The practical use of cre and loxP technologies in mouse auditory research

Methods in Molecular Biology

Volumn 493, Issue , 2009, Pages 87-102

  Yu, Yiling ^a,b   Zuo, Jian ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b FUDAN UNIVERSITY   (China)

Author keywords

Auditory; Bacterial artificial chromosome; Cre; Hair cell; Knockout mice; loxP; Transgenic mice

Indexed keywords

BACTERIA (MICROORGANISMS); MUS; MUS MUSCULUS;

EID: 84934436874     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-59745-523-7_6     Document Type: Review

References (40)

1. Gao, J., Wu, X. and Zuo, J. (2004) Targeting hearing genes in mice. Brain Res. Mol. Brain Res. 132, 192-207.
2. Holt, J. R., Gillespie, S. K., Provance, D. W., Shah, K., Shokat, K. M., Corey, D. P., Mercer, J. A., and Gillespie, P. G. (2002) Achemical genetic strategy implicates myosin-1c in adaptation by hair cells. Cell 108, 371-381.
3. Stauffer, E. A., Scarborough, J. D., Hirono, M., Miller, E. D., Shah, K., Mercer, J. A., Holt, J. R., and Gillespie, P. G. (2005) Fast adaptation in vestibular hair cells requires myosin-1c activity. Neuron 47, 541-553.
4. Zambrowicz, B. P., Abuin, A., Ramirez-Solis, R., Richter, L. J., Piggott, J., BeltrandelRio, H., et al. (2003) Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc. Natl. Acad. Sci. USA 100, 14109-14114.
5. Coates, C. J., Kaminski, J. M., Summers, J. B., Segal, D. J., Miller, A. D., and Kolb, A. F. (2005) Site-directed genome modification: derivatives of DNA-modifying enzymes as targeting tools. Trends Biotechnol. 23, 407-419.
6. Tian, Y., James, S., Zuo, J., Fritzsch, B., and Beisel, K. W. (2006) Conditional and inducible gene recombineering in the mouse inner ear. Brain Res 1091, 243-254.
7. Nagy, A. (2000) Cre recombinase: the universal reagent for genome tailoring. Genesis 26, 99-109.
8. Zuo, J. (2002) Transgenic and gene targeting studies of hair cell function in mouse inner ear. J. Neurobiol. 53, 286-305.
9. Kuhn, R., Schwenk, F., Aguet, M., and Rajewsky, K. (1995) Inducible gene targeting in mice. Science 269, 1427-1429.
10. No, D., Yao, T. P., and Evans, R. M. (1996) Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl. Acad. Sci. USA 93, 3346-3351.
11. Shimizu, E., Tang, Y. P., Rampon, C., and Tsien, J. Z. (2000) NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation [In Process Citation]. Science 290, 1170-1174.
12. Utomo, A. R., Nikitin, A. Y., and Lee, W. H. (1999) Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice. Nat. Biotechnol. 17, 1091-1096.
13. Bond, C. T., Herson, P. S., Strassmaier, T., Hammond, R., Stackman, R., Maylie, J., and Adelman, J. P. (2004) Small conductance Ca2+-activated K+channel knock-out mice reveal the identity of calcium-dependent after-hyperpolarization currents. J. Neurosci. 24, 5301-5306.
14. Hammond, R. S., Bond, C. T., Strassmaier, T., Ngo-Anh, T. J., Adelman, J. P., Maylie, J., and Stackman, R. W. (2006) Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity. J. Neurosci. 26, 1844-1853.
15. Brocard, J., Warot, X., Wendling, O., Messaddeq, N., Vonesch, J. L., Chambon, P., and Metzger, D. (1997) Spatio-temporally controlled site-specific somatic mutagenesis in the mouse. Proc. Natl. Acad. Sci. USA 94, 14559-14563.
16. Danielian, P. S., Muccino, D., Rowitch, D. H., Michael, S. K., and McMahon, A. P. (1998) Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr. Biol. 8, 1323-1326.
17. Indra, A. K., Warot, X., Brocard, J., Bornert, J. M., Xiao, J. H., Chambon, P., and Metzger, D. (1999) Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res. 27, 4324-4327.
18. Li, M., Indra, A. K., Warot, X., Brocard, J., Messaddeq, N., Kato, S., Metzger, D., and Chambon, P. (2000) Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis. Nature 407, 633-636.
