Predictive medicine: Outcomes, challenges and opportunities in the Synergy-COPD project

Journal of Translational Medicine

Volumn 12, Issue , 2014, Pages

  Miralles, Felip ^a   Gomez Cabrero, David ^b   Lluch Ariet, Magí ^a,e   Tegnér, Jesper ^b   Cascante, Marta ^c,d   Roca, Josep ^c,d  

^a Barcelona Digital Technology Centre   (Spain)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF BARCELONA   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

^e UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOBRIDGE DATABASE; BIOINFORMATICS; BIOMEDICAL TECHNOLOGY ASSESSMENT; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL PRACTICE; CLUSTER ANALYSIS; COMMUNICATION PROTOCOL; COMORBIDITY; COMPUTER INTERFACE; COMPUTER NETWORK; COMPUTER PREDICTION; COMPUTER SIMULATION; CONCEPTUAL FRAMEWORK; DATA ANALYSIS; DATA ANALYSIS SOFTWARE; DECISION SUPPORT SYSTEM; DISEASE COURSE; GENETIC ASSOCIATION; GENETIC DATABASE; GENETIC HETEROGENEITY; HEALTH CARE PLANNING; HEALTH CARE SYSTEM; HEALTH PROGRAM; ICD-9-CM; KNOWLEDGE BASE; MEDICAL INFORMATICS; MEDICAL INFORMATION SYSTEM; MEDICAL RESEARCH; MEDICARE; MUSCLE DISEASE; OUTCOME ASSESSMENT; PERFORMANCE MEASUREMENT SYSTEM; PROCESS DESIGN; PROCESS OPTIMIZATION; REVIEW; RISK ASSESSMENT; SKELETAL MUSCLE; SYSTEM ANALYSIS; CHRONIC DISEASE; HUMAN; LUNG DISEASE; PATHOPHYSIOLOGY; PROGNOSIS; PROGRAM DEVELOPMENT; PULMONOLOGY; THEORETICAL MODEL; TRANSLATIONAL RESEARCH; TRENDS;

CHRONIC DISEASE; CLUSTER ANALYSIS; COMORBIDITY; HUMANS; LUNG DISEASES; MODELS, THEORETICAL; MUSCLE, SKELETAL; PROGNOSIS; PROGRAM DEVELOPMENT; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY MEDICINE; RISK ASSESSMENT; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84934886494     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-12-S2-S12     Document Type: Review

References (64)

