The meditative mind: A comprehensive meta-Analysis of mri studies

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Boccia, Maddalena ^a   Piccardi, Laura ^b   Guariglia, Paola ^c,d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

^d KORE UNIVERSITY OF ENNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE BEHAVIOR; ARTICLE; AUTOREGULATION; BRAIN FUNCTION; BRAIN REGION; BRAIN SIZE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MEDITATION; MENTAL TASK; META ANALYSIS; NEUROIMAGING; PROBLEM SOLVING; SELF CONCEPT; ATTENTION; BRAIN; BRAIN MAPPING; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSIOLOGY;

ATTENTION; BRAIN; BRAIN MAPPING; HUMANS; MAGNETIC RESONANCE IMAGING; MEDITATION; NEUROIMAGING;

EID: 84935022976     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/419808     Document Type: Article

References (97)

1. B. Tomasino, A. Chiesa, and F. Fabbro, "Disentangling the neural mechanisms involved in Hinduism-And Buddhism-related meditations, " Brain and Cognition, vol. 90, pp. 32-40, 2014
2. R. J. Davidson and D. J. Goleman, "The role of attention in meditation and hypnosis: a psychobiological perspective on transformations of consciousness, " International Journal ofClinical and Experimental Hypnosis, vol. 25, no. 4, pp. 291-308, 1977
3. J. and resen, "Meditationmeets behaviouralmedicine: the story of experimental research on meditation, " Journal of Consciousness Studies, vol. 7, no. 11-12, pp. 17-73, 2000
4. B. A. Wallace, "The Buddhist tradition of Samatha:methods for refining and examining consciousness, " Journal of Consciousness Studies, vol. 6, no. 3, pp. 175-187, 1999
5. K. W. Brown and R. M. Ryan, "The benefits of being present: mindfulness and its role in psychological well-being, " Journal of Personality and Social Psychology, vol. 84, no. 4, pp. 822-848, 2003
6. E. Luders, A. W. Toga, N. Lepore, and C. Gaser, "The underlying anatomical correlates of long-term meditation: larger hippocampal and frontal volumes of gray matter, " NeuroImage, vol. 45, no. 3, pp. 672-678, 2009
7. A. P. Jha, E. A. Stanley, A. Kiyonaga, L. Wong, and L. Gelf and , "Examining the protective effects of mindfulness training on working memory capacity and affective experience, " Emotion, vol. 10, no. 1, pp. 54-64, 2010
8. A. P. Jha, J. Krompinger, and M. J. Baime, "Mindfulness training modifies subsystems of attention, " Cognitive, Affective and Behavioral Neuroscience, vol. 7, no. 2, pp. 109-119, 2007
9. N. Srinivasan and S. Baijal, "Concentrativemeditation enhances preattentive processing: a mismatch negativity study, " NeuroReport, vol. 18, no. 16, pp. 1709-1712, 2007
10. K. A. MacLean, E. Ferrer, S. R. Aichele et al., "Intensive meditation training improves perceptual discrimination and sustained attention, " Psychological Science, vol. 21, no. 6, pp. 829-839, 2010
11. P. Condon, G. Desbordes, W. B. Miller, and D. DeSteno, "Meditation increases compassionate responses to suffering, " Psychological Science, vol. 24, no. 10, pp. 2125-2127, 2013
12. B. K. Hlzel, U. Ott, H. Hempel et al., "Differential engagement of anterior cingulate and adjacentmedial frontal cortex in adept meditators and non-meditators, " Neuroscience Letters, vol. 421, no. 1, pp. 16-21, 2007
13. A. Lutz, J. Dunne, and R. Davidson, "Meditation and the neuroscience of consciousness: an introduction, " in The Cambridge H and book of Consciousness, P. Zelazo, M. Moscovitch, and E. Thompson, Eds., pp. 499-554, Cambridge University Press, Cambridge, UK, 2007