19. Auwerx, J., Avner, P., Baldock, R., Ballabio, A., Balling, R., Barbacid, M., et al. (2004) The European dimension for the mouse genome mutagenesis program. Nat. Genet. 36, 925-927.
20. Gong, S., Doughty, M., Harbaugh, C. R., Cummins, A., Hatten, M. E., Heintz, N., and Gerfen, C. R. (2007) Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs. J. Neurosci. 27, 9817-9823.
21. Hebert, J. M. and McConnell, S. K. (2000) Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev. Biol. 222, 296-306.
22. Matei, V., Pauley, S., Kaing, S., Rowitch, D., Beisel, K. W., Morris, K., Feng, F., Jones, K., Lee, J., and Fritzsch, B. (2005) Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit. Dev. Dyn. 234, 633-650.
23. Ohyama, T. and Groves, A. K. (2004) Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome. Genesis 38, 195-199.
24. Sage, C., Huang, M., Karimi, K., Gutierrez, G., Vollrath, M. A., Zhang, D. S., Garcia-Anoveros, J., Hinds, P. W., Corwin, J. T., Corey, D. P., and Chen, Z. Y. (2005) Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science 307, 1114-1118.
25. Sage, C., Huang, M., Vollrath, M. A., Brown, M. C., Hinds, P. W., Corey, D. P., Vetter, D. E., and Chen, Z. Y. (2006) Essential role of retinoblastoma protein in mammalian hair cell development and hearing. Proc. Natl. Acad. Sci. USA 103, 7345-7350.
26. Li, M., Tian, Y., Fritzsch, B., Gao, J., Wu, X., and Zuo, J. (2004) Inner hair cell Cre-expressing transgenic mouse. Genesis 39, 173-177.
27. Tian, Y., Li, M., Fritzsch, B., and Zuo, J. (2004) Creation of a transgenic mouse for hair-cell gene targeting by using a modified bacterial artificial chromosome containing Prestin. Dev. Dyn. 231, 199-203.
28. Chow, L. M., Tian, Y., Weber, T., Corbett, M., Zuo, J., and Baker, S. J. (2006) Inducible Cre recombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells. Dev. Dyn. 235, 2991-2998.
29. Editorial (2007) Toxic alert. Nature 449, 378.
30. Soriano, P. (1999) Generalized lacZ expression with the ROSA26 Cre reporter strain [letter]. Nat. Genet. 21, 70-71.
31. Novak, A., Guo, C., Yang, W., Nagy, A., and Lobe, C. G. (2000) Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis 28, 147-155.
32. Goodrich, L. V. (2007) A genetic dissection of auditory circuit assembly and function. ARO MidWinter Meeting, 241.
33. Johnson, K. R. and Zheng, Q. Y. (2002) Ahl2, a second locus affecting age-related hearing loss in mice. Genomics 80, 461-464.
34. Ohlemiller, K. K. (2004) Age-related hearing loss: the status of Schuknecht's typology. Curr. Opin. Otolaryngol. Head Neck Surg. 12, 439-443.
35. Kujawa, S. G. and Liberman, M. C. (2006) Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth. J. Neurosci. 26, 2115-2123.
36. Huynh, K., Edge, R., Gao, J., Zuo, J., Dallos, P., and Cheatham, M. A. (2006) Anatomy and physiology of prestin knockout mice back-crossed to the CBA/CaJ strain. ARO Midwinter Meeting, Abstr. 379.
37. Kiermayer, C., Conrad, M., Schneider, M., Schmidt, J., and Brielmeier, M. (2007) Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate. Genesis 45, 11-16.
38. Hong, S. B., Furihata, M., Baba, M., Zbar, B., and Schmidt, L. S. (2006) Vascular defects and liver damage by the acute inactivation of the VHL gene during mouse embryogenesis. Lab Invest. 86, 664-675.
39. Lantinga-van Leeuwen, I. S., Leonhard, W. N., van de Wal, A., Breuning, M. H., Verbeek, S., de Heer, E., and Peters, D. J. (2006) Transgenic mice expressing tamoxifen-inducible Cre for somatic gene modification in renal epithelial cells. Genesis 44, 225-232.
40. Guo, C., Yang, W., and Lobe, C. G. (2002) A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action. Genesis 32, 8-18.