Observational study of fibrinogen concentrate in massive hemorrhage: Evaluation of a multicenter register

Blood Coagulation and Fibrinolysis

Volumn 22, Issue 8, 2011, Pages 727-734

  Weiss, Georg ^a   Lison, Susanne ^a   Glaser, Martin ^b   Herberger, Susanne ^c   Johanning, Kai ^d   Strasser, Theresia ^e   Huber, Thomas ^f   Spannagl, Michael ^a   Heindl, Bernhard ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Traunstein Hospital   (Germany)

^c Ingolstadt Hospital   (Germany)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e Hospital Landshut   (Germany)

^f Rosenheim Hospital   (Germany)

Author keywords

Acquired hypofibrinogenemia; Fibrinogen concentrate; Massive hemorrhage; Thromboembolic complications

Indexed keywords

BLOOD CLOTTING FACTOR 13 CONCENTRATE; DESMOPRESSIN; FIBRINOGEN; FRESH FROZEN PLASMA; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBOCYTE CONCENTRATE; TRANEXAMIC ACID;

ACUTE DISEASE; ADULT; AGED; ARTICLE; BLEEDING; CLINICAL TRIAL; CONTROLLED STUDY; ERYTHROCYTE CONCENTRATE; FEMALE; FIBRINOGEN BLOOD LEVEL; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBSERVATIONAL STUDY; PERIOPERATIVE COMPLICATION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; SURVIVAL; THROMBOEMBOLISM;

ADULT; AFIBRINOGENEMIA; AGED; BLOOD COAGULATION; BLOOD COAGULATION DISORDERS; FEMALE; FIBRINOGEN; GERMANY; HEMORRHAGE; HEMOSTASIS, SURGICAL; HUMANS; INTRAOPERATIVE COMPLICATIONS; LOGISTIC MODELS; MALE; MIDDLE AGED; PLASMA; PROSPECTIVE STUDIES; THROMBELASTOGRAPHY;

EID: 84855195876     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0b013e32834cb343     Document Type: Article

References (33)

