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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 9, 2015, Pages 1836-1841

Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4

(14) McElroy, William T a Michael Seganish, W a Jason Herr, R b Harding, James b Yang, Jinhai b Yet, Larry b Komanduri, Venukrishnan c Prakash, Koraboina Chandra c Lavey, Brian a Tulshian, Deen a Greenlee, William J a Sondey, Christopher a Fischmann, Thierry O a Niu, Xiaoda a

a MERCK RESEARCH LABORATORIES (United States)

b ALBANY MOLECULAR RESEARCH INC (United States)

c AMRI Singapore Research Centre (Singapore)

Author keywords

Drug discovery; Inflammation; Interleukin receptor associated kinases; SAR; Structure based drug design

Indexed keywords

2,6-DIAMINOPYRIMIDINE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84934789081 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.03.043 Document Type: Article

Times cited : (16)

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