PGC-1α overexpression suppresses blood pressure elevation in DOCA-salt hypertensive mice

Bioscience Reports

Volumn 35, Issue 3, 2015, Pages

  Zhao, Qingbin ^a   Zhang, Junfang ^b   Wang, Huifang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b Department of Ophthalmology and Otorhinolaryngology   (China)

Author keywords

Deoxycorticosterone acetate (DOCA) salt; Endothelial dysfunction; Endothelial nitric oxide synthase (eNOS); Hypertension; Peroxisome proliferator activated receptor coactivator 1 (pgc 1 )

Indexed keywords

DEOXYCORTICOSTERONE ACETATE; DIHYDROFOLATE REDUCTASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HEAT SHOCK PROTEIN 90; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SUPEROXIDE; TETRAHYDROBIOPTERIN; NOS3 PROTEIN, MOUSE; PPARGC1A PROTEIN, MOUSE;

ADENOVIRUS INFECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; ENDOTHELIUM; ENDOTHELIUM CELL; GENE OVEREXPRESSION; HYPERTENSION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; VASODILATATION; ANIMAL; AORTA; BLOOD PRESSURE; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ADENOVIRIDAE; MUS;

ANIMALS; AORTA; BLOOD PRESSURE; CELLS, CULTURED; DESOXYCORTICOSTERONE ACETATE; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HSP90 HEAT-SHOCK PROTEINS; HYPERTENSION; MALE; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; VASODILATION;

EID: 84934926136     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20150076     Document Type: Article

References (27)

