Abbreviated Exposure to Hypoxia Is Sufficient to Induce CNS Dysmyelination, Modulate Spinal Motor Neuron Composition, and Impair Motor Development in Neonatal Mice

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Watzlawik, Jens O ^a   Kahoud, Robert J ^a   O'Toole, Ryan J ^b   White, Katherine A M ^b   Ogden, Alyssa R ^b   Painter, Meghan M ^a   Wootla, Bharath ^a   Papke, Louisa M ^a   Denic, Aleksandar ^a   Weimer, Jill M ^b   Carey, William A ^a   Rodriguez, Moses ^a  

^a Mayo Clinic   (United States)

^b SANFORD RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; TRANSCRIPTION FACTOR NKX2.2; NERVE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ATROPHY; BRAIN DEVELOPMENT; BRAIN WEIGHT; CELL COMPOSITION; CELL COUNT; CELL SIZE; CELL SURVIVAL; CONTROLLED STUDY; DEMYELINATING DISEASE; EXPOSURE; FEMALE; HISTOPATHOLOGY; HYPOXIA; MALE; MOTOR DEVELOPMENT; MOTOR DYSFUNCTION; MOUSE; MYELIN DEFICIENCY; NERVE CELL NECROSIS; NEURAL STEM CELL; NEUROMODULATION; NEWBORN; NONHUMAN; OLIGODENDROCYTE PROGENITOR CELL; PERINATAL PERIOD; POSTNATAL DEVELOPMENT; SPINAL CORD MOTONEURON; SUBVENTRICULAR ZONE; WEIGHT REDUCTION; WHITE MATTER INJURY; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; METABOLISM; MOTONEURON; MYELIN SHEATH; OLIGODENDROGLIA; PATHOLOGY; WHITE MATTER;

ANIMALIA; MUS;

ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; MICE; MOTOR NEURONS; MYELIN SHEATH; NERVE TISSUE PROTEINS; NEURAL STEM CELLS; OLIGODENDROGLIA; WHITE MATTER;

EID: 84934979526     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0128007     Document Type: Article

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