14. A. Lutz, H.A. Slagter, J.D. Dunne, and R. J. Davidson, "Attention regulation and monitoring in meditation, " Trends in Cognitive Sciences, vol. 12, no. 4, pp. 163-169, 2008
15. A. Chiesa, R. Calati, and A. Serretti, "Does mindfulness training improve cognitive abilities A systematic review of neuropsychological findings, " Clinical Psychology Review, vol. 31, no. 3, pp. 449-464, 2011
16. R. Chambers, B. C. Y. Lo, and N. B. Allen, "The impact of intensive mindfulness training on attentional control, cognitive style, and affect, " CognitiveTherapy and Research, vol. 32, no. 3, pp. 303-322, 2008
17. H. A. Slagter, A. Lutz, L. L. Greischar et al., "Mental training affects distribution of limited brain resources, " PLoS Biology, vol. 5, no. 6, article e138, 2007
18. F. Zeidan, S. K. Johnson, B. J. Diamond, Z. David, and P. Goolkasian, "Mindfulness meditation improves cognition: evidence of brief mental training, " Consciousness and Cognition, vol. 19, no. 2, pp. 597-605, 2010
19. E. Hargus, C. Crane, T. Barnhofer, and J. M. G. Williams, "Effects of mindfulness on meta-Awareness and specificity of describing prodromal symptoms in suicidal depression, " Emotion, vol. 10, no. 1, pp. 34-42, 2010
20. A. Heeren, N. van Broeck, and P. Philippot, "The effects of mindfulness on executive processes and autobiographical memory specificity, " Behaviour Research and Therapy, vol. 47, no. 5, pp. 403-409, 2009
21. C. N. M. Ortner, S. J. Kilner, and P. D. Zelazo, "Mindfulness meditation and reduced emotional interference on a cognitive task, " Motivation and Emotion, vol. 31, no. 4, pp. 271-283, 2007
22. T. Gard, B. K. Holzel, and S. W. Lazar, "The potential effects of meditation on age-related cognitive decline: a systematic review, " Annals of the New York Academy of Sciences, vol. 1307, no. 1, pp. 89-103, 2014
23. E. Larouche, C. Hudon, and S. Goulet, "Potential benefits of mindfulness-based interventions in mild cognitive impairment and Alzheimer's disease: an interdisciplinary perspective, " Behavioural Brain Research, vol. 276, pp. 199-212, 2015
24. E. Luders, F. Kurth, A. W. Toga, K. L. Narr, and C. Gaser, "Meditation effects within the hippocampal complex revealed by voxel-basedmorphometry and cytoarchitectonic probabilistic mapping, " Frontiers in Psychology, vol. 4, article 398, 2013
25. C. D. Conrad, K. J. McLaughlin, J. S. Harman et al., "Chronic glucocorticoids increase hippocampal vulnerability to neurotoxicity under conditions that produce CA3 dendritic retraction but fail to impair spatial recognition memory, " Journal of Neuroscience, vol. 27, no. 31, pp. 8278-8285, 2007
26. R. A. Baer, "Mindfulness training as a clinical intervention: a conceptual and empirical review, " Clinical Psychology: Science and Practice, vol. 10, no. 2, pp. 125-143, 2003
27. P. Grossman, L. Niemann, S. Schmidt, and H. Walach, "Mindfulness-based stress reduction and health benefits: a metaanalysis, " Journal of Psychosomatic Research, vol. 57, no. 1, pp. 35-43, 2004
28. A. P. King, T. M. Erickson, N. D. Giardino et al., "A pilot study of group mindfulness-based cognitive therapy (MBCT) for combat veteranswith posttraumatic stress disorder (PTSD), " Depression and Anxiety, vol. 30, no. 7, pp. 638-645, 2013
29. S. H. Ma and J. D. Teasdale, "Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects, " Journal of Consulting and Clinical Psychology, vol. 72, no. 1, pp. 31-40, 2004
30. J. D. Teasdale, Z. V. Segal, J. M. G. Williams, V. A. Ridgewaya, J. M. Soulsby, and M. A. Lau, "Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy, " Journal of Consulting and Clinical Psychology, vol. 68, no. 4, pp. 615-623, 2000
