메뉴 건너뛰기




Volumn 6, Issue JUN, 2015, Pages

Genetic manipulation of NK cells for cancer immunotherapy: Techniques and clinical implications

Author keywords

Cancer immunotherapy; Electroporation; Genetic manipulation; NK cells; Viral transduction

Indexed keywords

CHIMERIC ANTIGEN RECEPTOR; INTERLEUKIN 15; INTERLEUKIN 2; LENTIVIRUS VECTOR; NATURAL KILLER CELL RECEPTOR; RETROVIRUS VECTOR;

EID: 84935039266     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00266     Document Type: Review
Times cited : (179)

References (74)
  • 2
    • 0016746934 scopus 로고
    • Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells
    • Herberman RB, Nunn ME, Holden HT, Lavrin DH. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells. Int J Cancer (1975) 16:230-9. doi:10.1002/ijc.2910160204
    • (1975) Int J Cancer , vol.16 , pp. 230-239
    • Herberman, R.B.1    Nunn, M.E.2    Holden, H.T.3    Lavrin, D.H.4
  • 3
    • 0016711166 scopus 로고
    • Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic acid allogeneic tumors. I. Distribution of reactivity and specificity
    • Herberman RB, Nunn ME, Lavrin DH. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic acid allogeneic tumors. I. Distribution of reactivity and specificity. Int J Cancer (1975) 16:216-29. doi:10.1002/ijc.2910160204
    • (1975) Int J Cancer , vol.16 , pp. 216-229
    • Herberman, R.B.1    Nunn, M.E.2    Lavrin, D.H.3
  • 4
    • 0016835962 scopus 로고
    • Natural" killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell
    • Kiessling R, Klein E, Pross H, Wigzell H. "Natural" killer cells in the mouse. II. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Characteristics of the killer cell. Eur J Immunol (1975) 5:117-21. doi:10.1002/eji.1830050208
    • (1975) Eur J Immunol , vol.5 , pp. 117-121
    • Kiessling, R.1    Klein, E.2    Pross, H.3    Wigzell, H.4
  • 5
    • 0016762220 scopus 로고
    • Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype
    • Kiessling R, Klein E, Wigzell H. "Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol (1975) 5:112-7. doi:10.1002/eji.1830050208
    • (1975) Eur J Immunol , vol.5 , pp. 112-117
    • Kiessling, R.1    Klein, E.2    Wigzell, H.3
  • 6
    • 20144388509 scopus 로고    scopus 로고
    • Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
    • Miller JS, Soignier Y, Panoskaltsis-Mortari A, Mcnearney SA, Yun GH, Fautsch SK, et al. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood (2005) 105:3051-7. doi:10.1182/blood-2004-07-2974
    • (2005) Blood , vol.105 , pp. 3051-3057
    • Miller, J.S.1    Soignier, Y.2    Panoskaltsis-Mortari, A.3    Mcnearney, S.A.4    Yun, G.H.5    Fautsch, S.K.6
  • 7
    • 84868593211 scopus 로고    scopus 로고
    • Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen
    • Foley B, Cooley S, Verneris MR, Curtsinger J, Luo X, Waller EK, et al. Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen. J Immunol (2012) 189:5082-8. doi:10.4049/jimmunol.1201964
    • (2012) J Immunol , vol.189 , pp. 5082-5088
    • Foley, B.1    Cooley, S.2    Verneris, M.R.3    Curtsinger, J.4    Luo, X.5    Waller, E.K.6
  • 8
    • 84863338121 scopus 로고    scopus 로고
    • Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function
    • Foley B, Cooley S, Verneris MR, Pitt M, Curtsinger J, Luo X, et al. Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function. Blood (2012) 119:2665-74. doi:10.1182/blood-2011-10-386995
    • (2012) Blood , vol.119 , pp. 2665-2674
    • Foley, B.1    Cooley, S.2    Verneris, M.R.3    Pitt, M.4    Curtsinger, J.5    Luo, X.6
  • 9
    • 70350497327 scopus 로고    scopus 로고
    • Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors
    • Bryceson YT, Ljunggren HG, Long EO. Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors. Blood (2009) 114:2657-66. doi:10.1182/blood-2009-01-201632
    • (2009) Blood , vol.114 , pp. 2657-2666
    • Bryceson, Y.T.1    Ljunggren, H.G.2    Long, E.O.3
  • 10
    • 0037086131 scopus 로고    scopus 로고
    • Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    • Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science (2002) 295:2097-100. doi:10.1126/science.1068440
    • (2002) Science , vol.295 , pp. 2097-2100
    • Ruggeri, L.1    Capanni, M.2    Urbani, E.3    Perruccio, K.4    Shlomchik, W.D.5    Tosti, A.6
  • 11
    • 80051560743 scopus 로고    scopus 로고
    • Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk: evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients
    • Elmaagacli AH, Steckel NK, Koldehoff M, Hegerfeldt Y, Trenschel R, Ditschkowski M, et al. Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk: evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients. Blood (2011) 118:1402-12. doi:10.1182/blood-2010-08-304121
    • (2011) Blood , vol.118 , pp. 1402-1412
    • Elmaagacli, A.H.1    Steckel, N.K.2    Koldehoff, M.3    Hegerfeldt, Y.4    Trenschel, R.5    Ditschkowski, M.6
  • 12
    • 84902682889 scopus 로고    scopus 로고
    • Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein
    • Bachanova V, Cooley S, Defor TE, Verneris MR, Zhang B, Mckenna DH, et al. Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein. Blood (2014) 123:3855-63. doi:10.1182/blood-2013-10-532531
    • (2014) Blood , vol.123 , pp. 3855-3863
    • Bachanova, V.1    Cooley, S.2    Defor, T.E.3    Verneris, M.R.4    Zhang, B.5    Mckenna, D.H.6
  • 13
    • 84903777370 scopus 로고    scopus 로고
    • Ultra-low dose interleukin-2 promotes immune-modulating function of regulatory T cells and natural killer cells in healthy volunteers
    • Ito S, Bollard CM, Carlsten M, Melenhorst JJ, Biancotto A, Wang E, et al. Ultra-low dose interleukin-2 promotes immune-modulating function of regulatory T cells and natural killer cells in healthy volunteers. Mol Ther (2014) 22:1388-95. doi:10.1038/mt.2014.50
    • (2014) Mol Ther , vol.22 , pp. 1388-1395
    • Ito, S.1    Bollard, C.M.2    Carlsten, M.3    Melenhorst, J.J.4    Biancotto, A.5    Wang, E.6
  • 15
    • 84872865451 scopus 로고    scopus 로고
    • Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy
    • Sutlu T, Nystrom S, Gilljam M, Stellan B, Applequist SE, Alici E. Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy. Hum Gene Ther (2012) 23:1090-100. doi:10.1089/hum.2012.080
    • (2012) Hum Gene Ther , vol.23 , pp. 1090-1100
    • Sutlu, T.1    Nystrom, S.2    Gilljam, M.3    Stellan, B.4    Applequist, S.E.5    Alici, E.6
  • 16
    • 0032525193 scopus 로고    scopus 로고
    • Stable transduction of the interleukin-2 gene into human natural killer cell lines and their phenotypic and functional characterization in vitro and in vivo
    • Nagashima S, Mailliard R, Kashii Y, Reichert TE, Herberman RB, Robbins P, et al. Stable transduction of the interleukin-2 gene into human natural killer cell lines and their phenotypic and functional characterization in vitro and in vivo. Blood (1998) 91:3850-61.
    • (1998) Blood , vol.91 , pp. 3850-3861
    • Nagashima, S.1    Mailliard, R.2    Kashii, Y.3    Reichert, T.E.4    Herberman, R.B.5    Robbins, P.6
  • 17
    • 0037094006 scopus 로고    scopus 로고
    • SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells
    • Yusa S, Catina TL, Campbell KS. SHP-1- and phosphotyrosine-independent inhibitory signaling by a killer cell Ig-like receptor cytoplasmic domain in human NK cells. J Immunol (2002) 168:5047-57. doi:10.4049/jimmunol.168.10.5047
    • (2002) J Immunol , vol.168 , pp. 5047-5057
    • Yusa, S.1    Catina, T.L.2    Campbell, K.S.3
  • 18
    • 12944299796 scopus 로고    scopus 로고
    • Efficient infection of human natural killer cells with an EBV/retroviral hybrid vector
    • Becknell B, Trotta R, Yu J, Ding W, Mao HC, Hughes T, et al. Efficient infection of human natural killer cells with an EBV/retroviral hybrid vector. J Immunol Methods (2005) 296:115-23. doi:10.1016/j.jim.2004.11.012
    • (2005) J Immunol Methods , vol.296 , pp. 115-123
    • Becknell, B.1    Trotta, R.2    Yu, J.3    Ding, W.4    Mao, H.C.5    Hughes, T.6
  • 19
    • 44449090613 scopus 로고    scopus 로고
    • Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy
    • Binyamin L, Alpaugh RK, Hughes TL, Lutz CT, Campbell KS, Weiner LM. Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy. J Immunol (2008) 180:6392-401. doi:10.4049/jimmunol.180.9.6392
    • (2008) J Immunol , vol.180 , pp. 6392401
    • Binyamin, L.1    Alpaugh, R.K.2    Hughes, T.L.3    Lutz, C.T.4    Campbell, K.S.5    Weiner, L.M.6
  • 20
    • 27544465938 scopus 로고    scopus 로고
    • Efficient gene transfer into primary human natural killer cells by retroviral transduction
    • Guven H, Konstantinidis KV, Alici E, Aints A, Abedi-Valugerdi M, Christensson B, et al. Efficient gene transfer into primary human natural killer cells by retroviral transduction. Exp Hematol (2005) 33:1320-8. doi:10.1016/j.exphem.2005.07.006
    • (2005) Exp Hematol , vol.33 , pp. 1320-1328
