Monocyte and lymphocyte activation in bipolar disorder: A new piece in the puzzle of immune dysfunction in mood disorders

International Journal of Neuropsychopharmacology

Volumn 18, Issue 1, 2015, Pages

  Barbosa, Izabela Guimaraes ^a   Rocha, Natalia Pessoa ^a   Assis, Frankcineia ^a   Vieira, Erica Leandro Marciano ^a   Soares, Jair C ^b   Bauer, Moises Evandro ^c   Teixeira, Antonio Lucio ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Bipolar disorder; Cytokines; Lymphocytes; Mania; Monocytes

Indexed keywords

ANTICONVULSIVE AGENT; CD14 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LITHIUM; NEUROLEPTIC AGENT; TUMOR NECROSIS FACTOR; VALPROIC ACID; CYTOKINE; IL10 PROTEIN, HUMAN;

ADULT; ARTICLE; BIPOLAR I DISORDER; CD25+ T LYMPHOCYTE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DIABETES MELLITUS; DYSLIPIDEMIA; FEMALE; FLOW CYTOMETRY; HAMILTON DEPRESSION RATING SCALE; HUMAN; HUMAN CELL; HYPERTENSION; IMMUNOPATHOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; MALE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSYCHIATRY; YOUNG MANIA RATING SCALE; BIPOLAR DISORDER; BLOOD; BLOOD ANALYSIS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; REGULATORY T LYMPHOCYTE; STATISTICAL MODEL;

BIPOLAR DISORDER; BLOOD CHEMICAL ANALYSIS; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-10; LOGISTIC MODELS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MONOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 84934911152     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1093/ijnp/pyu021     Document Type: Article

References (33)

