-
1
-
-
33947576553
-
Shaping the future of biomarker research in breast cancer to ensure clinical relevance
-
Hinestrosa MC, Dickersin K, Klein P, et al. Shaping the future of biomarker research in breast cancer to ensure clinical relevance. Nat Rev Cancer 2007; 7: 309-15.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 309-315
-
-
Hinestrosa, M.C.1
Dickersin, K.2
Klein, P.3
-
2
-
-
33847638137
-
Estimates of the cancer incidence and mortality in Europe in 2006
-
Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007; 18: 581-92.
-
(2007)
Ann Oncol
, vol.18
, pp. 581-592
-
-
Ferlay, J.1
Autier, P.2
Boniol, M.3
Heanue, M.4
Colombet, M.5
Boyle, P.6
-
3
-
-
84859148851
-
CD44 Promotes Epithelial Mammary Gland Development and Exhibits Altered Localization during Cancer Progression
-
Louderbough JM, Brown JA, Nagle RB, Schroeder JA. CD44 Promotes Epithelial Mammary Gland Development and Exhibits Altered Localization during Cancer Progression. Genes Cancer. 2011;2:771-81.
-
(2011)
Genes Cancer
, vol.2
, pp. 771-781
-
-
Louderbough, J.M.1
Brown, J.A.2
Nagle, R.B.3
Schroeder, J.A.4
-
4
-
-
84864536555
-
Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts
-
Cufi S, Corominas-Faja B, Vazquez-Martin A, Oliveras-Ferraros C, Dorca J, Bosch-Barrera J, Martin-Castillo B, Menendez JA. Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts. Oncotarget. 2012;3:395-8.
-
(2012)
Oncotarget
, vol.3
, pp. 395-398
-
-
Cufi, S.1
Corominas-Faja, B.2
Vazquez-Martin, A.3
Oliveras-Ferraros, C.4
Dorca, J.5
Bosch-Barrera, J.6
Martin-Castillo, B.7
Menendez, J.A.8
-
5
-
-
34247890107
-
Pharmacokinetics, immunogenicity and safety of bivatuzumab mertansine, a novel CD44v6-targeting immunoconjugate, in patients with squamous cell carcinoma of the head and neck
-
Sauter A, Kloft C, Gronau S, et al. Pharmacokinetics, immunogenicity and safety of bivatuzumab mertansine, a novel CD44v6-targeting immunoconjugate, in patients with squamous cell carcinoma of the head and neck. Int J Oncol 2007; 30: 927-35.
-
(2007)
Int J Oncol
, vol.30
, pp. 927-935
-
-
Sauter, A.1
Kloft, C.2
Gronau, S.3
-
6
-
-
50049134725
-
Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma
-
Riechelmann H, Sauter A, Golze W, et al. Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma. Oral Oncol 2008; 44: 823-9.
-
(2008)
Oral Oncol
, vol.44
, pp. 823-829
-
-
Riechelmann, H.1
Sauter, A.2
Golze, W.3
-
7
-
-
33750685640
-
A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus
-
Tijink BM, Buter J, de Bree R, et al. A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus. Clin Cancer Res 2006; 12: 6064-72.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6064-6072
-
-
Tijink, B.M.1
Buter, J.2
de Bree, R.3
-
8
-
-
34247571007
-
Safety and pharmacokinetics of bivatuzumab mertansine in patients with CD44v6-positive metastatic breast cancer: final results of a phase I study
-
Rupp U, Schoendorf-Holland E, EichbaumM, et al. Safety and pharmacokinetics of bivatuzumab mertansine in patients with CD44v6-positive metastatic breast cancer: final results of a phase I study. Anticancer Drugs 2007; 18: 477-85.
-
(2007)
Anticancer Drugs
, vol.18
, pp. 477-485
-
-
Rupp, U.1
Schoendorf-Holland, E.2
Eichbaum, M.3
-
9
-
-
84886743503
-
Lung cancer tumorigenicity and drug resistance are maintained through ALDH(hi)CD44(hi) tumor initiating cells
-
Liu J, Xiao Z, Wong SK, Tin VP, Ho KY, Wang J, Sham MH, Wong MP. Lung cancer tumorigenicity and drug resistance are maintained through ALDH(hi)CD44(hi) tumor initiating cells. Oncotarget. 2013;4:1698-1711.
-
(2013)
Oncotarget
, vol.4
, pp. 1698-1711
-
-
Liu, J.1
Xiao, Z.2
Wong, S.K.3
Tin, V.P.4
Ho, K.Y.5
Wang, J.6
Sham, M.H.7
Wong, M.P.8
-
10
-
-
0028040021
-
Expression and modulation of CD44 variant isoforms in humans
-
Mackay CR, Terpe HJ, Stauder R, Marston WL, Stark H, Gunthert U. Expression and modulation of CD44 variant isoforms in humans. J Cell Biol 1994; 124: 71-82.