31. W. Kuyken, S. Byford, R. S. Taylor et al., "Mindfulness-based cognitive therapy to prevent relapse in recurrent depression, " Journal of Consulting and Clinical Psychology, vol. 76, no. 6, pp. 966-978, 2008
32. J. A. Brewer and K. A. Garrison, "The posterior cingulate cortex as a plausible mechanistic target of meditation: findings from neuroimaging, " Annals of theNew York Academy of Sciences, vol. 1307, no. 1, pp. 19-27, 2014
33. J. Xu, A. Vik, I. R. Groote et al., "Nondirectivemeditation activates default mode network and areas associated with memory retrieval and emotional processing, " Frontiers in Human Neuroscience, vol. 8, article 86, 2014
34. S. Davanger, Ellingsen, A. Holen, and K. Hugdahl, "Meditation-specific prefrontal cortical activation during Acem meditation: an fMRI study, " Perceptual and Motor Skills, vol. 111, no. 1, pp. 291-306, 2010
35. J. Dickenson, E. T. Berkman, J. Arch, and M. D. Lieberman, "Neural correlates of focused attention during a brief mindfulness induction, " Social Cognitive and Affective Neuroscience, vol. 8, no. 1, Article IDnss030, pp. 40-47, 2013
36. M. Engstrm, J. Pihlsgard, P. Lundberg, and B. Sderfeldt, "Functional magnetic resonance imaging of hippocampal activation during silentmantrameditation, " The Journal of Alternative and ComplementaryMedicine, vol. 16, no. 12, pp. 1253-1258, 2010
37. M. Allen, M. Dietz, K. S. Blair et al., "Cognitive-Affective neural plasticity following active-controlled mindfulness intervention, " Journal of Neuroscience, vol. 32, no. 44, pp. 15601-15610, 2012
38. J. A. Grant, J. Courtemanche, and P. Rainville, "A non-elaborativemental stance and decoupling of executive and pain-related cortices predicts low pain sensitivity in Zen meditators, " Pain, vol. 152, no. 1, pp. 150-156, 2011
39. A. Lutz, D. R. McFarlin, D. M. Perlman, T. V. Salomons, and R. J. Davidson, "Altered anterior insula activation during anticipation and experience of painful stimuli in expert meditators, " NeuroImage, vol. 64, no. 1, pp. 538-546, 2013
40. J. S. Mascaro, J. K. Rilling, L. T. Negi, and C. L. Raison, "Pre-existing brain function predicts subsequent practice of mindfulness and compassion meditation, " NeuroImage, vol. 69, pp. 35-42, 2013
41. J. S. Mascaro, J. K. Rilling, L. Tenzin Negi, and C. L. Raison, "Compassion meditation enhances empathic accuracy and related neural activity, " Social Cognitive and Affective Neuroscience, vol. 8, no. 1, Article ID nss095, pp. 48-55, 2013
42. N. A. S. Farb, Z. V. Segal, H. Mayberg et al., "Attending to the present: Mindfulness meditation reveals distinct neural modes of self-reference, " Social Cognitive and Affective Neuroscience, vol. 2, no. 4, pp. 313-322, 2007
43. W. Hasenkamp, C. D. Wilson-Mendenhall, E. Duncan, and L. W. Barsalou, "Mind w and ering and attention during focused meditation: a fine-grained temporal analysis of fluctuating cognitive states, " NeuroImage, vol. 59, no. 1, pp. 750-760, 2012
44. J. A. Brefczynski-Lewis, A. Lutz, H. S. Schaefer, D. B. Levinson, and R. J. Davidson, "Neural correlates of attentional expertise in long-termmeditation practitioners, " Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 27, pp. 11483-11488, 2007
45. V.A. Taylor, J. Grant, V. Daneault et al., "Impact ofmindfulness on the neural responses to emotional pictures in experienced and beginner meditators, " NeuroImage, vol. 57, no. 4, pp. 1524-1533, 2011
