메뉴 건너뛰기




Volumn 15, Issue 1, 2015, Pages

microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta/Smad pathway

Author keywords

Cholangiocarcinoma; Epithelial mesenchymal transition; miR 34a; Smad4; Transforming growth factor beta

Indexed keywords

MICRORNA 34A; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; MICRORNA; MIRN34 MICRORNA, HUMAN; SMAD4 PROTEIN, HUMAN;

EID: 84934955925     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1359-x     Document Type: Article
Times cited : (86)

References (45)
  • 1
    • 84909987959 scopus 로고    scopus 로고
    • Prognostic significance of epithelial-mesenchymal transition-related markers in extrahepatic cholangiocarcinoma: comprehensive immunohistochemical study using a tissue microarray
    • Nitta T, Mitsuhashi T, Hatanaka Y, Miyamoto M, Oba K, Tsuchikawa T, et al. Prognostic significance of epithelial-mesenchymal transition-related markers in extrahepatic cholangiocarcinoma: comprehensive immunohistochemical study using a tissue microarray. Br J Cancer. 2014;111(7):1363-72.
    • (2014) Br J Cancer , vol.111 , Issue.7 , pp. 1363-1372
    • Nitta, T.1    Mitsuhashi, T.2    Hatanaka, Y.3    Miyamoto, M.4    Oba, K.5    Tsuchikawa, T.6
  • 2
    • 33750491929 scopus 로고    scopus 로고
    • Cholangiocarcinoma: modern advances in understanding a deadly old disease
    • Malhi H, Gores GJ. Cholangiocarcinoma: modern advances in understanding a deadly old disease. J Hepatol. 2006;45(6):856-67.
    • (2006) J Hepatol , vol.45 , Issue.6 , pp. 856-867
    • Malhi, H.1    Gores, G.J.2
  • 3
    • 47149112544 scopus 로고    scopus 로고
    • Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment
    • Blechacz B, Gores GJ. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology. 2008;48(1):308-21.
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 308-321
    • Blechacz, B.1    Gores, G.J.2
  • 4
    • 84872496432 scopus 로고    scopus 로고
    • MicroRNAs as potential biomarkers in human solid tumors
    • Shen J, Stass SA, Jiang F. MicroRNAs as potential biomarkers in human solid tumors. Cancer Lett. 2013;329(2):125-36.
    • (2013) Cancer Lett , vol.329 , Issue.2 , pp. 125-136
    • Shen, J.1    Stass, S.A.2    Jiang, F.3
  • 5
    • 77952918274 scopus 로고    scopus 로고
    • Genetic variation in microRNA networks: the implications for cancer research
    • Ryan BM, Robles AI, Harris CC. Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer. 2010;10(6):389-402.
    • (2010) Nat Rev Cancer , vol.10 , Issue.6 , pp. 389-402
    • Ryan, B.M.1    Robles, A.I.2    Harris, C.C.3
  • 6
    • 84873296666 scopus 로고    scopus 로고
    • MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma?
    • Giordano S, Columbano A. MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma? Hepatology. 2013;57(2):840-7.
    • (2013) Hepatology , vol.57 , Issue.2 , pp. 840-847
    • Giordano, S.1    Columbano, A.2
  • 7
    • 34249817549 scopus 로고    scopus 로고
    • Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    • Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell. 2007;26(5):745-52.
    • (2007) Mol Cell , vol.26 , Issue.5 , pp. 745-752
    • Chang, T.C.1    Wentzel, E.A.2    Kent, O.A.3    Ramachandran, K.4    Mullendore, M.5    Lee, K.H.6
  • 8
    • 84868254278 scopus 로고    scopus 로고
    • miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma
    • Kasinski AL, Slack FJ. miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma. Cancer Res. 2012;72(21):5576-87.
    • (2012) Cancer Res , vol.72 , Issue.21 , pp. 5576-5587
    • Kasinski, A.L.1    Slack, F.J.2
  • 9
    • 79959968604 scopus 로고    scopus 로고
    • A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression
    • Yang H, Li TW, Peng J, Tang X, Ko KS, Xia M, et al. A mouse model of cholestasis-associated cholangiocarcinoma and transcription factors involved in progression. Gastroenterology. 2011;141(1):378-88. 388 e371-374.
    • (2011) Gastroenterology , vol.141 , Issue.1 , pp. 378-388
    • Yang, H.1    Li, T.W.2    Peng, J.3    Tang, X.4    Ko, K.S.5    Xia, M.6
  • 10
    • 84858632494 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo
    • Yan K, Gao J, Yang T, Ma Q, Qiu X, Fan Q, et al. MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. PLoS One. 2012;7(3), e33778.
    • (2012) PLoS One , vol.7 , Issue.3
    • Yan, K.1    Gao, J.2    Yang, T.3    Ma, Q.4    Qiu, X.5    Fan, Q.6
  • 11
    • 84872908276 scopus 로고    scopus 로고
    • MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1
    • Pang RT, Leung CO, Lee CL, Lam KK, Ye TM, Chiu PC, et al. MicroRNA-34a is a tumor suppressor in choriocarcinoma via regulation of Delta-like1. BMC Cancer. 2013;13:25.
    • (2013) BMC Cancer , vol.13 , pp. 25
    • Pang, R.T.1    Leung, C.O.2    Lee, C.L.3    Lam, K.K.4    Ye, T.M.5    Chiu, P.C.6
  • 12
    • 84877155928 scopus 로고    scopus 로고
    • Expression and regulatory function of miRNA-34a in targeting survivin in gastric cancer cells
    • Cao W, Fan R, Wang L, Cheng S, Li H, Jiang J, et al. Expression and regulatory function of miRNA-34a in targeting survivin in gastric cancer cells. Tumour Biol. 2013;34(2):963-71.
    • (2013) Tumour Biol , vol.34 , Issue.2 , pp. 963-971
    • Cao, W.1    Fan, R.2    Wang, L.3    Cheng, S.4    Li, H.5    Jiang, J.6
  • 13
    • 79955410765 scopus 로고    scopus 로고
    • Systematic proteome analysis identifies transcription factor YY1 as a direct target of miR-34a
    • Chen QR, Yu LR, Tsang P, Wei JS, Song YK, Cheuk A, et al. Systematic proteome analysis identifies transcription factor YY1 as a direct target of miR-34a. J Proteome Res. 2011;10(2):479-87.
    • (2011) J Proteome Res , vol.10 , Issue.2 , pp. 479-487
    • Chen, Q.R.1    Yu, L.R.2    Tsang, P.3    Wei, J.S.4    Song, Y.K.5    Cheuk, A.6
  • 14
    • 77953920780 scopus 로고    scopus 로고
    • MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells
    • Pang RT, Leung CO, Ye TM, Liu W, Chiu PC, Lam KK, et al. MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis. 2010;31(6):1037-44.
    • (2010) Carcinogenesis , vol.31 , Issue.6 , pp. 1037-1044
    • Pang, R.T.1    Leung, C.O.2    Ye, T.M.3    Liu, W.4    Chiu, P.C.5    Lam, K.K.6
  • 15
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
    • Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science. 2005;307(5715):1603-9.
    • (2005) Science , vol.307 , Issue.5715 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.R.4    Zhang, Y.5    Wrana, J.L.6
  • 16
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massague J. TGFbeta in cancer. Cell. 2008;134(2):215-30.
    • (2008) Cell , vol.134 , Issue.2 , pp. 215-230
    • Massague, J.1
  • 17
    • 84881569123 scopus 로고    scopus 로고
    • Low-dose paclitaxel inhibits the induction of epidermal-mesenchymal transition in the human cholangiocarcinoma CCKS-1 cell line
    • Hirose A, Tajima H, Ohta T, Tsukada T, Okamoto K, Nakanuma S, et al. Low-dose paclitaxel inhibits the induction of epidermal-mesenchymal transition in the human cholangiocarcinoma CCKS-1 cell line. Oncol Lett. 2013;6(4):915-20.
    • (2013) Oncol Lett , vol.6 , Issue.4 , pp. 915-920
    • Hirose, A.1    Tajima, H.2    Ohta, T.3    Tsukada, T.4    Okamoto, K.5    Nakanuma, S.6
  • 18
    • 84861560298 scopus 로고    scopus 로고
    • A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition
    • Seok JY, Na DC, Woo HG, Roncalli M, Kwon SM, Yoo JE, et al. A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition. Hepatology. 2012;55(6):1776-86.
    • (2012) Hepatology , vol.55 , Issue.6 , pp. 1776-1786
