메뉴 건너뛰기




Volumn 576, Issue , 2006, Pages 49-66

NAA synthesis and functional roles

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84934441822     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/0-387-30172-0_4     Document Type: Conference Paper
Times cited : (17)

References (56)
  • 4
    • 0024325294 scopus 로고
    • N-acetyl-L-aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain
    • Birken DL, Oldendorf WH. N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev 1989;13:23-31.
    • (1989) Neurosci Biobehav Rev , vol.13 , pp. 23-31
    • Birken, D.L.1    Oldendorf, W.H.2
  • 5
    • 0028978925 scopus 로고
    • N-acetylaspartate in neuropsychiatric disorders
    • Tsai G, Coyle JT. N-acetylaspartate in neuropsychiatric disorders. Prog Neurobiol 1995;46:531-40.
    • (1995) Prog Neurobiol , vol.46 , pp. 531-540
    • Tsai, G.1    Coyle, J.T.2
  • 6
    • 0033914812 scopus 로고    scopus 로고
    • Functions of N-acetyl-L-aspartate and N-acetyl-L- aspartylglutamate in the vertebrate brain: Role in glial cell-specific signaling
    • Baslow MH. Functions of N-acetyl-L-aspartate and N-acetyl-L- aspartylglutamate in the vertebrate brain: role in glial cell-specific signaling. J Neurochem 2000;75:453-9.
    • (2000) J Neurochem , vol.75 , pp. 453-459
    • Baslow, M.H.1
  • 7
    • 0031731910 scopus 로고    scopus 로고
    • N-acetyl aspartate: A marker for neuronal loss or mitochondrial dysfunction
    • Clark JB. N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunction. Dev Neurosci 1998;20:271-6.
    • (1998) Dev Neurosci , vol.20 , pp. 271-276
    • Clark, J.B.1
  • 8
    • 0006446370 scopus 로고
    • Biosynthesis of N-acetyl-L-aspartic acid
    • Goldstein FB. Biosynthesis of N-acetyl-L-aspartic acid. J Biol Chem 1959;234:2702-2706.
    • (1959) J Biol Chem , vol.234 , pp. 2702-2706
    • Goldstein, F.B.1
  • 9
    • 0014217150 scopus 로고
    • The enzymatic synthesis of N-acetyl-L-aspartic acid by a water-insoluble preparation of a cat brain acetone powder
    • Knizley H, Jr. The enzymatic synthesis of N-acetyl-L-aspartic acid by a water-insoluble preparation of a cat brain acetone powder. J Biol Chem 1967;242:4619-22.
    • (1967) J Biol Chem , vol.242 , pp. 4619-4622
    • Knizley Jr., H.1
  • 10
    • 0014670387 scopus 로고
    • The enzymatic synthesis of N-acetyl-L-aspartic acid by subcellular preparations of rat brain
    • Goldstein FB. The enzymatic synthesis of N-acetyl-L-aspartic acid by subcellular preparations of rat brain. J Biol Chem 1969;244:4257- 60.
    • (1969) J Biol Chem , vol.244 , pp. 4257-4260
    • Goldstein, F.B.1
  • 11
    • 0018622817 scopus 로고
    • Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport
    • Patel TB, Clark JB. Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport. Biochem J 1979;184:539-46.
    • (1979) Biochem J , vol.184 , pp. 539-546
    • Patel, T.B.1    Clark, J.B.2
  • 13
  • 14
    • 0027533585 scopus 로고
    • Enhanced carbodiimide fixation for immunohistochemistry: Application to the comparative distributions of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat brain
    • Moffett JR, Namboodiri MA, Neale JH. Enhanced carbodiimide fixation for immunohistochemistry: application to the comparative distributions of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat brain. J Histochem Cytochem 1993;41:559-70.