46. Y.-Y. Tang, R. Tang, and M. I. Posner, "Brief meditation training induces smoking reduction, " Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 34, pp. 13971-13975, 2013
47. A. Guleria, U. Kumar, S. S. K. Kishan, and C. L. Khetrapal, "Effect of "SOHAM" meditation on the human brain: an fMRI study, " Psychiatry Research-Neuroimaging, vol. 214, no. 3, pp. 462-465, 2013
48. B. K. Hlzel, J. Carmody, M. Vangel et al., "Mindfulness practice leads to increases in regional brain graymatter density, " Psychiatry Research-Neuroimaging, vol. 191, no. 1, pp. 36-43, 2011
49. D.-H. Kang, H. J. Jo, W. H. Jung et al., "The effect of meditation on brain structure: cortical thickness mapping and diffusion tensor imaging, " Social Cognitive and AffectiveNeuroscience, vol. 8, no. 1, Article IDnss056, pp. 27-33, 2013
50. F. Kurth, A. Mackenzie-Graham, A. W. Toga, and E. Luders, "Shifting brain asymmetry: the link between meditation and structural lateralization, " Social Cognitive and Affective Neuroscience, vol. 8, pp. 27-33, 2014
51. M.-K. Leung, C. C.H. Chan, J. Yin, C.-F. Lee, K.-F. So, and T. M. C. Lee, "Increased gray matter volume in the right angular and posterior parahippocampal gyri in loving-kindnessmeditators, " Social Cognitive&Affective Neuroscience, vol. 8, no. 1, pp. 34-39, 2013
52. E. Luders, A. W. Toga, N. Lepore, and C. Gaser, "The underlying anatomical correlates of long-term meditation: larger hippocampal and frontal volumes of gray matter, " NeuroImage, vol. 45, no. 3, pp. 672-678, 2009
53. P. Vestergaard-Poulsen, M. Van Beek, J. Skewes et al., "Longterm meditation is associated with increased gray matter density in the brain stem, " NeuroReport, vol. 20, no. 2, pp. 170-174, 2009
54. G.-X. Wei, T. Xu, F.-M. Fan et al., "Can taichi reshape the brain? A brain morphometry study, " PLoS ONE, vol. 8, no. 4, Article ID e61038, 2013
55. H. C. Lou, T. W. Kjaer, L. Friberg, G. Wildschiodtz, S. Holm, and M. Nowak, "A 15O-H2O PET study of meditation and the resting state of normal consciousness, " Human Brain Mapping, vol. 7, no. 2, pp. 98-105, 1999
56. A. Manna, A. Raffone, M. G. Perrucci et al., "Neural correlates of focused attention and cognitive monitoring in meditation, " Brain Research Bulletin, vol. 82, no. 1-2, pp. 46-56, 2010
57. M. Sperduti, P. Martinelli, and P. Piolino, "A neurocognitive model of meditation based on activation likelihood estimation (ALE) meta-Analysis, " Consciousness and Cognition, vol. 21, no. 1, pp. 269-276, 2012
58. S. B. Eickhoff, A. R. Laird, C. Grefkes, L. E. Wang, K. Zilles, and P. T. Fox, "Coordinate-based activation likelihood estimation meta-Analysis of neuroimaging data: a r and om-effects approach based on empirical estimates of spatial uncertainty, " Human Brain Mapping, vol. 30, no. 9, pp. 2907-2926, 2009
59. A. E. Cavanna and M. R. Trimble, "The precuneus: a review of its functional anatomy and behavioural correlates, " Brain, vol. 129, no. 3, pp. 564-583, 2006
60. K. C. R. Fox, S. Nijeboer, M. L. Dixon et al., "Is meditation associated with altered brain structureAsystematic review and meta-Analysis of morphometric neuroimaging in meditation practitioners, " Neuroscience &Biobehavioral Reviews, vol. 43, pp. 48-73, 2014
61. A. D. Craig, "How do you feel? Interoception: the sense of the physiological condition of the body, " Nature Reviews Neuroscience, vol. 3, no. 8, pp. 655-666, 2002
62. M. L. Seghier, "The angular gyrus: multiple functions and multiple subdivisions, " Neuroscientist, vol. 19, no. 1, pp. 43-61, 2013