    • Guven, H.1    Konstantinidis, K.V.2    Alici, E.3    Aints, A.4    Abedi-Valugerdi, M.5    Christensson, B.6
  • 21
    • 22044456688 scopus 로고    scopus 로고
    • Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells
    • Imai C, Iwamoto S, Campana D. Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells. Blood (2005) 106:376-83. doi:10.1182/blood-2004-12-4797
    • (2005) Blood , vol.106 , pp. 376-383
    • Imai, C.1    Iwamoto, S.2    Campana, D.3
  • 23
    • 68049142423 scopus 로고    scopus 로고
    • 2B4 (CD244) signaling by recombinant antigen-specific chimeric receptors costimulates natural killer cell activation to leukemia and neuroblastoma cells
    • Altvater B, Landmeier S, Pscherer S, Temme J, Schweer K, Kailayangiri S, et al. 2B4 (CD244) signaling by recombinant antigen-specific chimeric receptors costimulates natural killer cell activation to leukemia and neuroblastoma cells. Clin Cancer Res (2009) 15:4857-66. doi:10.1158/1078-0432.CCR-08-2810
    • (2009) Clin Cancer Res , vol.15 , pp. 4857-4866
    • Altvater, B.1    Landmeier, S.2    Pscherer, S.3    Temme, J.4    Schweer, K.5    Kailayangiri, S.6
  • 24
    • 84875469893 scopus 로고    scopus 로고
    • A chimeric receptor with NKG2D specificity enhances natural killer cell activation and killing of tumor cells
    • Chang YH, Connolly J, Shimasaki N, Mimura K, Kono K, Campana D. A chimeric receptor with NKG2D specificity enhances natural killer cell activation and killing of tumor cells. Cancer Res (2013) 73:1777-86. doi:10.1158/0008-5472.CAN-12-3558
    • (2013) Cancer Res , vol.73 , pp. 1777-1786
    • Chang, Y.H.1    Connolly, J.2    Shimasaki, N.3    Mimura, K.4    Kono, K.5    Campana, D.6
  • 25
    • 84905989882 scopus 로고    scopus 로고
    • Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15
    • Imamura M, Shook D, Kamiya T, Shimasaki N, Chai SM, Coustan-Smith E, et al. Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15. Blood (2014) 124:1081-8. doi:10.1182/blood-2014-02-556837
    • (2014) Blood , vol.124 , pp. 1081-1088
    • Imamura, M.1    Shook, D.2    Kamiya, T.3    Shimasaki, N.4    Chai, S.M.5    Coustan-Smith, E.6
  • 26
    • 33748568194 scopus 로고    scopus 로고
    • High-efficient lentiviral vector-mediated gene transfer into primary human NK cells
    • Micucci F, Zingoni A, Piccoli M, Frati L, Santoni A, Galandrini R. High-efficient lentiviral vector-mediated gene transfer into primary human NK cells. Exp Hematol (2006) 34:1344-52. doi:10.1016/j.exphem.2006.06.001
    • (2006) Exp Hematol , vol.34 , pp. 1344-1352
    • Micucci, F.1    Zingoni, A.2    Piccoli, M.3    Frati, L.4    Santoni, A.5    Galandrini, R.6
  • 27
    • 77449150694 scopus 로고    scopus 로고
    • Lentiviral gene transduction in human and mouse NK cell lines
    • Savan R, Chan T, Young HA. Lentiviral gene transduction in human and mouse NK cell lines. Methods Mol Biol (2010) 612:209-21. doi:10.1007/978-1-60761-362-6_14
    • (2010) Methods Mol Biol , vol.612 , pp. 209-221
    • Savan, R.1    Chan, T.2    Young, H.A.3
  • 28
    • 84859990187 scopus 로고    scopus 로고
    • Comparison of mRNA and lentiviral based transfection of natural killer cells with chimeric antigen receptors recognizing lymphoid antigens
    • Boissel L, Betancur M, Lu W, Wels WS, Marino T, Van Etten RA, et al. Comparison of mRNA and lentiviral based transfection of natural killer cells with chimeric antigen receptors recognizing lymphoid antigens. Leuk Lymphoma (2012) 53:958-65. doi:10.3109/10428194.2011.634048
    • (2012) Leuk Lymphoma , vol.53 , pp. 958-965
    • Boissel, L.1    Betancur, M.2    Lu, W.3    Wels, W.S.4    Marino, T.5    Van Etten, R.A.6
  • 29
    • 84866541747 scopus 로고    scopus 로고
    • Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor
    • Sahm C, Schonfeld K, Wels WS. Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor. Cancer Immunol Immunother (2012) 61:1451-61. doi:10.1007/s00262-012-1212-x
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1451-1461
    • Sahm, C.1    Schonfeld, K.2    Wels, W.S.3
  • 30
    • 33750959905 scopus 로고    scopus 로고
    • The effect of silencing NKG2D through RNA interference on receptor functions in interleukin-2-activated human natural killer cells
    • Baeriswyl V, Wodnar-Filipowicz A, Kalberer CP. The effect of silencing NKG2D through RNA interference on receptor functions in interleukin-2-activated human natural killer cells. Haematologica (2006) 91:1538-41.
