Physiology and pathophysiology of the epithelial barrier of the female reproductive tract role of ion channels

Advances in Experimental Medicine and Biology

Volumn 763, Issue , 2013, Pages 193-217

  Chan, Hsiao Chang ^a   Chen, Hui ^a   Ruan, Yechun ^a   Sun, Tingting ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BICARBONATE; CADHERIN; CLAUDIN 5; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL SODIUM CHANNEL; ION CHANNEL; MESSENGER RNA; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 1; VASCULOTROPIN;

ACIDITY; ALKALINITY; ARTICLE; BLOOD VESSEL PERMEABILITY; CAUSAL ATTRIBUTION; CELL JUNCTION; CELL MEMBRANE PERMEABILITY; CHLAMYDIASIS; EMBRYO DEVELOPMENT; ENDOMETRIUM; EPITHELIUM CELL; FEMALE INFERTILITY; HORMONAL REGULATION; HORMONE RESPONSE; HUMAN; HYDROSALPINX; ION TRANSPORT; NONHUMAN; OVARY HYPERSTIMULATION; PATHOGENESIS; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; SPERMATOZOON CAPACITATION; UPREGULATION; UTERINE CERVIX MUCUS;

EID: 84934437504     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-4711-5_10     Document Type: Article

References (164)

1. Caillouette JC, Sharp CF Jr,Zimmerman GJ, et al. Vaginal pH as a marker for bacterial pathogens and mcnopausal status. Am J Obstct Gynccol1997; 176(6):1270-1275; discussion 1275-1277
2. Masters WH. The sexual response cycle of the human female: Vaginal lubrication. Ann N Y Acad Sci 1959; 83:301-317
3. Owen DH, Katz DF. A vaginal fluid simulant. Contraception 1999; 59(2):91-95
4. Pcctcrs F, Snauwacrt R, Scgcrs J et al. Obscrvations on candidal vaginitis. Vaginal pH, microbiology, and cytology. Am J Obstet Gynecol 1972; 112(1 ):80-86
5. Zuck TT, DuncanDRL. Thc timc of ovulation in thchuman fcmalc. AmJ ObstctGynccol1939; 38:310-313
6. Val ore EV, Park CH, Tgreti SL, et al. Antimicrobial components of vaginal fluid. Am J Obstet Gynecol 2002; 187(3):561-568
7. Wagner G, Levin RJ. Electrolytes in vaginal fluid during the menstrual cycle of coitally active and inactive womcn. J Rcprod Fcrti11980; 60(1):17-27
8. Eggert-Kruse W, Botz T, Pohl S, et al. Antimicrobial activity of human cervical mucus. Hum Reprod 2000; 15(4):778-784
9. World Health Organization, WHO laboratory manual for the examination of human semen and sperm-cervical mucus intcraction. 4 cd. 2003, Cambridgc: Cambridgc Univcrsity Prcss
10. Lamar JK, Shettles LB, Delfs E. Cyelic penetrability of human cervical mucus to spermatozoa in vitro. AMJ Physiol1940; 129:234-241
11. Macdonald RR, Lumley IE. Endocervical pH measured in vivo through the normal menstrual cycle. Obstet Gyncco11970; 35(2):202-206
12. Moghissi KS. Cyclic changes of cervical mucus in normal and progestin-Treated women. Fertil Steril 1966; 17(5):663-675
13. Breckenridge MA, Pederson DP, Pommerenke WT. A pH study of human cervical secretions. Fertil Steril 1950; 1(5):427-434
14. Eggert-Kruse W, Kohler A, Rohr G, et al. The pH as an important determinant of sperm-mucus interaction. Fcrtil Stcri11993; 59(3):617-628
15. Jenkins J, Anthony F, Purdie B, et al. Acidic endocervical mucus: A potentially reversible cause of sub fertility. Contcmp Rcv Obstct Gynaccol1989; 1:273-278
16. Zavos PM, Cohen MR. The pH of cervical mucus and the post-coital test. Fertil Steril 1980; 34(3):234-238
17. Ansari AH, Gould KG, Ansari VM. Sodium bicarbonatc douching for improvcmcnt of thc post-coital tcst. Fertil Steril 1980; 33(6):608-612
18. Evcrhardt E, Dony JM, J anscn H et al.lmprovcmcnt of ccrvical mucus viscoelasticity and spcrm pcnctration with sodium bicarbonate douching. Hum Reprod 1990; 5(2): 133-137
