT) for outpatients with bipolar disorder. J Affect Disord 146(1):132-136
84. Sole B, Bonnin CM, Mayoral M, Amann BL, Torres I, Gonzalez-Pinto A et al (2015) Functional remediation for patients with bipolar II disorder: improvement of functioning and subsyndromal symptoms. Eur Neuropsychopharmacol 25(2):257-264
85. Williams JM, Alatiq Y, Crane C, Barnhofer T, Fennell MJ, Duggan DS et al (2008) Mindfulness-based cognitive therapy (MBCT) in bipolar disorder: preliminary evaluation of immediate effects on between-episode functioning. J Affect Disord 107(1-3):275-279
86. Ives-Deliperi VL, Howells F, Stein DJ, Meintjes EM, Horn N (2013) The effects of mindfulness-based cognitive therapy in patients with bipolar disorder: a controlled functional MRI investigation. J Affect Disord 150(3):1152-1157
87. Perich T, Manicavasagar V, Mitchell PB, Ball JR, Hadzi-Pavlovic D (2013) A randomized controlled trial of mindfulness-based cognitive therapy for bipolar disorder. Acta Psychiatr Scand 127(5):333-343
88. Perich T, Manicavasagar V, Mitchell PB, Ball JR (2013) The association between meditation practice and treatment outcome in mindfulness-based cognitive therapy for bipolar disorder. Behav Res Ther 51(7):338-343
89. Howells FM, Ives-Deliperi VL, Horn NR, Stein DJ (2012) Mindfulness based cognitive therapy improves frontal control in bipolar disorder: a pilot EEG study. BMC Psychiatry 12:15
90. Stange JP, Eisner LR, Holzel BK, Peckham AD, Dougherty DD, Rauch SL et al (2011) Mindfulness-based cognitive therapy for bipolar disorder: effects on cognitive functioning. J Psychiatr Pract 17(6):410-419
91. Van DS, Jeffrey J, Katz MR (2013) A randomized, controlled, pilot study of dialectical behavior therapy skills in a psychoeducational group for individuals with bipolar disorder. J Affect Disord 145(3):386-393
92. Bos EH, Merea R, van den Brink E, Sanderman R, Bartels-Velthuis AA (2014) Mindfulness training in a heterogeneous psychiatric sample: outcome evaluation and comparison of different diagnostic groups. J Clin Psychol 70(1):60-71
93. Colom F, Vieta E, Sanchez-Moreno J, Martinez-Aran A, Reinares M, Goikolea JM et al (2005) Stabilizing the stabilizer: group psychoeducation enhances the stability of serum lithium levels. Bipolar Disord 7(Suppl 5):32-36
94. Simoneau B, Lavallee P, Anderson PC, Bailey M, Bantle G, Berthiaume S et al (1999) Discovery of non-peptidic P2-P3 butanediamide renin inhibitors with high oral efficacy. Bioorg Med Chem 7(3):489-508
95. Scott J, Colom F, Vieta E (2007) A meta-analysis of relapse rates with adjunctive psychological therapies compared to usual psychiatric treatment for bipolar disorders. Int J Neuropsychopharmacol 10(1):123-129
96. Reinares M, Colom F, Rosa AR, Bonnin CM, Franco C, Sole B et al (2010) The impact of staging bipolar disorder on treatment outcome of family psychoeducation. J Affect Disord 123(1-3):81-86
97. Lam DH, Burbeck R, Wright K, Pilling S (2009) Psychological therapies in bipolar disorder: the effect of illness history on relapse prevention-a systematic review. Bipolar Disord 11(5):474-482
98. Kapczinski F, Dias VV, Kauer-Sant'Anna M, Frey BN, Grassi-Oliveira R, Colom F et al (2009) Clinical implications of a staging model for bipolar disorders. Expert Rev Neurother 9(7):957-966
99. Berk M, Conus P, Lucas N, Hallam K, Malhi GS, Dodd S et al (2007) Setting the stage: from prodrome to treatment resistance in bipolar disorder. Bipolar Disord 9(7):671-678
100. Miklowitz DJ, Axelson DA, George EL, Taylor DO, Schneck CD, Sullivan AE et al (2009) Expressed emotion moderates the effects of family-focused treatment for bipolar adolescents. J Am Acad Child Adolesc Psychiatry 48(6):643-651
101. Vieta E (2010) Individualizing treatment for patients with schizoaffective disorder. J Clin Psychiatry 71(10):e26
102. Murru A, Pacchiarotti I, Nivoli AM, Colom F, Vieta E (2012) Is schizoaffective disorder still a neglected condition in the scientific literature? Psychother Psychosom 81(6):389-390
103. Fountoulakis KN, Gonda X, Siamouli M, Rihmer Z (2009) Psychotherapeutic intervention and suicide risk reduction in bipolar disorder: a review of the evidence. J Affect Disord 113(1-2):21-29
104. Fountoulakis KN, Siamouli M (2009) Re: how well do psychosocial interventions work in bipolar disorder? Can J Psychiatry 54(8):578
105. Weiss RD, Griffin ML, Kolodziej ME, Greenfield SF, Najavits LM, Daley DC et al (2007) A randomized trial of integrated group therapy versus group drug counseling for patients with bipolar disorder and substance dependence. Am J Psychiatry 164(1):100-107
106. Weiss RD, Griffin ML, Jaffee WB, Bender RE, Graff FS, Gallop RJ et al (2009) A "community-friendly" version of integrated group therapy for patients with bipolar disorder and substance dependence: a randomized controlled trial. Drug Alcohol Depend 104(3):212-219
107. Gonzalez-Isasi A, Echeburua E, Mosquera F, Ibanez B, Aizpuru F, Gonzalez-Pinto A (2010) Long-term efficacy of a psychological intervention program for patients with refractory bipolar disorder: a pilot study. Psychiatry Res 176(2-3):161-165
108. Lam D, Donaldson C, Brown Y, Malliaris Y (2005) Burden and marital and sexual satisfaction in the partners of bipolar patients. Bipolar Disord 7(5):431-440