Is256 abolishes gelatinase activity and biofilm formation in a mutant of the nosocomial pathogen enterococcus faecalis v583

Canadian Journal of Microbiology

Volumn 61, Issue 7, 2015, Pages 517-519

  Perez, Marta ^a   Calles Enríquez, Marina ^a   del Rio, Beatriz ^a   Ladero, Victor ^a   Martín, María Cruz ^a   Fernández, María ^a   Alvarez, Miguel A ^a  

^a DEPARTMENT OF MICROBIOLOGY AND BIOCHEMISTRY OF DAIRY PRODUCTS   (Spain)

Author keywords

Biofilm; Enterococcus faecalis; Gelatinase; Insertion sequence

Indexed keywords

GELATINASE; BACTERIAL PROTEIN; TRANSPOSON;

BACTERIUM; BIOFILM; DRUG RESISTANCE; ENZYME ACTIVITY; GENE EXPRESSION; MUTATION; NEW RECORD; PATHOGEN; PATHOGENICITY; PROBIOTICS; VIRULENCE;

ARTICLE; BIOFILM; ENDOCARDITIS; ENTEROCOCCUS FAECALIS; ENZYME ACTIVITY; GENE INSERTION SEQUENCE; HOSPITAL INFECTION; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENICITY ISLAND; PERITONITIS; PRIORITY JOURNAL; QUORUM SENSING; SEQUENCE ANALYSIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; CROSS INFECTION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; GRAM POSITIVE INFECTION; HUMAN; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; TRANSPOSON;

ENTEROCOCCUS FAECALIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

BACTERIAL PROTEINS; BIOFILMS; CROSS INFECTION; DNA TRANSPOSABLE ELEMENTS; ENTEROCOCCUS FAECALIS; GELATINASES; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; MUTAGENESIS, INSERTIONAL; QUORUM SENSING;

EID: 84934757630     PISSN: 00084166     EISSN: 14803275     Source Type: Journal    
DOI: 10.1139/cjm-2015-0090     Document Type: Article

References (21)

