Clinical characteristics of infections in humans due to Staphylococcus epidermidis

Methods in Molecular Biology

Volumn 1106, Issue , 2014, Pages 1-16

  Rupp, Mark E ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Bacteremia; Biofilm; Health care associated infection; Infection; Staphylococcus epidermidis

Indexed keywords

ANTIBIOTIC RESISTANCE; ARTICLE; BACTEREMIA; BACTERIAL COLONIZATION; BACTERIAL TRANSMISSION; BLOOD VESSEL GRAFT; BREAST IMPLANT; CEREBROSPINAL FLUID; ENDOCARDITIS; ENDOPHTHALMITIS; HUMAN; INFECTION; INTRAVASCULAR CATHETER; MASTITIS; ORTHOPEDIC PROSTHESIS; PERITONEAL DIALYSIS CATHETER; PRIORITY JOURNAL; SHUNT INFECTION; STAPHYLOCOCCUS EPIDERMIDIS; SURGICAL INFECTION;

BACTEREMIA; BIOFILMS; CATHETER-RELATED INFECTIONS; CROSS INFECTION; DRUG RESISTANCE, BACTERIAL; HUMANS; PROSTHESIS-RELATED INFECTIONS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS EPIDERMIDIS; SURGICAL WOUND INFECTION;

EID: 84934437833     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-736-5_1     Document Type: Article

References (122)

1. Grice EA, Kong HH, Conlan S et al (2009) Topographical and temporal diversity of the human skin microbiome. Science 324: 1190-1192
2. Rupp ME, Archer GL (1994) Coagulasenegative staphylococci: Pathogens associated with medical progress. Clin Infect Dis 19: 231-243
3. Otto M (2009) Staphylococcus epidermidis -the 'accidental' pathogen. Nat Rev Microbiol 7:555-567
4. Rogers KL, Fey PD, Rupp ME (2009) Epidemiology of infections due to coagulasenegative staphylococci. In: Crossley KB, Jefferson KK, Archer G, Fowler VG Jr (eds) The Staphylococci in human disease, 2nd edn. Blackwell Publishing, Oxford, pp 310-332
5. Sievert DM, Ricks P, Edwards JR et al (2013) Antimicrobial-resistant pathogens associated with healthcare-associated infections: Summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010. Infect Control Hosp Epidemiol 34:1-14
6. Mack D, Horstkotte MA, Rhode H et al (2006) Coagulase-negative staphylococci. In: Pace JL, Rupp ME, Finch RG (eds) Biofi lms, infection, and antimicrobial therapy. Taylor & Francis, Boca Raton, FL, pp 109-153
7. O'Gara JP, Humphreys H (2001) Staphylococcus epidermidis biofi lms: Importance and implications. J Med Microbiol 50: 582-587
8. von Eiff C, Peters G, Heilmann C (2002) Pathogenesis of infections due to coagulasenegative staphylococci. Lancet Infect Dis 2: 677-685
9. Bannerman TL, Peacock SJ (2007) Staphylococcus, Micrococcus, and other catalase-positive cocci. In: Murray PR, Baron EJ, Jorgensen JH et al (eds) Manual of clinical microbiology. American Society for Microbiology, Washington, DC, pp 390-411
10. Kloos WE, Musselwhite MS (1975) Distribution and persistence of Staphylococcus and Micrococcus species and other aerobic bacteria on human skin. Appl Microbiol 30:381-385
11. Barbier F, Lebeaux D, Hernandez D et al (2011) High prevalence of the arginine catabolic mobile element in carriage isolates of methicillin-resistant Staphylococcus epidermidis. J Antimicrob Chemother 66:29-36
12. Neely AN, Maley MP (2000) Survival of enterococci and staphylococci on hospital fabrics and plastics. J Clin Micro 38:724-726
13. Sidhu MS, Heir E, Leegaard T et al (2002) Frequency of disinfectant resistance genes and genetic linkage with B-lactamase transposon Tn 552 among clinical staphylococci. Antimicrob Agents Chemother 46: 2797-2803
14. Frank DN, Feazel LM, Bessesen MT et al (2010) The human microbiota and Staphylococcus aureus carriage. PLoS One 5:e10598
15. Cogen AL, Yamasaki K, Sanchez KM et al (2010) Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. J Invest Dermatol 130:192-200
16. Iwase T, Uehara Y, Shinji H et al (2010) Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofi lm formation and nasal colonization. Nature 20:346-349
