Is cycloxygenase-2 (COX-2) a major component of the mechanism responsible for microvascular remodeling in the brain?

Advances in Experimental Medicine and Biology

Volumn 578, Issue , 2006, Pages 297-303

  LaManna, Joseph C ^a   Sun, Xiaoyan ^a   Ivy, Andre D ^a   Ward, Nicole L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84934442810     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/0-387-29540-2_47     Document Type: Conference Paper

References (31)

1. J. C. LaManna, L.M. Vendel, and R.M. Farrell: Brain adaptation to chronic hypobaric hypoxia in rats. J.Appl.Physiol. 72:2238-2243 (1992).
2. N.-T. Kuo, D. Benhayon, R.J. Przybylski, R.J. Martin, and J.C. LaManna: Prolonged hypoxia increases vascular endothelial growth factor mRNA and protein in adult mouse brain. J.Appl.Physiol. 86:260-264 (1999).
3. J. C. Chávez, F. Agani, P. Pichiule, and J.C. LaManna: Expression of hypoxic inducible factor 1α in the brain of rats during chronic hypoxia. J.Appl.Physiol. 89:1937-1942 (2000).
4. P. Pichiule and J.C. LaManna: Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia. J.Appl.Physiol. 93:1131-1139 (2002).
5. M. Gassmann and R.H. Wenger: HIF-1, a mediator of the molecular response to hypoxia. News Physiol Sci 12:214-218 (1997).
6. J. A. Forsythe, B.-H. Jiang, N.V. Iyer, F. Agani, S.W. Leung, R.D. Koos, and G.L. Semenza: Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol.Cell.Biol. 16:4604-4613 (1996).
7. H. F. Bunn and R.O. Poyton: Oxygen sensing and molecular adaptation to hypoxia. Physiol.Rev. 76:839-885 (1996).
8. P. Pichiule, J.C. Chavez, and J.C. LaManna: Hypoxic regulation of angiopoietin-2 expression in endothelial cells. J Biol.Chem. 279:12171-12180 (2004).
9. J. C. LaManna, J.C. Chavez, and P. Pichiule: Structural and functional adaptation to hypoxia in the rat brain. J.Exp.Biol. 207:3163-3169 (2004).
10. S. I. Harik, R.N. Kalaria, L. Andersson, P. Lundahl, and G. Perry: Immunocytochemical localization of the erythroid glucose transporter: Abundance in tissues with barrier functions. J.Neurosci. 10:3862-3872 (1990).
11. S. I. Harik, W.D. Lust, S.C. Jones, K.L. Lauro, S. Pundik, and J.C. LaManna: Brain glucose metabolism in hypobaric hypoxia. J.Appl.Physiol. 79:136-140 (1995).
12. P. Pichiule, J.C. Chavez, and J.C. LaManna: Hypoxic regulation of angiopoietin-2 expression in endothelial cells. J.Biol.Chem. (in press)(2004).
13. C. D. Funk: Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294:1871-1875 (2001).
14. L. Parente and M. Perretti: Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. Biochem.Pharmacol. 65:153-159 (2003).
15. C. D. Breder, D. Dewitt, and R.P. Kraig: Characterization of inducible cyclooxygenase in rat brain. J Comp Neurol. 355:296-315 (1995).
16. N. G. Bazan: Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor. J Lipid Res. 44:2221-2233 (2003).
17. T. Wyss-Coray and L. Mucke: Inflammation in neurodegenerative disease - a double-edged sword. Neuron 35:419-432 (2002).
18. P. Teismann, M. Vila, D.K. Choi, K. Tieu, D.C. Wu, V. Jackson-Lewis, and S. Przedborski: COX-2 and neurodegeneration in Parkinson's disease. Ann.N.Y.Acad.Sci. 991:272-277 (2003).
19. J. J. Hoozemans, R. Veerhuis, A.J. Rozemuller, and P. Eikelenboom: Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease. Curr.Drug Targets. 4:461-468 (2003).
20. P. L. McGeer and E.G. McGeer: Inflammation, autotoxicity and Alzheimer disease. Neurobiol.Aging 22:799-809 (2001).
21. Z. Xiang, L. Ho, J. Valdellon, D. Borchelt, K. Kelley, L. Spielman, P.S. Aisen, and G.M. Pasinetti: Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. Neurobiol.Aging 23:327-334 (2002).
22. M. Nagayama, K. Niwa, T. Nagayama, M.E. Ross, and C. Iadecola: The cyclooxygenase-2 inhibitor NS-398 ameliorates ischemic brain injury in wild-type mice but not in mice with deletion of the inducible nitric oxide synthase gene. J Cereb.Blood Flow Metab 19:1213-1219 (1999).
23. S. Nogawa, F. Zhang, M.E. Ross, and C. Iadecola: Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci. 17:2746-2755 (1997).
24. K. Hara, D.L. Kong, F.R. Sharp, and P.R. Weinstein: Effect of selective inhibition of cyclooxygenase 2 on temporary focal cerebral ischemia in rats. Neurosci.Lett. 256:53-56 (1998).
25. T. Kuwano, S. Nakao, H. Yamamoto, M. Tsuneyoshi, T. Yamamoto, M. Kuwano, and M. Ono: Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis. FASEB J. 18:300-310 (2004).
26. M. A. Iniguez, A. Rodriguez, O.V. Volpert, M. Fresno, and J.M. Redondo: Cyclooxygenase-2: a therapeutic target in angiogenesis. Trends Mol.Med. 9:73-78 (2003).
27. J. J. Hoozemans, R. Veerhuis, I. Janssen, A.J. Rozemuller, and P. Eikelenboom: Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease. Exp.Gerontol. 36:559-570 (2001).
28. N. G. Kim, H. Lee, E. Son, O.Y. Kwon, J.Y. Park, J.H. Park, G.J. Cho, W.S. Choi, and K. Suk: Hypoxic induction of caspase-11/caspase-1/interleukin- 1beta in brain microglia. Brain Res.Mol.Brain Res. 114:107-114 (2003).
29. L. Ho, H. Osaka, P.S. Aisen, and G.M. Pasinetti: Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death. J Neuroimmunol. 89:142-149 (1998).
30. C. Iadecola, K. Niwa, S. Nogawa, X. Zhao, M. Nagayama, E. Araki, S. Morham, and M.E. Ross: Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc.Natl.Acad.Sci.U.S.A 98:1294-1299 (2001).
31. S. J. Hewett, T.F. Uliasz, A.S. Vidwans, and J.A. Hewett: Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture. J Pharmacol.Exp.Ther. 293:417-425 (2000).