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Volumn 63, Issue 12, 2014, Pages 4130-4142

Genetic insulin resistance is a potent regulator of gene expression and proliferation in human iPS cells

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR; INSR PROTEIN, HUMAN; LEUKOCYTE ANTIGEN;

EID: 84911943623     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0109     Document Type: Article
Times cited : (38)

References (48)
  • 1
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-872
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 2
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-1920
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 3
    • 84856007232 scopus 로고    scopus 로고
    • The promise of induced pluripotent stem cells in research and therapy
    • Robinton DA, Daley GQ. The promise of induced pluripotent stem cells in research and therapy. Nature 2012;481:295-305
    • (2012) Nature , vol.481 , pp. 295-305
    • Robinton, D.A.1    Daley, G.Q.2
  • 4
    • 84862777293 scopus 로고    scopus 로고
    • Programming human pluripotent stem cells into white and brown adipocytes
    • Ahfeldt T, Schinzel RT, Lee YK, et al. Programming human pluripotent stem cells into white and brown adipocytes. Nat Cell Biol 2012;14:209-219
    • (2012) Nat Cell Biol , vol.14 , pp. 209-219
    • Ahfeldt, T.1    Schinzel, R.T.2    Lee, Y.K.3
  • 5
    • 84887945008 scopus 로고    scopus 로고
    • A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species
    • Xu C, Tabebordbar M, Iovino S, et al. A zebrafish embryo culture system defines factors that promote vertebrate myogenesis across species. Cell 2013;155:909-921
    • (2013) Cell , vol.155 , pp. 909-921
    • Xu, C.1    Tabebordbar, M.2    Iovino, S.3
  • 7
    • 0029806674 scopus 로고    scopus 로고
    • Nuclear magnetic resonance studies of glucose metabolism in non-insulin-dependent diabetes mellitus subjects
    • Shulman RG. Nuclear magnetic resonance studies of glucose metabolism in non-insulin-dependent diabetes mellitus subjects. Mol Med 1996;2:533-540
    • (1996) Mol Med , vol.2 , pp. 533-540
    • Shulman, R.G.1
  • 8
    • 0017154704 scopus 로고
    • The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man
    • Kahn CR, Flier JS, Bar RS, et al. The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med 1976;294:739-745
    • (1976) N Engl J Med , vol.294 , pp. 739-745
    • Kahn, C.R.1    Flier, J.S.2    Bar, R.S.3
  • 9
    • 0020365331 scopus 로고
    • Extreme insulin resistance in association with abnormally high binding affinity of insulin receptors from a patient with leprechaunism: Evidence for a defect intrinsic to the receptor
    • Taylor SI, Hedo JA, Underhill LH, Kasuga M, Elders MJ, Roth J. Extreme insulin resistance in association with abnormally high binding affinity of insulin receptors from a patient with leprechaunism: evidence for a defect intrinsic to the receptor. J Clin Endocrinol Metab 1982;55:1108-1113
    • (1982) J Clin Endocrinol Metab , vol.55 , pp. 1108-1113
    • Taylor, S.I.1    Hedo, J.A.2    Underhill, L.H.3    Kasuga, M.4    Elders, M.J.5    Roth, J.6
  • 11
    • 0026761432 scopus 로고
    • Mutations in the insulin receptor gene
    • Taylor SI, Cama A, Accili D, et al. Mutations in the insulin receptor gene. Endocr Rev 1992;13:566-595
    • (1992) Endocr Rev , vol.13 , pp. 566-595
    • Taylor, S.I.1    Cama, A.2    Accili, D.3
  • 14
    • 0025635908 scopus 로고
    • Mutagenesis of lysine 460 in the human insulin receptor. Effects upon receptor recycling and cooperative interactions among binding sites
    • Kadowaki H, Kadowaki T, Cama A, et al. Mutagenesis of lysine 460 in the human insulin receptor. Effects upon receptor recycling and cooperative interactions among binding sites. J Biol Chem 1990;265:21285-21296
    • (1990) J Biol Chem , vol.265 , pp. 21285-21296
    • Kadowaki, H.1    Kadowaki, T.2    Cama, A.3
  • 15
    • 84861617752 scopus 로고    scopus 로고
    • A novel mutation of the insulin receptor gene in a preterm infant with Donohue syndrome and heart failure
