An aminopropyl carbazole derivative induces neurogenesis by increasing final cell division in neural stem cells

Biomolecules and Therapeutics

Volumn 23, Issue 4, 2015, Pages 313-319

  Shin, Jae Yeon ^a   Kong, Sun Young ^a   Yoon, Hye Jin ^b   Ann, Jihyae ^b   Lee, Jeewoo ^b   Kim, Hyun Jung ^a  

^a Chung Ang University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Aminopropyl carbazoles; Final cell division; Neural stem cells; Neurodegenerative diseases; Neurogenesis

Indexed keywords

EID: 84934288627     PISSN: 19769148     EISSN: 20054483     Source Type: Journal    
DOI: 10.4062/biomolther.2015.016     Document Type: Editorial

References (26)

1. Anacker, C., Zunszain, P. A., Cattaneo, A., Carvalho, L. A., Garabedian, M. J., Thuret, S., Price, J. and Pariante, C. M. (2011) Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol. Psychiatry 16, 738-750
2. Bossy-Wetzel, E., Schwarzenbacher, R. and Lipton, S. A. (2004) Molecular pathways to neurodegeneration. Nat. Med. 10 Suppl, S2-9
3. Coles-Takabe, B. L., Brain, I., Purpura, K. A., Karpowicz, P., Zandstra, P. W., Morshead, C. M. and van der Kooy, D. (2008) Don't look: growing clonal versus nonclonal neural stem cell colonies. Stem Cells 26, 2938-2944
4. De Jesus-Cortes, H., Xu, P., Drawbridge, J., Estill, S. J., Huntington, P., Tran, S., Britt, J., Tesla, R., Morlock, L., Naidoo, J., Melito, L M., Wang, G., Williams, N. S., Ready, J. M., McKnight, S. L. and Pieper, A. A. (2012) Neuroprotective effi cacy of aminopropyl carbazoles in a mouse model of Parkinson disease. Proc. Natl. Acad Sci. U.S.A. 109, 17010-17015
5. Fischer, A., Sananbenesi, F., Wang, X., Dobbin, M. and Tsai, L. H (2007) Recovery of learning and memory is associated with chromatin remodelling. Nature 447, 178-182
6. Gage, F. H. (2000) Mammalian neural stem cells. Science 287, 1433-1438
7. Gamm, D. M., Wright, L. S., Capowski, E. E., Shearer, R. L., Meyer, J S., Kim, H. J., Schneider, B. L., Melvan, J. N. and Svendsen, C. N (2008) Regulation of prenatal human retinal neurosphere growth and cell fate potential by retinal pigment epithelium and Mash1 Stem Cells 26, 3182-3193
8. Kim, H. J. and Jin, C. Y. (2012) Stem cells in drug screening for neurodegenerative disease. Korean J. Physiol. Pharmacol. 16, 1-9
9. Kim, H. J., Leeds, P. and Chuang, D. M. (2009a) The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain. J Neurochem. 110, 1226-1240
10. Kim, H. J., McMillan, E., Han, F. and Svendsen, C. N. (2009b) Regionally specifi ed human neural progenitor cells derived from the mesencephalon and forebrain undergo increased neurogenesis following overexpression of ASCL1. Stem Cells 27, 390-398
11. Kim, H. J., Sugimori, M., Nakafuku, M. and Svendsen, C. N. (2007) Control of neurogenesis and tyrosine hydroxylase expression in neural progenitor cells through bHLH proteins and Nurr1. Exp Neurol. 203, 394-405
12. Kim, W., Kim, J. H., Kong, S. Y., Park, M. H., Sohn, U. D. and Kim, H J. (2013) Comparison of ectopic gene expression methods in rat neural stem cells. Korean J. Physiol. Pharmacol. 17, 23-30
13. Kong, S. Y., Park, M. H., Lee, M., Kim, J. O., Lee, H. R., Han, B. W., Svendsen, C. N., Sung, S. H. and Kim, H. J. (2015) Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells. PloS one 10, e0118188