    • Seok, J.Y.1    Na, D.C.2    Woo, H.G.3    Roncalli, M.4    Kwon, S.M.5    Yoo, J.E.6
  • 19
    • 84855999650 scopus 로고    scopus 로고
    • E/N-cadherin switch mediates cancer progression via TGF-beta-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma
    • Araki K, Shimura T, Suzuki H, Tsutsumi S, Wada W, Yajima T, et al. E/N-cadherin switch mediates cancer progression via TGF-beta-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma. Br J Cancer. 2011;105(12):1885-93.
    • (2011) Br J Cancer , vol.105 , Issue.12 , pp. 1885-1893
    • Araki, K.1    Shimura, T.2    Suzuki, H.3    Tsutsumi, S.4    Wada, W.5    Yajima, T.6
  • 20
    • 0036055766 scopus 로고    scopus 로고
    • Correlation between laminin-5 gamma2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue
    • Katoh K, Nakanishi Y, Akimoto S, Yoshimura K, Takagi M, Sakamoto M, et al. Correlation between laminin-5 gamma2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue. Oncology. 2002;62(4):318-26.
    • (2002) Oncology , vol.62 , Issue.4 , pp. 318-326
    • Katoh, K.1    Nakanishi, Y.2    Akimoto, S.3    Yoshimura, K.4    Takagi, M.5    Sakamoto, M.6
  • 21
    • 77954821918 scopus 로고    scopus 로고
    • Farnesoid X receptor activation mediates head-to-tail chromatin looping in the Nr0b2 gene encoding small heterodimer partner
    • Li G, Thomas AM, Hart SN, Zhong X, Wu D, Guo GL. Farnesoid X receptor activation mediates head-to-tail chromatin looping in the Nr0b2 gene encoding small heterodimer partner. Mol Endocrinol. 2010;24(7):1404-12.
    • (2010) Mol Endocrinol , vol.24 , Issue.7 , pp. 1404-1412
    • Li, G.1    Thomas, A.M.2    Hart, S.N.3    Zhong, X.4    Wu, D.5    Guo, G.L.6
  • 22
    • 84859986063 scopus 로고    scopus 로고
    • Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding
    • Li G, Thomas AM, Williams JA, Kong B, Liu J, Inaba Y, et al. Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding. PLoS One. 2012;7(4), e35895.
    • (2012) PLoS One , vol.7 , Issue.4
    • Li, G.1    Thomas, A.M.2    Williams, J.A.3    Kong, B.4    Liu, J.5    Inaba, Y.6
  • 23
    • 84893752303 scopus 로고    scopus 로고
    • JNK inhibitor SP600125 enhances TGF-beta-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner
    • Lin Y, Zhang B, Liang H, Lu Y, Ai X, Chen X. JNK inhibitor SP600125 enhances TGF-beta-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner. Mol Med Rep. 2013;8(6):1623-9.
    • (2013) Mol Med Rep , vol.8 , Issue.6 , pp. 1623-1629
    • Lin, Y.1    Zhang, B.2    Liang, H.3    Lu, Y.4    Ai, X.5    Chen, X.6
  • 25
    • 68249092353 scopus 로고    scopus 로고
    • A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition
    • Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, Albanell J, et al. A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol. 2009;11(8):943-50.
    • (2009) Nat Cell Biol , vol.11 , Issue.8 , pp. 943-950
    • Vincent, T.1    Neve, E.P.2    Johnson, J.R.3    Kukalev, A.4    Rojo, F.5    Albanell, J.6
  • 26
    • 84863230238 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1
    • Wu J, Wu G, Lv L, Ren YF, Zhang XJ, Xue YF, et al. MicroRNA-34a inhibits migration and invasion of colon cancer cells via targeting to Fra-1. Carcinogenesis. 2012;33(3):519-28.
    • (2012) Carcinogenesis , vol.33 , Issue.3 , pp. 519-528
    • Wu, J.1    Wu, G.2    Lv, L.3    Ren, Y.F.4    Zhang, X.J.5    Xue, Y.F.6
  • 27
    • 84903607614 scopus 로고    scopus 로고
    • MicroRNA-34A inhibits the growth, invasion and metastasis of gastric cancer by targeting PDGFR and MET expression
    • Peng Y, Guo JJ, Liu YM, Wu XL. MicroRNA-34A inhibits the growth, invasion and metastasis of gastric cancer by targeting PDGFR and MET expression. Biosci Rep. 2014;34(3):art:e00112.
    • (2014) Biosci Rep , vol.34 , Issue.3
    • Peng, Y.1    Guo, J.J.2    Liu, Y.M.3    Wu, X.L.4