    • Nobile S, Semple RK, Carnielli VP. A novel mutation of the insulin receptor gene in a preterm infant with Donohue syndrome and heart failure. J Pediatr Endocrinol Metab 2012;25:363-366
    • (2012) J Pediatr Endocrinol Metab , vol.25 , pp. 363-366
    • Nobile, S.1    Semple, R.K.2    Carnielli, V.P.3
  • 17
    • 0026332513 scopus 로고
    • A leucine to proline mutation at position 233 in the insulin receptor inhibits cleavage of the proreceptor and transport to the cell surface
    • Maassen JA, Van der Vorm ER, Van der Zon GC, Klinkhamer MP, Krans HM, Möller W. A leucine to proline mutation at position 233 in the insulin receptor inhibits cleavage of the proreceptor and transport to the cell surface. Biochemistry 1991;30:10778-10783
    • (1991) Biochemistry , vol.30 , pp. 10778-10783
    • Maassen, J.A.1    Van Der Vorm, E.R.2    Van Der Zon, G.C.3    Klinkhamer, M.P.4    Krans, H.M.5    Möller, W.6
  • 18
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 1979;76:4350-4354
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 19
    • 33747735518 scopus 로고    scopus 로고
    • Elevated plasma adiponectin in humans with genetically defective insulin receptors
    • Semple RK, Soos MA, Luan J, et al. Elevated plasma adiponectin in humans with genetically defective insulin receptors. J Clin Endocrinol Metab 2006;91: 3219-3223
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3219-3223
    • Semple, R.K.1    Soos, M.A.2    Luan, J.3
  • 21
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009;4:44-57
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 22
    • 15244358503 scopus 로고    scopus 로고
    • Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals
    • Xie X, Lu J, Kulbokas EJ, et al. Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals. Nature 2005;434:338-345
    • (2005) Nature , vol.434 , pp. 338-345
    • Xie, X.1    Lu, J.2    Kulbokas, E.J.3
  • 23
    • 0025064309 scopus 로고
    • A nonsense mutation causing decreased levels of insulin receptor mRNA: Detection by a simplified technique for direct sequencing of genomic DNA amplified by the polymerase chain reaction
    • Kadowaki T, Kadowaki H, Taylor SI. A nonsense mutation causing decreased levels of insulin receptor mRNA: detection by a simplified technique for direct sequencing of genomic DNA amplified by the polymerase chain reaction. Proc Natl Acad Sci U S A 1990;87:658-662
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 658-662
    • Kadowaki, T.1    Kadowaki, H.2    Taylor, S.I.3
  • 24
    • 0024578445 scopus 로고
    • Insulin-receptor gene and its expression in patients with insulin resistance
    • Muller-Wieland D, Taub R, Tewari DS, et al. Insulin-receptor gene and its expression in patients with insulin resistance. Diabetes 1989;38:31-38
    • (1989) Diabetes , vol.38 , pp. 31-38
    • Muller-Wieland, D.1    Taub, R.2    Tewari, D.S.3
  • 25
    • 0025823448 scopus 로고
    • ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
    • Boulton TG, Nye SH, Robbins DJ, et al. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 1991;65:663-675
    • (1991) Cell , vol.65 , pp. 663-675
    • Boulton, T.G.1    Nye, S.H.2    Robbins, D.J.3
  • 26
    • 0032570815 scopus 로고    scopus 로고
    • Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis
    • Ueki K, Yamamoto-Honda R, Kaburagi Y, et al. Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis. J Biol Chem 1998;273:5315-5322
    • (1998) J Biol Chem , vol.273 , pp. 5315-5322
    • Ueki, K.1    Yamamoto-Honda, R.2    Kaburagi, Y.3
  • 28
    • 34548824200 scopus 로고    scopus 로고
    • Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes
    • Bouzakri K, Koistinen HA, Zierath JR. Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes. Curr Diabetes Rev 2005;1:167-174
    • (2005) Curr Diabetes Rev , vol.1 , pp. 167-174
    • Bouzakri, K.1    Koistinen, H.A.2    Zierath, J.R.3
  • 29
    • 12244269348 scopus 로고    scopus 로고