-
(1994)
J Cell Biol
, vol.124
, pp. 71-82
-
-
Mackay, C.R.1
Terpe, H.J.2
Stauder, R.3
Marston, W.L.4
Stark, H.5
Gunthert, U.6
-
11
-
-
34250869509
-
Hyaluronic acid-paclitaxel: antitumor efficacy against CD44(+) human ovarian carcinoma xenografts
-
Auzenne E, Ghosh SC, Khodadadian M, et al. Hyaluronic acid-paclitaxel: antitumor efficacy against CD44(+) human ovarian carcinoma xenografts. Neoplasia 2007; 9: 479-86.
-
(2007)
Neoplasia
, vol.9
, pp. 479-486
-
-
Auzenne, E.1
Ghosh, S.C.2
Khodadadian, M.3
-
12
-
-
0347285397
-
Loading mitomycin C inside long circulating hyaluronan targeted nano-liposomes increases its antitumor activity in three mice tumor models
-
Peer D, Margalit R. Loading mitomycin C inside long circulating hyaluronan targeted nano-liposomes increases its antitumor activity in three mice tumor models. Int J Cancer 2004; 108: 780-9.
-
(2004)
Int J Cancer
, vol.108
, pp. 780-789
-
-
Peer, D.1
Margalit, R.2
-
13
-
-
0032567715
-
Glycosylation provides both stimulatory and inhibitory effects on cell surface and soluble CD44 binding to hyaluronan
-
Skelton TP, Zeng C, Nocks A, Stamenkovic I. Glycosylation provides both stimulatory and inhibitory effects on cell surface and soluble CD44 binding to hyaluronan. J Cell Biol 1998; 140: 431-46.
-
(1998)
J Cell Biol
, vol.140
, pp. 431-446
-
-
Skelton, T.P.1
Zeng, C.2
Nocks, A.3
Stamenkovic, I.4
-
14
-
-
0032167434
-
Two different functions for CD44 proteins in human myelopoiesis
-
Moll J, Khaldoyanidi S, Sleeman JP, et al. Two different functions for CD44 proteins in human myelopoiesis. J Clin Invest 1998; 102: 1024-34.
-
(1998)
J Clin Invest
, vol.102
, pp. 1024-1034
-
-
Moll, J.1
Khaldoyanidi, S.2
Sleeman, J.P.3
-
15
-
-
77952635340
-
Two-state conformations in the hyaluronan-binding domain regulate CD44 adhesiveness under flow condition
-
Ogino S, Nishida N, Umemoto R, et al. Two-state conformations in the hyaluronan-binding domain regulate CD44 adhesiveness under flow condition. Structure 2010; 18: 649-56.
-
(2010)
Structure
, vol.18
, pp. 649-656
-
-
Ogino, S.1
Nishida, N.2
Umemoto, R.3
-
16
-
-
0037969876
-
Mononuclear leukocytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid:polycytidylic acid:interalpha-trypsin inhibitor is crucial to structure and function
-
de la Motte CA, Hascall VC, Drazba J, Bandyopadhyay SK, Strong SA. Mononuclear leukocytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid:polycytidylic acid:interalpha-trypsin inhibitor is crucial to structure and function. Am J Pathol 2003; 163: 121-33.
-
(2003)
Am J Pathol
, vol.163
, pp. 121-133
-
-
de la Motte, C.A.1
Hascall, V.C.2
Drazba, J.3
Bandyopadhyay, S.K.4
Strong, S.A.5
-
17
-
-
78149322286
-
Inhibition of the phosphatidylinositol-3-kinase pathway abrogates polyinosinic:polycytidylic acid-stimulated hyaluronan-mediated human mucosal smooth muscle cell binding of U937 monocytic cells
-
Bandyopadhyay SK, de la Motte CA, Majors AK, Strong SA. Inhibition of the phosphatidylinositol-3-kinase pathway abrogates polyinosinic:polycytidylic acid-stimulated hyaluronan-mediated human mucosal smooth muscle cell binding of U937 monocytic cells. J Interferon Cytokine Res 2010; 30: 809-16.
-
(2010)
J Interferon Cytokine Res
, vol.30
, pp. 809-816
-
-
Bandyopadhyay, S.K.1
de la Motte, C.A.2
Majors, A.K.3
Strong, S.A.4
-
18
-
-
0025338724
-
Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition
-
Miyake K, Underhill CB, Lesley J, Kincade PW. Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J Exp Med 1990; 172: 69-75.
-
(1990)
J Exp Med
, vol.172
, pp. 69-75
-
-
Miyake, K.1
Underhill, C.B.2
Lesley, J.3
Kincade, P.W.4
-
19
-
-
0026537561
-
Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody
-
Lesley J, He Q, Miyake K, Hamann A, Hyman R, Kincade PW. Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody. J Exp Med 1992; 175: 257-66.