17. Ahlstrand E, Persson L, Tidefelt U (2012) Alteration of the colonization pattern of coagulase-negative staphylococci in patients undergoing treatment for hematologic malignancy. Eur J Clin Microbiol Infect Dis 31: 1679-87
18. Zingg W, Demartines N, Imhof A et al (2009) Rapid colonization with methicillin-resistant coagulase-negative staphylococci after surgery. World J Surg 33:2058-2062
19. Huebner J, Pier GB, Maslow JN et al (1994) Endemic nosocomial transmission of Staphylococcus epidermidis bacteremia isolates in a neonatal intensive care unit over 10 years. J Infect Dis 169:526-531
20. Krediet TG, Mascini EM, vanRooij E et al (2004) Molecular epidemiology of coagulasenegative staphylococci causing sepsis in a neonatal intensive care unit over an 11-year period. J Clin Microbiol 42:992-995
21. Kozitskaya S, Olson ME, Fey PD et al (2005) Clonal analysis of Staphylococcus epidermidis isolates carrying or lacking biofi lm-mediating genes by multilocus sequence typing. J Clin Microbiol 43:4751-4757
22. Widerstrom M, Monsen T, Karlsson C et al (2006) Molecular epidemiology of meticillinresistant coagulase-negative staphylococci in a Swedish county hospital: Evidence of intraand interhospital clonal spread. J Hosp Infect 64:177-183
23. Gordon RJ, Miragaia M, Weinberg AD et al (2012) Staphylococcus epidermidis colonization is highly clonal across US cardiac centers. J Infect Dis 205:1391-1398
24. Widerstrom M, Monsen T, Karlsson C et al (2009) Clonality among multidrug-resistant hospital-associated Staphylococcus epidermidis in northern Europe. Scand J Infect Dis 41: 642-649
25. Streit JM, Jones RN, Sader HS et al (2004) Assessment of pathogen occurrences and resistance profi les among infected patients in the intensive care unit: Report from the SENTRY Antimicrobial Surveillance Program (North America, 2001). Int J Antimicrob Agents 24:111-118
26. Jones RN, Ross JE, Castanheira M et al (2008) United States resistance surveillance results for linezolid (LEADER Program for 2007). Diagn Microbiol Infect Dis 62:416-426
27. Hope R, Livermore DM, Brick G et al (2008) Non-susceptibility trends among staphylococci from bacteraemias in the UK and Ireland, 2001-06. J Antimicrob Chemother 62(Suppl 2):ii65-ii74
28. Sieradzki K, Villari P, Tomasz A (1998) Decreased susceptibilities to teicoplanin and vancomycin among coagulase-negative methicillin-resistant clinical isolates of staphylococci. Antimicrob Agents Chemother 42:100-107
29. Sieradzki K, Roberts RB, Serur D et al (1999) Heterogeneously vancomycin-resistant Staphylococcus epidermidis strain causing recurrent peritonitis in a dialysis patient during vancomycin therapy. J Clin Microbiol 37:39-44
30. Nunes AP, Teixeira LM, Iorio NL et al (2006) Heterogeneous resistance to vancomycin in Staphylococcus epidermidis, Staphylococcus haemolyticus and Staphylococcus warneri clinical strains: Characterisation of glycopeptide susceptibility profi les and cell wall thickening. Int J Antimicrob Agents 27:307-315
31. Froggatt JW, Johnston JL, Galetto DW et al (1989) Antimicrobial resistance in nosocomial isolates of Staphylococcus haemolyticus . Antimicrob Agents Chemother 33:460-466
32. Clinical and Laboratory Standards Institute (2013) Performance standards for antimicrobial susceptibility testing: Twenty-third information supplement. CLSI Document M100-S23. Clinical and Laboratory Standards Institute, Wayne, PA
33. Vazquez GJ, Archer GL (1980) Antibiotic therapy of experimental Staphylococcus epidermidis endocarditis. Antimicrob Agents Chemother 17:280-285
34. Lewis K (2007) Persister cells, dormancy and infectious disease. Nat Rev Microbiol 5:48-56
35. Fey PD (2010) Modality of bacterial growth presents unique targets: How do we treat biofi lm-mediated infections? Curr Opin Microbiol 13:610-615