1. Palatini, P., Casiglia, E., Gasowski, J., Gluszek, J., Jankowski, P., Narkiewicz, K., Saladini, F., Stolarz-Skrzypek, K., Tikhonoff, V., Van Bortel, L. et al. (2011) Arterial stiffness, central hemodynamics, and cardiovascular risk in hypertension. Vasc. Health Risk Manag. 7, 725-739 CrossRef PubMed
2. Mancia, G., Messerli, F., Bakris, G., Zhou, Q., Champion, A. and Pepine, C.J. (2007) Blood pressure control and improved cardiovascular outcomes in the International Verapamil SR-Trandolapril Study. Hypertension 50, 299-305 CrossRef PubMed
3. Toque, H.A., Nunes, K.P., Rojas, M., Bhatta, A., Yao, L., Xu, Z., Romero, M.J., Webb, R.C., Caldwell, R.B. and Caldwell, R.W. (2013) Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension. Front. Immunol. 4, 219 CrossRef PubMed
4. White, R.M., Rivera, C.O. and Davison, C.B. (1996) Differential contribution of endothelial function to vascular reactivity in conduit and resistance arteries from deoxycorticosterone-salt hypertensive rats. Hypertension 27, 1245-1253 CrossRef PubMed
5. Du, Y.H., Guan, Y.Y., Alp, N.J., Channon, K.M. and Chen, A.F. (2008) Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension. Circulation 117, 1045-1054 CrossRef PubMed
6. Sun, J. and Liao, J.K. (2004) Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase. Arterioscler. Thromb. Vasc. Biol. 24, 2238-2244 CrossRef PubMed
7. Wei, Q. and Xia, Y. (2005) Roles of 3-phosphoinositide-dependent kinase 1 in the regulation of endothelial nitric-oxide synthase phosphorylation and function by heat shock protein 90. J. Biol. Chem. 280, 18081-18086 CrossRef PubMed
8. Toporsian, M., Gros, R., Kabir, M.G., Vera, S., Govindaraju, K., Eidelman, D.H., Husain, M. and Letarte, M. (2005) A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in hereditary hemorrhagic telangiectasia. Circ. Res. 96, 684-692 CrossRef PubMed
9. Landmesser, U., Dikalov, S., Price, S.R., McCann, L., Fukai, T., Holland, S.M., Mitch, W.E. and Harrison, D.G. (2003) Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J. Clin. Invest. 111, 1201-1209 CrossRef PubMed
10. Zheng, J.S., Yang, X.Q., Lookingland, K.J., Fink, G.D., Hesslinger, C., Kapatos, G., Kovesdi, I. and Chen, A.F. (2003) Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. Circulation 108, 1238-1245 CrossRef PubMed
11. Puigserver, P., Wu, Z., Park, C.W., Graves, R., Wright, M. and Spiegelman, B.M. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839 CrossRef PubMed
12. Handschin, C. and Spiegelman, B.M. (2006) Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr. Rev. 27, 728-735 CrossRef PubMed
13. Valle, I., Alvarez-Barrientos, A., Arza, E., Lamas, S. and Monsalve, M. (2005) PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells. Cardiovasc. Res. 66, 562-573 CrossRef PubMed
14. Rowe, G.C., Jiang, A. and Arany, Z. (2010) PGC-1 coactivators in cardiac development and disease. Circ. Res. 107, 825-838 CrossRef PubMed
15. Ramjiawan, A., Bagchi, R.A., Albak, L. and Czubryt, M.P. (2013) Mechanism of cardiomyocyte PGC-1alpha gene regulation by ERRalpha. Biochem. Cell Biol. 91, 148-154 CrossRef PubMed
16. Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S., Wu, P.H. et al. (2005) Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab. 1, 259-271 CrossRef PubMed
17. Valero-Munoz, M., Martin-Fernandez, B., Ballesteros, S., Martinez-Martinez, E., Blanco-Rivero, J., Balfagon, G., Cachofeiro, V., Lahera, V. and de las Heras, N. (2013) Relevance of vascular peroxisome proliferator-activated receptor gamma coactivator-1alpha to molecular alterations in atherosclerosis. Exp. Physiol. 98, 999-1008 CrossRef PubMed
18. Valero-Munoz, M., Martin-Fernandez, B., Ballesteros, S., Lahera, V. and de las Heras, N. (2014) Carob pod insoluble fiber exerts anti-atherosclerotic effects in rabbits through sirtuin-1 and peroxisome proliferator-activated receptor-gamma coactivator-1alpha. J. Nutr. 144, 1378-1384 CrossRef PubMed
19. Kim, H.J., Park, K.G., Yoo, E.K., Kim, Y.H., Kim, Y.N., Kim, H.S., Kim, H.T., Park, J.Y., Lee, K.U., Jang, W.G. et al. (2007) Effects of PGC-1alpha on TNF-alpha-induced MCP-1 and VCAM-1 expression and NF-kappaB activation in human aortic smooth muscle and endothelial cells. Antioxid. Redox Signal. 9, 301-307 CrossRef PubMed
20. Leopold, J.A., Dam, A., Maron, B.A., Scribner, A.W., Liao, R., Handy, D.E., Stanton, R.C., Pitt, B. and Loscalzo, J. (2007) Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat. Med. 13, 189-197 CrossRef PubMed
21. Li, Y.H., Xu, Q., Xu, W.H., Guo, X.H., Zhang, S. and Chen, Y.D. (2015) Mechanisms of protection against diabetes-induced impairment of endothelium-dependent vasorelaxation by Tanshinone IIA. Biochim. Biophys. Acta 1850, 813-823 CrossRef PubMed
22. Lin, J., Handschin, C. and Spiegelman, B.M. (2005) Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 1, 361-370 CrossRef PubMed
23. Zhu, L., Sun, G., Zhang, H., Zhang, Y., Chen, X., Jiang, X., Jiang, X., Krauss, S., Zhang, J., Xiang, Y. and Zhang, C.Y. (2009) PGC-1alpha is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells. PLoS One 4, e4182 CrossRef PubMed
24. Duan, S.Z., Usher, M.G. and Mortensen, R.M. (2008) Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature. Circ. Res. 102, 283-294 CrossRef PubMed
25. Pritchard, K. A., Jr, Groszek, L., Smalley, D.M., Sessa, W.C., Wu, M., Villalon, P., Wolin, M.S. and Stemerman, M.B. (1995) Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ. Res. 77, 510-518 CrossRef PubMed
26. Dumitrescu, C., Biondi, R., Xia, Y., Cardounel, A.J., Druhan, L.J., Ambrosio, G. and Zweier, J.L. (2007) Myocardial ischemia results in tetrahydrobiopterin (BH4) oxidation with impaired endothelial function ameliorated by BH4. Proc. Natl. Acad. Sci. U.S.A. 104, 15081-15086 CrossRef PubMed
27. Pritchard, K. A., Jr, Ackerman, A.W., Gross, E.R., Stepp, D.W., Shi, Y., Fontana, J.T., Baker, J.E. and Sessa, W.C. (2001) Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. J. Biol. Chem. 276, 17621-17624 CrossRef PubMed