63. D.R. Vago and S. A. David, "Self-Awareness, self-regulation, and self-transcendence (S-ART): a framework for underst and ing the neurobiological mechanisms of mindfulness, " Frontiers in Human Neuroscience, vol. 6, no. 296, pp. 1-30, 2012
64. G. Northoff, A. Heinzel, M. de Greck, F. Bermpohl, H. Dobrowolny, and J. Panksepp, "Self-referential processing in our brain-A meta-Analysis of imaging studies on the self, " Neuroimage, vol. 31, no. 1, pp. 440-457, 2006
65. L. van der Meer, S. Costafreda, A. Aleman, and A. S. David, "Self-reflection and the brain: a theoretical review and meta-Analysis of neuroimaging studies with implications for schizophrenia, " Neuroscience and Biobehavioral Reviews, vol. 34, no. 6, pp. 935-946, 2010
66. S. Whitfield-Gabrieli, J. M. Moran, A. Nieto-Castann, C. Triantafyllou, R. Saxe, and J. D. E. Gabrieli, "Associations and dissociations between default and self-reference networks in the human brain, " NeuroImage, vol. 55, no. 1, pp. 225-232, 2011
67. N. David, B. H. Bewernick, M. X. Cohen et al., "Neural representations of self versus other: visual-spatial perspective taking and agency in a virtual ball-tossing game, " Journal of Cognitive Neuroscience, vol. 18, no. 6, pp. 898-910, 2006
68. M. Beauregard, J. Lvesque, and P. Bourgouin, "Neural correlates of conscious self-regulation of emotion, " The Journal of Neuroscience, vol. 21, no. 18, Article ID RC165, 2001
69. C. S. Carter, M. Mintun, and J. D. Cohen, "Interference and facilitation effects during selective attention: an H2 15O PET study of stroop task performance, " NeuroImage, vol. 2, no. 4, pp. 264-272, 1995
70. J. Levesque, F. Eugene, Y. Joanette et al., "Neural circuitry underlying voluntary suppression of sadness, " Biological Psychiatry, vol. 53, no. 6, pp. 502-510, 2003
71. A.W. MacDonald , J.D. Cohen, V. A. Stenger, and C. S. Carter, "Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control, " Science, vol. 288, no. 5472, pp. 1835-1838, 2000
72. M. I. Posner and S. E. Petersen, "The attention system of the human brain, " Annual Review of Neuroscience, vol. 13, pp. 25-42, 1990
73. W. B. Scoville and B. Milner, "Loss of recentmemory after bilateral hippocampal lesions, " Journal of Neurology, Neurosurgery& Psychiatry, vol. 20, no. 1, pp. 11-21, 1957
74. L. R. Squire and S. Zola-Morgan, "The medial temporal lobe memory system, " Science, vol. 253, no. 5026, pp. 1380-1386, 1991
75. M.D. Barense, R.N. A. Henson, A. C.H. Lee, and K. S. Graham, "Medial temporal lobe activity during complex discrimination of faces, objects, and scenes: effects of viewpoint, " Hippocampus, vol. 20, no. 3, pp. 389-401, 2010
76. R. K. Lech and B. Suchan, "The medial temporal lobe:memory and beyond, " Behavioural Brain Research, vol. 254, pp. 45-49, 2013
77. T. Kircher, V. Arolt, A. Jansen et al., "Effect of cognitivebehavioral therapy on neural correlates of fear conditioning in panic disorder, " Biological Psychiatry, vol. 73, no. 1, pp. 93-101, 2013
78. G. L. Shulman, J. A. Fiez, M. Corbetta et al., "Common blood flow changes across visual tasks: II. Decreases in cerebral cortex, " Journal of Cognitive Neuroscience, vol. 9, no. 5, pp. 648-663, 1997
79. R. C. Gur, L. H. Mozley, P. D. Mozley et al., "Sex differences in regional cerebral glucose metabolism during a resting state, " Science, vol. 267, no. 5197, pp. 528-531, 1995
80. J. R. Binder, J. A. Frost, T. A. Hammeke, P. S. F. Bellgowan, S. M. Rao, and R. W. Cox, "Conceptual processing during the conscious resting state: a functional MRI study, " Journal of Cognitive Neuroscience, vol. 11, no. 1, pp. 80-95, 1999
