Physiological and pathophysiological role of the epithelial sodium channel in the control of blood pressure

Kidney and Blood Pressure Research

Volumn 19, Issue 3-4, 1996, Pages 160-165

  Hummler, Edith ^a   Rossier, Bernard C ^a  

^a Instilut de Pharmacologie et de Toxicologic de I Université   (Switzerland)

Author keywords

Human disease; Hypertension; Hypotension; Kidney; Mouse model; Pseudoaldosteronism; Sodium reabsorption; Transgenic mice

Indexed keywords

CARRIER PROTEIN; SODIUM CHANNEL; SODIUM ION;

ARTERIAL PRESSURE; BLOOD PRESSURE REGULATION; CONFERENCE PAPER; ENVIRONMENTAL FACTOR; EPITHELIUM; ESSENTIAL HYPERTENSION; GENE MUTATION; HEREDITY; HOMEOSTASIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SODIUM BALANCE; SODIUM TRANSPORT; SODIUM URINE LEVEL;

ANIMALS; BLOOD PRESSURE; CARRIER PROTEINS; EPITHELIUM; HUMANS; HYPERTENSION; ION TRANSPORT; KIDNEY TUBULES; POINT MUTATION; SODIUM CHANNELS;

EID: 0029794111     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000174065     Document Type: Article

References (49)

