Tolerance mechanisms in the late phase of the antibody response

Advances in Experimental Medicine and Biology

Volumn 596, Issue , 2007, Pages 163-168

  Goodnow, Christopher C ^a   Campbell, James A ^a   Rui, Lixin ^a   Vinuesa, Carola G ^a  

^a Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY RESPONSE; CELL DIFFERENTIATION; CONFERENCE PAPER; GERMINAL CENTER; IMMUNOLOGICAL TOLERANCE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL;

EID: 84934436940     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/0-387-46530-8_15     Document Type: Conference Paper

References (27)

1. Liston, A., S. Lesage, J. Wilson, L. Peltonen, and C.C. Goodnow. 2003. Aire regulates negative selection of organ-specific T cells. Nat Immunol 4:350-354.
2. Liston, A., D.H. Gray, S. Lesage, A.L. Fletcher, J. Wilson, K.E. Webster, H.S. Scott, R.L. Boyd, L. Peltonen, and C.C. Goodnow. 2004. Gene dosage-limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J Exp Med 200:1015-1026.
3. Khattri, R., T. Cox, S.A. Yasayko, and F. Ramsdell. 2003. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 4:337-342.
4. Fontenot, J.D., M.A. Gavin, and A.Y. Rudensky. 2003. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 4:330-336.
5. Schwartz, R.H. 2003. T Cell Anergy. Annu Rev Immunol 21:305-334.
6. Goodnow, C.C., J. Sprent, B.F. de St Groth, and C.G. Vinuesa. 2005. Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 435:590-597.
7. Rieux-Laucat, F., F. Le Deist, C. Hivroz, A. Roberts, K. Debatin, A. Fischer, and J. de Villartay. 1995. Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity. Science 268:1347-1349.
8. Lenardo, M., K.M. Chan, F. Hornung, H. McFarland, R. Siegel, J. Wang, and L. Zheng. 1999. Mature T lymphocyte apoptosis - immune regulation in a dynamic and unpredictable antigenic environment. Annu Rev Immunol 17:221-253.
9. MacLennan, I.C. 1994. Germinal centers. Annu Rev Immunol 12:117-139.
10. Radic, M.Z., and M. Weigert. 1994. Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu. Rev. Immunol. 12:487-520.
11. Cappione, A.J., A.E. Pugh-Bernard, J.H. Anolik, and I. Sanz. 2004. Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes. J Immunol 172:4298-4307.
12. Pugh-Bernard, A.E., G.J. Silverman, A.J. Cappione, M.E. Villano, D.H. Ryan, R.A. Insel, and I. Sanz. 2001. Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J Clin Invest 108:1061-1070.
13. Cappione, A., J.H. Anolik, A. Pugh-Bernard, J. Barnard, P. Dutcher, G. Silverman, and I. Sanz. 2005. Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus. J Clin Invest 115:3205-3216.
14. Shokat, K.M., and C.C. Goodnow. 1995. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature 375:334-338.
15. Pulendran, B., G. Kannourakis, S. Nouri, K.G. Smith, and G.J. Nossal. 1995. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. Nature 375:331-334.
16. Vinuesa, C.G., M.C. Cook, C. Angelucci, V. Athanasopoulos, L. Rui, K.M. Hill, D. Yu, H. Domashenz, B. Whittle, T. Lambe, I.S. Roberts, R.R. Copley, J.I. Bell, R.J. Cornall, and C.C. Goodnow. 2005. A novel RING-type ubiquitin ligase family member essential to repress follicular helper T cells and autoimmunity. Nature 435:452-458.
17. Nelms, K.A., and C.C. Goodnow. 2001. Genome-wide ENU mutagenesis to reveal immune regulators. Immunity 15:409-418.
18. Vinuesa, C.G., and C.C. Goodnow. 2004. Illuminating autoimmune regulators through controlled variation of the mouse genome sequence. Immunity 20:669-679.
19. Hutloff, A., A.M. Dittrich, K.C. Beier, B. Eljaschewitsch, R. Kraft, I. Anagnostopoulos, and R.A. Kroczek. 1999. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397:263-266.
20. Grimbacher, B., A. Hutloff, M. Schlesier, E. Glocker, K. Warnatz, R. Drager, H. Eibel, B. Fischer, A.A. Schaffer, H.W. Mages, R.A. Kroczek, and H.H. Peter. 2003. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol 4:261-268.
21. McAdam, A.J., R.J. Greenwald, M.A. Levin, T. Chernova, N. Malenkovich, V. Ling, G.J. Freeman, and A.H. Sharpe. 2001. ICOS is critical for CD40-mediated antibody class switching. Nature 409:102-105.
22. Scott, B.G., H. Yang, E. Tuzun, C. Dong, R.A. Flavell, and P. Christadoss. 2004. ICOS is essential for the development of experimental autoimmune myasthenia gravis. J Neuroimmunol 153:16-25.
23. Tafuri, A., A. Shahinian, F. Bladt, S.K. Yoshinaga, M. Jordana, A. Wakeham, L.M. Boucher, D. Bouchard, V.S. Chan, G. Duncan, B. Odermatt, A. Ho, A. Itie, T. Horan, J.S. Whoriskey, T. Pawson, J.M. Penninger, P.S. Ohashi, and T.W. Mak. 2001. ICOS is essential for effective T-helper-cell responses. Nature 409:105-109.
24. Dong, C., A.E. Juedes, U.A. Temann, S. Shresta, J.P. Allison, N.H. Ruddle, and R.A. Flavell. 2001. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409:97-101.
25. Calame, K.L., K.I. Lin, and C. Tunyaplin. 2003. Regulatory mechanisms that determine the development and function of plasma cells. Annu Rev Immunol 21:205-230.
26. Rui, L., C.G. Vinuesa, J. Blasioli, and C.C. Goodnow. 2003. Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nat Immunol 4:594-600.
27. Healy, J.I., R.E. Dolmetsch, L.A. Timmerman, J.G. Cyster, M.L. Thomas, G.R. Crabtree, R.S. Lewis, and C.C. Goodnow. 1997. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity 6:419-428.