    • (2006) Haematologica , vol.91 , pp. 1538-1541
    • Baeriswyl, V.1    Wodnar-Filipowicz, A.2    Kalberer, C.P.3
  • 31
    • 58549116741 scopus 로고    scopus 로고
    • Permanent silencing of NKG2A expression for cell-based therapeutics
    • Figueiredo C, Seltsam A, Blasczyk R. Permanent silencing of NKG2A expression for cell-based therapeutics. J Mol Med (Berl) (2009) 87:199-210. doi:10.1007/s00109-008-0417-0
    • (2009) J Mol Med (Berl) , vol.87 , pp. 199-210
    • Figueiredo, C.1    Seltsam, A.2    Blasczyk, R.3
  • 32
    • 0347003695 scopus 로고    scopus 로고
    • Efficient gene transfer into the human natural killer cell line, NKL, using the amaxa nucleofection system
    • Maasho K, Marusina A, Reynolds NM, Coligan JE, Borrego F. Efficient gene transfer into the human natural killer cell line, NKL, using the amaxa nucleofection system. J Immunol Methods (2004) 284:133-40. doi:10.1016/j.jim.2003.10.010
    • (2004) J Immunol Methods , vol.284 , pp. 133-140
    • Maasho, K.1    Marusina, A.2    Reynolds, N.M.3    Coligan, J.E.4    Borrego, F.5
  • 33
    • 44649174949 scopus 로고    scopus 로고
    • Delivery of DNA into natural killer cells for immunotherapy
    • Schoenberg K, Trompeter HI, Uhrberg M. Delivery of DNA into natural killer cells for immunotherapy. Methods Mol Biol (2008) 423:165-72. doi:10.1007/978-1-59745-194-9_11
    • (2008) Methods Mol Biol , vol.423 , pp. 165-172
    • Schoenberg, K.1    Trompeter, H.I.2    Uhrberg, M.3
  • 34
    • 84881494584 scopus 로고    scopus 로고
    • Blocking transforming growth factor-beta signaling pathway augments antitumor effect of adoptive NK-92 cell therapy
    • Yang B, Liu H, Shi W, Wang Z, Sun S, Zhang G, et al. Blocking transforming growth factor-beta signaling pathway augments antitumor effect of adoptive NK-92 cell therapy. Int Immunopharmacol (2013) 17:198-204. doi:10.1016/j.intimp.2013.06.003
    • (2013) Int Immunopharmacol , vol.17 , pp. 198-204
    • Yang, B.1    Liu, H.2    Shi, W.3    Wang, Z.4    Sun, S.5    Zhang, G.6
  • 35
    • 84916211311 scopus 로고    scopus 로고
    • Specific growth inhibition of ErbB2expressing human breast cancer cells by genetically modified NK92 cells
    • Liu H, Yang B, Sun T, Lin L, Hu Y, Deng M, et al. Specific growth inhibition of ErbB2expressing human breast cancer cells by genetically modified NK92 cells. Oncol Rep (2015) 33:95-102. doi:10.3892/or.2014.3548
    • (2015) Oncol Rep , vol.33 , pp. 95-102
    • Liu, H.1    Yang, B.2    Sun, T.3    Lin, L.4    Hu, Y.5    Deng, M.6
  • 36
    • 0036221688 scopus 로고    scopus 로고
    • Human natural killer cell line modified with a chimeric immunoglobulin T-cell receptor gene leads to tumor growth inhibition in vivo
    • Schirrmann T, Pecher G. Human natural killer cell line modified with a chimeric immunoglobulin T-cell receptor gene leads to tumor growth inhibition in vivo. Cancer Gene Ther (2002) 9:390-8. doi:10.1038/sj.cgt.7700453
    • (2002) Cancer Gene Ther , vol.9 , pp. 390-398
    • Schirrmann, T.1    Pecher, G.2
  • 37
    • 12944303104 scopus 로고    scopus 로고
    • Cost efficient and effective gene transfer into the human natural killer cell line, NK92
    • Grund EM, Muise-Helmericks RC. Cost efficient and effective gene transfer into the human natural killer cell line, NK92. J Immunol Methods (2005) 296:31-6. doi:10.1016/j.jim.2004.10.008
    • (2005) J Immunol Methods , vol.296 , pp. 31-36
    • Grund, E.M.1    Muise-Helmericks, R.C.2
  • 38
    • 12344276425 scopus 로고    scopus 로고
    • Specific targeting of CD33(+) leukemia cells by a natural killer cell line modified with a chimeric receptor
    • Schirrmann T, Pecher G. Specific targeting of CD33(+) leukemia cells by a natural killer cell line modified with a chimeric receptor. Leuk Res (2005) 29:301-6. doi:10.1016/j.leukres.2004.07.005
    • (2005) Leuk Res , vol.29 , pp. 301-306
    • Schirrmann, T.1    Pecher, G.2
  • 39
    • 67549118956 scopus 로고    scopus 로고
    • Transfection with mRNA for CD19 specific chimeric antigen receptor restores NK cell mediated killing of CLL cells
    • Boissel L, Betancur M, Wels WS, Tuncer H, Klingemann H. Transfection with mRNA for CD19 specific chimeric antigen receptor restores NK cell mediated killing of CLL cells. Leuk Res (2009) 33:1255-9. doi:10.1016/j.leukres.2008.11.024