19. Lccsc HJ. Thc formation and function of oviduct fluid. J Rcprod Fcrtil 1988; 82(2):843-856
20. Maas DH, Storey BT, Mastroianni L Jr. Hydrogen ion and carbon dioxide content of the oviductal fluid of thc rhcsus monkcy (Macaca mulatta). Fcrtility Stcrility 1977; 28(9):981-985
21. Hadek. Alteration of pH in the sheep's oviduct. Nature 1953; 171 :976
22. Engle CC, Dunn JS, Hood RO et al. Amino acids in sow and rabbit oviduct fluids. J Anim Sci 1968; 27: 1786
23. Nichol R, Hunter RH, Cooke GM. Oviduct fluid pH in intact and unilaterally ovariectomized pigs. Can J Physiol Pharmacol1997; 75(9):1069-1074
24. Murdoch RN, White TG. The influence of the female genital tract on the metabolism of rabbit spermatozoa. Dircct cffcct oftubal and utcrinc fluids, bicarbonatc, and othcr factors. Australian Journal of Biological Sciences 1968; 21 (5):961-972
25. Odor DL, Blandau RJ. Obscrvations on thc solitary cilium of rabbit oviductal cpithclium: Its motility and ultrastructure. Am J Anat 1985; 174(4):437-453
26. Vishwakarma P. Thc pH and bicarbonatc-ion contcnt ofthc oviduct and utcrinc fluids. Fcrtility & Stcrility 1962; 13:481-485
27. Casslen B, Nilsson B. Human utcrinc fluid, cxamincd in undilutcd samples for osmolarity and thc concentrations of inorganic ions, albumin, glucose, and urea. Am J Obstet Gynecol1984; 150(7):877-881
28. Clemetson CA, Kim JK, De Jesus TP, et al. Human uterine fluid potassium and the menstrual cycle. J Obstet Gynaccol Br Commonw 1973; 80(6):553-561
29. Clemetson CA, Mallikarjuneswara VR, Moshfeghi MM, et al. The effects of oestrogen and progesterone on the sodium and potassium concentrations of rat uterine fluid. J Endocrinol1970; 47(3):309-319
30. Iritani A, Sato E, Nishikawa Y. Secretion rates and chemical composition of oviduct and uterine fluids in sows. J Anim Sci 1974; 39(3):582-588
31. Nilsson BO, Ljung L. X-ray micro analyses of cations (Na, K, Ca) and anions (S, P, Cl) in uterine secretions during blastocyst implantation in the rat. J Exp Zoo11985; 234(3):415-421
32. Nordenvall M, Ulmsten U, Ungerstedt U. Influence of progesterone on the sodium and potassium concentrations of rat uterine fluid investigated by microdialysis. Gynecol Obstet Invest 1989; 28(2):73-77
33. Dickens CJ, Maguiness SD, Comer MT, et al. Human tubal fluid: Formation and composition during vascular perfusion of the fallopian tube. Hum Reprod 1995; 10(3):505-508
34. Hunter RH. Fallopian tube fluid: The physiological medium for fertilization and early embryo development. ed. The Fallopian Tubes: Their Role in Fertility and Infertility Berlin: Springer-Verlag, 1988; 30-52
35. Miller JG, SchultzGA. Amino acid content of pre-implantation rabbit embryos and fluids ofthe reproductive tract. BioI Reprod 1987; 36(1):125-129
36. Tay n, Rutherford AJ, Killick SR, et al. Human tubal fluid: Production, nutrient composition and response to adrenergic agents. Hum Reprod 1997; 12(11):2451-2456
37. Downing SJ, Maguiness SD, Watson A, et al. Electrophysiological basis of human fallopian tubal fluid formation. J Reprod Ferti11997; 111(1):29-34
38. Leese HJ, Tay n, Reischl J, et al. Formation of Fallopian tubal fluid: Role of a neglected epithelium. Reproduction 2001; 121(3):339-346
39. Long JA, Evans HM. The oestrous cycle in the rat and its associated phenomena. Proc Natl Acad Sci USA 1922; 8(3):8-39
40. He Q, Tsang LL, Ajonuma LC, et al. Abnormally up-regulated cystic fibrosis transmembrane conductance regulator expression and uterine fluid accumulation contribute to Chlamydia trachomatis-induced female infertility. Fertil Steri12010; 93(8):2608-2614