1. Ward R: Familial aggregation and genetic epidemiology of blood pressure; in Laragh JH, Brenner BM (eds): Hypertension: Pathophysiology, Diagnosis, and Management, New York, Raven, 1990, pp 81-100.
2. Rossier BC, Palmer LG: Mechanisms of aldosterone action on sodium and potassium transport: in Seldin DW, Giebiesch G (eds): The Kidney: Physiology and Pathophysiology, New York, Raven, 1992, pp 1373-1409.
3. Cancssa CM, Horisbcrgcr JD, Rossier BC: Amiloride-sensitive epithelial Na' channel is made of three homologous subunits, Nature 1994;367:463-467.
4. Duc C, Fannan N, Canessa CM, Bonvalet JP: Cell-specific expression of epithelial sodium channel a, 1 and y subunits in aldosterone-responsive cpithclia from the rat: Localization by in situ hybridization and immunocytochemis-try, J Cell Biol 1994;127:1907-1921.
5. Volk KA, Sigmund RD, Snyder PM; McDonald FJ, Welsh MJ, Stokes .IB: rENaC is the predominant Na channel in the apical membrane of the rat renal inner medullary collecting duct, J Clin Invest 1996;96:2748-2757.
6. Canessa CM, Schild L, Buell G, Thorens B, Gauschi I, Horisberger JD, Rossier BC: Epithelial sodium channel related to proteins involved in neurodegeneration, Nature 1993:361:467-470.
7. Lingueglia E, Champigny G, Lazdunski M, Barbry P: Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel, Nature 1995;378:730-733.
8. Waldmann R, Champigny G, Bassilana F, Voil-Icy N, Lazdunski M: Molecular cloning and functional expression of a novel amiloride-sensitive Na channel, J Biol Client 1995;270: 27411-27414.
9. Price MP, Snyder PM, Welsh MJ: Cloning and expression of a novel human brain Na channel, JBiolChem 1996:271:7897-7882.
10. Driscoll M, Chalfic M: Developmental and abnormal cell death in G elegans, Trends Neurol Sci 1992:15:15-19.
11. Liddle GW, Bledsoe T, Coppagc WS: A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion, Trans Assoc Am Physicians 1963:76:199-213.
12. Botcro-Velez M, Curtis JJ, Warnock DG: Brief report: L.iddle's syndrome revisited - A disorder of sodium reabsorption in the distal tubule, N Engl J Med 1994;330:178-181.
13. Horisberger JD, Puoti A, Canessa CM, Rossier BC: The amiloride receptor, J Clin Invest 1994; 72:695-697.
14. Puoti A, May A, Cancssa CM, Horisberger JD, Schild L, Rossier BC : The highly selective low-conductance epithelial Na channel of Xenopus laevis A6 kidney cells, Am J Physiol 1995:269: CI88-C197.
15. Fuller CM, Awayda MS, Arrate MP, Bradford NL, Morris RG, Canessa CM, Rossier BC, Be-nos DJ: Cloning of a bovine renal epithelial Na channel subunit, Am J Physiol 1995:269:C641-C654.
16. Lingueglia E, Voillcy N, Waldmann R, Lazdunski M, Barbry P: Expression cloning of an epithelial amiloride-sensitive Na channel, FEBSLett 1993:318:95-99.
17. McDonald FJ, Snyder PM, McCray PB Jr, Welsh MJ: Cloning, expression, and tissue distribution of a human amiloride-sensitive Na' channel, Am J Physiol 1994;266:L728-L734.
18. McDonald FJ, Price MP, Snyder PM, Welsh MJ: Cloning and expression of the 3- and y-subunits of the human epithelial sodium channe, J Am J Physiol 1995:268:CI I57-C1163.
19. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JRJ, Ulick S, Bilora RV, Findling JW, Canessa CM, Rossier BC, Lifton RP: Liddle’s syndrome: Heritable human hypertension caused by mutations in the 3 subunit of the epithelial sodium channel, Cell 1994;79:407-414.
20. Schild L, Cancssa CM, Shimkets RA, Warnock DG, Lifton RP, Rossier BC: A mutation in the epithelial sodium channel causing Liddle’s disease increases channel activity in the Xenopus laevis oocyte expression system, Proc Natl Acad Sci USA 1995:95:5699-5703.
21. Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, Cancssa CM, Iwa-saki T, Rossier BC, Lifton RP: Hypertension caused by a truncated epithelial sodium channel y subunit: Genetic heterogeneity of Liddle syndrome, Nat Genet 1995:11:76-82.
22. Rotin D, Bar-Sagi D, O’Brodovich H, Herilai-nen J, Leltto VP, Canessa CM, Rossier BC, Downey GP: An SH3 binding region in the epithelial Na channel (urENaC) mediates its localization at the apical membrane, EMBO .1 1994;13:4440-4450.
23. McDonald FJ, Welsh MJ: Binding of the pro-line-rich region of the epithelial Na channel to SH3 domains and its association with specific cellular proteins, Biochem .1 1995:312:491-497.
24. Tamura H, Schild L, Enomoto N, Matsui N, Ma-rumo F, Rossier BC, Sasaki S: Liddle disease caused by a missense mutation of 3 subunit of the epithelial sodium channel gene, J Clin Invest 1996;97:1780-1784.