    • (2009) Leuk Res , vol.33 , pp. 1255-1259
    • Boissel, L.1    Betancur, M.2    Wels, W.S.3    Tuncer, H.4    Klingemann, H.5
  • 40
    • 76749149456 scopus 로고    scopus 로고
    • Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method
    • Li L, Liu LN, Feller S, Allen C, Shivakumar R, Fratantoni J, et al. Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method. Cancer Gene Ther (2010) 17:147-54. doi:10.1038/cgt.2009.61
    • (2010) Cancer Gene Ther , vol.17 , pp. 147-154
    • Li, L.1    Liu, L.N.2    Feller, S.3    Allen, C.4    Shivakumar, R.5    Fratantoni, J.6
  • 41
    • 84863915982 scopus 로고    scopus 로고
    • A clinically adaptable method to enhance the cytotoxicity of natural killer cells against B-cell malignancies
    • Shimasaki N, Fujisaki H, Cho D, Masselli M, Lockey T, Eldridge P, et al. A clinically adaptable method to enhance the cytotoxicity of natural killer cells against B-cell malignancies. Cytotherapy (2012) 14:830-40. doi:10.3109/14653249.2012.671519
    • (2012) Cytotherapy , vol.14 , pp. 830-840
    • Shimasaki, N.1    Fujisaki, H.2    Cho, D.3    Masselli, M.4    Lockey, T.5    Eldridge, P.6
  • 42
    • 34250781067 scopus 로고    scopus 로고
    • Lentiviral vectors mediate stable and efficient gene delivery into primary murine natural killer cells
    • Tran J, Kung SK. Lentiviral vectors mediate stable and efficient gene delivery into primary murine natural killer cells. Mol Ther (2007) 15:1331-9. doi:10.1038/sj.mt.6300184
    • (2007) Mol Ther , vol.15 , pp. 1331-1339
    • Tran, J.1    Kung, S.K.2
  • 43
    • 0038745599 scopus 로고    scopus 로고
    • Progress and problems with the use of viral vectors for gene therapy
    • Thomas CE, Ehrhardt A, Kay MA. Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet (2003) 4:346-58. doi:10.1038/nrg1066
    • (2003) Nat Rev Genet , vol.4 , pp. 346-358
    • Thomas, C.E.1    Ehrhardt, A.2    Kay, M.A.3
  • 44
    • 84859443778 scopus 로고    scopus 로고
    • Retroviral integrations in gene therapy trials
    • Biasco L, Baricordi C, Aiuti A. Retroviral integrations in gene therapy trials. Mol Ther (2012) 20:709-16. doi:10.1038/mt.2011.289
    • (2012) Mol Ther , vol.20 , pp. 709-716
    • Biasco, L.1    Baricordi, C.2    Aiuti, A.3
  • 45
    • 12944260838 scopus 로고    scopus 로고
    • Characterization of stem cell factor gene-modified human natural killer cell line, NK-92 cells: implication in NK cell-based adoptive cellular immunotherapy
    • Zhang J, Sun R, Wei H, Zhang J, Tian Z. Characterization of stem cell factor gene-modified human natural killer cell line, NK-92 cells: implication in NK cell-based adoptive cellular immunotherapy. Oncol Rep (2004) 11:1097-106. doi:10.3892/or.11.5.1097
    • (2004) Oncol Rep , vol.11 , pp. 1097-1106
    • Zhang, J.1    Sun, R.2    Wei, H.3    Zhang, J.4    Tian, Z.5
  • 46
    • 0028307209 scopus 로고
    • Restoration of lytic function in a human natural killer cell line by gene transfection
    • Liu JH, Wei S, Blanchard DK, Djeu JY. Restoration of lytic function in a human natural killer cell line by gene transfection. Cell Immunol (1994) 156:24-35. doi:10.1006/cimm.1994.1150
    • (1994) Cell Immunol , vol.156 , pp. 24-35
    • Liu, J.H.1    Wei, S.2    Blanchard, D.K.3    Djeu, J.Y.4
  • 47
    • 19944427687 scopus 로고    scopus 로고
    • In vivo tracking of genetically engineered, anti-HER2/neu directed natural killer cells to HER2/neu positive mammary tumors with magnetic resonance imaging
    • Daldrup-Link HE, Meier R, Rudelius M, Piontek G, Piert M, Metz S, et al. In vivo tracking of genetically engineered, anti-HER2/neu directed natural killer cells to HER2/neu positive mammary tumors with magnetic resonance imaging. Eur Radiol (2005) 15:4-13. doi:10.1007/s00330-004-2526-7
    • (2005) Eur Radiol , vol.15 , pp. 4-13
    • Daldrup-Link, H.E.1    Meier, R.2    Rudelius, M.3    Piontek, G.4    Piert, M.5    Metz, S.6
  • 48
    • 84894325649 scopus 로고    scopus 로고
    • Transfection of chimeric anti-CD138 gene enhances natural killer cell activation and killing of multiple myeloma cells
    • Jiang H, Zhang W, Shang P, Zhang H, Fu W, Ye F, et al. Transfection of chimeric anti-CD138 gene enhances natural killer cell activation and killing of multiple myeloma cells. Mol Oncol (2014) 8:297-310. doi:10.1016/j.molonc.2013.12.001