36. Srinivasan A, Wise M, Bell M et al (2011) Vital signs: Central line-associated blood stream infections -United States 2001, 2008, and 2009. MMWR Morb Mortal Wkly Rep 60:243-248
37. Maki DG, Kluger DM, Crnich CJ (2006) The risk of bloodstream infection in adults with different intravascular devices: A systematic review of 200 published prospective studies. Mayo Clin Proc 81:1159-1171
38. Hewlett AL, Rupp ME (2012) Healthcareassociated infections related to the use of intravascular devices inserted for short-term vascular access. In: Mayhall CG (ed) Hospital epidemiology and infection control, 4th edn. Wolters Kluwer, Philadelphia, pp 241-247
39. Sherertz RJ, Heard SO, Raad II (1997) Diagnosis of triple-lumen catheter infection: Comparison of roll plate, sonication, and fl ushing methodologies. J Clin Microbiol 35:641-646
40. Maki DG, Weise CE, Sarafi n HW (1977) A semiquantitative culture method for identifying intravenous catheter-related infection. N Engl J Med 296:1305-1309
41. Raad I, Hanna HA, Alakech B et al (2004) Differential time to positivity: A useful method for diagnosing catheter-related bloodstream infections. Ann Intern Med 140:18-25
42. Lebeaux D, Larroque B, Gellen-Dautremer J et al (2012) Clinical outcome after a totally implantable venous access port-related infection in cancer patients. Medicine 91:309-318
43. Molina J, Penuela I, Lepe J et al (2013) Mortality and hospital stay related to coagulase-negative Staphylococci bacteremia in non-critical patients. J Infect 66:155-162
44. Mermel LA, Allon M, Bouza E et al (2009) Clinical practice guidelines for the diagnosis and management of intravascular catheterrelated infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis 49:1-45
45. O'Horo JC, Silva GLM, Safdar N (2011) Anti-infective locks for treatment of central line-associated bloodstream infection: A systematic review and meta-analysis. Am J Nephrol 34:415-422
46. Raad I, Davis S, Khan A et al (1992) Impact of central venous catheter removal on the recurrence of catheter-related coagulasenegative staphylococcal bacteremia. Infect Control Hosp Epidemiol 13:215-221
47. O'Grady NP, Alexander M, Burns LA et al (2011) Summary of recommendations: Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis 52:1087-1099
48. Snaterse M, Ruger W, Scholte WJM et al (2010) Antibiotic-based catheter lock solutions for prevention of catheter-related bloodstream infection: A systematic review of randomized controlled trials. J Hosp Infect 75:1-11
49. Weinstein MP, Towns ML, Quartey SM et al (1997) The clinical signifi cance of positive blood cultures in the 1990s: A prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 24:584-602
50. Hall KK, Lyman JA (2006) Updated review of blood culture contamination. Clin Microbiol Rev 19:788-802
51. Pien BC, Sundaram P, Raoof N et al (2010) The clinical and prognostic importance of positive blood cultures in adults. Am J Med 123:819-828.132
52. Souvenir D, Anderson DE Jr, Palpant S et al (1998) Blood cultures positive for coagulasenegative staphylococci: Antisepsis, pseudobacteremia, and therapy of patients. J Clin Microbiol 36:1923-1926
53. Van der Heijden YF, Miller G, Wright PW et al (2011) Clinical impact of blood cultures contaminated with coagulase-negative staphylococci at an academic medical center. Infect Control Hosp Epidemiol 32:623-625
54. Spitalnic SJ, Woolard RH, Mermel LA (1995) The signifi cance of changing needles when inoculating blood cultures: A meta-analysis. Clin Infect Dis 21:1103-1106
55. Schifman RB, Strand CL, Meier FA et al (1998) Blood culture contamination: A College of American Pathologists Q-Probes study involving 640 institutions and 497134 specimens from adult patients. Arch Pathol Lab Med 122:216-221