1. Hiippala ST, Myllala GJ, Vahtera EM. Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg 1995; 81:360-365.
2. Spahn DR, Roissant R. Coagulopathy and blood component transfusion in trauma. Br J Anaesth 2005; 95:130-139. (Pubitemid 41487135)
3. Hardy JF, deMoerloose P, Samama CM. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anesth 2004; 51:293-310.
4. Johansson PI,Ostrowski SR, Secher NH.Management of major blood loss: an update. Acta Anaesthesiol Scand 2010; 54:1039-1049.
5. German Medical Association (GMA). Cross sectional guidelines for therapy with blood components and plasma derivates: 4th revised edition. Executive Committee of the German Medical Association on the recommendation of the Scientific Advisory Board 2008. http://wwwbaek.de/downloads/ Querschnittsleitlinie-Gesamtdokumentenglisch-07032011.
6. Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, et al. Management of bleeding following major trauma: an updated European guideline. Crit Care 2010; 14:R52.
7. Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology. Br J Haematol 2009; 145:24-33.
8. American Society of Anesthesiologists (ASA). Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Anesthesiology 2006; 105:198-208.
9. Australasian Society of Blood Transfusion (ASBT). Clinical practice guidelines for the use of blood components: red blood cells, fresh frozen plasma, cryoprecipitate: the Australasian Society of Blood Transfusion. Australasian Society of Blood Transfusion 2001. http//:wwwnhmrc.gov.au/-files- nhmrc/file/publications/synopses/cp78.
10. Duguid J, O'Shaughnessy DF, Atterbury C, Bolton-Mags P, Murphy M, Thomas D, et al. Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant. British Committee for Standards in Haematology, Blood transfusion Task Force. Br J Haematol 2004; 126:11-28.
11. Dané s AF, Cuenca LG, Bueno SR, Mendarte Barrenechea L, Ronsano JB. Efficacy and tolerability of human fibrinogen concentrate administration to patients with acquired fibrinogen deficiency and active or in high-risk severe bleeding. Vox Sang 2008; 94:221-226. (Pubitemid 351379659)
12. Karlsson M, Ternström L, Hyllner M, Baghaei F, Flinck A, Skrtic S, et al. Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery: a prospective, randomized pilot study. Thromb Haemost 2009; 102:137-144.
13. Fenger-Eriksen C, Lindberg-Larsen M, Christensen AQ, Ingerslev J, Soørensen B. Fibrinogen concentrate substitution therapy in patients with massive haemorrhage and low plasma fibrinogen concentrations. Br J Anaesth 2008; 101:769-773.
14. Rahe-Meyer N, Pichlmaier M, Haverich A, Solomon C, Wintherhalter M, Piepenbrock S, et al. Bleeding management with fibrinogen concentrate targeting a high-normal plasma fibrinogen level: a pilot study. Br J Anaesth 2009; 102:785-792.
15. Mittermayr M, Streif W, Haas T, Fries D, Velik-Salchner C, Klingler A, et al. Hemostatic changes after crystalloid or colloid fluid administration during major orthopaedic surgery: the role of fibrinogen administration. Anesth Analg 2007; 105:905-917. (Pubitemid 47479300)
16. Fenger-Eriksen C, Jensen T, Kristensen B, Jensen K, Toønnesen T, Ingerslev J, et al. Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial. J Thromb Haemost 2009; 7:795-802.
17. Weinkove R, Rangarajan S. Fibrinogen concentrate for acquired hypofibrinogenaemic states. Transfus Med 2008; 18:151-157. (Pubitemid 351847329)
18. Bell SF, Rayment R, Collins PW, Collis RE. The use of fibrinogen concentrate to correct hypofibrinogenaemia rapidly during obstetric haemorrhage. Int J Obstet Anesth 2010; 19:218-223.
19. Solomon C, Pichlmaier U, Schoechl H, Hagl C, Raymondos K, Scheinichen D, et al. Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery. Br J Anaesth 2010; 104:555-562.
20. Fries D, Krismer A, Klingler A, Streif W, Klima G, Wenzel V, et al. Effect of fibrinogen on reversal of dilutional coagulopathy: a porcine model. Br J Anaesth 2005; 95:172-177. (Pubitemid 41487140)
21. De Lorenzo C, Calatzis A, Welsch U, Heindl B. Fibrinogen concentrate reverses dilutional coagulopathy induced in vitro by saline but no by hydroxyethyl starch 6%. Anesth Analg 2006; 102:1194-2000.
22. Fenger-Eriksen C, Anker-Moller E, Heslop J, Ingerslev J, Soørensen B. Thrombelastographic whole blood conformation after ex vivo addition of plasma substitutes: improvement of the induced coagulopathy with fibrinogen concentrate. Br J Anaesth 2005; 94:324-329. (Pubitemid 40352852)
23. Bolliger D, Szlam F, Molinaro RJ, Rahe-Meyer N, Levy JH, Tanaka KA. Finding the optimal concentration range for fibrinogen replacement after severe haemodilution: an in vitro model. Br J Anaesth 2009; 102:793-799.
24. Thorarinsdottir HR, Sigurbjornsson FT, Hreinsson K, Onundarson PT, Gudbjartsson T, Sigurdsson GH. Effects of fibrinogen concentrate administration during severe henorhage. Acta Anaesthesiol Scand 2010; 54:1077-1082.
25. Manco-Johnson MJ, DiMichele D, Castaman D, Freeman S, Knaub S, Kalina F, et al. Pharmacokinetics and safety of fibrinogen concentrate. J Thromb Haemost 2009; 7:2064-2069.
26. Dickneite G, Pragst I, Joch C, Bergmann GE. Animal model and clinical evidence indicating low thrombogenic potential of fibrinogen concentrate (haemocomplettan p). Blood Coagul Fibrinolysis 2009; 20:535-540.
27. Spahn DR, Cerny V, Coats TJ, Duranteau J, Fernández-Mondé jar E, Gordini G, et al. Management of bleeding following major trauma: a European guideline. Crit Care 2007; 11:R17.
28. Doyle S, O'Brien P, Murphy K, Flemming C, O'Donnell J. Coagulation factor content of solvent/detergent plasma compared with fresh frozen plasma. Blood Coagul Fibrinolysis 2003; 14:283-287. (Pubitemid 36589151)
29. Annecke T, Geisenberger T, Kürzl R, Penning R, Heindl B. Algorithm-based coagulation management of catastrophic amniotic fluid embolism. Blood Coagul Fibrinolysis 2010; 21:95-100.
30. Brenni M, Worn M, Bruesch M, Spahn D, Gantner M. Successful rotational thromboelastometry-guided treatment of traumatic haemorrhage, hyperfibrinolysis and coagulopathy. Acta Anaesthesiol Scand 2010; 54:111-117.
31. White R, Romano P, Hong Zhou M, Rodrigo J, Bargar W. Incidence and time course of thromboembolic outcomes following total hip or knee arthroplasty. Arch Intern Med 1998; 158:1525-1531. (Pubitemid 28340985)
32. Devereaux P, Goldman L,Cook D, Gilbert K, Leslie K,Guyatt G. Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk. CMAJ 2005; 173:627-634. (Pubitemid 41345578)
33. Adam S, Karger R, Kretschmer V. Photo-optical methods can lead to clinically relevant overestimation of fibrinogen concentration in plasma diluted with hydroxyethyl starch. Clin Appl Thromb Hemost 2010; 16:461-471.