41. Casslen B. Uterine fluid volume. Cyclic variations and possible extrauterine contributions. J Reprod Med 1986; 31(6):506-510
42. Kopito LE, Kosasky HJ, Sturgis SH, et al. Water and electrolytes in human cervical mucus. Fertil Steril 1973; 24(7):499-506
43. Chan HC, Liu CQ, Fong SK, et al. Electrogenic ion transport in the mouse endometrium: Functional aspects of the cultured epithelium. Biochim Biophys Acta 1997; 1356(2): 140-148
44. Matthews CJ, McEwan GT, Redfern CP, et al. Absorptive apical amiloride-sensitive Na+ conductance in human endometrial epithelium. J Physiol 1998; 513(Pt 2):443-452
45. Deachapunya C, Palmer-Densmore M, O'Grady SM. Insulin stimulates transepithelial sodium transport by activation of a protein phosphatase that increases Na-K ATPase activity in endometrial epithelial cells. J GenPhysiol1999; 114(4):561-574
46. Chan HC, Fong SK, So SC, et al. Stimulation of anion secretion by beta-Adrenoceptors in the mouse endometrial epithelium. J Physiol1997; 501(Pt 3):517-525
47. Chan HC, Liu CQ, Fong SK, et al. Regulation of CI-secretion by extracellular ATP in cultured mouse endometrial epithelium. J Membr BioI 1997; 156(1):45-52
48. Chan LN, Tsang LL, Rowlands DK, et al. Distribution and regulation ofENaC subunit and CFTR mRNA expression in murine female reproductive tract. J Membr BioI 2002; 185(2): 165-176
49. Fong SK, Chan HC. Regulation of anion secretion by prostaglandin E2 in the mouse endometrial epithelium. BioI Reprod 1998; 58(4):1020-1025
50. Fong SK, Liu CQ, Chan HC. Cellular mechanisms of adrenaline-stimulated anion secretion by the mouse endometrial epithelium. BioI Reprod 1998; 59(6): 1342-1348
51. Sheppard DN, Welsh MJ. Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents. J Gen Physiol1992; 100(4):573-591
52. Reisin IL, Prat AG, Abraham EH, et al. The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel. J BioI Chern 1994; 269(32):20584-20591
53. Haws C, Finkbeiner WE, Widdicombe JH, et al. CFTR in Calu-3 human airway cells: Channel properties and role in cAMP-Activated CI-conductance. Am J Physiol1994; 266(5 Pt 1):L502-L512
54. Deachapunya C, O'Grady SM. Regulation of chloride secretion across porcine endometrial epithelial cells by prostaglandin E2. J Physiol1998; 508(Pt 1):31-47
55. Chan LN, Chung YW, Leung PS, et al. Activation of an adenosine 3',5'-cyelic monophosphate-dependent CI-conductance in response to neurohormonal stimuli in mouse endometrial epithelial cells: The role of cystic fibrosis transmembrane conductance regulator. Bioi Reprod 1999; 60(2):374-380
56. Wang XF, Zhou CX, Shi QX, et al. InvolvementofCFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm. Nat Cell BioI 2003; 5(10):902-906
57. Wang XF, Yu MK, Leung KM, et al. Involvement of Na+-HC03-cotransporter in mediating cyclic adenosine 3',5'-monophosphate-dependent HC03-secretion by mouse endometrial epithelium. BioI Reprod2002; 66(6):1846-1852
58. Wang XF, Yu MK, Lam SY, et al. Expression, immunolocalization, and functional activity of Na+/H+exchanger isoforms in mouse endometrial epithelium. BioI Reprod 2003; 68(1):302-308
59. Brunton WJ, Brinster RL. Active chloride transport in the isolated rabbit oviduct. AM J Physiol1971; 221 (2):658-661
60. Gott AL, Gray SM, James AF, et al. The mechanism and control of rabbit oviduct fluid formation. BioI Reprod 1988; 39(4):758-763
61. Dickens CJ, Southgate J, Leese HJ. Use of primary cultures of rabbit oviduct epithelial cells to study the ionic basis of tubal fluid formation. J Reprod Fertil 1993; 98(2):603-610
