Generation of Distal Airway Epithelium from Multipotent Human Foregut Stem Cells

Stem Cells and Development

Volumn 24, Issue 14, 2015, Pages 1680-1690

  Hannan, Nicholas R F ^a   Sampaziotis, Fotios ^a   Segeritz, Charis Patricia ^a   Hanley, Neil A ^b   Vallier, Ludovic ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP2; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR NKX2.1; UNCLASSIFIED DRUG; CFTR PROTEIN, HUMAN; FGF10 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR 10; FORKHEAD TRANSCRIPTION FACTOR; FOXP2 PROTEIN, HUMAN; GATA6 PROTEIN, HUMAN; NUCLEAR PROTEIN; SFTPC PROTEIN, HUMAN; SURFACTANT PROTEIN C; THYROID NUCLEAR FACTOR 1;

ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG SCREENING; ENDODERM; FOREGUT; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS CELL; MULTIPOTENT STEM CELL; PANCREAS CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; BIOLOGICAL THERAPY; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; EPITHELIUM; GROWTH, DEVELOPMENT AND AGING; INDUCED PLURIPOTENT STEM CELL; LUNG; METABOLISM; PATHOLOGY; PROCEDURES; RESPIRATORY MUCOSA; SECRETION (PROCESS);

CELL DIFFERENTIATION; CELL LINE; CELL- AND TISSUE-BASED THERAPY; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ENDODERM; EPITHELIUM; FIBROBLAST GROWTH FACTOR 10; FORKHEAD TRANSCRIPTION FACTORS; GATA6 TRANSCRIPTION FACTOR; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LUNG; NUCLEAR PROTEINS; PULMONARY SURFACTANT-ASSOCIATED PROTEIN C; RESPIRATORY MUCOSA; TRANSCRIPTION FACTORS;

EID: 84934342533     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2014.0512     Document Type: Article

References (28)

1. Knight DA and ST Holgate. (2003). The airway epithelium: structural and functional properties in health and disease. Respirology 8:432-446.
2. Forrest IA, DM Murphy, C Ward, D Jones, GE Johnson, L Archer, FK Gould, TE Cawston, JL Lordan and PA Corris. (2005). Primary airway epithelial cell culture from lung transplant recipients. Eur Respir J 26:1080-1085.
3. Huang SX, MN Islam, J O'Neill, Z Hu, YG Yang, YW Chen, M Mumau, MD Green, G Vunjak-Novakovic, J Bhattacharya and HW Snoeck. (2014). Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol 32:84-91.
4. Wong AP, CE Bear, S Chin, P Pasceri, TO Thompson, LJ Huan, F Ratjen, J Ellis and J Rossant. (2012). Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat Biotechnol 30:876-882.
5. Wang D, DL Haviland, AR Burns, E Zsigmond and RA Wetsel. (2007). A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A 104:4449-4454.
6. Hannan NR, RP Fordham, YA Syed, V Moignard, A Berry, R Bautista, NA Hanley, KB Jensen and L Vallier. (2013). Generation of multipotent foregut stem cells from human pluripotent stem cells. Stem Cell Reports 1:293-306.
7. Lewis SL and PP Tam. (2006). Definitive endoderm of the mouse embryo: formation, cell fates, and morphogenetic function. Dev Dyn 235:2315-2329.
8. Maeda Y, V Dave and JA Whitsett. (2007). Transcriptional control of lung morphogenesis. Physiol Rev 87: 219-244.
9. Chen F, TJ Desai, J Qian, K Niederreither, J Lu and WV Cardoso. (2007). Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Development 134:2969-2979.
10. Fagman H and M Nilsson. (2011). Morphogenetics of early thyroid development. J Mol Endocrinol 46:R33-R42.
11. Rawlins EL. (2011). The building blocks of mammalian lung development. Dev Dyn 240:463-476.
12. Cardoso WV and J Lu. (2006). Regulation of early lung morphogenesis: questions, facts and controversies. Development 133:1611-1624.
13. Hannan NR, CP Segeritz, T Touboul and L Vallier. (2013). Production of hepatocyte-like cells from human pluripotent stem cells. Nat Protoc 8:430-437.
14. Peters K, S Werner, X Liao, S Wert, J Whitsett and L Williams. (1994). Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung. EMBO J 13: 3296-3301.
15. Min H, DM Danilenko, SA Scully, B Bolon, BD Ring, JE Tarpley, M DeRose and WS Simonet. (1998). Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev 12:3156-3161.
16. Wang Z, P Dolle, WV Cardoso and K Niederreither. (2006). Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives. Dev Biol 297:433-445.
17. Weaver M, NR Dunn and BL Hogan. (2000). Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. Development 127:2695-2704.
18. Rashid ST, S Corbineau, N Hannan, SJ Marciniak, E Miranda, G Alexander, I Huang-Doran, J Griffin, L Ahrlund-Richter, et al. (2010). Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest 120:3127-3136.
19. Yusa K, ST Rashid, H Strick-Marchand, I Varela, PQ Liu, DE Paschon, E Miranda, A Ordonez, NR Hannan, et al. (2011). Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells. Nature 478:391-394.
20. Goss CH and F Ratjen. (2013). Update in cystic fibrosis 2012. Am J Respir Crit Care Med 187:915-919.
21. Quon BS and ML Aitken. (2012). Cystic fibrosis: what to expect now in the early adult years. Paediatr Respir Rev 13:206-214.
22. Warwick WJ. (1978). The incidence of cystic fibrosis in Caucasian populations. Helv Paediatr Acta 33:117-125.
23. Davies JC, EW Alton and A Bush. (2007). Cystic fibrosis. BMJ 335:1255-1259.
24. Seki T, S Yuasa, M Oda, T Egashira, K Yae, D Kusumoto, H Nakata, S Tohyama, H Hashimoto, et al. (2010). Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells. Cell Stem Cell 7:11-14.
25. Liu X and DC Dawson. (2014). Cystic fibrosis transmembrane conductance regulator (CFTR) potentiators protect G551D but not DeltaF508 CFTR from thermal instability. Biochemistry 53:5613-5618.
26. Liu X, N O'Donnell, A Landstrom, WR Skach and DC Dawson. (2012). Thermal instability of DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: Protection by single suppressor mutations and inhibiting channel activity. Biochemistry 51:5113-5124.
27. Wang W, GO Okeyo, B Tao, JS Hong and KL Kirk. (2011). Thermally unstable gating of the most common cystic fibrosis mutant channel (DeltaF508): ''rescue'' by suppressor mutations in nucleotide binding domain 1 and by constitutive mutations in the cytosolic loops. J Biol Chem 286:41937-41948.
28. Rawlins EL. (2008). Lung epithelial progenitor cells: lessons from development. Proc Am Thorac Soc 5:675-681.