-
(1992)
J Exp Med
, vol.175
, pp. 257-266
-
-
Lesley, J.1
He, Q.2
Miyake, K.3
Hamann, A.4
Hyman, R.5
Kincade, P.W.6
-
20
-
-
51749085805
-
Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway
-
Park G, Yoon BS, Moon JH, et al. Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway. J Invest Dermatol 2008; 128: 2429-41.
-
(2008)
J Invest Dermatol
, vol.128
, pp. 2429-2441
-
-
Park, G.1
Yoon, B.S.2
Moon, J.H.3
-
21
-
-
84879459539
-
The use of HA oligosaccharideloaded nanoparticles to breach the endogenous hyaluronan glycocalyx for breast cancer therapy
-
Yang C, Liu Y, He Y, et al. The use of HA oligosaccharideloaded nanoparticles to breach the endogenous hyaluronan glycocalyx for breast cancer therapy. Biomaterials 2013; 34: 6829-38.
-
(2013)
Biomaterials
, vol.34
, pp. 6829-6838
-
-
Yang, C.1
Liu, Y.2
He, Y.3
-
22
-
-
84871121656
-
The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering
-
Yang C, Cao M, Liu H, et al. The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering. J Biol Chem 2012; 287: 43094-107.
-
(2012)
J Biol Chem
, vol.287
, pp. 43094-43107
-
-
Yang, C.1
Cao, M.2
Liu, H.3
-
23
-
-
84865713442
-
Global quantitative phosphoproteome analysis of human tumor xenografts treated with a CD44 antagonist
-
Weigand S, Herting F, Maisel D, et al. Global quantitative phosphoproteome analysis of human tumor xenografts treated with a CD44 antagonist. Cancer Res 2012; 72: 4329-39.
-
(2012)
Cancer Res
, vol.72
, pp. 4329-4339
-
-
Weigand, S.1
Herting, F.2
Maisel, D.3
-
24
-
-
0026801075
-
CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells
-
Lesley J, Hyman R. CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells. Eur J Immunol 1992; 22: 2719-23.
-
(1992)
Eur J Immunol
, vol.22
, pp. 2719-2723
-
-
Lesley, J.1
Hyman, R.2
-
25
-
-
84872323830
-
Characteristics of CD44 alternative splice pattern in the course of human colorectal adenocarcinoma progression
-
Bánky B, Rásó-Barnett L, Barbai T, Tímár J, Becságh P, Rásó E. Characteristics of CD44 alternative splice pattern in the course of human colorectal adenocarcinoma progression. Mol Cancer. 2012;11:83. doi: 10.1186/1476-4598-11-83.
-
(2012)
Mol Cancer
, vol.11
, pp. 83
-
-
Bánky, B.1
Rásó-Barnett, L.2
Barbai, T.3
Tímár, J.4
Becságh, P.5
Rásó, E.6
-
26
-
-
84865507272
-
Hypoxia regulates CD44 and its variant isoforms through HIF-1a in triple negative breast cancer
-
Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM. Hypoxia regulates CD44 and its variant isoforms through HIF-1a in triple negative breast cancer. PLoS One. 2012;7:e44078.
-
(2012)
PLoS One
, vol.7
-
-
Krishnamachary, B.1
Penet, M.F.2
Nimmagadda, S.3
Mironchik, Y.4
Raman, V.5
Solaiyappan, M.6
Semenza, G.L.7
Pomper, M.G.8
Bhujwalla, Z.M.9
-
27
-
-
33847265880
-
Hyaluronan as carrier of carboranes for tumor targeting in boron neutron capture therapy
-
Meo CD, Panza L, Capitani D, et al. Hyaluronan as carrier of carboranes for tumor targeting in boron neutron capture therapy. Biomacromolecules 2007; 8: 552-9.
-
(2007)
Biomacromolecules
, vol.8
, pp. 552-559
-
-
Meo, C.D.1
Panza, L.2
Capitani, D.3
-
28
-
-
79955761548
-
Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers
-
Bachar G, Cohen K, Hod R, et al. Hyaluronan-grafted particle clusters loaded with Mitomycin C as selective nanovectors for primary head and neck cancers. Biomaterials 2011; 32: 4840-8.
-
(2011)
Biomaterials
, vol.32
, pp. 4840-4848
-
-
Bachar, G.1
Cohen, K.2
Hod, R.3
-
29
-
-
84880256689
-
CD44variant exon 9 plays an important role in colon cancer initiating cells
-
Kimura Y, Goi T, Nakazawa T, Hirono Y, Katayama K, Urano T, Yamaguchi A. CD44variant exon 9 plays an important role in colon cancer initiating cells. Oncotarget. 2013;4:785-91.