81. C. Sol-Padulls, D. Bartrs-Faz, C. Junqu et al., "Brain structure and function related to cognitive reserve variables in normal aging, mild cognitive impairment and Alzheimer's disease, " Neurobiology ofAging, vol. 30, no. 7, pp. 1114-1124, 2009
82. F. M. Howells, V. L. Ives-Deliperi, N. R. Horn, and D. J. Stein, "Mindfulness based cognitive therapy improves frontal control in bipolar disorder: a pilot EEG study, " BMC Psychiatry, vol. 12, article 15, 2012
83. H. F. Coelho, P. H. Canter, and E. Ernst, "Mindfulness-based cognitive therapy: evaluating current evidence and informing future research, " Journal of Consulting and Clinical Psychology, vol. 75, no. 6, pp. 1000-1005, 2007
84. Y. W. Kim, S.-H. Lee, T. K. Choi et al., "Effectiveness of mindfulness-based cognitive therapy as an adjuvant to pharmacotherapy in patients with panic disorder or generalized anxiety disorder, "Depression&Anxiety, vol. 26, no. 7, pp.601-606, 2009
85. S. Bowen, K. Witkiewitz, T. M. Dillworth et al., "Mindfulness meditation and substance use in an incarcerated population, " Psychology of Addictive Behaviors, vol. 20, no. 3, pp. 343-347, 2006
86. J. D. Creswell, B. M. Way, N. I. Eisenberger, and M. D. Lieberman, "Neural correlates of dispositional mindfulness during affect labeling, " Psychosomatic Medicine, vol. 69, no. 6, pp. 560-565, 2007
87. X. Ding, Y. Y. Tang, C. Cao et al., "Short-term meditation modulates brain activity of insight evoked with solution cue, " Social Cognitive and Affective Neuroscience, 2014
88. N. A. S. Farb, A. K. Anderson, H. Mayberg, J. Bean, D. McKeon, and Z. V. Segal, "Minding one's emotions: mindfulness training alters the neural expression of sadness, " Emotion, vol. 10, no. 1, pp. 25-33, 2010
89. N. A. S. Farb, Z. V. Segal, and A. K. Anderson, "Mindfulness meditation training alters cortical representations of interoceptive attention, " Social Cognitive and Affective Neuroscience, vol. 8, no. 1, Article IDnss066, pp. 15-26, 2013
90. V. L. Ives-Deliperi, M. Solms, and E. M. Meintjes, "The neural substrates of mindfulness: an fMRI investigation, " Social Neuroscience, vol. 6, no. 3, pp. 231-242, 2011
91. J. H. Jang, W.H. Jung, D. H. Kang et al., "Increased defaultmode network connectivity associated withmeditation, " Neuroscience Letters, vol. 487, no. 3, pp. 358-362, 2011
92. L. A. Kilpatrick, B. Y. Suyenobu, S. R. Smith et al., "Impact of mindfulness-based stress reduction training on intrinsic brain connectivity, " NeuroImage, vol. 56, no. 1, pp. 290-298, 2011
93. T. M. C. Lee, M.-K. Leung, W.-K. Hou et al., "Distinct neural activity associated with focused-Attention meditation and loving-kindnessmeditation, " PLoS ONE, vol. 7, no. 8, Article ID e40054, 2012
94. A. Lutz, L. L. Greischar, D. M. Perlman, and R. J. Davidson, "BOLD signal in insula is differentially related to cardiac function during compassion meditation in experts vs. novices, " NeuroImage, vol. 47, no. 3, pp. 1038-1046, 2009
95. D. A. Monti, K. M. Kash, E. J. S. Kunkel et al., "Changes in cerebral blood flow and anxiety associated with an 8-week mindfulness programme in women with breast cancer, " Stress and Health, vol. 28, no. 5, pp. 397-407, 2012
96. D. W. Orme-Johnson, R. H. Schneider, Y. D. Son, S. Nidich, and Z.-H. Cho, "Neuroimaging of meditation's effect on brain reactivity to pain, " NeuroReport, vol. 17, no. 12, pp. 1359-1363, 2006
97. D. J. J. Wang, H. Rao, M. Korczykowski et al., "Cerebral blood flow changes associated with different meditation practices and perceived depth of meditation, " Psychiatry Research-Neuroimaging, vol. 191, no. 1, pp. 60-67, 2011