25. Snyder PM, Price MP, McDonald FJ, Adams CM, Volk KA, Zciher BG, Stokes JB, Welsh MJ: Mechanism by which Liddle’s syndrome mutations increase activity of a human epithelial Na channel, Cell 1995;83:969-978.
26. Schild L, Lu Y, Gautschi I, Schnceberger E, Lifton RP, Bossier BC: Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome, EMBO J, in press.
27. Chen HI, Sudol M: The WW domain of Ycs-as-sociation protein binds a novel proline-rich ligand that differs from the consensus established for SI 13-binding modules, Proc Natl Acas Sci USA 1995:92:7819-7823.
28. Kumar S, Tomooka Y, Noda M: Cloning of a cDNA which encodes a novel ubiquitin-like protein, Biochem Biophvs Res Commun 1992: 185:1155-1161.
29. Staub O, Dho S, Henry P, Correa J, Ishikawa T, McGledc J, Rotin D: WW domains of NEDD4 bind to the proline rich regions in the epithelial Na channel deleted in Liddle’s syndrome, EMBO J, in press.
30. Chang SS, Gründcr S, Hanukoglu A, Rosier A, Mathew PM, I lanukoglu I, Schild L, Shimkets RA, Nelson-Williams C, Rossier BC, Lifton RP: Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperka-laemic acidosis, pseudohypoaldosteronism type I, Nat Genet 1996:12:248-253.
31. Cheek DB, Perry JW: A salt wasting syndrome in infancy, Arch Dis Child 1957:33:252-256.
32. Dillon MJ: Pseudohypoaldosteronism, Arch Dis Child 1980:55:427-434.
33. Kim IIS, Krege JH, Kluckman KD, Hagaman JR, llodgin JB, Best CF, Jennettc JC, Coffman TM, Maeda N, Smithies O: Genetic control of blood pressure and the angiotensinogen locus, Proc Natl Acad Sci USA 1995;92:2735-2739.
34. Ho M., Oliverio ML, Mannon PJ, Besl CF, Macda N, Smithies O, Coffman TM: Regulation of blood pressure by the type IA angiotensin II re-eeptor gene, Proc Natl Acad Sei USA 1995;92: 3521-3525.
35. Krcge JH, John SWM, Langenbach LL, Hodgin HB, Hagaman JR, Bachman ES, Jennctte JC, O'Brien DA, Smithies O: Male-female differences in fertility and blood pressure in AC'E-de-ficient mice, Nature 1995:375:146-148.
36. Carpenter C, Honkanen AA, Mashimo H, Gross KA, Huang P, Fishman MC: Renal abnormalities in mutant mice, Nature 1996:380:292.
37. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC: Hypertension in mice lacking the gene for endothelial nitric oxide synthase, Nature 1995:377: 239-242.
38. Huang Z, Huang PL, Panahian N, Dalkara T, Fishman MC, Moskowitz MA: Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase, Science 1994:265:1883-1885.
39. Mullins JJ, Peters J, Ganten D: Fulminant hypertension in transgenic rats harboring the mouse Rcn-2 gene, Nature 1990:344:541-544.
40. Stcinhelper ME, Cochrane KL, Field LJ: Hypotension in transgenic mice expressing atrial natriuretic factor fusion genes, Hypertension 1990:16:301-307.
41. Kuro-o M, Hanaoka K, Hiroi Y, Noguchi T, Fujimori Y, Takewaki S, Hayasaka M, Katoh II, Miyagishi A, Nagai R, Yazaki Y, Nabcshima Y: Salt-sensitive hypertension in transgenic mice overexpressing Na -proton exchanger, Cire Res 1995;76:148-153.
42. Hummler E, Barker P, Gatzy J, Becrmann F, Verdumo C, Schmidt A, Boucher R, Rossicr BC: Early death due to defective neonatal lung liquid clearance in «ENaC-deficient mice, Nat Genet 1996;12:325-328.
43. O'Brodovich H, Canessa CM, Ucda .1, Rafii B, Rossicr BC, Edclson J: Expression of the epithelial Na channel in the developing rat lung, Am J Physiol 1993;265:C491-C496.
44. Tehepichev S, Ucda J, Canessa C, Rossicr BC, O’Brodovich H: Lung epithelial Na channel subunits arc differentially regulated during development and by steroids, Am J Physiol 1995: 269:C805-C812.
45. Boucher RC, Cotton CU, Gatzy JT, Knowles MR, Yankaskas JR: Evidence for reduced CL and increased Na permeability in cystic fibrosis human primary cell cultures, Am J Physiol 1988:405:77-103.
46. Willumsen NJ, Boucher RC : Transcellular sodium transport in cultured cystic fibrosis human nasal epithelium, Am J Physiol 1991:261: C332-C341.
47. Jiang C, Finkbcincr WE, Widdicombe JH, McCray PB, Miller SS: Altered fluid transport across airway epithelium in cystic fibrosis, Science 1993;262:424-427.
48. Roudier-Pujol C, Rochat A, Escoubet B, Eugene E, Barrandon Y, Bonvalet JP, Farman N: Differential expression of epithelial sodium channel subunit mRNAs in rat skin, J Cell Sci 1996;109:379-385.
49. Kencuch S, Lombes M, Delahaye F, Eugène E, Bonvalet JP, Farman N: Human skin as target for aldosterone: Coexpression of mineralocorti-coid receptors and 11 -phydroxysteroid dehydrogenase, J Clin Endocrinol Metab 1994:79: 1334-1341.