Activation of Yes-Associated Protein in Low-Grade Meningiomas Is Regulated by Merlin, Cell Density, and Extracellular Matrix Stiffness

Journal of Neuropathology and Experimental Neurology

Volumn 74, Issue 7, 2015, Pages 704-709

  Tanahashi, Kuniaki ^a   Natsume, Atsushi ^a   Ohka, Fumiharu ^a   Motomura, Kazuya ^a   Alim, Adiljan ^a   Tanaka, Ichidai ^b,c   Senga, Takeshi ^a   Harada, Ichiro ^d   Fukuyama, Ryuichi ^e   Sumiyoshi, Naoyuki ^e   Sekido, Yoshitaka ^b   Wakabayashi, Toshihiko ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^e Aichi Prefectural Welfare Federation of Agriculture Co operative Associations Konan Kosei Hospital   (Japan)

Author keywords

Meningioma; Merlin; YAP

Indexed keywords

MERLIN; NUCLEAR PROTEIN; TUMOR PROTEIN; UNCLASSIFIED DRUG; YES ASSOCIATED PROTEIN; KI 67 ANTIGEN; TRANSCRIPTION FACTOR; YY1AP1 PROTEIN, HUMAN;

ARTICLE; CANCER CELL LINE; CANCER GRADING; CASE REPORT; CELL COUNT; CELL DENSITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; EXTRACELLULAR MATRIX STIFFNESS; GENE LOSS; HKBMM CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IOMM LEE CELL LINE; MENINGIOMA; NF2 GENE; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WORLD HEALTH ORGANIZATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEUROFIBROMATOSIS TYPE 2; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

CELL COUNT; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KI-67 ANTIGEN; MENINGEAL NEOPLASMS; MENINGIOMA; NEUROFIBROMATOSIS 2; NEUROFIBROMIN 2; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS;

EID: 84934294813     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0000000000000211     Document Type: Article

References (29)

1. Evans DG. Neurofibromatosis 2 [Bilateral acoustic neurofibromatosis, central neurofibromatosis, NF2, neurofibromatosis type II]. Genet Med 2009;11:599-610
2. Hartmann C, Sieberns J, Gehlhaar C, et al. NF2 mutations in secretory and other rare variants of meningiomas. Brain Pathol 2006;16:15-9
3. Kros J, de Greve K, van Tilborg A, et al. NF2 status of meningiomas is associated with tumour localization and histology. J Pathol 2001;194:367-72
4. Wellenreuther R, Kraus JA, Lenartz D, et al. Analysis of the neurofibromatosis 2 gene reveals molecular variants of meningioma. Am J Pathol 1995;146:827-32
5. Kalamarides M, Niwa-Kawakita M, Leblois H, et al. Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse. Genes Dev 2002;16:1060-5
6. Kalamarides M, Stemmer-Rachamimov AO, Takahashi M, et al. Natural history of meningioma development in mice reveals: a synergy of Nf2 and p16(Ink4a) mutations. Brain Pathol 2008;18:62-70
7. Morrison H, Sherman LS, Legg J, et al. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev 2001;15:968-80
8. Fernandez-Valle C, Tang Y, Ricard J, et al. Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology. Nat Genet 2002;31:354-62
9. Curto M, Cole BK, Lallemand D, et al. Contact-dependent inhibition of EGFR signaling by Nf2/Merlin. J Cell Biol 2007;177:893-903
10. Mizuno T, Murakami H, Fujii M, et al. YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes. Oncogene 2012;31:5117-22
11. Fernandez LA, Northcott PA, Dalton J, et al. YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev 2009;23:2729-41
12. Helias-Rodzewicz Z, Perot G, Chibon F, et al. YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas. Genes Chromosomes Cancer 2010;49:1161-71
13. Imoto I, Yang ZQ, Pimkhaokham A, et al. Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas. Cancer research 2001;61:6629-34
14. Dupont S, Morsut L, Aragona M, et al. Role of YAP/TAZ in mechanotransduction. Nature 2011;474:179-83
15. Halder G, Dupont S, Piccolo S. Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol 2012;13:591-600
16. Striedinger K, VandenBerg SR, Baia GS, et al. The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP. Neoplasia 2008;10:1204-12
17. Baia GS, Caballero OL, Orr BA, et al. Yes-associated protein 1 is activated and functions as an oncogene in meningiomas. Molecular cancer research: MCR 2012;10:904-13
18. Yip AK, Iwasaki K, Ursekar C, et al. Cellular response to substrate rigidity is governed by either stress or strain. Biophys J 2013;104:19-29
19. Hao Y, Chun A, Cheung K, et al. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem 2008;283:5496-509
20. Zhao B, Wei X, Li W, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 2007;21:2747-61
21. Kim NG, Koh E, Chen X, et al. E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc Natl Acad Sci USA 2011;108:11930-35
22. Zhao B, Li L, Tumaneng K, et al. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF (beta-TRCP). Genes Dev 2010;24:72-85
23. Schlegelmilch K, Mohseni M, Kirak O, et al. Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell 2011;144:782-95
24. Zhao B, Lei QY, Guan KL. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr Opin Cell Biol 2008;20:638-46
25. Hamaratoglu F, Willecke M, Kango-Singh M, et al. The tumour-suppressor genes NF2/Merlin and expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 2006;8:27-36
26. Dong J, Feldmann G, Huang J, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 2007;130:1120-33
27. Edgar BA. From cell structure to transcription: Hippo forges a new path. Cell 2006;124:267-73
28. Pan D. Hippo signaling in organ size control. Genes Dev 2007;21:886-97
29. Pan D. The hippo signaling pathway in development and cancer. Dev Cell 2010;19:491-505