62. Keating N, Quinlan LR. Effect of basolateral adenosine triphosphate on chloride secretion by bovine oviductal epithelium. Bioi Reprod 2008; 78(6): 1119-1126
63. Dickens CJ,LeeseHJ. The regulation of rabbit oviduct fluid formation. J ReprodFertil1994; 100(2):577-581
64. Leung AY, Wong PY, Gabriel SE, et al. cAMP-but not Ca(2+)-regulated CI-conductance in the oviduct is defective in mouse model of cystic fibrosis. AM J Physiol1995; 268(3 Pt 1):C708-C712
65. Chen MH, Chen H, Zhou Z, et al. Involvement of CFTR in oviductal HC03-secretion and its effect on soluble adenylate cyelase-dependent early embryo development. Hum Reprod 2010; 25(7): 1744-1754
66. Agre P, Preston GM, Smith BL, et al. Aquaporin CHIP: The archetypal molecular water channel. AM J Physiol1993; 265(4 Pt 2):F463-F476
67. He RH, Sheng JZ, Luo Q, et al. Aquaporin-2 expression in human endometrium correlates with serum ovarian steroid hormones. Life Sci 2006; 79(5):423-429
68. Hildenbrand A, Lalitkumar L, Nielsen S, et al. Expression of aquaporin 2 in human endometrium. Fertil Steri12006; 86(5):1452-1458
69. Lindsay LA, Murphy CR. Redistribution ofaquaporins in uterine epithelial cells at the time of implantation in the rat. Acta Histochem 2004; 106(4):299-307
70. Lindsay LA, Murphy CR. Redistribution of aquaporins I and 5 in the rat uterus is dependent on progesterone: A study with light and electron microscopy. Reproduction 2006; 131(2):369-378
71. Skowronski MT, Kwon TH, Nielsen S. Immunolocalization of aquaporin I, 5, and 9 in the female pig reproductive system. J Histochem Cytochem 2009; 57(1):61-67
72. Branes MC, Morales B, Rios M, et al. Regulation of the immunoexpression of aquaporin 9 by ovarian hormones in the rat oviductal epithelium. Am J Physiol Cell Physiol2005; 288(5):CI 048-1057
73. Skowronski MT, Skowronska A, Nielsen S. Fluctuation of aquaporin I, 5, and 9 expression in the pig oviduct during the estrous cycle and early pregnancy. J Histochem Cytochem 2011; 59(4):419-427
74. Welsh MJ, Smith AE. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell 1993; 73(7): 1251-1254
75. Di A, Brown ME, Deriy LV, et al. CFTR regulates phagosome acidification in macrophages and alters bactericidal activity. Nat Cell BioI 2006; 8(9):933-944
76. Guo Y, Su M, McNutt MA, et al. Expression and distribution of cystic fibrosis transmembrane conductance regulator in neurons of the human brain. J Histochem Cytochem 2009; 57(12):1113-1120
77. Tousson A, Van Tine BA, Naren AP, et al. Characterization of CFTR expression and chloride channel activity in human endothelia. Am J Physiol1998; 275(6 Pt 1):CI555-CI564
78. Quinton PM. Physiological basis of cystic fibrosis: A historical perspective. Physiol Rev 1999; 79(Suppl I ):S3-S22
79. Zhang WK, Wang D, Duan Y, et al. Mechanosensitive gating ofCFTR. Nat Cell Bio12010; 12(5):507-512
80. Rubenstein RC, Lockwood SR, Lide E, et al. Regulation of endogenous ENaC functional expression by CFTR and DeltaF508-CFTR in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 20 II; 300(l):L88-Ll 01
81. Gawenis LR, Franklin CL, Simpson JE, et al. cAMP inhibition of murine intestinal NalH exchange requires CFTR-mediated cell shrinkage of villus epithelium. Gastroenterology 2003; 125(4): 1148-1163
82. Park M, Ko SB, Choi JY, et al. The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HC03-salvage transporter human Na+-HC03-cotransport isoform 3. J BioI Chern 2002; 277(52):50503-50509
83. Li C, Naren AP. CFTR chloride channel in the apical compartments: Spatiotemporal coupling to its interacting partners. IntegrBiol (Cam b) 2010; 2(4):161-177
