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Volumn 6, Issue 17, 2015, Pages 15283-15296

Selective killing of breast cancer cells expressing activated CD44 using CD44 ligand-coated nanoparticles in vitro and in vivo

Author keywords

Breast cancer; CD44; Hyaluronan; Selective targeting therapy

Indexed keywords

ANTINEOPLASTIC AGENT; CD44 PROTEIN, HUMAN; DRUG CARRIER; HERMES ANTIGEN; HYALURONIC ACID; NANOPARTICLE; PACLITAXEL;

EID: 84934300726     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3681     Document Type: Article
Times cited : (37)

References (38)
  • 1
    • 33947576553 scopus 로고    scopus 로고
    • Shaping the future of biomarker research in breast cancer to ensure clinical relevance
    • Hinestrosa MC, Dickersin K, Klein P, et al. Shaping the future of biomarker research in breast cancer to ensure clinical relevance. Nat Rev Cancer 2007; 7: 309-15.
    • (2007) Nat Rev Cancer , vol.7 , pp. 309-315
    • Hinestrosa, M.C.1    Dickersin, K.2    Klein, P.3
  • 3
    • 84859148851 scopus 로고    scopus 로고
    • CD44 Promotes Epithelial Mammary Gland Development and Exhibits Altered Localization during Cancer Progression
    • Louderbough JM, Brown JA, Nagle RB, Schroeder JA. CD44 Promotes Epithelial Mammary Gland Development and Exhibits Altered Localization during Cancer Progression. Genes Cancer. 2011;2:771-81.
    • (2011) Genes Cancer , vol.2 , pp. 771-781
    • Louderbough, J.M.1    Brown, J.A.2    Nagle, R.B.3    Schroeder, J.A.4
  • 4
    • 84864536555 scopus 로고    scopus 로고
    • Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts
    • Cufi S, Corominas-Faja B, Vazquez-Martin A, Oliveras-Ferraros C, Dorca J, Bosch-Barrera J, Martin-Castillo B, Menendez JA. Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts. Oncotarget. 2012;3:395-8.
    • (2012) Oncotarget , vol.3 , pp. 395-398
    • Cufi, S.1    Corominas-Faja, B.2    Vazquez-Martin, A.3    Oliveras-Ferraros, C.4    Dorca, J.5    Bosch-Barrera, J.6    Martin-Castillo, B.7    Menendez, J.A.8
  • 5
    • 34247890107 scopus 로고    scopus 로고
    • Pharmacokinetics, immunogenicity and safety of bivatuzumab mertansine, a novel CD44v6-targeting immunoconjugate, in patients with squamous cell carcinoma of the head and neck
    • Sauter A, Kloft C, Gronau S, et al. Pharmacokinetics, immunogenicity and safety of bivatuzumab mertansine, a novel CD44v6-targeting immunoconjugate, in patients with squamous cell carcinoma of the head and neck. Int J Oncol 2007; 30: 927-35.
    • (2007) Int J Oncol , vol.30 , pp. 927-935
    • Sauter, A.1    Kloft, C.2    Gronau, S.3
  • 6
    • 50049134725 scopus 로고    scopus 로고
    • Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma
    • Riechelmann H, Sauter A, Golze W, et al. Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma. Oral Oncol 2008; 44: 823-9.
    • (2008) Oral Oncol , vol.44 , pp. 823-829
    • Riechelmann, H.1    Sauter, A.2    Golze, W.3
  • 7
    • 33750685640 scopus 로고    scopus 로고
    • A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus
    • Tijink BM, Buter J, de Bree R, et al. A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus. Clin Cancer Res 2006; 12: 6064-72.
    • (2006) Clin Cancer Res , vol.12 , pp. 6064-6072
    • Tijink, B.M.1    Buter, J.2    de Bree, R.3
  • 8
    • 34247571007 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of bivatuzumab mertansine in patients with CD44v6-positive metastatic breast cancer: final results of a phase I study
    • Rupp U, Schoendorf-Holland E, EichbaumM, et al. Safety and pharmacokinetics of bivatuzumab mertansine in patients with CD44v6-positive metastatic breast cancer: final results of a phase I study. Anticancer Drugs 2007; 18: 477-85.
    • (2007) Anticancer Drugs , vol.18 , pp. 477-485
    • Rupp, U.1    Schoendorf-Holland, E.2    Eichbaum, M.3
  • 9
    • 84886743503 scopus 로고    scopus 로고
    • Lung cancer tumorigenicity and drug resistance are maintained through ALDH(hi)CD44(hi) tumor initiating cells