56. Demitrovicova A, Hricak V, Karvay M et al (2007) Endocarditis due to coagulase-negative staphylococci: Data from a 22-years national survey. Scand J Infect Dis 39:655-656
57. Lalani T, Kanafani ZA, Chu VH et al (2006) Prosthetic valve endocarditis due to coagulasenegative staphylococci: Fi ndings from the International Collaboration on Endocarditis Merged Database. Eur J Clin Microbiol Infect Dis 25:365-368
58. Wang A, Athan E, Pappas PA et al (2007) Contemporary clinical profi le and outcome of prosthetic valve endocarditis. JAMA 297: 1354-1361
59. Lee JH, Burner KD, Fealey ME et al (2011) Prosthetic valve endocarditis: Clinicopathological correlates in 122 surgical specimens from 116 patients (1985-2004). Cardiovasc Pathol 20:26-35
60. Baddour LM, Wilson WR, Bayer AS et al (2005) Infective endocarditis: Diagnosis, antimicrobial therapy, and management of complications: A statement for health care professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: Endorsed by the Infectious Diseases Society of America. Circulation 11:e394-e434
61. Agvald-Ohman C, Lund B, Edlund C (2004) Multiresistant coagulase-negative staphylococci disseminate frequently between intubated patients in a multidisciplinary intensive care unit. Crit Care 8:42-47
62. Chu VH, Woods CW, Miro JM et al (2008) Emergence of coagulase-negative staphylococci as a cause of native valve endocarditis. Clin Infect Dis 46:232-242
63. Castonguay MC, Burner KD, Edwards WD et al (2013) Surgical pathology of native valve endocarditis in 310 specimens from 287 patients (1985-2004). Cardiovasc Pathol 22:19-27
64. Caputo GM, Archer GL, Calderwood SB et al (1987) Native valve endocarditis due to coagulase-negative staphylococci. Clinical and microbiologic features. Am J Med 83:619-625
65. Chambers ST (2005) Diagnosis and management of staphylococcal infections of pacemakers and cardiac defi brillators. Intern Med J 35(Suppl 2):S63-S71
66. Athan E, Chu VH, Tattevin P et al (2012) Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices. JAMA 16:1727-1735
67. del Rio A, Anguera I, Miro JM et al (2003) Surgical treatment of pacemaker and defi brillator lead endocarditis: The impact of electrode lead extraction on outcome. Chest 124:1451-1459
68. Chua JD, Wilkoff BL, Lee I et al (2000) Diagnosis and management of infections involving implantable electrophysiologic cardiac devices. Ann Intern Med 133:604-608
69. Le KY, Sohail MR, Friedman PA et al (2012) Clinical features and outcomes of cardiovascular implantable electronic device infections due to staphylococcal species. Am J Cardiol 110:1143-1149
70. Baddour LM, Bettmann MA, Bolger AF et al (2003) Nonvalvular cardiovascular devicerelated infections. Circulation 108:2015-2031
71. Perera GB, Fujitani RM, Kubaska SM (2006) Aortic graft infection: Update on management and treatment options. Vasc Endovascular Surg 40:1-10
72. Stewart AH, Eyers PS, Earnshaw JJ (2007) Prevention of infection in peripheral arterial reconstruction: A systematic review and metaanalysis. J Vasc Surg 46:148-155
73. Leroy O, Meybeck A, Sarraz-Bournet B et al (2012) Vascular graft infections. Curr Opin Infect Dis 25:154-158
74. Saleem BR, Meerwaldt R, Tielliu IFJ et al (2010) Conservative treatment of vascular prosthetic graft infection is associated with high mortality. Am J Surg 200:47-52
75. Trampuz A, Piper KE, Jacobson MJ et al (2007) Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med 357:654-663
76. Zimmerli W, Trampuz A, Ochsner PE (2004) Prosthetic-joint infections. N Engl J Med 351:1645-1654
77. Teterycz D, Ferry T, Lew D et al (2010) Outcome of orthopedic implant infections due to different staphylococci. Int J Infect Dis 14:913-918
78. Del Pozo JL, Patel R (2009) Infection associated with prosthetic joints. N Engl J Med 361:787-794
79. Kwee TC, Kwee RM, Abass A (2008) FDGPTE for diagnosing joint infection: Systematic review and metaanalysis. Eur J Nucl Med Mol Imaging 35:2122-2132