  • 28
    • 84855996930 scopus 로고    scopus 로고
    • MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma
    • Jamieson NB, Morran DC, Morton JP, Ali A, Dickson EJ, Carter CR, et al. MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma. Clin Cancer Res. 2012;18(2):534-45.
    • (2012) Clin Cancer Res , vol.18 , Issue.2 , pp. 534-545
    • Jamieson, N.B.1    Morran, D.C.2    Morton, J.P.3    Ali, A.4    Dickson, E.J.5    Carter, C.R.6
  • 29
    • 84872764785 scopus 로고    scopus 로고
    • Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells
    • Li J, Wang K, Chen X, Meng H, Song M, Wang Y, et al. Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells. BMC Mol Biol. 2012;13:4.
    • (2012) BMC Mol Biol , vol.13 , pp. 4
    • Li, J.1    Wang, K.2    Chen, X.3    Meng, H.4    Song, M.5    Wang, Y.6
  • 30
    • 34548687035 scopus 로고    scopus 로고
    • mir-29 regulates Mcl-1 protein expression and apoptosis
    • Mott JL, Kobayashi S, Bronk SF, Gores GJ. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene. 2007;26(42):6133-40.
    • (2007) Oncogene , vol.26 , Issue.42 , pp. 6133-6140
    • Mott, J.L.1    Kobayashi, S.2    Bronk, S.F.3    Gores, G.J.4
  • 31
    • 84877263372 scopus 로고    scopus 로고
    • Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance
    • Karakatsanis A, Papaconstantinou I, Gazouli M, Lyberopoulou A, Polymeneas G, Voros D. Expression of microRNAs, miR-21, miR-31, miR-122, miR-145, miR-146a, miR-200c, miR-221, miR-222, and miR-223 in patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma and its prognostic significance. Mol Carcinog. 2013;52(4):297-303.
    • (2013) Mol Carcinog , vol.52 , Issue.4 , pp. 297-303
    • Karakatsanis, A.1    Papaconstantinou, I.2    Gazouli, M.3    Lyberopoulou, A.4    Polymeneas, G.5    Voros, D.6
  • 32
    • 84876569990 scopus 로고    scopus 로고
    • miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF)
    • Zhang J, Han C, Zhu H, Song K, Wu T. miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF). Am J Pathol. 2013;182(5):1629-39.
    • (2013) Am J Pathol , vol.182 , Issue.5 , pp. 1629-1639
    • Zhang, J.1    Han, C.2    Zhu, H.3    Song, K.4    Wu, T.5
  • 33
    • 84866602061 scopus 로고    scopus 로고
    • Epigenetic regulation of miR-124 by hepatitis C virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3
    • Zeng B, Li Z, Chen R, Guo N, Zhou J, Zhou Q, et al. Epigenetic regulation of miR-124 by hepatitis C virus core protein promotes migration and invasion of intrahepatic cholangiocarcinoma cells by targeting SMYD3. FEBS Lett. 2012;586(19):3271-8.
    • (2012) FEBS Lett , vol.586 , Issue.19 , pp. 3271-3278
    • Zeng, B.1    Li, Z.2    Chen, R.3    Guo, N.4    Zhou, J.5    Zhou, Q.6
  • 34
    • 84867707606 scopus 로고    scopus 로고
    • Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch
    • An F, Yamanaka S, Allen S, Roberts LR, Gores GJ, Pawlik TM, et al. Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch. PLoS One. 2012;7(10), e45606.
    • (2012) PLoS One , vol.7 , Issue.10
    • An, F.1    Yamanaka, S.2    Allen, S.3    Roberts, L.R.4    Gores, G.J.5    Pawlik, T.M.6
  • 35
    • 84864831353 scopus 로고    scopus 로고
    • Mutual regulation between microRNA-373 and methyl-CpG-binding domain protein 2 in hilar cholangiocarcinoma
    • Chen YJ, Luo J, Yang GY, Yang K, Wen SQ, Zou SQ. Mutual regulation between microRNA-373 and methyl-CpG-binding domain protein 2 in hilar cholangiocarcinoma. World J Gastroenterol. 2012;18(29):3849-61.
    • (2012) World J Gastroenterol , vol.18 , Issue.29 , pp. 3849-3861
    • Chen, Y.J.1    Luo, J.2    Yang, G.Y.3    Yang, K.4    Wen, S.Q.5    Zou, S.Q.6
  • 36
    • 84880786960 scopus 로고    scopus 로고
    • MiR-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line