84. Kellenberger S, SchildL. Epithelial sodium channel/degenerin family of ion channels: A variety offunctions for a shared structure. Physiol Rev 2002; 82(3):735-767
85. Hummler E, Rossier BC. Physiological and pathophysiological role of the epithelial sodium channel in the control of blood pressure. Kidney Blood Press Res 1996; 19(3-4): 160-165
86. Soundararajan R, Pearce D, Hughey RP, et al. Role of epithelial sodium channels and their regulators in hypertension. J Bioi Chern 2010; 285(40):30363-30369
87. Hummler E, Barker P, Gatzy J, et al. Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet 1996; 12(3):325-328
88. Schwartz GJ, Burg MB. Mineralocorticoid effects on cation transport by cortical collecting tubules in vitro. Am J Physiol1978; 235(6):F576-F585
89. Schild L, Canessa CM, Shimkets RA, et al. A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system. Proc Natl Acad Sci USA 1995; 92(12):5699-5703
90. Chang SS, Grunder S, Hanukoglu A, et al. Mutations in subunits ofthe epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type I. Nat Genet 1996; 12(3):248-253
91. Mularoni A, Beck L, Sadir R, et al. Down-regulation by progesterone of CFTR expression in endometrial epithelial cells: A studyby competitiveRT-PCR. BiochemBiophysRe sCommun 1995;217(3):1105-1111
92. Rochwerger L, Buchwald M. Stimulation of the cystic fibrosis transmembrane regulator expression by estrogen in vivo. Endocrinology 1993; 133(2):921-930
93. Rochwerger L, Dho S, Parker L, et al. Estrogen-dependent expression ofthe cystic fibrosis transmembrane regulator gene in a novel uterine epithelial cell line. J Cell Sci 1994; I 07(Pt 9):2439-2448
94. Salleh N, Baines DL, N aftalin RJ, et al. The hormonal control of uterine luminal fluid secretion and absorption. JMembrBiol2005; 206(1):17-28
95. Laube M, Kuppers E, Thome UH. Modulation of sodium transport in alveolar epithelial cells by estradiol and progesterone. Pediatr Res 2011; 69(3):200-205
96. Gambling L, Dunford S, Wilson CA, et al. Estrogen and progesterone regulate alpha, beta, and gammaENaC subunit mRNA levels in female rat kidney. Kidney Tnt 2004; 65(5): 1774-1781
97. Chang CT, Sun CY, Pong CY, et al. Interaction of estrogen and progesterone in the regulation of sodium channels in collecting tubular cells. Chang Gung Med J 2007; 30(4):305-312
98. Ajonuma LC, Chan PK, Ng EH, et al. Involvement of cystic fibrosis transmembrane conductance regulator (CFTR) in the pathogenesis of hydrosalpinx induced by Chlamydia trachomatis infection. J Obstet Gynaecol Res 2008; 34(6):923-930
99. Yang JZ, Ajonuma LC, Tsang LL, et al. Differential expression and localization of CFTR and ENaC in mouse endometrium during pre-implantation. Cell Biollnt 2004; 28(6):433-439
100. Chan LN, Wang XF, Tsang LL, et al. Tnhibition of ami lori de-sensitive Na(+) absorption by activation of CFTR in mouse endometrial epithelium. Pflugers Arch 2001; 443 Suppll:S132-S136
101. Bishop DW. Active secretion in the rabbit oviduct. Am J Physiol 1956; 187(2):347-352
102. Richardson LL, Oliphant G. Steroid concentrations in rabbit oviducal fluid during oestrus and pseudopregnancy. J Reprod Fertil 1981; 62(2):427-431
103. Perkins JL. Fluid flow ofthe oviduct. In Johnson AD, Foley CW, ed. The Oviduct and its Functions. New York, London: Academic Press, 1974: 119-132
104. Roberts GP, Parker JM, Symonds HW. Proteins in the luminal fluid from the bovine oviduct. J Reprod Ferti11975; 45(2):301-313