80. Atkins BL, Athanasou N, Deeks JJ et al (1998) Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty. J Clin Microbiol 36:2932-2939
81. Vergidis P, Greenwood-Quaintance KE, Sanchez-Sotelo J et al (2011) Implant sonication for the diagnosis of prosthetic elbow infection. J Shoulder Elbow Surg 20:1275-1281
82. Maduka-Ezeh AN, Greenwood-Quaintance KE, Karau MJ et al (2012) Antimicrobial susceptibility and biofi lm formation of staphylococcus epidermidis small colony variant associated with prosthetic joint infection. Diagn Microbiol Infect Dis 74:224-229
83. Singer J, Merz A, Frommelt L et al (2012) High rate of infection control with one-stage revision of septic knee prostheses excluding MRSA and MRSE. Clin Orthop Relat Res 470:1461-1471
84. Conen A, Walti LN, Merlo A et al (2008) Characteristics and treatment outcome of cerebrospinal fl uid shunt-associated infections in adults: A retrospective analysis over an 11-year period. Clin Infect Dis 47:73-82
85. Tunkel AR, Hartman BJ, Kaplan SL et al (2004) Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 39:1267-1284
86. Ratilal B, Costa J, Sampaio C (2006) Antibiotic prophylaxis for preventing meningitis in patients with basilar skull fractures. Cochrane Database Syst Rev 1, CD004884
87. Ritz R, Roser F, Morgalla M et al (2007) Do antibiotic-impregnated shunts in hydrocephalus therapy reduce the risk of infection? An observational study in 258 patients. BMC Infect Dis 7:38
88. Mangram AJ, Horan TC, Pearson ML et al (1999) Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol 20:250-278
89. Vas S, Oreopoulos DG (2001) Infections in patients undergoing peritoneal dialysis. Infect Dis Clin North Am 15:743-774
90. Baretti P, Montelli AC, Batalha JEN et al (2009) The role of virulence factors in the outcome of staphylococcal peritonitis in CAPD patients. BMC Infect Dis 9:212
91. Burke M, Hawley CM, Badve SV et al (2011) Relapsing and recurrent peritoneal dialysisassociated peritonitis: A multicenter registry study. Am J Kidney Dis 58:429-436
92. de Kaspar HM, Kreidl KO, Singh K et al (2004) Comparison of pre-operative conjunctival bacterial fl ora in patients undergoing glaucoma or cataract surgery. J Glaucoma 13: 507-509
93. Mollan SP, Gao A, Lockwood A et al (2007) Postcataract endophthalmitis: Incidence and microbial isolates in a United Kingdom region from 1996 through 2004. J Cataract Refract Surg 33:265-268
94. Hanscom TA (2004) Postoperative endophthalmitis. Clin Infect Dis 38:542-546
95. Haider SA, Hassett P, Bron AJ (2001) Intraocular vancomycin levels after intravitreal injection in post cataract extraction endophthalmitis. Retina 21:210-213
96. Carson CC (2003) Diagnosis, treatment and prevention of penile prosthesis infection. Int J Impot Res 15(Suppl 5):S139-S146
97. Darouiche RO (2004) Treatment of infections associated with surgical implants. N Engl J Med 350:1422-1429
98. Delgado S, Arroyo R, Jimenez E et al (2009) Staphylococcus epidermidis strains isolated from breast milk of women suffering infectious mastitis: Potential virulence traits and resistance to antibiotics. BMC Microbiol 9:82
99. Del Pozo JL, Tran NV, Petty PM et al (2009) Pilot study of association of bacteria on breast implants with capsular contracture. J Clin Microbiol 47:1333-1337
100. Sampedro MF, Patel R (2007) Infections associated with long-term prosthetic devices. Infect Dis Clin North Am 21:785-819
101. Paluch-Oles J, Magrys A, Koziol-Montewka M et al (2011) The phenotypic and genetic biofi lm formation characteristics of coagulasenegative staphylococci isolates in children with otitis media. Int J Pediatr Otorhinolaryngol 75:126-30
102. Whitfeld M, Gunasingam N, Leow LJ et al (2011) Staphylococcus epidermidis: A possible role in the pustules of rosacea. J Am Acad Dermatol 1:49-52