    • (2014) Mol Oncol , vol.8 , pp. 297-310
    • Jiang, H.1    Zhang, W.2    Shang, P.3    Zhang, H.4    Fu, W.5    Ye, F.6
  • 49
    • 42449139629 scopus 로고    scopus 로고
    • Functional characterization of interleukin-15 gene transduction into the human natural killer cell line NKL
    • Jiang W, Zhang J, Tian Z. Functional characterization of interleukin-15 gene transduction into the human natural killer cell line NKL. Cytotherapy (2008) 10:265-74. doi:10.1080/14653240801965156
    • (2008) Cytotherapy , vol.10 , pp. 265-274
    • Jiang, W.1    Zhang, J.2    Tian, Z.3
  • 50
    • 84900314611 scopus 로고    scopus 로고
    • CRISPR-Cas systems for editing, regulating and targeting genomes
    • Sander JD, Joung JK. CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol (2014) 32:347-55. doi:10.1038/nbt.2842
    • (2014) Nat Biotechnol , vol.32 , pp. 347-355
    • Sander, J.D.1    Joung, J.K.2
  • 51
    • 12844272200 scopus 로고    scopus 로고
    • Targeting IL-2 to the endoplasmic reticulum confines autocrine growth stimulation to NK-92 cells
    • Konstantinidis KV, Alici E, Aints A, Christensson B, Ljunggren HG, Dilber MS. Targeting IL-2 to the endoplasmic reticulum confines autocrine growth stimulation to NK-92 cells. Exp Hematol (2005) 33:159-64. doi:10.1016/j.exphem.2004.11.003
    • (2005) Exp Hematol , vol.33 , pp. 159-164
    • Konstantinidis, K.V.1    Alici, E.2    Aints, A.3    Christensson, B.4    Ljunggren, H.G.5    Dilber, M.S.6
  • 52
    • 84900460098 scopus 로고    scopus 로고
    • hIL-15 gene-modified human natural killer cells (NKL-IL15) augments the anti-human hepatocellular carcinoma effect in vivo
    • Jiang W, Zhang C, Tian Z, Zhang J. hIL-15 gene-modified human natural killer cells (NKL-IL15) augments the anti-human hepatocellular carcinoma effect in vivo. Immunobiology (2014) 219:547-53. doi:10.1016/j.imbio.2014.03.007
    • (2014) Immunobiology , vol.219 , pp. 547-553
    • Jiang, W.1    Zhang, C.2    Tian, Z.3    Zhang, J.4
  • 53
    • 84902582355 scopus 로고    scopus 로고
    • Retargeting NK-92 cells by means of CD19- and CD20-specific chimeric antigen receptors compares favorably with antibody-dependent cellular cytotoxicity
    • Boissel L, Betancur-Boissel M, Lu W, Krause DS, Van Etten RA, Wels WS, et al. Retargeting NK-92 cells by means of CD19- and CD20-specific chimeric antigen receptors compares favorably with antibody-dependent cellular cytotoxicity. Oncoimmunology (2013) 2:e26527. doi:10.4161/onci.26527
    • (2013) Oncoimmunology , vol.2
    • Boissel, L.1    Betancur-Boissel, M.2    Lu, W.3    Krause, D.S.4    Van Etten, R.A.5    Wels, W.S.6
  • 54
    • 37349039692 scopus 로고    scopus 로고
    • Expression of a CD20-specific chimeric antigen receptor enhances cytotoxic activity of NK cells and overcomes NK-resistance of lymphoma and leukemia cells
    • Muller T, Uherek C, Maki G, Chow KU, Schimpf A, Klingemann HG, et al. Expression of a CD20-specific chimeric antigen receptor enhances cytotoxic activity of NK cells and overcomes NK-resistance of lymphoma and leukemia cells. Cancer Immunol Immunother (2008) 57:411-23. doi:10.1007/s00262-007-0383-3
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 411-423
    • Muller, T.1    Uherek, C.2    Maki, G.3    Chow, K.U.4    Schimpf, A.5    Klingemann, H.G.6
  • 55
    • 84898461706 scopus 로고    scopus 로고
    • CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma
    • Chu J, Deng Y, Benson DM, He S, Hughes T, Zhang J, et al. CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma. Leukemia (2014) 28:917-27. doi:10.1038/leu.2013.279
    • (2014) Leukemia , vol.28 , pp. 917-927
    • Chu, J.1    Deng, Y.2    Benson, D.M.3    He, S.4    Hughes, T.5    Zhang, J.6
  • 56
    • 84856267795 scopus 로고    scopus 로고
    • NK cells engineered to express a GD2 -specific antigen receptor display built-in ADCC-like activity against tumour cells of neuroectodermal origin
    • Esser R, Muller T, Stefes D, Kloess S, Seidel D, Gillies SD, et al. NK cells engineered to express a GD2 -specific antigen receptor display built-in ADCC-like activity against tumour cells of neuroectodermal origin. J Cell Mol Med (2012) 16:569-81. doi:10.1111/j.1582-4934.2011.01343.x
    • (2012) J Cell Mol Med , vol.16 , pp. 569-581