1. Synergy-COPD: Modelling and simulation environment for systems medicine: Chronic obstructive pulmonary disease (COPD) as a use case., FP7-ICT-270086 2011-2014.
2. Vestbo J, Hurd SS, Agusti AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, et al: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. American journal of respiratory and critical care medicine 2013, 187:347-365.
3. Vestbo J, Agusti A, Wouters EF, Bakke P, Calverley PM, Celli B, Coxson H, Crim C, Edwards LD, Locantore N, et al: Should we view chronic obstructive pulmonary disease differently after ECLIPSE? A clinical perspective from the study team. American journal of respiratory and critical care medicine 2014, 189:1022-1030.
4. Bousquet J, Anto J, Sterk P, Adcock I, Chung K, Roca J, Agusti A, Brightling C, Cambon-Thomsen A, Cesario A, et al: Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome medicine 2011, 3:43.
5. Hood L, Auffray C: Participatory medicine: a driving force for revolutionizing healthcare. Genome medicine 2013, 5:110.
6. Cano I L-AM, Gomez-Cabrero D, Maier D, Kalko S, Cascante M, Tégner J, Miralles F, Herrera D, Roca J, Synergy COPD consortium: Biomedical Research in a Digital Health Framework. BMC Journal of Translational Medicine 2014.
7. Barnes PJ, Celli BR: Systemic manifestations and comorbidities of COPD. European Respiratory Jornal 2009, 33:1165-1185.
8. Sinden NJ, Stockley RA: Systemic inflammation and comorbidity in COPD: a result of 'overspill' of inflammatory mediators from the lungs? Review of the evidence. Thorax 2010, 65:930-936.
9. Loscalzo J, Barabasi AL: Systems biology and the future of medicine. Wiley Interdiscip Rev Syst Biol Med 2011, 3:619-627.
10. Handy DE, Loscalzo J, Leopold JA: Systems analysis of oxidant stress in the vasculature. IUBMB life 2013, 65:911-920.
11. Silverman EK, Loscalzo J: Network medicine approaches to the genetics of complex diseases. Discovery medicine 2012, 14:143-152.
12. Maltais F, Decramer M, Casaburi R, Barreiro E, Burelle Y, Debigare R, Dekhuijzen PN, Franssen F, Gayan-Ramirez G, Gea J, et al: An official american thoracic society/european respiratory society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine 2014, 189: e15-62.
13. Divo M, Cote C, de Torres JP, Casanova C, Marin JM, Pinto-Plata V, Zulueta J, Cabrera C, Zagaceta J, Hunninghake G, Celli B: Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine 2012, 186:155-161.
14. Vanfleteren LE, Spruit MA, Groenen M, Gaffron S, van Empel VP, Bruijnzeel PL, Rutten EP, Op't Roodt J, Wouters EF, Franssen FM: Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine 2013, 187:728-735.
15. Fabbri LM, Beghe B, Agusti A: COPD and the solar system: introducing the chronic obstructive pulmonary disease comorbidome. American journal of respiratory and critical care medicine 2012, 186:117-119.
16. Maier D, Kalus W, Wolff M, Kalko SG, Roca J, Marin de Mas I, Turan N, Cascante M, Falciani F, Hernandez M, et al: Knowledge management for Systems Biology a general and visually driven framework applied to translational medicine. BMC systems biology 2011, 5:38.
17. Huertas Migueláñez M, Mercedes MD, Isaac Cano, Dieter Maier, David Gomez-Cabrero, Magi Lluch-Ariet, Felip Miralles: Simulation Environment and Graphical Visualization Environment: a COPD use-case. BMC Journal of Translational Medicine 2014, 12(S2):S7.
18. Gomez-Cabrero D MJ, Cano I, Abugessaisa I, Huertas-Migueláñez M, Tenyi A, Marin de Mas I, Kiani N, Marabita F, Falciani F, Burrowes K, Maier D, Wagner P, Selivanov V, Cascante M, Roca J, Barabási A, Tegnér J: Systems Medicine: from molecular features and models to the clinic in COPD. BMC Journal of Translational Medicine 2014, 12(S2):S4.
19. Roca J VC, Cano I, Selivanov V, Barreiro E, Maier D, Falciani F, Wagner P, Cascante M, Garcia-Aymerich J, Kalko S, Marin I, Tegner J, Escarrabill J, Agustí A, Gomez-Cabrero D, Synergy COPD consortium: Challenges for Health Risk Assessment, Stratification and Management. BMC Journal of Translational Medicine 2014.
20. Velickovski FCL, Roca J, Burgos F, Galdiz J, Nueria M, Lluch Ariet M: Clinical Decision Support Systems (CDSS) for preventive management of COPD patients. BMC Journal of Translational Medicine 2014, 12(S2):S9.
21. Gomez-Cabrero D L-AM, Tegner J, Cascante M, Miralles F, Roca J, Synergy-COPD consortium: Synergy-COPD: A systems approach for understanding and managing Chronic Diseases. BMC Journal of Translational Medicine 2014, 12(S2):S2.
22. Garcia-Aymerich J, Gomez FP, Benet M, Farrero E, Basagana X, Gayete A, Pare C, Freixa X, Ferrer J, Ferrer A, et al: Identification and prospective validation of clinically relevant chronic obstructive pulmonary disease (COPD) subtypes. Thorax 2011, 66:430-437.
23. o 037909; 2006-2009.
24. Turan N, Kalko S, Stincone A, Clarke K, Sabah A, Howlett K, Curnow SJ, Rodriguez DA, Cascante M, O'Neill L, et al: A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease. PLoS Comput Biol 2011, 7: e1002129.
25. Rodriguez DA, Kalko S, Puig-Vilanova E, Perez-Olabarria M, Falciani F, Gea J, Cascante M, Barreiro E, Roca J: Muscle and blood redox status after exercise training in severe COPD patients. Free radical biology & medicine 2012, 52:88-94.
26. Rodriguez DA GA-V, Diaz-Moralli S, Reed M, Gomez FP, Falciani F, Günther U, Roca J, Cascante M: Plasma metabolic profile in COPD patients: effects of exercise and endurance training. Metabolomics 2012, 8:508-516.
27. Thomson E, Ferreira-Cerca S, Hurt E: Eukaryotic ribosome biogenesis at a glance. J Cell Sci 2013, 126:4815-4821.
28. Laplante M, Sabatini DM: mTOR signaling in growth control and disease. Cell 2012, 149:274-293.