1. Altamura AC, Serati M, Albano A, Paoli RA, Glick ID, Dell'Osso B (2011) An epidemiologic and clinical overview of medical and psychopathological comorbidities in major psychoses. Eur Arch Psychiatry Clin Neurosci 261:489-508.
2. Amorim P (2000) Mini international neuropsychiatric interview (MINI): validação de entrevista breve para diagnóstico de transtornos mentais. Rev Bras Psiquiatr 22:106-115.
3. Bachen EA, Chesney MA, Criswell LA (2009) Prevalence of mood and anxiety disorders in women with systemic lupus erythematosus. Arthritis Rheum 61:822-829.
4. Barbosa IG, Huguet RB, Mendonça VA, Sousa LP, Neves FS, Bauer ME, Teixeira AL (2011) Increased plasma levels of soluble TNF receptor I in patients with bipolar disorder. Eur Arch Psychiatry Clin Neurosci 261:139-143.
5. Barbosa IG, Machado-Vieira R, Soares JC, Teixeira AL (in press) The immunology of bipolar disorder. Neuroimmunomodulation.
6. Bluestone JA, Abbas AK (2003) Natural versus adaptive regulatory T cells. Nat Rev Immunol 3:253-257.
7. Breunis MN, Kupka RW, Nolen WA, Suppes T, Denicoff KD, Leverich GS, Post RM, Drexhage HA (2003) High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorder. Biol Psychiatry 53:157-165.
8. do Prado CH, Rizzo LB, Wieck A, Lopes RP, Teixeira AL, Grassi- Oliveira R, Bauer ME (2013) Reduced regulatory T cells are associated with higher levels of Th1/TH17 cytokines and activated MAPK in type 1 bipolar disorder. Psychoneuroendocrinology 38:667-676.
9. Drexhage RC, Hoogenboezem TH, Versnel MA, Berghout A, Nolen WA, Drexhage HA (2011) The activation of monocyte and T cell networks in patients with bipolar disorder. Brain Behav Immun 25:1206-1213.
10. Eaton WW, Pedersen MG, Nielsen PR, Mortensen PB (2010) Autoimmune diseases, bipolar disorder, and non-affective psychosis. Bipolar Disord 12:638-646.
11. Edwards LJ, Constantinescu CS (2004) A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic. Mult Scler J 10:575-581.
12. Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Psychol 6:278-296.
13. Knijff EM, Ruwhof C, de Wit HJ, Kupka RW, Vonk R, Akkerhuis GW, Nolen WA, Drexhage HA (2006) Monocyte-derived dendritic cells in bipolar disorder. Biol Psychiatry 59:317-326.
14. Knijff EM, Breunis MN, Kupka RW, de Wit HJ, Ruwhof C, Akkerhuis GW, Nolen WA, Drexhage HA (2007) An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment. Bipolar Disord 9:743-753.
15. Knijff EM, Breunis MN, van Geest MC, Kupka RW, Ruwhof C, de Wit HJ, Nolen WA, Drexhage HA (2007) A relative resistance of T cells to dexamethasone in bipolar disorder. Bipolar Disord 8:740-750.
16. Kupka RW, Nolen WA, Post RM, McElroy SL, Altshuler LL, Denicoff KD, Frye MA, Keck PE Jr, Leverich GS, Rush AJ, Suppes T, Pollio C, Drexhage HA (2002) High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure. Biol Psychiatry 51:305-311.
17. McAdams C, Leonard BE (1993) Neutrophil and monocyte phagocytosis in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 17:971-984.
18. McIntyre RS, Soczynska JK, Beyer JL, Woldeyohannes HO, Law CW, Miranda A, Konarski JZ, Kennedy SH (2007) Medical comorbidity in bipolar disorder: re-prioritizing unmet needs. Curr Opin Psychiatry 20:406-416.
19. Modabbernia A, Taslimi S, Brietzke E, Ashrafi M (2013) Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies. Biol Psychiatry 74:15-25.
20. Munkholm K, Vinberg M, Vedel Kessing L (2013) Cytokines in bipolar disorder: a systematic review and meta-analysis. J Affect Disord 144:16-27.
21. O'Garra A, Vieira PL, Vieira P, Goldfeld AE (2004) IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage. J Clin Invest 114:1372-1378.
22. Padmos RC, Hillegers MH, Knijff EM, Vonk R, Bouvy A, Staal FJ, de Ridder D, Kupka RW, Nolen WA, Drexhage HA (2008) A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch Gen Psychiatry 65:395-407.
23. Padmos RC, Van Baal GC, Vonk R, Wijkhuijs AJ, Kahn RS, Nolen WA, Drexhage HA (2009) Genetic and environmental influences on pro-inflammatory monocytes in bipolar disorder: a twin study. Arch Gen Psychiatry 66:957-965.
24. Rapaport MH (1994) Immune parameters in euthymic bipolar patients and normal volunteers. J Affect Disord 32:149-156.
25. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl 20):22-33.
26. Smith RS (1991) The macrophage theory of depression. Med Hypotheses 35:298-306.
27. Soeiro-de-Souza MG, Dias VV, Figueira ML, Forlenza OV, Gattaz WF, Zarate CA Jr, Machado-Vieira R (2012) Translating neurotrophic and cellular plasticity: from pathophysiology to improved therapeutics for bipolar disorder. Acta Psychiatr Scand 126:332-341.
28. Teixeira AL, Barbosa IG, Machado-Vieira R, Rizzo LB, Wieck A, Bauer ME (2013) Novel biomarkers for bipolar disorder. Exp Opin Med Diagnost 7:147-159.
29. Torres KC, Souza BR, Miranda DM, Nicolato R, Neves FS, Barros AG, Dutra WO, Gollob KJ, Correa H, Romano-Silva MA (2009) The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 33:214-219.
30. Watkins CC, Sawa A, Pomper MG (2014) Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application. Transl Psychiatry 4:e350.
31. Wieck A, Grassi-Oliveira R, do Prado CH, Rizzo LB, de Oliveira AS, Kommers-Molina J, Viola TW, Teixeira AL, Bauer ME (2013) Differential neuroendocrine and immune responses to acute psychosocial stress in women with type 1 bipolar disorder. Brain Behav Immun 34:47-55.
32. Yolken RH, Torrey EF (1995) Viruses, schizophrenia, and bipolar disorder. Clin Microbiol Rev 8:131-145.
33. Young RC, Biggs JT, Ziegler VE, Meyer DA (1978) A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133:429-435.