    • Liu J, Xiao Z, Wong SK, Tin VP, Ho KY, Wang J, Sham MH, Wong MP. Lung cancer tumorigenicity and drug resistance are maintained through ALDH(hi)CD44(hi) tumor initiating cells. Oncotarget. 2013;4:1698-1711.
    • (2013) Oncotarget , vol.4 , pp. 1698-1711
    • Liu, J.1    Xiao, Z.2    Wong, S.K.3    Tin, V.P.4    Ho, K.Y.5    Wang, J.6    Sham, M.H.7    Wong, M.P.8
  • 11
    • 34250869509 scopus 로고    scopus 로고
    • Hyaluronic acid-paclitaxel: antitumor efficacy against CD44(+) human ovarian carcinoma xenografts
    • Auzenne E, Ghosh SC, Khodadadian M, et al. Hyaluronic acid-paclitaxel: antitumor efficacy against CD44(+) human ovarian carcinoma xenografts. Neoplasia 2007; 9: 479-86.
    • (2007) Neoplasia , vol.9 , pp. 479-486
    • Auzenne, E.1    Ghosh, S.C.2    Khodadadian, M.3
  • 12
    • 0347285397 scopus 로고    scopus 로고
    • Loading mitomycin C inside long circulating hyaluronan targeted nano-liposomes increases its antitumor activity in three mice tumor models
    • Peer D, Margalit R. Loading mitomycin C inside long circulating hyaluronan targeted nano-liposomes increases its antitumor activity in three mice tumor models. Int J Cancer 2004; 108: 780-9.
    • (2004) Int J Cancer , vol.108 , pp. 780-789
    • Peer, D.1    Margalit, R.2
  • 13
    • 0032567715 scopus 로고    scopus 로고
    • Glycosylation provides both stimulatory and inhibitory effects on cell surface and soluble CD44 binding to hyaluronan
    • Skelton TP, Zeng C, Nocks A, Stamenkovic I. Glycosylation provides both stimulatory and inhibitory effects on cell surface and soluble CD44 binding to hyaluronan. J Cell Biol 1998; 140: 431-46.
    • (1998) J Cell Biol , vol.140 , pp. 431-446
    • Skelton, T.P.1    Zeng, C.2    Nocks, A.3    Stamenkovic, I.4
  • 14
    • 0032167434 scopus 로고    scopus 로고
    • Two different functions for CD44 proteins in human myelopoiesis
    • Moll J, Khaldoyanidi S, Sleeman JP, et al. Two different functions for CD44 proteins in human myelopoiesis. J Clin Invest 1998; 102: 1024-34.
    • (1998) J Clin Invest , vol.102 , pp. 1024-1034
    • Moll, J.1    Khaldoyanidi, S.2    Sleeman, J.P.3
  • 15
    • 77952635340 scopus 로고    scopus 로고
    • Two-state conformations in the hyaluronan-binding domain regulate CD44 adhesiveness under flow condition
    • Ogino S, Nishida N, Umemoto R, et al. Two-state conformations in the hyaluronan-binding domain regulate CD44 adhesiveness under flow condition. Structure 2010; 18: 649-56.
    • (2010) Structure , vol.18 , pp. 649-656
    • Ogino, S.1    Nishida, N.2    Umemoto, R.3
  • 16
    • 0037969876 scopus 로고    scopus 로고
    • Mononuclear leukocytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid:polycytidylic acid:interalpha-trypsin inhibitor is crucial to structure and function
    • de la Motte CA, Hascall VC, Drazba J, Bandyopadhyay SK, Strong SA. Mononuclear leukocytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid:polycytidylic acid:interalpha-trypsin inhibitor is crucial to structure and function. Am J Pathol 2003; 163: 121-33.
    • (2003) Am J Pathol , vol.163 , pp. 121-133
    • de la Motte, C.A.1    Hascall, V.C.2    Drazba, J.3    Bandyopadhyay, S.K.4    Strong, S.A.5
  • 17
    • 78149322286 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol-3-kinase pathway abrogates polyinosinic:polycytidylic acid-stimulated hyaluronan-mediated human mucosal smooth muscle cell binding of U937 monocytic cells
    • Bandyopadhyay SK, de la Motte CA, Majors AK, Strong SA. Inhibition of the phosphatidylinositol-3-kinase pathway abrogates polyinosinic:polycytidylic acid-stimulated hyaluronan-mediated human mucosal smooth muscle cell binding of U937 monocytic cells. J Interferon Cytokine Res 2010; 30: 809-16.
    • (2010) J Interferon Cytokine Res , vol.30 , pp. 809-816
    • Bandyopadhyay, S.K.1    de la Motte, C.A.2    Majors, A.K.3    Strong, S.A.4
  • 18
    • 0025338724 scopus 로고
    • Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition
    • Miyake K, Underhill CB, Lesley J, Kincade PW. Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J Exp Med 1990; 172: 69-75.
    • (1990) J Exp Med , vol.172 , pp. 69-75
    • Miyake, K.1    Underhill, C.B.2    Lesley, J.3    Kincade, P.W.4
  • 19
    • 0026537561 scopus 로고
    • Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody
    • Lesley J, He Q, Miyake K, Hamann A, Hyman R, Kincade PW. Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody. J Exp Med 1992; 175: 257-66.
    • (1992) J Exp Med , vol.175 , pp. 257-266
    • Lesley, J.1    He, Q.2    Miyake, K.3    Hamann, A.4    Hyman, R.5    Kincade, P.W.6
  • 20
    • 51749085805 scopus 로고    scopus 로고
    • Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway
    • Park G, Yoon BS, Moon JH, et al. Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway. J Invest Dermatol 2008; 128: 2429-41.
    • (2008) J Invest Dermatol , vol.128 , pp. 2429-2441
    • Park, G.1    Yoon, B.S.2    Moon, J.H.3
  • 21
    • 84879459539 scopus 로고    scopus 로고
    • The use of HA oligosaccharideloaded nanoparticles to breach the endogenous hyaluronan glycocalyx for breast cancer therapy
    • Yang C, Liu Y, He Y, et al. The use of HA oligosaccharideloaded nanoparticles to breach the endogenous hyaluronan glycocalyx for breast cancer therapy. Biomaterials 2013; 34: 6829-38.
    • (2013) Biomaterials , vol.34 , pp. 6829-6838
    • Yang, C.1    Liu, Y.2    He, Y.3
  • 22
    • 84871121656 scopus 로고    scopus 로고
    • The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering
    • Yang C, Cao M, Liu H, et al. The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering. J Biol Chem 2012; 287: 43094-107.
    • (2012) J Biol Chem , vol.287 , pp. 43094-43107
    • Yang, C.1    Cao, M.2    Liu, H.3
  • 23
    • 84865713442 scopus 로고    scopus 로고
    • Global quantitative phosphoproteome analysis of human tumor xenografts treated with a CD44 antagonist
    • Weigand S, Herting F, Maisel D, et al. Global quantitative phosphoproteome analysis of human tumor xenografts treated with a CD44 antagonist. Cancer Res 2012; 72: 4329-39.
    • (2012) Cancer Res , vol.72 , pp. 4329-4339
    • Weigand, S.1    Herting, F.2    Maisel, D.3
  • 24
    • 0026801075 scopus 로고
    • CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells
    • Lesley J, Hyman R. CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells. Eur J Immunol 1992; 22: 2719-23.
    • (1992) Eur J Immunol , vol.22 , pp. 2719-2723
    • Lesley, J.1    Hyman, R.2
  • 25
    • 84872323830 scopus 로고    scopus 로고
    • Characteristics of CD44 alternative splice pattern in the course of human colorectal adenocarcinoma progression
    • Bánky B, Rásó-Barnett L, Barbai T, Tímár J, Becságh P, Rásó E. Characteristics of CD44 alternative splice pattern in the course of human colorectal adenocarcinoma progression. Mol Cancer. 2012;11:83. doi: 10.1186/1476-4598-11-83.
    • (2012) Mol Cancer , vol.11 , pp. 83
    • Bánky, B.1    Rásó-Barnett, L.2    Barbai, T.3    Tímár, J.4    Becságh, P.5    Rásó, E.6
  • 27
    • 33847265880 scopus 로고    scopus 로고
    • Hyaluronan as carrier of carboranes for tumor targeting in boron neutron capture therapy
    • Meo CD, Panza L, Capitani D, et al. Hyaluronan as carrier of carboranes for tumor targeting in boron neutron capture therapy. Biomacromolecules 2007; 8: 552-9.
    • (2007) Biomacromolecules , vol.8 , pp. 552-559
    • Meo, C.D.1    Panza, L.2    Capitani, D.3
  • 28
    • 79955761548 scopus 로고    scopus 로고
    • Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers
    • Bachar G, Cohen K, Hod R, et al. Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers. Biomaterials 2011; 32: 4840-8.
    • (2011) Biomaterials , vol.32 , pp. 4840-4848
    • Bachar, G.1    Cohen, K.2    Hod, R.3
  • 30
    • 79959956046 scopus 로고    scopus 로고
    • The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(-) stem cell-like breast cancer cells in human tumors
    • Marotta LL, Almendro V, Marusyk A, et al. The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(-) stem cell-like breast cancer cells in human tumors. J Clin Invest 2011; 121: 2723-35.