105. Mastroianni L Jr, Beer F, Shah U, et al. Endocrine regulation of oviduct secretions in the rabbit. Endocrinology 1961; 68:92-100
106. McDonald MF, Bellve AR. Influence of oestrogen and progesterone on flow offluid from the Fallopian tube in the ovariectomized ewe. J Reprod Fertil 1969; 20(1 ):51-61
107. Chen M, Du J, Jiang W, et al. Functional expression of cystic fibrosis transmembrane conductance regulator in rat oviduct epithelium. Acta Biochim Biophys Sin (Shanghai) 2008; 40(10):864-872
108. Donaldson SH, Poligone EG, Stutts MJ. CFTR regulation of ENaC. Methods Mol Med 2002; 70:343-364
109. Kunzelmann K. ENaC is inhibited by an increase in the intracellular CI(-) concentration mediated through activation ofCI(-) channels. Pflugers Arch 2003; 445(4):504-512
110. Wang XF, Chan HC. Adenosine triphosphate induces inhibition ofNa( +) absorption in mouse endometrial epithelium: A Ca(2+ )-dependent mechanism. BioI Reprod 2000; 63(6): 1918-1924
111. Chan LN, Wang XF, Tsang LL, et al. Suppression ofCFTR-mediated CI(-) secretion by enhanced expression of epithelial Na( +) channels in mouse endometrial epithelium. Biochem Biophys Res Commun 2000; 276(1 ):40-44
112. Wang XF, Tsang LL, So SC, et al. Suppression of ATP-induced CI(-)secretion by enhanced expression of epithelial Na( + )channels in mouse endometrial epithelium. Cell Bioi Tnt 2001; 25(10): 1017-1020
113. Benos DJ, Awayda MS, Berdiev BK, et al. Diversity and regulation of amiloride-sensitive Na+ channels. Kidney Tnt 1996; 49(6): 1632-1637
114. Tsang LL, Chan LN, Chan He. Altered cyelic expression of epithelial Na+ channel subunits and cystic fibrosis transmembrane conductance regulator in mouse endometrium by a low sodium diet. Cell BioI Int 2004; 28(7):549-555
115. Tsang LL, Chan LN, Wang XF, et al. Enhanced epithelial Na( +) channel (ENaC) activity in mouse endometrial epithelium by upregulation of gammaENaC subunit. Jpn J Physiol2001; 51(4):539-543
116. Calhoun DA. Aldosteronism and hypertension. Clin J Am Soc Nephrol 2006; I (5): I 039-1 045
117. Yang JZ, Ho AL, Ajonuma LC, et al. Differential effects of Matrigel and its components on functional activity of CFTR and ENaC in mouse endometrial epithelial cells. Cell BioI Int 2003; 27(7):543-548
118. Althaus M, Bogdan R, Clauss WG, et al. Mechano-sensitivity of epithelial sodium channels (ENaCs): Laminar shear stress increases ion channel open probability. FASEB J 2007; 21(10):2389-2399
119. Bengrine A, Li J, Hamm LL, et al. Indirect activation of the epithelial Na+ channel by trypsin. J BioI Chern 2007; 282(37):26884-26896
120. Donaldson SH, Hirsh A, Li DC, et al. Regulation of the epithelial sodium channel by serine proteases in human airways. J BioI Chern 2002; 277(10):8338-8345
121. He Q, Chen H, Wong CH, et al. Regulatory mechanism underlying cyclic changes in mouse uterine bicarbonate secretion: Role of estrogen. Reproduction 2010; 140(6):903-910
122. Boatman DE, Robbins RS. Bicarbonate: Carbon-dioxide regulation of sperm capacitation, hyperactivated motility, and acrosome reactions. BioI Reprod 1991; 44(5):806-813
123. Shi QX, RoldanER. Bicarbonate/C02 is not required for zona pellucida-or progesterone-inducedacrosomal exocytosis of mouse spermatozoa but is essential for capacitation. BioI Reprod 1995; 52(3):540-546
124. Oppenheimer EA, Case AL, Esterly JR, et al. Cervical mucus in cystic fibrosis: A possible cause of infertility. Am J Obstet Gynecol 1970; 108(4):673-674
125. Kopito LE, Kosasky HJ, Shwachman H. Water and electrolytes in cervical mucus from patients with cystic fibrosis. Fertil Steril 1973; 24(7):512-516