    • (1993) J Histochem Cytochem , vol.41 , pp. 559-570
    • Moffett, J.R.1    Namboodiri, M.A.2    Neale, J.H.3
  • 15
    • 0027379536 scopus 로고
    • Abnormal acidic amino acids and N-acetylaspartylglutamate in hereditary canine motoneuron disease
    • Tsai G, Cork LC, Slusher BS, Price D, Coyle JT. Abnormal acidic amino acids and N-acetylaspartylglutamate in hereditary canine motoneuron disease. Brain Res 1993;629:305-9.
    • (1993) Brain Res , vol.629 , pp. 305-309
    • Tsai, G.1    Cork, L.C.2    Slusher, B.S.3    Price, D.4    Coyle, J.T.5
  • 16
    • 0033384017 scopus 로고    scopus 로고
    • Expression of aspartoacylase activity in cultured rat macroglial cells is limited to oligodendrocytes
    • Baslow MH, Suckow RF, Sapirstein V, Hungund BL. Expression of aspartoacylase activity in cultured rat macroglial cells is limited to oligodendrocytes. J Mol Neurosci 1999;13:47-53.
    • (1999) J Mol Neurosci , vol.13 , pp. 47-53
    • Baslow, M.H.1    Suckow, R.F.2    Sapirstein, V.3    Hungund, B.L.4
  • 17
    • 0037111922 scopus 로고    scopus 로고
    • Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: Therapeutic implications for Canavan disease
    • Kirmani BF, Jacobowitz DM, Kallarakal AT, Namboodiri MA. Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease. Brain Res Mol Brain Res 2002;107:176-82.
    • (2002) Brain Res Mol Brain Res , vol.107 , pp. 176-182
    • Kirmani, B.F.1    Jacobowitz, D.M.2    Kallarakal, A.T.3    Namboodiri, M.A.4
  • 20
    • 0000398884 scopus 로고
    • Amino acid acylases I and II from hog kidney
    • Birnbaum SM. Amino acid acylases I and II from hog kidney. Methods in Enzymology 1955;2:115-119.
    • (1955) Methods in Enzymology , vol.2 , pp. 115-119
    • Birnbaum, S.M.1
  • 21
    • 0017293461 scopus 로고
    • Amidohydrolases of brain; enzymatic hydrolysis of N-acetyl-L-aspartate and other N-acyl-L-amino acids
    • Goldstein FB. Amidohydrolases of brain; enzymatic hydrolysis of N-acetyl-L-aspartate and other N-acyl-L-amino acids. J Neurochem 1976;26:45-9.
    • (1976) J Neurochem , vol.26 , pp. 45-49
    • Goldstein, F.B.1
  • 22
    • 0025959891 scopus 로고
    • Purification, characterization, and localization of aspartoacylase from bovine brain
    • Kaul R, Casanova J, Johnson AB, Tang P, Matalon R. Purification, characterization, and localization of aspartoacylase from bovine brain. J Neurochem 1991;56:129-35.
    • (1991) J Neurochem , vol.56 , pp. 129-135
    • Kaul, R.1    Casanova, J.2    Johnson, A.B.3    Tang, P.4    Matalon, R.5
  • 23
    • 0028178607 scopus 로고
    • Canavan disease: Genomic organization and localization of human ASPA to 17p13-ter and conservation of the ASPA gene during evolution
    • Kaul R, Balamurugan K, Gao GP, Matalon R. Canavan disease: genomic organization and localization of human ASPA to 17p13-ter and conservation of the ASPA gene during evolution. Genomics 1994;21:364-70.
    • (1994) Genomics , vol.21 , pp. 364-370
    • Kaul, R.1    Balamurugan, K.2    Gao, G.P.3    Matalon, R.4
  • 24
    • 0027362434 scopus 로고
    • Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease
    • Kaul R, Gao GP, Balamurugan K, Matalon R. Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease. Nat Genet 1993;5:118-23.
    • (1993) Nat Genet , vol.5 , pp. 118-123
    • Kaul, R.1    Gao, G.P.2    Balamurugan, K.3    Matalon, R.4
  • 28
    • 4143095824 scopus 로고    scopus 로고
    • Biosynthesis of NAAG by an enzyme-mediated process in rat central nervous system neurons and glia
    • Gehl LM, Saab OH, Bzdega T, Wroblewska B, Neale JH. Biosynthesis of NAAG by an enzyme-mediated process in rat central nervous system neurons and glia. J Neurochem 2004;90:989-97.
