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Volumn 2014, Issue , 2014, Pages

The Role of the Blood-Brain Barrier in the Pathogenesis of Senile Plaques in Alzheimer's Disease

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CARRIER PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LIPOPROTEIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MULTIDRUG RESISTANCE PROTEIN; VASCULOTROPIN;

EID: 84934986449     PISSN: 20908024     EISSN: 20900252     Source Type: Journal    
DOI: 10.1155/2014/191863     Document Type: Article
Times cited : (50)

References (34)
  • 1
    • 0042309247 scopus 로고
    • Neuritic (senile) and amyloid plaques
    • B. Reisberg, Ed., Free Press, New York, NY, USA
    • H. M. Wisniewski, "Neuritic (senile) and amyloid plaques", in Alzheimer's Disease, B. Reisberg, Ed., pp. 57-61, Free Press, New York, NY, USA, 1983.
    • (1983) Alzheimer's Disease , pp. 57-61
    • Wisniewski, H.M.1
  • 2
    • 47549088485 scopus 로고    scopus 로고
    • Distinct pools of β-amyloid in Alzheimer disease-affected brain: A clinicopathologic study
    • J. R. Steinerman, M. Irizarry, N. Scarmeas et al., "Distinct pools of β-amyloid in Alzheimer disease-affected brain: a clinicopathologic study", Archives of Neurology, vol. 65, no. 7, pp. 906-912, 2008.
    • (2008) Archives of Neurology , vol.65 , Issue.7 , pp. 906-912
    • Steinerman, J.R.1    Irizarry, M.2    Scarmeas, N.3
  • 3
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • J. A. Hardy and G. A. Higgins, "Alzheimer's disease: the amyloid cascade hypothesis", Science, vol. 256, no. 5054, pp. 184-185, 1992.
    • (1992) Science , vol.256 , Issue.5054 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 4
    • 67349142021 scopus 로고    scopus 로고
    • Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    • R. D. Bell and B. V. Zlokovic, "Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease", Acta Neuropathologica, vol. 118, no. 1, pp. 103-113, 2009.
    • (2009) Acta Neuropathologica , vol.118 , Issue.1 , pp. 103-113
    • Bell, R.D.1    Zlokovic, B.V.2
  • 5
    • 78649518938 scopus 로고    scopus 로고
    • The case for blood-brain barrier dysfunction in the pathogenesis of Alzheimer's disease
    • B. Jeynes and J. Provias, "The case for blood-brain barrier dysfunction in the pathogenesis of Alzheimer's disease", Journal of Neuroscience Research, vol. 89, no. 1, pp. 22-28, 2011.
    • (2011) Journal of Neuroscience Research , vol.89 , Issue.1 , pp. 22-28
    • Jeynes, B.1    Provias, J.2
  • 6
    • 84885018413 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease
    • M. A. Erickson and W. A. Banks, "Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease", Journal of Cerebral Blood Flow and Metabolism, vol. 33, no. 10, pp. 1500-1513, 2013.
    • (2013) Journal of Cerebral Blood Flow and Metabolism , vol.33 , Issue.10 , pp. 1500-1513
    • Erickson, M.A.1    Banks, W.A.2
  • 7
    • 0035047718 scopus 로고    scopus 로고
    • Cerebral microvascular pathology in aging and Alzheimer's disease
    • E. Farkas and P. G. M. Luiten, "Cerebral microvascular pathology in aging and Alzheimer's disease", Progress in Neurobiology, vol. 64, no. 6, pp. 575-611, 2001.
    • (2001) Progress in Neurobiology , vol.64 , Issue.6 , pp. 575-611
    • Farkas, E.1    Luiten, P.G.M.2
  • 8
    • 33749143872 scopus 로고    scopus 로고
    • The possible role of capillary cerebral amyloid angiopathy in Alzheimer lesion development: A regional comparison
    • B. Jeynes and J. Provias, "The possible role of capillary cerebral amyloid angiopathy in Alzheimer lesion development: a regional comparison", Acta Neuropathologica, vol. 112, no. 4, pp. 417-427, 2006.
    • (2006) Acta Neuropathologica , vol.112 , Issue.4 , pp. 417-427
    • Jeynes, B.1    Provias, J.2
  • 9
    • 84878887419 scopus 로고    scopus 로고
    • Amyloid-β interacts with blood-brain barrier function in dementia: A systematic review
    • S. Burgmans, H. J. Van De Haar, F. R. J. Verhey, and W. H. Backes, "Amyloid-β interacts with blood-brain barrier function in dementia: a systematic review", Journal of Alzheimer's Disease, vol. 35, no. 4, pp. 859-873, 2013.
    • (2013) Journal of Alzheimer's Disease , vol.35 , Issue.4 , pp. 859-873
    • Burgmans, S.1    Van De Haar, H.J.2    Verhey, F.R.J.3    Backes, W.H.4
  • 10
    • 77957963537 scopus 로고    scopus 로고
    • Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging
    • G. D. Silverberg, A. A. Messier, M. C. Miller et al., "Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging", Journal of Neuropathology and Experimental Neurology, vol. 69, no. 10, pp. 1034-1043, 2010.