126. Quinton PM. Role of epithelial HC03 transport in mucin secretion: Lessons from cystic fibrosis. Am J Physiol Cell Physiol2010; 299(6):CI222-CI233
127. Muchekehu RW, Quinton PM. A new role for bicarbonate secretion in cervico-uterine mucus release. J Physiol 2010; 588(Pt 13):2329-2342
128. Garcia MA, Yang N, Quinton PM. Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion. J Clin Invest 2009; 119(9):2613-2622
129. Epelboin S, Hubert D, Patrat C, et al. Management of assisted reproductive technologies in women with cystic fibrosis. Fertil Steri12001; 76(6):1280-1281
130. Okamura N, Tajima Y, Soejima A, et al. Sodium bicarbonate in seminal plasma stimulates the motility of mammalian spermatozoa through direct activation of adenylate cyclase. J BioI Chern 1985; 260(17):9699-9705
131. Vishwakarma P. The pH and bicarbonate-ion content of the oviduct and uterine fluids. Fertil Steril 1962; 13:481-485
132. Matzuk MM, Lamb DJ. Genetic dissection of mammalian fertility pathways. Nat Cell BioI 2002; 4 Suppl:s41-s49
133. Delvigne A, Rozenberg S. Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): A review. Hum Reprod Update 2002; 8(6):559-577
134. Schenker JG, Weinstein D. Ovarian hyperstimulation syndrome: A current survey. Fertil Steril 1978; 30(3):255-268
135. Nastri CO, Ferriani RA, Rocha IA, et al. Ovarian hyperstimulation syndrome: Pathophysiology and prevention. J Assist Reprod Genet; 27(2-3):121-128
136. Enskog A, Nilsson L, Brannstrom M. Plasma levels of free vascular endothelial growth factor(165 (VEGF(l65 are not elevated during gonadotropin stimulation in in vitro fertilization (IVF) patients developing ovarian hyperstimulation syndrome (OHSS): Results of a prospective cohort study with matched controls. Eur J Obstet Gynecol Reprod BioI 2001 ; 96(2): 196-201
137. Geva E, Amit A, Lessing JB, et al. Follicular fluid levels of vascular endothelial growth factor. Are they predictive markers for ovarian hyperstimulation syndrome? J Reprod Med 1999; 44(2):91-96
138. Kobayashi H, Okada Y, Asahina T, et al. The kallikrein-kinin system, but not vascular endothelial growth factor, plays a role in the increased vascular permeability associated with ovarian hyperstimulation syndrome. J Mol Endocrinol 1998; 20(3):363-374
139. McElhinney B, Ardill J, Caldwell C, et al. Variations in serum vascular endothelial growth factor binding profiles and the development of ovarian hyperstimulation syndrome. Fertil Steril 2002; 78(2):286-290
140. Gomez R, Simon C, Remohi J, et al. Administration of moderate and high doses of gonadotropins to female rats increases ovarian vascular endothelial growth factor (VEGF) and VEGF receptor-2 expression that is associated to vascular hyperpermeability. BioI Reprod 2003; 68(6) :2164-2171
141. Wang TH, Homg SG, Chang CL, et al. Human chorionic gonadotropin-induced ovarian hyperstimulation syndrome is associated with up-regulation of vascular endothelial growth factor. J Clin Endocrinol Metab 2002; 87(7):3300-3308
142. Villasante A, Pacheco A, Ruiz A, et al. Vascular endothelial cadherin regulates vascular permeability: Implications for ovarian hyperstimulation syndrome. J Clin Endocrinol Metab 2007; 92( I ):314-321
143. Rodewald M, Herr D, Duncan WC, et al. Molecular mechanisms of ovarian hyperstimulation syndrome: Paraerine reduction of endothelial claudin 5 by hCG in vitro is associated with increased endothelial permeability. Hum Reprod 2009; 24(5): 1191-1199
144. Gabriel SE, Brigman KN, Koller BH, et al. Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model. Science 1994; 266(5182):107-109