    • (2004) J Neurochem , vol.90 , pp. 989-997
    • Gehl, L.M.1    Saab, O.H.2    Bzdega, T.3    Wroblewska, B.4    Neale, J.H.5
  • 29
    • 0023232412 scopus 로고
    • Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain
    • Robinson MB, Blakely RD, Couto R, Coyle JT. Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain. J Biol Chem 1987;262:14498-506.
    • (1987) J Biol Chem , vol.262 , pp. 14498-14506
    • Robinson, M.B.1    Blakely, R.D.2    Couto, R.3    Coyle, J.T.4
  • 30
    • 0025614993 scopus 로고
    • Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization
    • Slusher BS, Robinson MB, Tsai G, Simmons ML, Richards SS, Coyle JT. Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization. J Biol Chem 1990;265:21297-301.
    • (1990) J Biol Chem , vol.265 , pp. 21297-21301
    • Slusher, B.S.1    Robinson, M.B.2    Tsai, G.3    Simmons, M.L.4    Richards, S.S.5    Coyle, J.T.6
  • 33
    • 1342285559 scopus 로고    scopus 로고
    • N-Acetylaspartate synthase is bimodally expressed in microsomes and mitochondria of brain
    • Lu ZH, Chakraborty G, Ledeen RW, Yahya D, Wu G. N-Acetylaspartate synthase is bimodally expressed in microsomes and mitochondria of brain. Brain Res Mol Brain Res 2004;122:71-8.
    • (2004) Brain Res Mol Brain Res , vol.122 , pp. 71-78
    • Lu, Z.H.1    Chakraborty, G.2    Ledeen, R.W.3    Yahya, D.4    Wu, G.5
  • 34
    • 0037108846 scopus 로고    scopus 로고
    • A radiometric assay for aspartoacylase activity in cultured oligodendrocytes
    • Madhavarao CN, Hammer JA, Quarles RH, Namboodiri MA. A radiometric assay for aspartoacylase activity in cultured oligodendrocytes. Anal Biochem 2002;308:314-9.
    • (2002) Anal Biochem , vol.308 , pp. 314-319
    • Madhavarao, C.N.1    Hammer, J.A.2    Quarles, R.H.3    Namboodiri, M.A.4
  • 36
    • 0028036798 scopus 로고
    • Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle
    • Yudkoff M, Nelson D, Daikhin Y, Erecinska M. Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle. J Biol Chem 1994;269:27414-20.
    • (1994) J Biol Chem , vol.269 , pp. 27414-27420
    • Yudkoff, M.1    Nelson, D.2    Daikhin, Y.3    Erecinska, M.4
  • 37
    • 0023879595 scopus 로고
    • Influence of the malate-aspartate shuttle on oxidative metabolism in synaptosomes
    • Cheeseman AJ, Clark JB. Influence of the malate-aspartate shuttle on oxidative metabolism in synaptosomes. J Neurochem 1988;50:1559-65.
    • (1988) J Neurochem , vol.50 , pp. 1559-1565
    • Cheeseman, A.J.1    Clark, J.B.2
  • 39
    • 0034782504 scopus 로고    scopus 로고
    • N-Acetylaspartate reduction as a measure of injury severity and mitochondrial dysfunction following diffuse traumatic brain injury
    • Signoretti S, Marmarou A, Tavazzi B, Lazzarino G, Beaumont A, Vagnozzi R. N-Acetylaspartate reduction as a measure of injury severity and mitochondrial dysfunction following diffuse traumatic brain injury. J Neurotrauma 2001;18:977-91.
    • (2001) J Neurotrauma , vol.18 , pp. 977-991
    • Signoretti, S.1    Marmarou, A.2    Tavazzi, B.3    Lazzarino, G.4    Beaumont, A.5    Vagnozzi, R.6
  • 40
    • 0036091568 scopus 로고    scopus 로고
    • Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease
    • Block W, Jessen F, Traber F, Flacke S, Manka C, Lamerichs R, Keller E, Heun R, Schild H. Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease. Arch Neurol 2002;59:828-34.