    • Iwaki J, Kikuchi K, Mizuguchi Y, Kawahigashi Y, Yoshida H, Uchida E, et al. MiR-376c down-regulation accelerates EGF-dependent migration by targeting GRB2 in the HuCCT1 human intrahepatic cholangiocarcinoma cell line. PLoS One. 2013;8(7), e69496.
    • (2013) PLoS One , vol.8 , Issue.7
    • Iwaki, J.1    Kikuchi, K.2    Mizuguchi, Y.3    Kawahigashi, Y.4    Yoshida, H.5    Uchida, E.6
  • 37
    • 84863415971 scopus 로고    scopus 로고
    • MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma
    • Yamamura S, Saini S, Majid S, Hirata H, Ueno K, Chang I, et al. MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma. Carcinogenesis. 2012;33(2):294-300.
    • (2012) Carcinogenesis , vol.33 , Issue.2 , pp. 294-300
    • Yamamura, S.1    Saini, S.2    Majid, S.3    Hirata, H.4    Ueno, K.5    Chang, I.6
  • 38
    • 84964247793 scopus 로고    scopus 로고
    • MicroRNA-34a regulates cardiac fibrosis after myocardial infarction by targeting Smad4
    • Huang Y, Qi Y, Du JQ, Zhang DF. MicroRNA-34a regulates cardiac fibrosis after myocardial infarction by targeting Smad4. Expert Opin Ther Targets. 2014;18(12):1355-65.
    • (2014) Expert Opin Ther Targets , vol.18 , Issue.12 , pp. 1355-1365
    • Huang, Y.1    Qi, Y.2    Du, J.Q.3    Zhang, D.F.4
  • 39
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119(6):1420-8.
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 40
    • 58149093172 scopus 로고    scopus 로고
    • FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination
    • Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, et al. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell. 2009;136(1):123-35.
    • (2009) Cell , vol.136 , Issue.1 , pp. 123-135
    • Dupont, S.1    Mamidi, A.2    Cordenonsi, M.3    Montagner, M.4    Zacchigna, L.5    Adorno, M.6
  • 41
    • 84902679822 scopus 로고    scopus 로고
    • MicroRNA-26b inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting USP9X
    • Shen G, Lin Y, Yang X, Zhang J, Xu Z, Jia H. MicroRNA-26b inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting USP9X. BMC Cancer. 2014;14:393.
    • (2014) BMC Cancer , vol.14 , pp. 393
    • Shen, G.1    Lin, Y.2    Yang, X.3    Zhang, J.4    Xu, Z.5    Jia, H.6
  • 42
    • 84902294127 scopus 로고    scopus 로고
    • Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells
    • Li H, Xu L, Li C, Zhao L, Ma Y, Zheng H, et al. Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells. Mol Cancer. 2014;13:136.
    • (2014) Mol Cancer , vol.13 , pp. 136
    • Li, H.1    Xu, L.2    Li, C.3    Zhao, L.4    Ma, Y.5    Zheng, H.6
  • 43
    • 84874547217 scopus 로고    scopus 로고
    • MicroRNA-204-5p regulates epithelial-to-mesenchymal transition during human posterior capsule opacification by targeting SMAD4
    • Wang Y, Li W, Zang X, Chen N, Liu T, Tsonis PA, et al. MicroRNA-204-5p regulates epithelial-to-mesenchymal transition during human posterior capsule opacification by targeting SMAD4. Invest Ophthalmol Vis Sci. 2013;54(1):323-32.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , Issue.1 , pp. 323-332
    • Wang, Y.1    Li, W.2    Zang, X.3    Chen, N.4    Liu, T.5    Tsonis, P.A.6
  • 44
    • 84901245983 scopus 로고    scopus 로고
    • MicroRNA-7 inhibits tumor metastasis and reverses epithelial-mesenchymal transition through AKT/ERK1/2 inactivation by targeting EGFR in epithelial ovarian cancer
    • Zhou X, Hu Y, Dai L, Wang Y, Zhou J, Wang W, et al. MicroRNA-7 inhibits tumor metastasis and reverses epithelial-mesenchymal transition through AKT/ERK1/2 inactivation by targeting EGFR in epithelial ovarian cancer. PLoS One. 2014;9(5), e96718.
    • (2014) PLoS One , vol.9 , Issue.5
    • Zhou, X.1    Hu, Y.2    Dai, L.3    Wang, Y.4    Zhou, J.5    Wang, W.6
  • 45


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.