145. Ajonuma LC, Tsang LL, Zhang GH, et al. Estrogen-induced abnormally high cystic fibrosis transmembrane conductance regulator expression results in ovarian hyperstimulation syndrome. Mol Endoerinol2005; 19(12):3038-3044
146. Manau D, Balasch J, Arroyo V, et al. Circulatory dysfunction in asymptomatic in vitro fertilization patients. Relationship with hyperestrogenemia and activity of endogenous vasodilators. J Clin Endoerinol Metab 1998; 83(5):1489-1493
147. Cates W Jr, Wasserheit IN. Genital ehlamydial infections: Epidemiology and reproductive sequelae. Am J Obstet Gynecol1991; 164(6 Pt 2): 1771-1781
148. Walters MD, Eddy CA, Gibbs RS, et al. Antibodies to Chlamydia traehomatis and risk for tubal pregnancy. Am J Obstet Gynecol1988; 159(4):942-946
149. Wolner-Hanssen P, Mardh P A, Moller B, et al. Endometrial infection in women with Chlamydial salpingitis. Sex Transm Dis 1982; 9(2):84-88
150. Jones RB, Mammel JB, Shepard MK, et al. Recovery of Chlamydia traehomatis from the endometrium of women at risk for ehlamydial infection. Am J Obstet Gyneeol1986; 155(1):35-39
151. Witkin SS, Sultan KM, Neal GS, et al. Unsuspected Chlamydia traehomatis infection and in vitro fertilization outcome. Am J Obstet Gyneeo11994; 171(5):1208-1214
152. Spandorfer SD, Neuer A, LaVerda D, et al. Previously undetected Chlamydia traehomatis infection, immunity to heat shock proteins and tubal occlusion in women undergoing in-vitro fertilization. Hum Reprod 1999; 14(1 ):60-64
153. Ajonuma LC, N g EH, Chan LN, et al. Ultrastructural characterization of whole hydrosalpinx from infertile Chinese women. Cell Bioi Tnt 2005; 29(10):849-856
154. Ajonuma LC, Ng EH, Chow PH, et al. Increased cystic fibrosis transmembrane conductance regulator (CFTR) expression in the human hydrosalpinx. Hum Reprod 2005; 20(5): 1228-1234
155. Ajonuma LC, He Q, Sheung Chan PK, et al. Involvement of cystic fibrosis transmembrane conductance regulator in infection-induced edema. Cell BioI Tnt 2008; 32(7):801-806
156. Mansour RT, Aboulghar MA, Serour GI, et al. Fluid accumulation of the uterine cavity before embryo transfer: A possible hindrance for implantation. J Tn Vitro Fert Embryo Transf 1991; 8(3): 157-159
157. Lebeeh PE, Svendsen PA, Ostergaard E. The effects of small doses ofmegestrol acetate on the cervical mucus. Tnt J Fertil 1970; 15(2):65-76
158. Edwards RG, Talbert L, Israclstam D, et al. Diffusion chamber for exposing spermatozoa to human uterine secretions. Am J Obstet Gyneeol 1968; 102(3):388-396
159. Kar AB, Engineer AD, Goel R, et al. Effect of an intrauterine contraceptive device on biochemical composition of uterine fluid. Am J Obstet Gyneeol 1968; 10 I (7):966-970
160. Maas DHA, Reiss G, Braun D. pH, pC02, and lactate concentration in human uterine fluid. Arch Androl 1983; II: 188
161. Lippes J, Enders RG, Pragay DA, et al. The collection and analysis of human fallopian tubal fluid. Contraception 1972; 5(2):85-103
162. Borland RM, Hazra S, Biggers JD, et al. The elemental composition of the environments of the gametes and pre-implantation embryo during the initiation of pregnancy. BioI Reprod 1977; 16(2): 147-157
163. David A, Brackett BG, Garcia CR, et al. Composition of rabbit oviduct fluid in ligated segments of the Fallopian tube. J Reprod Fertil 1969; 19(2):285-289
164. Strandell A, Sjogren A, Bentin-Ley U, et al. Hydrosalpinx fluid docs not adversely affect the normal development of human embryos and implantation in vitro. Hum Reprod 1998; 13(10):2921-2925