-
(2013)
Oncotarget
, vol.4
, pp. 785-791
-
-
Kimura, Y.1
Goi, T.2
Nakazawa, T.3
Hirono, Y.4
Katayama, K.5
Urano, T.6
Yamaguchi, A.7
-
30
-
-
79959956046
-
The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(-) stem cell-like breast cancer cells in human tumors
-
Marotta LL, Almendro V, Marusyk A, et al. The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(-) stem cell-like breast cancer cells in human tumors. J Clin Invest 2011; 121: 2723-35.
-
(2011)
J Clin Invest
, vol.121
, pp. 2723-2735
-
-
Marotta, L.L.1
Almendro, V.2
Marusyk, A.3
-
31
-
-
10844290511
-
Phase I therapy study with (186)Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma
-
Borjesson PK, Postema EJ, Roos JC, et al. Phase I therapy study with (186)Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma. Clin Cancer Res 2003; 9: 3961S-72S.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3961S-3972S
-
-
Borjesson, P.K.1
Postema, E.J.2
Roos, J.C.3
-
32
-
-
0041854151
-
Safety, biodistribution, pharmacokinetics, and immunogenicity of 99mTc-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with squamous cell carcinoma of the head and neck
-
Colnot DR, Roos JC, de Bree R, et al. Safety, biodistribution, pharmacokinetics, and immunogenicity of 99mTc-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with squamous cell carcinoma of the head and neck. Cancer Immunol Immunother 2003; 52: 576-82.
-
(2003)
Cancer Immunol Immunother
, vol.52
, pp. 576-582
-
-
Colnot, D.R.1
Roos, J.C.2
de Bree, R.3
-
33
-
-
0035866799
-
Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells
-
Eliaz RE, Szoka FC, Jr. Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells. Cancer Res 2001; 61: 2592-601.
-
(2001)
Cancer Res
, vol.61
, pp. 2592-2601
-
-
Eliaz, R.E.1
Szoka, F.C.2
-
34
-
-
84883470829
-
Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblastphenotype via TWIST activation in the tumor microenvironment
-
Spaeth EL, Labaff AM, Toole BP, Klopp A, Andreeff M, Marini FC. Mesenchymal CD44 expression contributes to the acquisition of an activated fibroblastphenotype via TWIST activation in the tumor microenvironment. Cancer Res 2013; 73: 5347-59.
-
(2013)
Cancer Res
, vol.73
, pp. 5347-5359
-
-
Spaeth, E.L.1
Labaff, A.M.2
Toole, B.P.3
Klopp, A.4
Andreeff, M.5
Marini, F.C.6
-
35
-
-
61349189010
-
CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance
-
Klingbeil P, Marhaba R, Jung T, Kirmse R, Ludwig T, Zöller M. CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance. Mol Cancer Res. 2009; 7:168-79.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 168-179
-
-
Klingbeil, P.1
Marhaba, R.2
Jung, T.3
Kirmse, R.4
Ludwig, T.5
Zöller, M.6
-
36
-
-
0030271770
-
Prognostic value of immunohistochemically detected CD44 isoforms CD44v5, CD44v6 and CD44v7-8 in human breast cancer
-
Tempfer C, Lösch A, Heinzl H, Häusler G, Hanzal E, Kölbl H, Breitenecker G, Kainz C. Prognostic value of immunohistochemically detected CD44 isoforms CD44v5, CD44v6 and CD44v7-8 in human breast cancer. Eur J Cancer. 1996; 32A:2023-5.
-
(1996)
Eur J Cancer
, vol.32A
, pp. 2023-2025
-
-
Tempfer, C.1
Lösch, A.2
Heinzl, H.3
Häusler, G.4
Hanzal, E.5
Kölbl, H.6
Breitenecker, G.7
Kainz, C.8
-
37
-
-
0029939903
-
Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation
-
Fan X, Long A, Goggins M, Fan X, Keeling PW, Kelleher D. Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisation. Gut. 1996; 38:507-12.
-
(1996)
Gut
, vol.38
, pp. 507-512
-
-
Fan, X.1
Long, A.2
Goggins, M.3
Fan, X.4
Keeling, P.W.5
Kelleher, D.6
-
38
-
-
3142783426
-
Tumor-targeted hyaluronan nanoliposomes increase the antitumor activity of liposomal Doxorubicin in syngeneic and human xenograft mouse tumor models
-
Peer D, Margalit R. Tumor-targeted hyaluronan nanoliposomes increase the antitumor activity of liposomal Doxorubicin in syngeneic and human xenograft mouse tumor models. Neoplasia 2004; 6: 343-53.
-
(2004)
Neoplasia
, vol.6
, pp. 343-353
-
-
Peer, D.1
Margalit, R.2
|