Discovery of novel SPAK inhibitors that block WNK kinase signaling to cation chloride transporters

Journal of the American Society of Nephrology

Volumn 26, Issue 7, 2015, Pages 1525-1536

  Kikuchi, Eriko ^a   Mori, Takayasu ^a   Zeniya, Moko ^a   Isobe, Kiyoshi ^a   Ishigami Yuasa, Mari ^b   Fujii, Shinya ^b   Kagechika, Hiroyuki ^b   Ishihara, Tomoaki ^c   Mizushima, Tohru ^c   Sasaki, Sei ^a   Sohara, Eisei ^a   Rai, Tatemitsu ^a   Uchida, Shinichi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1S 14279; ACTIN; ADENOSINE TRIPHOSPHATE; ANTIHYPERTENSIVE AGENT; CLOSANTEL; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE WNK; SODIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 1; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2; SPS1 RELATED PROLINE ALANINE RICH PROTEIN KINASE; SPS1 RELATED PROLINE ALANINE RICH PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; PAS DOMAIN KINASES; PRKWNK1 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; SALICYLANILIDE DERIVATIVE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG REPOSITIONING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH THROUGHPUT SCREENING; HYPOTENSION; IN VITRO STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECTS; GENETICS; HYPERTENSION; ION TRANSPORT; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; RANDOMIZATION; SENSITIVITY AND SPECIFICITY;

ANIMALS; ANTIHYPERTENSIVE AGENTS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HYPERTENSION; ION TRANSPORT; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RANDOM ALLOCATION; SALICYLANILIDES; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS;

EID: 84934766234     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2014060560     Document Type: Article

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