Modulation of human valve interstitial cell phenotype and function using a fibroblast growth factor 2 formulation

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Latif, Najma ^a,b   Quillon, Alfred ^c   Sarathchandra, Padmini ^a   McCormack, Ann ^a   Lozanoski, Alec ^a   Yacoub, Magdi H ^a,b   Chester, Adrian H ^a,b  

^a HAREFIELD HOSPITAL   (United Kingdom)

^b QATAR CARDIOVASCULAR RESEARCH CENTER   (Qatar)

^c UNIVERSITÉ LYON 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; CYTOSKELETON PROTEIN; FIBROBLAST GROWTH FACTOR 2; FIBRONECTIN; SCLEROPROTEIN; ACTA2 PROTEIN, HUMAN; ACTIN; CULTURE MEDIUM;

ADULT; ARTICLE; CELL ACTIVATION; CELL CONTRACTION ASSAY; CELL CYCLE; CELL DIFFERENTIATION; CELL ELONGATION; CELL FUNCTION; CELL MIGRATION; CELL ULTRASTRUCTURE; CHILD; ENDOTHELIUM CELL; FEMALE; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; LEYDIG CELL; MALE; PHENOTYPE; PROTEIN EXPRESSION; VALVE INTERSTITIAL CELL; ADOLESCENT; AORTA VALVE; CELL CULTURE; CELL MOTION; CELL PROLIFERATION; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; FLOW CYTOMETRY; FOCAL ADHESION; INTERSTITIAL CELL OF CAJAL; METABOLISM; MIDDLE AGED; PHARMACOLOGY; TIME FACTOR; ULTRASTRUCTURE; YOUNG ADULT;

ACTINS; ADOLESCENT; ADULT; AORTIC VALVE; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CHILD; CULTURE MEDIA; FIBROBLAST GROWTH FACTOR 2; FLOW CYTOMETRY; FOCAL ADHESIONS; HUMANS; INTERSTITIAL CELLS OF CAJAL; MIDDLE AGED; PHENOTYPE; TIME FACTORS; YOUNG ADULT;

EID: 84934964709     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127844     Document Type: Article

References (43)

