A hypothetical astrocyte–microglia lactate shuttle derived from a 1H NMR metabolomics analysis of cerebrospinal fluid from a cohort of South African children with tuberculous meningitis

Metabolomics

Volumn 11, Issue 4, 2015, Pages 822-837

  Mason, Shayne ^a   van Furth, A Marceline ^b   Mienie, Lodewyk J ^a   Engelke, Udo F H ^c   Wevers, Ron A ^c   Solomons, Regan ^d   Reinecke, Carolus J ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Cerebrospinal fluid (CSF); Nuclear magnetic resonance (NMR) metabolomics; Tuberculous meningitis (TBM); Astrocyte microglia lactate shuttle (AMLS) hypothesis

Indexed keywords

2 OXOGLUTARIC ACID; 3 HYDROXYBUTYRIC ACID; ACETIC ACID; ACETOACETIC ACID; ACETONE; ALANINE; ALCOHOL; BETAINE; CHOLINE; CITRIC ACID; CREATINE; CREATININE; DIMETHYL SULFONE; FORMIC ACID; GLUCOSE; GLUTAMINE; INOSITOL; ISOLEUCINE; LACTIC ACID; LEUCINE; LYSINE; MANNOSE; PHENYLALANINE; PROPYLENE GLYCOL; PYRUVIC ACID; SUCCINIC ACID; THREONINE; TYROSINE; UNINDEXED DRUG; VALINE;

ARTICLE; ASTROCYTE; CEREBROSPINAL FLUID ANALYSIS; CHEMOMETRIC ANALYSIS; CHILD; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; ENERGY METABOLISM; FEEDBACK SYSTEM; HUMAN; IMMUNE RESPONSE; INFANT; METABOLITE; METABOLOMICS; MICROGLIA; PEDIATRICS; PROTON NUCLEAR MAGNETIC RESONANCE; SCHOOL CHILD; SOUTH AFRICAN; TUBERCULOUS MENINGITIS;

EID: 84934999646     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-014-0741-z     Document Type: Article

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