1. Bourgogne, A., Hilsenbeck, S.G., Dunny, G.M., and Murray, B.E. 2006. Compari-son of OG1RF and an isogenic fsrB deletion mutant by transcriptional analysis: the Fsr system of Enterococcus faecalis is more than the activator of gelatinase and serine protease. J. Bacteriol. 188(8): 2875-2884. doi:10.1128/JB.188.8.2875-2884.2006. PMID:16585749.
2. Cafiso, V., Bertuccio, T., Santagati, M., Demelio, V., Spina, D., Nicoletti, G., and Stefani, S. 2007. agr-Genotyping and transcriptional analysis of biofilmproducing Staphylococcus aureus. FEMS Immunol. Med. Microbiol. 51(1): 220-227. doi:10.1111/j.1574-695X.2007.00298.x. PMID:17854479.
3. Galloway-Pena, J.R., Bourgogne, A., Qin, X., and Murray, B.E. 2011. Diversity of the fsr-gelE region of the Enterococcus faecalis genome but conservation in strains with partial deletions of the fsr operon. Appl. Environ. Microbiol. 77(2): 442-451. doi:10.1128/AEM.00756-10. PMID:21097591.
4. Hancock, L.E., and Perego, M. 2004. The Enterococcus faecalis fsr two-component system controls biofilm development through production of gelatinase. J. Bacteriol. 186(17): 5629-5639. doi:10.1128/JB.186.17.5629-5639.2004. PMID: 15317767.
5. Hennig, S., and Ziebuhr, W. 2010. Characterization of the transposase encoded by IS256, the prototype of a major family of bacterial insertion sequence elements. J. Bacteriol. 192(16): 4153-4163. doi:10.1128/JB.00226-10. PMID: 20543074.
6. Jonsson, M., Saleihan, Z., Nes, I.F., and Holo, H. 2009. Construction and characterization of three lactate dehydrogenase-negative Enterococcus faecalis V583 mutants. Appl. Environ. Microbiol. 75(14): 4901-4903. doi:10.1128/AEM.00344-09. PMID:19465534.
7. Ladero, V., Fernandez, M., Calles-Enriquez, M., Sanchez-Llana, E., Canedo, E., Martin, M.C., and Alvarez, M.A. 2012. Is the production of the biogenic amines tyramine and putrescine a species-level trait in enterococci? Food Microbiol. 30(1): 132-138. doi:10.1016/j.fm.2011.12.016. PMID:22265293.
8. Nakayama, J., Chen, S., Oyama, N., Nishiguchi, K., Azab, E.A., Tanaka, E., et al. 2006. Revised model for Enterococcus faecalis fsr quorum-sensing system: the small open reading frame fsrD encodes the gelatinase biosynthesis-activating pheromone propeptide corresponding to staphylococcal AgrD. J. Bacteriol. 188(23): 8321-8326. doi:10.1128/JB.00865-06. PMID:16980448.
9. Pan, S.C., Wang, J.T., Chen, Y.C., Chang, Y.Y., Chen, M.L., and Chang, S.C. 2012. Incidence of and risk factors for infection or colonization of vancomycin-resistant enterococci in patients in the intensive care unit. PLoS One, 7(10): e47297. doi:10.1371/journal.pone.0047297. PMID:23071778.
10. Paulsen, I.T., Banerjei, L., Myers, G.S., Nelson, K.E., Seshadri, R., Read, T.D., et al. 2003. Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science, 299(5615): 2071-2074. doi:10.1126/science.1080613. PMID:12663927.
11. Perez, M., Calles-Enríquez, M., Ingolf, N., Martin, M.C., Fernandez, M., Ladero, V., and Alvarez, M.A. 2015. Tyramine biosynthesis is transcriptionally induced at low pH and improves the fitness of Enterococcus faecalis in acidic environ-ments. Appl. Microbiol. Biotechnol. 99: 3547-3558. doi:10.1007/s00253-014-6301-7. PMID:25529314.
12. Reviriego, C., Eaton, T., Martin, R., Jimenez, E., Fernandez, L., Gasson, M.J., and Rodriguez, J.M. 2005. Screening of virulence determinants in Enterococcus faecium strains isolated from breast milk. J. Hum. Lact. 21(2): 131-137. doi:10.1177/0890334405275394. PMID:15886339.
13. Sahm, D.F., Kissinger, J., Gilmore, M.S., Murray, P.R., Mulder, R., Solliday, J., and Clarke, B. 1989. In vitro susceptibility studies of vancomycin-resistant Enterococcus faecalis. Antimicrob. Agents Chemother. 33(9): 1588-1591. doi:10.1128/AAC.33.9.1588. PMID:2554802.
14. Shankar, J., Walker, R.G., Ward, D., and Horsburgh, M.J. 2012. The Enterococcus faecalis exoproteome: identification and temporal regulation by Fsr. PLoS One, 7(3): e33450. doi:10.1371/journal.pone.0033450. PMID:22428053.
15. Shankar, N., Baghdayan, A.S., and Gilmore, M.S. 2002. Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis. Nature, 13(6890): 746-750. doi:10.1038/nature00802. PMID:12066186.
16. Teixeira, N., Santos, S., Marujo, P., Yokohata, R., Iyer, V.S., Nakayama, J., et al. 2012. The incongruent gelatinase genotype and phenotype in Enterococcus faecalis are due to shutting off the ability to respond to the gelatinase biosynthesis-activating pheromone (GBAP) quorum-sensing signal. Microbi-ology, 158(2): 519-528. doi:10.1099/mic.0.055574-0. PMID:22117005.
17. Teixeira, N., Varahan, S., Gorman, M.J., Palmer, K.L., Zaidman-Remy, A., Yokohata, R., et al. 2013. Drosophila host model reveals new Enterococcus faecalis quorum-sensing associated virulence factors. PLoS One, 8(5): e64740. doi:10.1371/journal.pone.0064740. PMID:23734216.
18. Thomas, V.C., Hiromasa, Y., Harms, N., Thurlow, L., Tomich, J., and Hancock, L.E. 2009. A fratricidal mechanism is responsible for eDNA release and contributes to biofilm development of Enterococcus faecalis. Mol. Microbiol. 72(4): 1022-1036. doi:10.1111/j.1365-2958.2009.06703.x. PMID:19400795.
19. Thurlow, L.R., Thomas, V.C., Narayanan, S., Olson, S., Fleming, S.D., and Hancock, L.E. 2010. Gelatinase contributes to the pathogenesis of endocardi-tis caused by Enterococcus faecalis. Infect. Immun. 78(11): 4936-4943. doi:10.1128/IAI.01118-09. PMID:20713628.
20. Valle, J., Vergara-Irigaray, M., Merino, N., Penades, J.R., and Lasa, I. 2007.B regulates IS256-mediated Staphylococcus aureus biofilm phenotypic variation. J. Bacteriol. 189(7): 2886-2896. doi:10.1128/JB.01767-06. PMID:17277051.
21. Ziebuhr, W., Krimmer, V., Rachid, S., Lossner, I., Gotz, F., and Hacker, J. 1999. A novel mechanism of phase variation of virulence in Staphylococcus epidermidis: evidence for control of the polysaccharide intercellular adhesin synthesis by alternating insertion and excision of the insertion sequence element IS256. Mol. Microbiol. 32(2): 345-356. doi:10.1046/j.1365-2958.1999.01353.x. PMID: 10231490.