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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 16, 2015, Pages 3295-3300

Novel (pyrazolyl)benzenesulfonamides with a nitric oxide-releasing moiety as selective cyclooxygenase-2 inhibitors

(6) Bechmann, Nicole a,b Kniess, Torsten a Köckerling, Martin c Pigorsch, Arne c Steinbach, Jörg a,b Pietzsch, Jens a,b

a INSTITUTE OF ION BEAM PHYSICS AND MATERIALS RESEARCH (Germany)

b DRESDEN UNIVERSITY OF TECHNOLOGY (Germany)

c UNIVERSITY OF ROSTOCK (Germany)

Author keywords

Anti inflammatory therapy; Cardiovascular side effects; Celecoxib; Direct indirect NO coupling; Griess assay; Organic nitrate

Indexed keywords

(PYRAZOLYL)BENZENESULFONAMIDE DERIVATIVE; 4 [3 (HYDROXYMETHYL) 5 (PARA TOLYL) 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; ANTIINFLAMMATORY AGENT; BENZENESULFONAMIDE DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DICHLORINATED CHLORO [3 (CHLOROMETHYL) 5 (PARA TOLYL) 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; MONOCHLORINATED 4 [3 (CHLOROMETHYL) 5 (PARA TOLYL) 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; NITRIC OXIDE DONOR; ORGANIC NITRATE; UNCLASSIFIED DRUG; [1 (4 SULFAMOYLPHENYL) 5 (PARA TOLYL) 1H PYRAZOL 3 YL]METHYL NITRATE; [4 CHLORO 1 (4 SULFAMOLYPHENYL) 5 (PARA TOLYL) 1H PYRAZOL 3 YL]METHYL NITRATE; BENZENESULFONAMIDE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; SULFONAMIDE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CHLORINATION; HUMAN; IC50; CARDIOVASCULAR DISEASE; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; METABOLISM; SYNTHESIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARDIOVASCULAR DISEASES; CYCLOOXYGENASE 2 INHIBITORS; ENZYME ACTIVATION; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; NITRIC OXIDE; SULFONAMIDES;

EID: 84934844110 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.05.059 Document Type: Article

Times cited : (22)

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