    • (2010) Journal of Neuropathology and Experimental Neurology , vol.69 , Issue.10 , pp. 1034-1043
    • Silverberg, G.D.1    Messier, A.A.2    Miller, M.C.3
  • 11
    • 53549086409 scopus 로고    scopus 로고
    • Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis
    • B. Jeynes and J. Provias, "Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis", Current Alzheimer Research, vol. 5, no. 5, pp. 432-437, 2008.
    • (2008) Current Alzheimer Research , vol.5 , Issue.5 , pp. 432-437
    • Jeynes, B.1    Provias, J.2
  • 12
    • 0036167595 scopus 로고    scopus 로고
    • Increased intrathecal levels of the angiogenic factors VEGF and TGF-β in Alzheimer's disease and vascular dementia
    • E. Tarkowski, R. Issa, M. Sjögren et al., "Increased intrathecal levels of the angiogenic factors VEGF and TGF-β in Alzheimer's disease and vascular dementia", Neurobiology of Aging, vol. 23, no. 2, pp. 237-243, 2002.
    • (2002) Neurobiology of Aging , vol.23 , Issue.2 , pp. 237-243
    • Tarkowski, E.1    Issa, R.2    Sjögren, M.3
  • 13
    • 84881372319 scopus 로고    scopus 로고
    • Decreased serum levels of the angiogenic factors VEGF and TGF-β1 in Alzheimer's disease and amnesticmild cognitive impairment
    • L. Huang, J. Jia, and R. Liu, "Decreased serum levels of the angiogenic factors VEGF and TGF-β1 in Alzheimer's disease and amnesticmild cognitive impairment", Neuroscience Letters, vol. 550, no. 6, pp. 60-63, 2013.
    • (2013) Neuroscience Letters , vol.550 , Issue.6 , pp. 60-63
    • Huang, L.1    Jia, J.2    Liu, R.3
  • 14
    • 84874324519 scopus 로고    scopus 로고
    • Neurovascular unit and the effects of dosage in VEGF toxicity: Role for oxidative stress and thrombin
    • A. Sanchez, D. Tripathy, J. Luo, X. Yin, J. Martinez, and P. Grammas, "Neurovascular unit and the effects of dosage in VEGF toxicity: role for oxidative stress and thrombin", Journal of Alzheimer's Disease, vol. 34, no. 1, pp. 281-291, 2013.
    • (2013) Journal of Alzheimer's Disease , vol.34 , Issue.1 , pp. 281-291
    • Sanchez, A.1    Tripathy, D.2    Luo, J.3    Yin, X.4    Martinez, J.5    Grammas, P.6
  • 15
    • 80055112704 scopus 로고    scopus 로고
    • The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis
    • J. Zhao, T. O'Connor, and R. Vassar, "The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis", Journal of Neuroinflammation, vol. 8, article 150, 2011.
    • (2011) Journal of Neuroinflammation , vol.8
    • Zhao, J.1    O'Connor, T.2    Vassar, R.3
  • 16
    • 84872233407 scopus 로고    scopus 로고
    • Tight junctions at the blood brain barrier: Physiological architecture and disease-associated dysregulation
    • A.-C. Luissint, C. Artus, F. Glacial, K. Ganeshamoorthy, and P.-O. Couraud, "Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation", Fluids and Barriers of the CNS, vol. 9, no. 1, article 23, 2012.
    • (2012) Fluids and Barriers of the CNS , vol.9 , Issue.1
    • Luissint, A.-C.1    Artus, C.2    Glacial, F.3    Ganeshamoorthy, K.4    Couraud, P.-O.5
  • 17
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimerrelated changes
    • H. Braak and E. Braak, "Neuropathological stageing of Alzheimerrelated changes", Acta Neuropathologica, vol. 82, no. 4, pp. 239-259, 1991.
    • (1991) Acta Neuropathologica , vol.82 , Issue.4 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 18
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • S. S. Mirra, A. Heyman, D. McKeel et al., "The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease", Neurology, vol. 41, no. 4, pp. 479-486, 1991.
    • (1991) Neurology , vol.41 , Issue.4 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3
  • 19
    • 77950664220 scopus 로고    scopus 로고
    • Transporters in the brain endothelial barrier
    • M. Ueno, T. Nakagawa, B. Wu et al., "Transporters in the brain endothelial barrier", Current Medicinal Chemistry, vol. 17, no. 12, pp. 1125-1138, 2010.
    • (2010) Current Medicinal Chemistry , vol.17 , Issue.12 , pp. 1125-1138
    • Ueno, M.1    Nakagawa, T.2    Wu, B.3
  • 20
    • 84891709799 scopus 로고    scopus 로고
    • VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival
    • P. Religa, R. Cao, D. Religa et al., "VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival", Scientific Reports, vol. 3, no. 3, article 2053, 2013.
    • (2013) Scientific Reports , vol.3 , Issue.3
    • Religa, P.1    Cao, R.2    Religa, D.3
  • 21
    • 79953075804 scopus 로고    scopus 로고
    • Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease
    • P. Grammas, "Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease", Journal of Neuroinflammation, vol. 8, article 26, 2011.
