Translocator protein 18 kDa (TSPO): Old dogma, new mice, new structure, and new questions for neuroprotection

Neural Regeneration Research

Volumn 10, Issue 6, 2015, Pages 878-880

  Kim, Eun Jung ^a   Yu, Seong Woon ^a  

^a Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOGRAFT INFLAMMATORY FACTOR 1; ARGINASE 1; CD11B ANTIGEN; CELL MEMBRANE PROTEIN; CHOLESTEROL; INTERLEUKIN 10; INTERLEUKIN 6; MANNOSE RECEPTOR; MANNOSE RECEPTOR C1; NEUROTOXIN; NITRIC OXIDE; PORPHYRIN; PREGNENOLONE; TESTOSTERONE; TRANSLOCATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; GENE; HORMONE SYNTHESIS; HUMAN; MICROGLIA; NERVE INJURY; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION; PROTEIN STRUCTURE; UPREGULATION;

EID: 84934763348     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.4103/1673-5374.158338     Document Type: Article

References (10)

1. Bae KR, Shim HJ, Balu D, Kim SR, Yu SW (2014) Translocator protein 18 kDa negatively regulates inflammation in microglia. J Neuroimmune Pharmacol 9:424-437
2. Banati RB (2002) Visualising microglial activation in vivo. Glia 40:206-217
3. Banati RB, Middleton RJ, Chan R, Hatty CR, Kam WWY, Quin C, Graeber MB, Parmar A, Zahra D, Callaghan P, Fok S, Howell NR, Gregoire M, Szabo A, Pham T, Davis E, Liu GJ (2014) Positron emission tomography and functional characterization of a complete PBR/TSPO knockout. Nat Commun 5:5452
4. Guo Y, Kalathur RC, Liu Q, Kloss B, Bruni R, Ginter C, Kloppmann E, Rost B, Hendrickson WA (2015) Structure and activity of tryptophan- rich TSPO proteins. Science 347:551-555
5. Jaremko Ł, Jaremko M, Giller K, Becker S, Zweckstetter M (2014) Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science 343:1363-1366
6. Li F, Liu J, Zheng Y, Garavito RM, Ferguson-Miller S (2015) Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism. Science 347:555-558
7. Morohaku K, Pelton SH, Daugherty DJ, Butler WR, Deng W, Selvaraj V (2014) Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis. Endocrinology 155:89-97
8. Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown A (1997) Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis. Steroids 62:21-28
9. Sileikyte J, Blachly-Dyson E, Sewell R, Carpi A, Menabo R, Di Lisa F, Ricchelli F, Bernardi P, Forte M (2014) Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (Translocator Protein of 18 kDa (TSPO)). J Biol Chem 289:13769-13781
10. Tu LN, Morohaku K, Manna PR, Pelton SH, Butler WR, Stocco DM, Selvaraj V (2014) Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis. J Biol Chem 289:27444-27454.