    • (2011) J Clin Invest , vol.121 , pp. 2723-2735
    • Marotta, L.L.1    Almendro, V.2    Marusyk, A.3
  • 31
    • 10844290511 scopus 로고    scopus 로고
    • Phase I therapy study with (186)Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma
    • Borjesson PK, Postema EJ, Roos JC, et al. Phase I therapy study with (186)Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma. Clin Cancer Res 2003; 9: 3961S-72S.
    • (2003) Clin Cancer Res , vol.9 , pp. 3961S-3972S
    • Borjesson, P.K.1    Postema, E.J.2    Roos, J.C.3
  • 32
    • 0041854151 scopus 로고    scopus 로고
    • Safety, biodistribution, pharmacokinetics, and immunogenicity of 99mTc-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with squamous cell carcinoma of the head and neck
    • Colnot DR, Roos JC, de Bree R, et al. Safety, biodistribution, pharmacokinetics, and immunogenicity of 99mTc-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with squamous cell carcinoma of the head and neck. Cancer Immunol Immunother 2003; 52: 576-82.
    • (2003) Cancer Immunol Immunother , vol.52 , pp. 576-582
    • Colnot, D.R.1    Roos, J.C.2    de Bree, R.3
  • 33
    • 0035866799 scopus 로고    scopus 로고
    • Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells
    • Eliaz RE, Szoka FC, Jr. Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells. Cancer Res 2001; 61: 2592-601.
    • (2001) Cancer Res , vol.61 , pp. 2592-2601
    • Eliaz, R.E.1    Szoka, F.C.2
  • 34
    • 84883470829 scopus 로고    scopus 로고
    • Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblastphenotype via TWIST activation in the tumor microenvironment
    • Spaeth EL, Labaff AM, Toole BP, Klopp A, Andreeff M, Marini FC. Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblastphenotype via TWIST activation in the tumor microenvironment. Cancer Res 2013; 73: 5347-59.
    • (2013) Cancer Res , vol.73 , pp. 5347-5359
    • Spaeth, E.L.1    Labaff, A.M.2    Toole, B.P.3    Klopp, A.4    Andreeff, M.5    Marini, F.C.6
  • 35
    • 61349189010 scopus 로고    scopus 로고
    • CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance
    • Klingbeil P, Marhaba R, Jung T, Kirmse R, Ludwig T, Zöller M. CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance. Mol Cancer Res. 2009; 7:168-79.
    • (2009) Mol Cancer Res , vol.7 , pp. 168-179
    • Klingbeil, P.1    Marhaba, R.2    Jung, T.3    Kirmse, R.4    Ludwig, T.5    Zöller, M.6
  • 36
    • 0030271770 scopus 로고    scopus 로고
    • Prognostic value of immunohistochemically detected CD44 isoforms CD44v5, CD44v6 and CD44v7-8 in human breast cancer
    • Tempfer C, Lösch A, Heinzl H, Häusler G, Hanzal E, Kölbl H, Breitenecker G, Kainz C. Prognostic value of immunohistochemically detected CD44 isoforms CD44v5, CD44v6 and CD44v7-8 in human breast cancer. Eur J Cancer. 1996; 32A:2023-5.
    • (1996) Eur J Cancer , vol.32A , pp. 2023-2025
    • Tempfer, C.1    Lösch, A.2    Heinzl, H.3    Häusler, G.4    Hanzal, E.5    Kölbl, H.6    Breitenecker, G.7    Kainz, C.8
  • 37
    • 0029939903 scopus 로고    scopus 로고
    • Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation
    • Fan X, Long A, Goggins M, Fan X, Keeling PW, Kelleher D. Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation. Gut. 1996; 38:507-12.
    • (1996) Gut , vol.38 , pp. 507-512
    • Fan, X.1    Long, A.2    Goggins, M.3    Fan, X.4    Keeling, P.W.5    Kelleher, D.6
  • 38
    • 3142783426 scopus 로고    scopus 로고
    • Tumor-targeted hyaluronan nanoliposomes increase the antitumor activity of liposomal Doxorubicin in syngeneic and human xenograft mouse tumor models
    • Peer D, Margalit R. Tumor-targeted hyaluronan nanoliposomes increase the antitumor activity of liposomal Doxorubicin in syngeneic and human xenograft mouse tumor models. Neoplasia 2004; 6: 343-53.
    • (2004) Neoplasia , vol.6 , pp. 343-353
    • Peer, D.1    Margalit, R.2


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