    • Esser, R.1    Muller, T.2    Stefes, D.3    Kloess, S.4    Seidel, D.5    Gillies, S.D.6
  • 57
    • 77956884540 scopus 로고    scopus 로고
    • Direct and indirect antitumor effects by human peripheral blood lymphocytes expressing both chimeric immune receptor and interleukin-2 in ovarian cancer xenograft model
    • Lee JM, Yoon SH, Kim HS, Kim SY, Sohn HJ, Oh ST, et al. Direct and indirect antitumor effects by human peripheral blood lymphocytes expressing both chimeric immune receptor and interleukin-2 in ovarian cancer xenograft model. Cancer Gene Ther (2010) 17:742-50. doi:10.1038/cgt.2010.30
    • (2010) Cancer Gene Ther , vol.17 , pp. 742-750
    • Lee, J.M.1    Yoon, S.H.2    Kim, H.S.3    Kim, S.Y.4    Sohn, H.J.5    Oh, S.T.6
  • 58
    • 84909989344 scopus 로고    scopus 로고
    • A chimeric antigen receptor for TRAIL-receptor 1 induces apoptosis in various types of tumor cells
    • Kobayashi E, Kishi H, Ozawa T, Hamana H, Nakagawa H, Jin A, et al. A chimeric antigen receptor for TRAIL-receptor 1 induces apoptosis in various types of tumor cells. Biochem Biophys Res Commun (2014) 453:798-803. doi:10.1016/j.bbrc.2014.10.024
    • (2014) Biochem Biophys Res Commun , vol.453 , pp. 798-803
    • Kobayashi, E.1    Kishi, H.2    Ozawa, T.3    Hamana, H.4    Nakagawa, H.5    Jin, A.6
  • 59
    • 84888339587 scopus 로고    scopus 로고
    • Retargeting NK-92 for anti-melanoma activity by a TCR-like single-domain antibody
    • Zhang G, Liu R, Zhu X, Wang L, Ma J, Han H, et al. Retargeting NK-92 for anti-melanoma activity by a TCR-like single-domain antibody. Immunol Cell Biol (2013) 91:615-24. doi:10.1038/icb.2013.45
    • (2013) Immunol Cell Biol , vol.91 , pp. 615-624
    • Zhang, G.1    Liu, R.2    Zhu, X.3    Wang, L.4    Ma, J.5    Han, H.6
  • 60
    • 84906783175 scopus 로고    scopus 로고
    • Bringing natural killer cells to the clinic: ex vivo manipulation
    • Childs RW, Berg M. Bringing natural killer cells to the clinic: ex vivo manipulation. Hematology Am Soc Hematol Educ Program (2013) 2013:234-46. doi:10.1182/asheducation-2013.1.234
    • (2013) Hematology Am Soc Hematol Educ Program , vol.2013 , pp. 234-246
    • Childs, R.W.1    Berg, M.2
  • 61
    • 84903995132 scopus 로고    scopus 로고
    • Expansion and homing of adoptively transferred human natural killer cells in immunodeficient mice varies with product preparation and in vivo cytokine administration: implications for clinical therapy
    • Miller JS, Rooney CM, Curtsinger J, Mcelmurry R, Mccullar V, Verneris MR, et al. Expansion and homing of adoptively transferred human natural killer cells in immunodeficient mice varies with product preparation and in vivo cytokine administration: implications for clinical therapy. Biol Blood Marrow Transplant (2014) 20:1252-7. doi:10.1016/j.bbmt.2014.05.004
    • (2014) Biol Blood Marrow Transplant , vol.20 , pp. 1252-1257
    • Miller, J.S.1    Rooney, C.M.2    Curtsinger, J.3    Mcelmurry, R.4    Mccullar, V.5    Verneris, M.R.6
  • 62
    • 84861906931 scopus 로고    scopus 로고
    • Engineering lymph node homing of ex vivo-expanded human natural killer cells via trogocytosis of the chemokine receptor CCR7
    • Somanchi SS, Somanchi A, Cooper LJ, Lee DA. Engineering lymph node homing of ex vivo-expanded human natural killer cells via trogocytosis of the chemokine receptor CCR7. Blood (2012) 119:5164-72. doi:10.1182/blood-2011-11-389924
    • (2012) Blood , vol.119 , pp. 5164-5172
    • Somanchi, S.S.1    Somanchi, A.2    Cooper, L.J.3    Lee, D.A.4
  • 63
    • 84925502725 scopus 로고    scopus 로고
    • CXCL10-induced migration of adoptively transferred human natural killer cells toward solid tumors causes regression of tumor growth in vivo
    • Wennerberg E, Kremer V, Childs R, Lundqvist A. CXCL10-induced migration of adoptively transferred human natural killer cells toward solid tumors causes regression of tumor growth in vivo. Cancer Immunol Immunother (2015) 64:225-35. doi:10.1007/s00262-014-1629-5
    • (2015) Cancer Immunol Immunother , vol.64 , pp. 225-235
    • Wennerberg, E.1    Kremer, V.2    Childs, R.3    Lundqvist, A.4
  • 64
    • 84890181067 scopus 로고    scopus 로고
    • Design and development of therapies using chimeric antigen receptor-expressing T cells