1. Chester AH, El-Hamamsy I, Butcher JT, Latif N, Bertazzo S, Yacoub MH. The living aortic valve: From molecules to function. Global cardiology science & practice. 2014; 2014(1):52-77. doi: 10.5339/gcsp.2014.11 PMID: 25054122; PubMed Central PMCID: PMC4104380.
2. Latif N, Sarathchandra P, Chester AH, Yacoub MH. Expression of smooth muscle cell markers and coactivators in calcified aortic valves. European heart journal. 2014. doi: 10.1093/eurheartj/eht547 PMID: 24419809.
3. Bairati A, DeBiasi S. Presence of a smooth muscle system in aortic valve leaflets. Anatomy and embryology. 1981; 161(3):329-40. doi: 10.1007/BF00301830 PMID: 7187826.
4. Hinton RB, Yutzey KE. Heart valve structure and function in development and disease. Annual review of physiology. 2011; 73:29-46. doi: 10.1146/annurev-physiol-012110-142145 PMID: 20809794.
5. Rabkin-Aikawa E, Farber M, Aikawa M, Schoen FJ. Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves. The Journal of heart valve disease. 2004; 13(5):841-7. PMID: 15473488.
6. Aikawa E, Whittaker P, Farber M, Mendelson K, Padera RF, Aikawa M, et al. Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering. Circulation. 2006; 113(10):1344-52. doi: 10.1161/CIRCULATIONAHA.105.591768 PMID: 16534030.
7. Lester W, Rosenthal A, Granton B, Gotlieb AI. Porcine mitral valve interstitial cells in culture. Laboratory investigation; a journal of technical methods and pathology. 1988; 59(5):710-9. PMID: 3054314.
8. Liu AC, Joag VR, Gotlieb AI. The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology. The American journal of pathology. 2007; 171(5):1407-18. doi: 10.2353/ajpath.2007.070251 PMID: 17823281; PubMed Central PMCID: PMC2043503.
9. Balachandran K, Sucosky P, Jo H, Yoganathan AP. Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease. American journal of physiology Heart and circulatory physiology. 2009; 296(3):H756-64. doi: 10.1152/ajpheart.00900.2008 PMID: 19151254.
10. Taylor PM, Allen SP, Yacoub MH. Phenotypic and functional characterization of interstitial cells from human heart valves, pericardium and skin. The Journal of heart valve disease. 2000; 9(1):150-8. PMID: 10678389.
11. Della Rocca F, Sartore S, Guidolin D, Bertiplaglia B, Gerosa G, Casarotto D, et al. Cell composition of the human pulmonary valve: a comparative study with the aortic valve-the VESALIO Project. Vitalitate Exornatum Succedaneum Aorticum labore Ingegnoso Obtinebitur. The Annals of thoracic surgery. 2000; 70(5):1594-600. PMID: 11093493.
12. Messier RH Jr., Bass BL, Aly HM, Jones JL, Domkowski PW, Wallace RB, et al. Dual structural and functional phenotypes of the porcine aortic valve interstitial population: characteristics of the leaflet myofibroblast. The Journal of surgical research. 1994; 57(1):1-21. doi: 10.1006/jsre.1994.1102 PMID: 8041124.
13. Latif N, Sarathchandra P, Thomas PS, Antoniw J, Batten P, Chester AH, et al. Characterization of structural and signaling molecules by human valve interstitial cells and comparison to human mesenchymal stem cells. The Journal of heart valve disease. 2007; 16(1):56-66. PMID: 17315384.
14. Zacks S, Rosenthal A, Granton B, Havenith M, Opas M, Gotlieb AI. Characterization of Cobblestone mitral valve interstitial cells. Archives of pathology & laboratory medicine. 1991; 115(8):774-9. PMID: 1863188.
15. Filip DA, Radu A, Simionescu M. Interstitial cells of the heart valves possess characteristics similar to smooth muscle cells. Circulation research. 1986; 59(3):310-20. doi: 10.1161/01.RES.59.3.310 PMID: 3769149.
16. Johnson CM, Hanson MN, Helgeson SC. Porcine cardiac valvular subendothelial cells in culture: cell isolation and growth characteristics. Journal of molecular and cellular cardiology. 1987; 19(12):1185-93. PMID: 3327949.
17. Rohr S. Cardiac fibroblasts in cell culture systems: myofibroblasts all along? Journal of cardiovascular pharmacology. 2011; 57(4):389-99. doi: 10.1097/FJC.0b013e3182137e17 PMID: 21326104.
18. Shimizu A, Tada K, Shukunami C, Hiraki Y, Kurokawa T, Magane N, et al. A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells. The Journal of biological chemistry. 2001; 276(14):11031-40. doi: 10.1074/jbc.M003535200 PMID: 11134040.
19. Gotlieb AI, Rosenthal A, Kazemian P. Fibroblast growth factor 2 regulation of mitral valve interstitial cell repair in vitro. The Journal of thoracic and cardiovascular surgery. 2002; 124(3):591-7. PMID: 12202876.
20. Cushing MC, Mariner PD, Liao JT, Sims EA, Anseth KS. Fibroblast growth factor represses Smad-mediated myofibroblast activation in aortic valvular interstitial cells. FASEB journal: official publication of the Federation of American Societies for Experimental Biology. 2008; 22(6):1769-77. doi: 10.1096/fj.07-087627 PMID: 18218921; PubMed Central PMCID: PMC2493079.
21. Han L, Gotlieb AI. Fibroblast growth factor-2 promotes in vitro mitral valve interstitial cell repair through transforming growth factor-beta/Smad signaling. The American journal of pathology. 2011; 178(1):119-27. doi: 10.1016/j.ajpath.2010.11.038 PMID: 21224050; PubMed Central PMCID: PMC3069900.
22. Han L, Gotlieb AI. Fibroblast growth factor-2 promotes in vitro heart valve interstitial cell repair through the Akt1 pathway. Cardiovascular pathology: the official journal of the Society for Cardiovascular Pathology. 2012; 21(5):382-9. doi: 10.1016/j.carpath.2011.12.001 PMID: 22227366.