    • Skeletal muscle GLUT1 transporter protein expression and basal leg glucose uptake are reduced in type 2 diabetes
    • Ciaraldi TP, Mudaliar S, Barzin A, et al. Skeletal muscle GLUT1 transporter protein expression and basal leg glucose uptake are reduced in type 2 diabetes. J Clin Endocrinol Metab 2005;90:352-358
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 352-358
    • Ciaraldi, T.P.1    Mudaliar, S.2    Barzin, A.3
  • 31
    • 0026694391 scopus 로고
    • Reduced mRNA and a nonsense mutation in the insulin-receptor gene produce heritable severe insulin resistance
    • Longo N, Langley SD, Griffin LD, Elsas LJ 2nd. Reduced mRNA and a nonsense mutation in the insulin-receptor gene produce heritable severe insulin resistance. Am J Hum Genet 1992;50:998-1007
    • (1992) Am J Hum Genet , vol.50 , pp. 998-1007
    • Longo, N.1    Langley, S.D.2    Griffin, L.D.3    Elsas, L.J.4
  • 32
    • 0025185691 scopus 로고
    • Substitution of lysine for asparagine at position 15 in the α-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affi nity of insulin binding
    • Kadowaki T, Kadowaki H, Accili D, Taylor SI. Substitution of lysine for asparagine at position 15 in the α-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affi nity of insulin binding. J Biol Chem 1990;265:19143-19150
    • (1990) J Biol Chem , vol.265 , pp. 19143-19150
    • Kadowaki, T.1    Kadowaki, H.2    Accili, D.3    Taylor, S.I.4
  • 33
    • 84873841370 scopus 로고    scopus 로고
    • White blood cells count and incidence of type 2 diabetes in young men
    • Twig G, Afek A, Shamiss A, et al. White blood cells count and incidence of type 2 diabetes in young men. Diabetes Care 2013;36:276-282
    • (2013) Diabetes Care , vol.36 , pp. 276-282
    • Twig, G.1    Afek, A.2    Shamiss, A.3
  • 34
    • 84878117734 scopus 로고    scopus 로고
    • iPSC-derived β cells model diabetes due to glucokinase deficiency
    • Hua H, Shang L, Martinez H, et al. iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest 2013;123:3146-3153
    • (2013) J Clin Invest , vol.123 , pp. 3146-3153
    • Hua, H.1    Shang, L.2    Martinez, H.3
  • 35
    • 0020664239 scopus 로고
    • Decreased insulin binding to cultured cells from a patient with the Rabson-Mendenhall syndrome: Dichotomy between studies with cultured lymphocytes and cultured fibroblasts
    • Taylor SI, Underhill LH, Hedo JA, Roth J, Rios MS, Blizzard RM. Decreased insulin binding to cultured cells from a patient with the Rabson-Mendenhall syndrome: dichotomy between studies with cultured lymphocytes and cultured fibroblasts. J Clin Endocrinol Metab 1983;56:856-861
    • (1983) J Clin Endocrinol Metab , vol.56 , pp. 856-861
    • Taylor, S.I.1    Underhill, L.H.2    Hedo, J.A.3    Roth, J.4    Rios, M.S.5    Blizzard, R.M.6
  • 36
    • 84881118694 scopus 로고    scopus 로고
    • Severe progressive obstructive cardiomyopathy and renal tubular dysfunction in Donohue syndrome with decreased insulin receptor autophosphorylation due to a novel INSR mutation
    • Hovnik T, Bratanič N, Podkrajšek KT, et al. Severe progressive obstructive cardiomyopathy and renal tubular dysfunction in Donohue syndrome with decreased insulin receptor autophosphorylation due to a novel INSR mutation. Eur J Pediatr 2013;172:1125-1129
    • (2013) Eur J Pediatr , vol.172 , pp. 1125-1129
    • Hovnik, T.1    Bratanič, N.2    Podkrajšek, K.T.3
  • 37
    • 0030833040 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase-1 and -2 respond differently to mitogenic and differentiative signaling pathways in myoblasts
    • Sarbassov DD, Jones LG, Peterson CA. Extracellular signal-regulated kinase-1 and -2 respond differently to mitogenic and differentiative signaling pathways in myoblasts. Mol Endocrinol 1997;11:2038-2047
    • (1997) Mol Endocrinol , vol.11 , pp. 2038-2047
    • Sarbassov, D.D.1    Jones, L.G.2    Peterson, C.A.3
  • 38
    • 77950353276 scopus 로고    scopus 로고
    • ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events