    • (2011) Journal of Neuroinflammation , vol.8
    • Grammas, P.1
  • 23
    • 84866464632 scopus 로고    scopus 로고
    • LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in alzheimer's disease
    • C. Spuch, S. Ortolano, and C. Navarro, "LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in alzheimer's disease", Frontiers in Physiology, vol. 3, article 269, 2012.
    • (2012) Frontiers in Physiology , vol.3
    • Spuch, C.1    Ortolano, S.2    Navarro, C.3
  • 24
    • 84865575547 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein 1: A physiological Aβ homeostatic mechanism with multiple therapeutic opportunities
    • A. P. Sagare, R. Deane, and B. V. Zlokovic, "Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities", Pharmacology & Therapeutics, vol. 136, no. 1, pp. 94-105, 2012.
    • (2012) Pharmacology & Therapeutics , vol.136 , Issue.1 , pp. 94-105
    • Sagare, A.P.1    Deane, R.2    Zlokovic, B.V.3
  • 26
    • 84896870717 scopus 로고    scopus 로고
    • LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo
    • T. Grimmer, O. Goldhardt, L.-H. Guo et al., "LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo", Neuro Image: Clinical, vol. 4, pp. 411-416, 2014.
    • (2014) Neuro Image: Clinical , vol.4 , pp. 411-416
    • Grimmer, T.1    Goldhardt, O.2    Guo, L.-H.3
  • 27
    • 0033762062 scopus 로고    scopus 로고
    • Modulation of amyloid β-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway
    • D. E. Kang, C. U. Pietrzik, L. Baum et al., "Modulation of amyloid β-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway", The Journal of Clinical Investigation, vol. 106, no. 9, pp. 1159-1166, 2000.
    • (2000) The Journal of Clinical Investigation , vol.106 , Issue.9 , pp. 1159-1166
    • Kang, D.E.1    Pietrzik, C.U.2    Baum, L.3
  • 28
    • 67849099661 scopus 로고    scopus 로고
    • Testing the neurovascular hypothesis of alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-β protein, and impairs cognition
    • L. B. Jaeger, S. Dohgu, M. C. Hwang et al., "Testing the neurovascular hypothesis of alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-β protein, and impairs cognition", Journal of Alzheimer's Disease, vol. 17, no. 3, pp. 553-570, 2009.
    • (2009) Journal of Alzheimer's Disease , vol.17 , Issue.3 , pp. 553-570
    • Jaeger, L.B.1    Dohgu, S.2    Hwang, M.C.3
  • 30
    • 78650524176 scopus 로고    scopus 로고
    • An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis
    • B. Jeynes and J. Provias, "An investigation into the role of P-glycoprotein in Alzheimer's disease lesion pathogenesis", Neuroscience Letters, vol. 487, no. 3, pp. 389-393, 2011.
    • (2011) Neuroscience Letters , vol.487 , Issue.3 , pp. 389-393
    • Jeynes, B.1    Provias, J.2
  • 31
    • 84905460903 scopus 로고    scopus 로고
    • P-glycoprotein altered expression in Alzheimer's disease: Regional anatomic variability
    • B. Jeynes and J. Provias, "P-glycoprotein altered expression in Alzheimer's disease: regional anatomic variability", Journal of Neurodegenerative Diseases, vol. 2013, Article ID 257953, 7 pages, 2013.
    • (2013) Journal of Neurodegenerative Diseases , vol.2013 , pp. 7
    • Jeynes, B.1    Provias, J.2
  • 32
    • 27644489474 scopus 로고    scopus 로고
    • P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mousemodel
    • J. R. Cirrito, R. Deane, A. M. Fagan et al., "P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mousemodel", Journal of Clinical Investigation, vol. 115, no. 11, pp. 3285-3290, 2005.
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.11 , pp. 3285-3290
    • Cirrito, J.R.1    Deane, R.2    Fagan, A.M.3
  • 33
    • 77951078680 scopus 로고    scopus 로고
    • Restoring bloodbrain barrier P-glycoprotein reduces brain amyloid-β in a mouse model of Alzheimer's disease
    • A. M. S. Hartz, D. S. Miller, and B. Bauer, "Restoring bloodbrain barrier P-glycoprotein reduces brain amyloid-β in a mouse model of Alzheimer's disease", Molecular Pharmacology, vol. 77, no. 5, pp. 715-723, 2010.
    • (2010) Molecular Pharmacology , vol.77 , Issue.5 , pp. 715-723
    • Hartz, A.M.S.1    Miller, D.S.2    Bauer, B.3
  • 34
    • 78650659385 scopus 로고    scopus 로고
    • Apical-to-basolateral transport through blood-brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein
    • P. Candela, F. Gosselet, J. Saint-Pol et al., "Apical-to-basolateral transport through blood-brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein", Journal of Alzheimer's Disease, vol. 22, no. 3, pp. 849-859, 2010.
    • (2010) Journal of Alzheimer's Disease , vol.22 , Issue.3 , pp. 849-859
    • Candela, P.1    Gosselet, F.2    Saint-Pol, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.