    • (2002) Arch Neurol , vol.59 , pp. 828-834
    • Block, W.1    Jessen, F.2    Traber, F.3    Flacke, S.4    Manka, C.5    Lamerichs, R.6    Keller, E.7    Heun, R.8    Schild, H.9
  • 42
    • 0035072775 scopus 로고    scopus 로고
    • Absence of N-acetylaspartate in the human brain: Impact on neurospectroscopy?
    • Martin E, Capone A, Schneider J, Hennig J, Thiel T. Absence of N-acetylaspartate in the human brain: impact on neurospectroscopy? Ann Neurol 2001;49:518-21.
    • (2001) Ann Neurol , vol.49 , pp. 518-521
    • Martin, E.1    Capone, A.2    Schneider, J.3    Hennig, J.4    Thiel, T.5
  • 46
    • 0034125561 scopus 로고    scopus 로고
    • Reduced concentrations of thalamic N-acetylaspartate in male patients with schizophrenia
    • Deicken RF, Johnson C, Eliaz Y, Schuff N. Reduced concentrations of thalamic N-acetylaspartate in male patients with schizophrenia. Am J Psychiatry 2000;157:644-7.
    • (2000) Am J Psychiatry , vol.157 , pp. 644-647
    • Deicken, R.F.1    Johnson, C.2    Eliaz, Y.3    Schuff, N.4
  • 49
    • 0032102114 scopus 로고    scopus 로고
    • Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy
    • Kalra S, Cashman NR, Genge A, Arnold DL. Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport 1998;9:1757-61.
    • (1998) Neuroreport , vol.9 , pp. 1757-1761
    • Kalra, S.1    Cashman, N.R.2    Genge, A.3    Arnold, D.L.4
  • 52
    • 0028842858 scopus 로고
    • Canavan disease: From spongy degeneration to molecular analysis
    • Matalon R, Michals K, Kaul R. Canavan disease: from spongy degeneration to molecular analysis. J Pediatr 1995;127:511-7.
    • (1995) J Pediatr , vol.127 , pp. 511-517
    • Matalon, R.1    Michals, K.2    Kaul, R.3
  • 53
    • 0034068954 scopus 로고    scopus 로고
    • Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3-nitropropionic acid
    • Dautry C, Vaufrey F, Brouillet E, Bizat N, Henry PG, Conde F, Bloch G, Hantraye P. Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3-nitropropionic acid. J Cereb Blood Flow Metab 2000;20:789-99.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 789-799
    • Dautry, C.1    Vaufrey, F.2    Brouillet, E.3    Bizat, N.4    Henry, P.G.5    Conde, F.6    Bloch, G.7    Hantraye, P.8
  • 54
    • 4644324464 scopus 로고    scopus 로고
    • The protective effect of cyclosporin A upon N-acetylaspartate and mitochondrial dysfunction following experimental diffuse traumatic brain injury
    • Signoretti S, Marmarou A, Tavazzi B, Dunbar J, Amorini AM, Lazzarino G, Vagnozzi R. The protective effect of cyclosporin A upon N-acetylaspartate and mitochondrial dysfunction following experimental diffuse traumatic brain injury. J Neurotrauma 2004;21:1154-67.
    • (2004) J Neurotrauma , vol.21 , pp. 1154-1167
    • Signoretti, S.1    Marmarou, A.2    Tavazzi, B.3    Dunbar, J.4    Amorini, A.M.5    Lazzarino, G.6    Vagnozzi, R.7
  • 55
    • 11144221598 scopus 로고    scopus 로고
    • Interdependence of N-acetyl aspartate and high-energy phosphates in healthy human brain
    • Pan JW, Takahashi K. Interdependence of N-acetyl aspartate and high-energy phosphates in healthy human brain. Ann Neurol 2005;57:92-7.
    • (2005) Ann Neurol , vol.57 , pp. 92-97
    • Pan, J.W.1    Takahashi, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.