23. Okada S, Matsuda M, Anafi M, Pawson T, Pessin JE. Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes. The EMBO journal. 1998; 17(9):2554-65. doi: 10.1093/emboj/17.9.2554 PMID: 9564038; PubMed Central PMCID: PMC1170597.
24. Iovino S, Burkart AM, Kriauciunas K, Warren L, Hughes KJ, Molla M, et al. Genetic Insulin Resistance is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells. Diabetes. 2014. doi: 10.2337/db14-0109 PMID: 25059784.
25. Strassburger K, Tiebe M, Pinna F, Breuhahn K, Teleman AA. Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP. Developmental biology. 2012; 367(2):187-96. doi: 10.1016/j.ydbio.2012.05.008 PMID: 22609549.
26. Galeone A, Brunetti G, Oranger A, Greco G, Di Benedetto A, Mori G, et al. Aortic valvular interstitial cells apoptosis and calcification are mediated by TNF-related apoptosis-inducing ligand. International journal of cardiology. 2013; 169(4):296-304. doi: 10.1016/j.ijcard.2013.09.012 PMID: 24148916.
27. Sun W, Zhao R, Yang Y, Wang H, Shao Y, Kong X. Comparative study of human aortic and mitral valve interstitial cell gene expression and cellular function. Genomics. 2013; 101(6):326-35. doi: 10.1016/j.ygeno.2013.03.004 PMID: 23542235.
28. Poggio P, Branchetti E, Grau JB, Lai EK, Gorman RC, Gorman JH 3rd, et al. Osteopontin-CD44v6 Interaction Mediates Calcium Deposition via Phospho-Akt in Valve Interstitial Cells From Patients With Noncalcified Aortic Valve Sclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2014. doi: 10.1161/ATVBAHA.113.303017 PMID: 25060796.
29. Hinz B. The myofibroblast: paradigm for a mechanically active cell. Journal of biomechanics. 2010; 43 (1):146-55. doi: 10.1016/j.jbiomech.2009.09.020 PMID: 19800625.
30. Nugent MA, Iozzo RV. Fibroblast growth factor-2. The international journal of biochemistry & cell biology. 2000; 32(2):115-20. PMID: 10687947.
31. Siddle K. Signalling by insulin and IGF receptors: supporting acts and new players. Journal of molecular endocrinology. 2011; 47(1):R1-10. doi: 10.1530/JME-11-0022 PMID: 21498522.
32. Hinton RB Jr., Lincoln J, Deutsch GH, Osinska H, Manning PB, Benson DW, et al. Extracellular matrix remodeling and organization in developing and diseased aortic valves. Circulation research. 2006; 98 (11):1431-8. doi: 10.1161/01.RES.0000224114.65109.4e PMID: 16645142.
33. Galbraith CG, Yamada KM, Sheetz MP. The relationship between force and focal complex development. The Journal of cell biology. 2002; 159(4):695-705. doi: 10.1083/jcb.200204153 PMID: 12446745; PubMed Central PMCID: PMC2173098.
34. Crider BJ, Risinger GM Jr., Haaksma CJ, Howard EW, Tomasek JJ. Myocardin-related transcription factors A and B are key regulators of TGF-beta1-induced fibroblast to myofibroblast differentiation. The Journal of investigative dermatology. 2011; 131(12):2378-85. doi: 10.1038/jid.2011.219 PMID: 21776010; PubMed Central PMCID: PMC3199034.
35. Miralles F, Posern G, Zaromytidou AI, Treisman R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell. 2003; 113(3):329-42. doi: 10.1016/S0092-8674(03)00278-2 PMID: 12732141.
36. Guettler S, Vartiainen MK, Miralles F, Larijani B, Treisman R. RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding. Molecular and cellular biology. 2008; 28(2):732-42. doi: 10.1128/MCB.01623-07 PMID: 18025109; PubMed Central PMCID: PMC2223415.
37. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nature reviews Molecular cell biology. 2002; 3(5):349-63. doi: 10.1038/nrm809 PMID: 11988769.
38. Small EM, Thatcher JE, Sutherland LB, Kinoshita H, Gerard RD, Richardson JA, et al. Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Circulation research. 2010; 107(2):294-304. doi: 10.1161/CIRCRESAHA.110.223172 PMID: 20558820; PubMed Central PMCID: PMC2921870.
39. Mack CP, Thompson MM, Lawrenz-Smith S, Owens GK. Smooth muscle alpha-actin CArG elements coordinate formation of a smooth muscle cell-selective, serum response factor-containing activation complex. Circulation research. 2000; 86(2):221-32. PMID: 10666419.
40. Liao S, Bodmer J, Pietras D, Azhar M, Doetschman T, Schultz Jel J. Biological functions of the low and high molecular weight protein isoforms of fibroblast growth factor-2 in cardiovascular development and disease. Developmental dynamics: an official publication of the American Association of Anatomists. 2009; 238(2):249-64. doi: 10.1002/dvdy.21677 PMID: 18773489; PubMed Central PMCID: PMC3115589.
41. Greenberg RS, Bernstein AM, Benezra M, Gelman IH, Taliana L, Masur SK. FAK-dependent regulation of myofibroblast differentiation. FASEB journal: official publication of the Federation of American Societies for Experimental Biology. 2006; 20(7):1006-8. doi: 10.1096/fj.05-4838fje PMID: 16585062.
42. Somers P, Cornelissen R, Thierens H, Van Nooten G. An optimized growth factor cocktail for ovine mesenchymal stem cells. Growth factors. 2012; 30(1):37-48. doi: 10.3109/08977194.2011.634411 PMID: 22077617.
43. Yip CY, Chen JH, Zhao R, Simmons CA. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arteriosclerosis, thrombosis, and vascular biology. 2009; 29(6):936-42. doi: 10.1161/ATVBAHA.108.182394 PMID: 19304575.