    • Dotti G, Gottschalk S, Savoldo B, Brenner MK. Design and development of therapies using chimeric antigen receptor-expressing T cells. Immunol Rev (2014) 257:107-26. doi:10.1111/imr.12131
    • (2014) Immunol Rev , vol.257 , pp. 107-126
    • Dotti, G.1    Gottschalk, S.2    Savoldo, B.3    Brenner, M.K.4
  • 65
    • 0036464719 scopus 로고    scopus 로고
    • Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene
    • Cartron G, Dacheux L, Salles G, Solal-Celigny P, Bardos P, Colombat P, et al. Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene. Blood (2002) 99:754-8. doi:10.1182/blood.V99.3.754
    • (2002) Blood , vol.99 , pp. 754-758
    • Cartron, G.1    Dacheux, L.2    Salles, G.3    Solal-Celigny, P.4    Bardos, P.5    Colombat, P.6
  • 66
    • 0642373290 scopus 로고    scopus 로고
    • Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
    • Weng WK, Levy R. Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol (2003) 21:3940-7. doi:10.1200/JCO.2003.05.013
    • (2003) J Clin Oncol , vol.21 , pp. 3940-3947
    • Weng, W.K.1    Levy, R.2
  • 67
    • 0030611089 scopus 로고    scopus 로고
    • A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease
    • Wu J, Edberg JC, Redecha PB, Bansal V, Guyre PM, Coleman K, et al. A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease. J Clin Invest (1997) 100:1059-70. doi:10.1172/JCI119616
    • (1997) J Clin Invest , vol.100 , pp. 1059-1070
    • Wu, J.1    Edberg, J.C.2    Redecha, P.B.3    Bansal, V.4    Guyre, P.M.5    Coleman, K.6
  • 68
    • 84935084557 scopus 로고    scopus 로고
    • Clinical-grade mRNA electroporation of NK cells: a novel and highly efficient method to genetically reprogram human NK cells for cancer immunotherapy
    • San Francisco
    • Carlsten M, Li L, Su S, Berg M, Reger R, Madhusudan P, et al. Clinical-grade mRNA electroporation of NK cells: a novel and highly efficient method to genetically reprogram human NK cells for cancer immunotherapy. ASH Annual Meeting Abstracts: San Francisco (2014).
    • (2014) ASH Annual Meeting Abstracts
    • Carlsten, M.1    Li, L.2    Su, S.3    Berg, M.4    Reger, R.5    Madhusudan, P.6
  • 69
  • 70
    • 84935052515 scopus 로고    scopus 로고
    • siRNA inactivation of the inhibitory receptor NKG2A augments the anti-tumor effects of adoptively transferred NK cells in tumor-bearing hosts
    • Furutani E, Su S, Smith A, Berg M, Childs R. siRNA inactivation of the inhibitory receptor NKG2A augments the anti-tumor effects of adoptively transferred NK cells in tumor-bearing hosts. ASH Annual Meeting Abstracts: Orlando (2010).
    • (2010) ASH Annual Meeting Abstracts: Orlando
    • Furutani, E.1    Su, S.2    Smith, A.3    Berg, M.4    Childs, R.5
  • 71
    • 77449104490 scopus 로고    scopus 로고
    • Introduction of shRNAs into human NK-like cell lines with retrovirus
    • Purdy AK, Campbell KS. Introduction of shRNAs into human NK-like cell lines with retrovirus. Methods Mol Biol (2010) 612:223-31. doi:10.1007/978-1-60761-362-6_15
    • (2010) Methods Mol Biol , vol.612 , pp. 223-231
    • Purdy, A.K.1    Campbell, K.S.2
  • 72
    • 0024529886 scopus 로고
    • Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene
    • Karasuyama H, Tohyama N, Tada T. Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J Exp Med (1989) 169:13-25. doi:10.1084/jem.169.1.13
    • (1989) J Exp Med , vol.169 , pp. 13-25
    • Karasuyama, H.1    Tohyama, N.2    Tada, T.3
  • 73
    • 84926433030 scopus 로고    scopus 로고
    • Improving the safety of cell therapy products by suicide gene transfer
    • Jones BS, Lamb LS, Goldman F, Di Stasi A. Improving the safety of cell therapy products by suicide gene transfer. Front Pharmacol (2014) 5:254. doi:10.3389/fphar.2014.00254
    • (2014) Front Pharmacol , vol.5 , pp. 254
    • Jones, B.S.1    Lamb, L.S.2    Goldman, F.3    Di Stasi, A.4
  • 74
    • 0030133617 scopus 로고    scopus 로고
    • A cytotoxic NK-cell line (NK-92) for ex vivo purging of leukemia from blood
    • Klingemann HG, Wong E, Maki G. A cytotoxic NK-cell line (NK-92) for ex vivo purging of leukemia from blood. Biol Blood Marrow Transplant (1996) 2:68-75.
    • (1996) Biol Blood Marrow Transplant , vol.2 , pp. 68-75
    • Klingemann, H.G.1    Wong, E.2    Maki, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.