103. Davidson LE, Boucher HW (2009) Infections in immunocompromised patients. In: Crossley KB, Jefferson KK, Archer G, Fowler VG Jr (eds) Staphylococci in human disease, 2nd edn. Blackwell Publishing, Oxford
104. Sganga G, Spanu T, Bianco G et al (2012) Bacterial bloodstream infections in liver transplantation: Etiologic agents and antimicrobial susceptibility profi les. Transplant Proc 44:1973-1976
105. Centers for Disease Control and Prevention. The national Healthcare Safety network (NHSN) Manual. Patient Safety Component. http://www.cdc.gov/nhsn/ PDFs/pscManual/ PSC-Manual-portfolio.pdf . Accessed 4 Apr 2013
106. Costa SF, Barone AA, Miceli MH et al (2006) Colonization and molecular epidemiology of coagulase-negative Staphylococcal bacteremia in cancer patients: A pilot study. Am J Infect Control 34:36-40
107. Kaufman D, Fairchild KD (2004) Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants. Clin Microbiol Rev 17:638-680
108. Stoll BJ, Hansen N, Fanaroff AA et al (2002) Late-onset sepsis in very low birth weight neonates: The experience of the NICHD Neonatal Research Network. Pediatrics 110(2002):285-291
109. Hira V, Kornelisse R, Slujter M et al (2013) Colonization dynamics of antibiotic-resistant coagulase-negative staphylococci in neonates. J Clin Microbiol 51:595-597
110. Dudeck MA, Horan TC, Peterson KD et al (2013) Centers for Disease Control and Prevention. National Healthcare Safety Network (NHSN) report, data summary for 2011, deviceassociated module. http://www.cdc.gov/nhsn. PDFs/dataStat/NHSN- Report-2011-Data-Summary.pdf . Accessed 4 April 2013
111. Brusselaers N, Monstrey S, Snoeij T et al (2010) Morbidity and mortality of bloodstream infections in patients with severe burn injury. Am J Crit Care 19:e81-e87
112. McCann MT, Gilmore BF, Gorman SP (2008) Staphylococcus epidermidis device-related infections: Pathogenesis and clinical management. J Pharm Pharmacol 60:1551-1571
113. Nuryastuti T, van der Mei HC, Busscher HJ et al (2009) Effect of cinnamon oil on ica A expression and biofi lm formation by Staphylococcus epidermidis . Appl Environ Microbiol 75:6850-6855
114. Hell E, Giske CG, Nelson A et al (2010) Human cathelicidin peptide LL37 inhibits both attachment capability and biofi lm formation of Staphylococcus epidermidis . Lett Appl Microbiol 50:211-215
115. Wang X, Yao X, Zu Z et al (2009) Effect of berberine on Staphylococcus epidermidis biofi lm formation. Int J Antimicrob Agents 34:60-66
116. Lonn-Stensrud J, Landin MA, Bennche T et al (2009) Furanones, potential agents for preventing Staphylococcus epidermidis biofi lm infections? J Antimicrob Chemother 62: 309-16
117. Saader HS, Biedenbach DJ, Paukner S et al (2012) Antimicrobial activity of the investigational pleuromutilin compound BC-3781 tested against gram-positive organisms commonly associated with acute bacterial skin and skin structure infections. Antimicrob Agents Chemother 56:1619-1623
118. Francolini I, Donelli G (2010) Prevention and control of biofi lm-based medical-devicerelated infections. FEMS Immunol Med Microbiol 59:227-238
119. Van Mellaert V, Shahrooei M, Hofmans D et al (2012) Immunoprophylaxis and immunotherapy of Staphylococcus epidermidis infections: Challenges and prospects. Expert Rev Vaccines 11:319-334
120. Kaplan J (2009) Therapeutic potential of biofi lm-dispersing enzymes. Int J Artif Organs 32:545-554
121. Phil M, Chavez de Paz LE, Schmidtchen A et al (2010) Effects of clinical isolates of Pseudomonas aeurginosa on Staphylococcus epidermidis biofi lm formation. FEMS Immunol Med Microbiol 59:504-512
122. Harris LG, Bexfi eld A, Nigam Y et al (2009) Disruption of Staphylococcus epidermidis biofi lms by medicinal maggot Lucilia sericata extcretions/ secretions. Int J Artif Organs 32:555-564