    • Shin S, Dimitri CA, Yoon SO, Dowdle W, Blenis J. ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. Mol Cell 2010;38:114-127
    • (2010) Mol Cell , vol.38 , pp. 114-127
    • Shin, S.1    Dimitri, C.A.2    Yoon, S.O.3    Dowdle, W.4    Blenis, J.5
  • 39
    • 0033152966 scopus 로고    scopus 로고
    • Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells
    • Burdon T, Stracey C, Chambers I, Nichols J, Smith A. Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev Biol 1999;210:30-43
    • (1999) Dev Biol , vol.210 , pp. 30-43
    • Burdon, T.1    Stracey, C.2    Chambers, I.3    Nichols, J.4    Smith, A.5
  • 40
    • 84880766910 scopus 로고    scopus 로고
    • Genome-wide kinase-chromatin interactions reveal the regulatory network of ERK signaling in human embryonic stem cells
    • Göke J, Chan YS, Yan J, Vingron M, Ng HH. Genome-wide kinase-chromatin interactions reveal the regulatory network of ERK signaling in human embryonic stem cells. Mol Cell 2013;50:844-855
    • (2013) Mol Cell , vol.50 , pp. 844-855
    • Göke, J.1    Chan, Y.S.2    Yan, J.3    Vingron, M.4    Ng, H.H.5
  • 41
    • 84875933577 scopus 로고    scopus 로고
    • Lin28: Primal regulator of growth and metabolism in stem cells
    • Shyh-Chang N, Daley GQ. Lin28: primal regulator of growth and metabolism in stem cells. Cell Stem Cell 2013;12:395-406
    • (2013) Cell Stem Cell , vol.12 , pp. 395-406
    • Shyh-Chang, N.1    Daley, G.Q.2
  • 42
    • 80053481600 scopus 로고    scopus 로고
    • The Lin28/let-7 axis regulates glucose metabolism
    • Zhu H, Shyh-Chang N, Segrè AV, et al.; DIAGRAM Consortium; MAGIC Investigators. The Lin28/let-7 axis regulates glucose metabolism. Cell 2011;147:81-94
    • (2011) Cell , vol.147 , pp. 81-94
    • Zhu, H.1    Shyh-Chang, N.2    Segrè, A.V.3
  • 43
    • 79957573195 scopus 로고    scopus 로고
    • Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors
    • Bami M, Episkopou V, Gavalas A, Gouti M. Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors. PLoS One 2011;6:e20197
    • (2011) PLoS One , vol.6 , pp. e20197
    • Bami, M.1    Episkopou, V.2    Gavalas, A.3    Gouti, M.4
  • 44
    • 78751474014 scopus 로고    scopus 로고
    • Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase
    • Oriente F, Iovino S, Cabaro S, et al. Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase. Diabetes 2011;60:138-147
    • (2011) Diabetes , vol.60 , pp. 138-147
    • Oriente, F.1    Iovino, S.2    Cabaro, S.3
  • 45
    • 84861662792 scopus 로고    scopus 로고
    • The engrailed homeobox genes are required in multiple cell lineages to coordinate sequential formation of fissures and growth of the cerebellum
    • Orvis GD, Hartzell AL, Smith JB, et al. The engrailed homeobox genes are required in multiple cell lineages to coordinate sequential formation of fissures and growth of the cerebellum. Dev Biol 2012;367:25-39
    • (2012) Dev Biol , vol.367 , pp. 25-39
    • Orvis, G.D.1    Hartzell, A.L.2    Smith, J.B.3
  • 46
    • 33845996144 scopus 로고    scopus 로고
    • Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed
    • McLean AB, D'Amour KA, Jones KL, et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells 2007;25:29-38
    • (2007) Stem Cells , vol.25 , pp. 29-38
    • McLean, A.B.1    D'Amour, K.A.2    Jones, K.L.3
  • 47
    • 45549091537 scopus 로고    scopus 로고
    • Diabetes risk begins in utero
    • Woo M, Patti ME. Diabetes risk begins in utero. Cell Metab 2008;8:5-7
    • (2008) Cell Metab , vol.8 , pp. 5-7
    • Woo, M.1    Patti, M.E.2
  • 48
    • 80053428731 scopus 로고    scopus 로고
    • Early life nutrition modulates muscle stem cell number: Implications for muscle mass and repair
    • Woo M, Isganaitis E, Cerletti M, et al. Early life nutrition modulates muscle stem cell number: implications for muscle mass and repair. Stem Cells Dev 2011;20:1763-1769
    • (2011) Stem Cells Dev , vol.20 , pp. 1763-1769
    • Woo, M.1    Isganaitis, E.2    Cerletti, M.3


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