14. Kowal, S. L., Dall, T. M., Chakrabarti, R., Storm, M. V. and Jain, A (2013) The current and projected economic burden of Parkinson's disease in the United States. Mov. Disord. 28, 311-318
15. Lairson, L. L., Lyssiotis, C. A., Zhu, S. and Schultz, P. G. (2013) Small molecule-based approaches to adult stem cell therapies. Annu Rev. Pharmacol. Toxicol. 53, 107-125
16. Lin, X. and Bulleit, R. F. (1997) Insulin-like growth factor I (IGF-I) is a critical trophic factor for developing cerebellar granule cells. Brain Res. Dev. Brain Res. 99, 234-242
17. MacMillan, K. S., Naidoo, J., Liang, J., Melito, L., Williams, N. S., Morlock, L., Huntington, P. J., Estill, S. J., Longgood, J., Becker, G L., McKnight, S. L., Pieper, A. A., De Brabander, J. K. and Ready, J. M. (2011) Development of proneurogenic, neuroprotective small molecules. J. Am. Chem. Soc. 133, 1428-1437
18. Noctor, S. C., Martínez-Cerdeño, V., Ivic, L. and Kriegstein, A. R. (2004) Cortical neurons arise in symmetric and asymmetric division zones and migrate through specifi c phases. Nat. Neurosci. 7, 136-144
19. Peng, Z. W., Xue, Y. Y., Wang, H. N., Wang, H. H., Xue, F., Kuang, F., Wang, B. R., Chen, Y. C., Zhang, L. Y. and Tan, Q. R. (2012) Sertraline promotes hippocampus-derived neural stem cells differentiating into neurons but not glia and attenuates LPS-induced cellular damage. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 36, 183-188
20. Pieper, A. A., Xie, S., Capota, E., Estill, S. J., Zhong, J., Long, J. M., Becker, G. L., Huntington, P., Goldman, S. E., Shen, C. H., Capota, M., Britt, J. K., Kotti, T., Ure, K., Brat, D. J., Williams, N. S., MacMillan, K. S., Naidoo, J., Melito, L., Hsieh, J., De Brabander, J., Ready, J. M. and McKnight, S. L. (2010) Discovery of a proneurogenic, neuroprotective chemical. Cell 142, 39-51
21. Taupin, P. and Gage, F. H. (2002) Adult neurogenesis and neural stem cells of the central nervous system in mammals. J. Neurosci. Res 69, 745-749
22. Tesla, R., Wolf, H. P., Xu, P., Drawbridge, J., Estill, S. J., Huntington, P., McDaniel, L., Knobbe, W., Burket, A., Tran, S., Starwalt, R., Morlock, L., Naidoo, J., Williams, N. S., Ready, J. M., McKnight, S L. and Pieper, A. A. (2012) Neuroprotective effi cacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. U.S.A. 109, 17016-17021
23. Wang, G., Han, T., Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A. A., Ready, J. M. and McKnight, S. L. (2014) P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 158, 1324-1334
24. Warashina, M., Min, K. H., Kuwabara, T., Huynh, A., Gage, F. H., Schultz, P. G. and Ding, S. (2006) A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew. Chem., Int. Ed. Engl. 45, 591-593
25. Yin, T. C., Britt, J. K., De Jesus-Cortes, H., Lu, Y., Genova, R. M., Khan, M. Z., Voorhees, J. R., Shao, J., Katzman, A. C., Huntington, P. J., Wassink, C., McDaniel, L., Newell, E. A., Dutca, L. M., Naidoo, J., Cui, H., Bassuk, A. G., Harper, M. M., McKnight, S L., Ready, J. M. and Pieper, A. A. (2014) P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury. Cell Rep. 8, 1731-1740
26. Yoon, H. J., Kong, S. Y., Park, M. H., Cho, Y., Kim, S. E., Shin, J Y., Jung, S., Lee, J., Farhanullah and Kim, H. J. (2013) Aminopropyl carbazole analogues as potent enhancers of neurogenesis Bioorg. Med. Chem.21, 7165-7174