29. Schieke SM, Finkel T: Mitochondrial signaling, TOR, and life span. Biol Chem 2006, 387:1357-1361.
30. Schieke SM, Phillips D, McCoy JP, Aponte AM, Shen RF, Balaban RS, Finkel T: The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem 2006, 281:27643-27652.
31. Saltiel AR, Kahn CR: Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414:799-806.
32. Davidsen PK HJ, Antczak P, Clarke K, Ferrer E, Peinado VI, Gonzalez G, Roca J, Egginton S, Barberá JA, Falciani F: A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD. Genome Medicine 2014, 6:59.
33. Hidalgo CA, Blumm N, Barabási A-L, Christakis NA: A Dynamic Network Approach for the Study of Human Phenotypes. PLoS Comput Biol 2009, 5: e1000353.
34. Goh KI CM, Valle D, Childs B, Vidal M, Barabasi LA: The human disease network. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:6.
35. Hare JM: Nitroso-Redox Balance in the Cardiovascular System. New England Journal of Medicine 2004, 351:2112-2114.
36. Burrowes Kelly S DT, Brightling C: Computational modelling of the obstructive lung diseases asthma and COPD. BMC Journal of Translational Medicine 2014.
37. de-Torres JP, Blanco D, Alcaide AB, Seijo LM, Bastarrika G, Pajares MJ, Munoz-Barrutia A, Ortiz-de-Solorzano C, Pio R, Campo A, et al: Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra. PloS one 2013, 8:e60260.
38. de-Torres JP, Casanova C, Marin JM, Zagaceta J, Alcaide AB, Seijo LM, Campo A, Carrizo S, Montes U, Cordoba-Lanus E, et al: Exploring the impact of screening with low-dose CT on lung cancer mortality in mild to moderate COPD patients: a pilot study. Respiratory medicine 2013, 107:702-707.
39. Cano I, Tényi Á, Schueller C, Wolff M, Huertas MM, Gomez-Cabrero D, Antczak P, Roca1 J, Cascante M, et al: The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research. Journal of Translational Medicine 2014.
40. Vidal M, Cusick Michael E, Barabási A-L: Interactome Networks and Human Disease. Cell 2011, 144:986-998.
41. Cano I, Mickael M, Gomez-Cabrero D, Tegnér J, Roca J, Wagner PD: Importance of mitochondrial in maximal O2 transport and utilization: A theoretical analysis. Respiratory Physiology & Neurobiology 2013, 189:477-483.
42. Wagner PD: Algebraic analysis of the determinants of VO2max. Respiration physiology 1993, 93:221-237.
43. Wagner PD: Determinants of Maximal Oxygen Transport and Utilization. Annual Review of Physiology 1996, 58:21-50.
44. Nagarajan R, Datta S, Scutari M, Beggs ML, Nolen GT, Peterson CA: Functional relationships between genes associated with differentiation potential of aged myogenic progenitors. Front Physiol 2010, 1.
45. Thomas R, Kaufman M: Multistationarity, the basis of cell differentiation and memory. I. Structural conditions of multistationarity and other nontrivial behavior. Chaos 2001, 11:170-179.
46. Thomas R, Kaufman M: Multistationarity, the basis of cell differentiation and memory. II. Logical analysis of regulatory networks in terms of feedback circuits. Chaos 2001, 11:180-195.
47. NEXES: Supporting Healthier and Independent Living for Chronic Patients and Elderly., CIP-ICT-PSP-225025 2008-2013.
48. Regions of Europe working together for health. [http://www. renewinghealth.eu/en/].
49. Miller WG, Tate JR, Barth JH, Jones GR: Harmonization: the sample, the measurement, and the report. Annals of laboratory medicine 2014, 34:187-197.
50. Campbell CA, Horvath AR: Harmonization of critical result management in laboratory medicine. Clinica Chimica Acta 2014, 432:135-147.
51. Uribe GA, Lopez DM, Blobel B: Towards automated biomedical ontology harmonization. Studies in health technology and informatics 2014, 200:62-68.
52. Kicinski M: Publication Bias in Recent Meta-Analyses. PloS one 2013, 8: e81823.
53. Brice A, Chalmers I: Medical journal editors and publication bias. Bmj 2013, 347:f6170.
54. Smulders YM: A two-step manuscript submission process can reduce publication bias. Journal of clinical epidemiology 2013, 66:946-947.
55. TA M: Genomewide asscoiation studies and assessment of the risk of disease. The New England journal of medicine 2010, 363:10.
56. Barabasi AL, Bonabeau E: Scale-free networks. Scientific American 2003, 288:60-69.
57. Barabasi AL: Network medicine-from obesity to the "diseasome". The New England journal of medicine 2007, 357:404-407.
58. de Chassey B, Navratil V, Tafforeau L, Hiet MS, Aublin-Gex A, Agaugue S, Meiffren G, Pradezynski F, Faria BF, Chantier T, et al: Hepatitis C virus infection protein network. Molecular systems biology 2008, 4:230.
59. Yeger-Lotem E, Riva L, Su LJ, Gitler AD, Cashikar AG, King OD, Auluck PK, Geddie ML, Valastyan JS, Karger DR, et al: Bridging high-throughput genetic and transcriptional data reveals cellular responses to alphasynuclein toxicity. Nature Genetics 2009, 41:316-323.
60. Bandyopadhyay S, Mehta M, Kuo D, Sung MK, Chuang R, Jaehnig EJ, Bodenmiller B, Licon K, Copeland W, Shales M, et al: Rewiring of genetic networks in response to DNA damage. Science 2010, 330:1385-1389, (New York, NY).
61. Saez-Rodriguez J, Alexopoulos LG, Epperlein J, Samaga R, Lauffenburger DA, Klamt S, Sorger PK: Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction. Molecular systems biology 2009, 5:331.
62. Ramirez F, Schlicker A, Assenov Y, Lengauer T, Albrecht M: Computational analysis of human protein interaction networks. Proteomics 2007, 7:2541-2552.
63. Loscalzo J, Kohane I, Barabasi AL: Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Molecular systems biology 2007, 3:124.
64. eHealth Action Plan 2012-2020. Green Paper on mobile health ("mHealth"). 2014 [http://ec.europa.eu/digital-agenda/en/news/greenpaper-mobile-health-mhealth].