Structural Analysis of Substrate, Reaction Intermediate, and Product Binding in Haemophilus influenzae Biotin Carboxylase

Biochemistry

Volumn 54, Issue 24, 2015, Pages 3860-3870

  Broussard, Tyler C ^a   Pakhomova, Svetlana ^a   Neau, David B ^b   Bonnot, Ross ^a   Waldrop, Grover L ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b Department of Chemistry and Chemical Biology Cornell University Argonne National Laboratory ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; BINS; CARBOXYLATION; CATALYSIS; CRYSTAL STRUCTURE; ESTERIFICATION; ESTERS; FATTY ACIDS; POLYPEPTIDES; PROTEINS; REACTION INTERMEDIATES;

ACETYL-COA CARBOXYLASE; BIOTIN CARBOXYL CARRIER PROTEIN; CATALYTIC MECHANISMS; FATTY ACID SYNTHESIS; GRAM-POSITIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; HIGH RESOLUTION CRYSTAL STRUCTURE; TETRAHEDRAL PHOSPHATES;

COENZYMES;

ACETAMIDE DERIVATIVE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID; BACTERIAL ENZYME; BICARBONATE; BIOTIN CARBOXYLASE; BIOTIN DERIVATIVE; CARBOXYL GROUP; CARBOXYLASE; ESTER; FOSCARNET; HYDROGEN; PHOSPHATE; UNCLASSIFIED DRUG; 5'-ADENYLYL (BETA,GAMMA-METHYLENE)DIPHOSPHONATE; BACTERIAL PROTEIN; BIOTIN; LIGASE; N1'-METHOXYCARBONYLBIOTIN METHYL ESTER; ORGANOPHOSPHORUS COMPOUND; PHOSPHONOACETAMIDE; PROTEIN SUBUNIT;

ARTICLE; BINDING SITE; CARBOXYLATION; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ELECTRON; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; HAEMOPHILUS INFLUENZAE; HALF LIFE TIME; HYDROGEN BOND; HYDROLYSIS; NONHUMAN; PH; PRIORITY JOURNAL; REACTION ANALYSIS; TURNOVER NUMBER; ANALOGS AND DERIVATIVES; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; ENZYME ACTIVE SITE; ENZYMOLOGY; METABOLISM; PROTEIN CONFORMATION; PROTEIN DATABASE; PROTEIN SUBUNIT; X RAY CRYSTALLOGRAPHY;

HAEMOPHILUS INFLUENZAE; NEGIBACTERIA; POSIBACTERIA;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; BACTERIAL PROTEINS; BICARBONATES; BIOCATALYSIS; BIOTIN; CARBON-NITROGEN LIGASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; FOSCARNET; HAEMOPHILUS INFLUENZAE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHATES; PROTEIN CONFORMATION; PROTEIN SUBUNITS;

EID: 84934949330     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00340     Document Type: Article

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