Umbelliferone ameliorates cerebral ischemia-reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

Neuroscience Letters

Volumn 600, Issue , 2015, Pages 182-187

  Wang, Xiangxiang ^a   Li, Ruipeng ^a   Wang, Xuan ^a   Fu, Qiang ^a   Ma, Shiping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cerebral ischemia reperfusion; NLRP3 inflammasome; PPAR ; TXNIP; Umbelliferone

Indexed keywords

CRYOPYRIN; CYTOKINE; INFLAMMASOME; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; THIOREDOXIN INTERACTING PROTEIN; UMBELLIFERONE; 7-HYDROXYCOUMARIN; ANTIOXIDANT; CARRIER PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; MALONALDEHYDE; NEUROPROTECTIVE AGENT; NOD-LIKE RECEPTOR 3, RAT; SUPEROXIDE DISMUTASE; TXNIP PROTEIN, RAT; UMBELLIFERONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFICACY; INFLAMMATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR UPREGULATION; REPERFUSION INJURY; ANIMAL; BIOSYNTHESIS; BRAIN INFARCTION; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; CARRIER PROTEINS; GENE EXPRESSION REGULATION; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; MALE; MALONDIALDEHYDE; NEUROPROTECTIVE AGENTS; PPAR GAMMA; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SUPEROXIDE DISMUTASE; UMBELLIFERONES;

EID: 84934970233     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.06.016     Document Type: Article

References (27)

1. Owens B. Stroke. Nature 2014, 510:S5.
2. Wu T.C., Grotta J.C. Stroke treatment and prevention five new things. Neurology 2010, 75:16-21.
3. Moskowitz A.Michael, Lo Eng H., Iadecola Costantino The science of stroke: mechanisms in search of treatments. Neuron 2010, 67:181-198.
4. Tschopp J. Mitochondria sovereign of inflammation?. Eur. J. Immunol. 2011, 41:1196-1202.
5. Zhou R., Tardivel A., Thorens B., Choi I., Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 2010, 11:136-140.
6. Fann D.Y.W., Lee S.Y., Manzanero S., Chunduri P., Sobey C.G., Arumugam T.V. Pathogenesis of acute stroke and the role of inflammasomes. Ageing Res. Rev. 2013, 12:941-966.
7. Zhou R., Yazdi A.S., Menu P., Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011, 469:221-225.
8. Zhao D., Islam M.N., Ahn B.R., Jung H.A., Kim B.W., Choi J.S. In vitro antioxidant and anti-inflammatory activities of Angelica decursiva. Arch. Pharm. Res. 2012, 35:179-192.
9. Subramaniam S.R., Ellis E.M. Neuroprotective effects of umbelliferone and esculetin in a mouse model of Parkinson's disease. J. Neurosci. Res. 2013, 91:453-461.
10. Naowaboot Jarinyaporn, et al. Umbelliferone increases the expression of Adipocyte-specific genes in 3 T3-L1 Adipocyte. Phytother. Res. 2014, 28(11):1671-1675.
11. Ramesh B., Pugalendi K.V. Antihyperglycemic effect of umbelliferone in streptozotocin-diabetic rats. J. Med. Food 2006, 9:562-566.
12. Kim Myung-Joo, et al. Dietary umbelliferone attenuates alcohol-induced fatty liver via regulation of PPARα and SREBP-1c in rats. Alcohol 2014, 48:707-715.
13. Chang T.H., Szabo E. Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma in non-small cell lung cancer. Cancer Res. 2000, 60:1129-1138.
14. Lehrke M., Lazar M.A. The many faces of PPARgamma. Cell 2005, 123:993-999.
15. Glatz Torben, et al. Peroxisome-proliferator-activated receptors (and peroxisome-proliferator-activated receptors β/) and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain. J. Hypertens. 2010, 28:1488-1497.
16. Luo Yumin, et al. Neuroprotection against focal ischemic brain injury by the peroxisome proliferator-activated receptor-agonist rosiglitazone. J. Neurochem. 2006, 97:435-448.
17. Ramesh B., Pugalendi K.V. Influence of umbelliferone on membrane-bound ATPases in streptozotocin-induced diabetic rats. Pharmacol. Rep. 2007, 59:339-348.
18. Xu L., Li Y., Fu Q., Ma S. Perillaldehyde attenuates cerebral ischemia-reperfusion injury-triggered overexpression of inflammatory cytokines via modulating Akt/JNK pathway in the rat brain cortex. Biochem. Biophys. Res. Commun. 2014, 454:65-70.
19. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20:84-91.
20. Crack P.J., Taylor J.M. Reactive oxygen species and the modulation of stroke. Free Radic. Biol. Med. 2005, 38:1433-1444.
21. Martinon Fabio Signaling by ROS drives inflammasome activation. Eur. J. Immunol. 2010, 40:616-619.
22. Yang Zhao, et al. MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage. Mol. Immunol. 2015, 65:267-276.
23. De Nardo D., Latz E. NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol. 2011, 32:373-379.
24. Gillespie William, Tyagi Neetu, Tyagi Suresh C. Role of PPAR, a nuclear hormone receptor in neuroprotection. Indian J. Biochem. Biophys. 2011, 48:73-81.
25. Glatz Torben, et al. Peroxisome-proliferator-activated receptors (and peroxisome-proliferator-activated receptors β/) and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain. J. Hypertens. 2010, 28:1488-1497.
26. Culman J., Zhao Y., Gohlke P., Herdegen T. PPAR-gamma therapeutic target for ischemic stroke. Trends Pharmacol. Sci. 2007, 28:244-249.
27. Collino M., Benetti E., Rogazzo M., Mastrocola R., Yaqoob M.M., et al. Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-agonism correlates with impaired NLRP3 inflammasome activation. Biochem. Pharmacol. 2013, 85:257-264.