Co-encapsulation of resveratrol and curcumin in lipid-core nanocapsules improves their in vitro antioxidant effects

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 88, Issue 1, 2014, Pages 178-185

  Coradini, K ^a   Lima, F O ^b   Oliveira, C M ^a   Chaves, P S ^a   Athayde, M L ^b   Carvalho, L M ^b   Beck, R C R ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Antioxidants; Curcumin; Lipid core nanocapsules; Nanoparticles; Photostability; Resveratrol

Indexed keywords

ANTIOXIDANT; CURCUMIN; FREE RADICAL; LIPID; NANOCAPSULE; NANOPARTICLE; POLYPHENOL; RESVERATROL; STILBENE DERIVATIVE;

CHEMISTRY; DRUG DELIVERY SYSTEM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFLAMMATION; NANOTECHNOLOGY; OXIDATIVE STRESS; PARTICLE SIZE; PH; TRANSMISSION ELECTRON MICROSCOPY;

ANTIOXIDANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CURCUMIN; DRUG DELIVERY SYSTEMS; FREE RADICALS; HUMANS; HYDROGEN-ION CONCENTRATION; INFLAMMATION; LIPIDS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOCAPSULES; NANOPARTICLES; NANOTECHNOLOGY; OXIDATIVE STRESS; PARTICLE SIZE; POLYPHENOLS; STILBENES;

EID: 84934287015     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2014.04.009     Document Type: Article

References (48)

1. K. Bisht, K.H. Wagner, and A.C. Bulmer Curcumin, resveratrol and flavonoids as anti-inflammatory, cyto- and DNA-protective dietary compounds Toxicology 278 2010 88 100
2. T. Ishrat, M.N. Hoda, M.B. Khan, S. Yousuf, M. Ahmad, M.M. Khan, A. Ahmad, and F. Islam Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT) Eur. Neuropsychopharmacol. 19 2009 636 647
3. S.S. Leonard, C. Xia, B.H. Jiang, B. Stinefelt, H. Klandorf, G.K. Harris, and X. Shi Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses Biochem. Biophys. Res. Commun. 309 2003 1017 1026
4. N. Aftab, and A. Vieira Antioxidant activities of curcumin and combinations of this curcuminoid with other phytochemicals Phytother. Res. 24 2010 500 502
5. O.F. Iwuchukwu, R.J. Tallarida, and S. Nagar Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells Life Sci. 88 2011 1047 1054
6. A. Malhotra, P. Nair, and D.K. Dhawan Modulatory effects of curcumin and resveratrol on lung carcinogenesis in mice Phytother. Res. 24 2010 1271 1277
7. A. Amri, J.C. Chaumeil, S. Sfar, and C. Charrueau Administration of resveratrol: what formulation solutions to bioavailability limitations? J. Controlled Release 158 2012 182 193
8. R.A. Sharma, A.J. Gescher, and W.P. Steward Curcumin: the story so far Eur. J. Cancer 41 2005 1955 1968
9. M.M. Yallapu, M. Jaggi, and S.C. Chauhan Curcumin nanoformulations: a future nanomedicine for cancer Drug Discov. Today 17 2012 71 80
10. V. Sanna, A.M. Roggio, S. Siliani, M. Piccinini, S. Marceddu, A. Mariani, and M. Sechi Development of novel cationic chitosan- and anionic alginate-coated poly(D,L-lactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol Int. J. Nanomed. 7 2012 5501 5516
11. C. Mohanty, and S.K. Sahoo The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation Biomaterials 31 2010 6597 6611
12. J. Shaikh, D.D. Ankola, V. Beniwal, D. Singh, and M.N. Kumar Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer Eur. J. Pharm. Sci. 37 2009 223 230
13. E.A. Oganesyan, Miroshnichenko II, N.S. Vikhrieva, A.A. Lyashenko, and S.Y. Leshkov Use of nanoparticles to increase the systemic bioavailability of trans-resveratrol Pharm. Chem. J. 44 2010 74 76
14. A.N. Lazar, S. Mourtas, I. Youssef, C. Parizot, A. Dauphin, B. Delatour, S.G. Antimisiaris, and C. Duyckaerts Curcumin-conjugated nanoliposomes with high affinity for Abeta deposits: possible applications to Alzheimer disease Nanomedicine 9 2013 712 721
15. W. Guo, A. Li, Z. Jia, Y. Yuan, H. Dai, and H. Li Transferrin modified PEG-PLA-resveratrol conjugates: in vitro and in vivo studies for glioma Eur. J. Pharmacol. 718 2013 41 47
16. A.R. Pohlmann, F.N. Fonseca, K. Paese, C.B. Detoni, K. Coradini, R.C. Beck, and S.S. Guterres Poly(-caprolactone) microcapsules and nanocapsules in drug delivery Expert Opin. Drug Deliv. 10 2013 623 638
17. A.F. Ourique, S. Azoubel, C.V. Ferreira, C.B. Silva, M.C. Marchiori, A.R. Pohlmann, S.S. Guterres, and R.C. Beck Lipid-core nanocapsules as a nanomedicine for parenteral administration of tretinoin: development and in vitro antitumor activity on human myeloid leukaemia cells J. Biomed. Nanotechnol. 6 2010 214 223
18. M.C. Fontana, K. Coradini, S.S. Guterres, A.R. Pohlmann, and R.C. Beck Nanoencapsulation as a way to control the release and to increase the photostability of clobetasol propionate: influence of the nanostructured system J. Biomed. Nanotechnol. 5 2009 254 263
19. A. Bernardi, E. Braganhol, E. Jager, F. Figueiro, M.I. Edelweiss, A.R. Pohlmann, S.S. Guterres, and A.M. Battastini Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model Cancer Lett. 281 2009 53 63
20. A. Bernardi, A.C. Zilberstein, E. Jager, M.M. Campos, F.B. Morrone, J.B. Calixto, A.R. Pohlmann, S.S. Guterres, and A.M. Battastini Effects of indomethacin-loaded nanocapsules in experimental models of inflammation in rats Br. J. Pharmacol. 158 2009 1104 1111
21. M.C. Fontana, J.F. Rezer, K. Coradini, D.B. Leal, and R.C. Beck Improved efficacy in the treatment of contact dermatitis in rats by a dermatological nanomedicine containing clobetasol propionate Eur. J. Pharm. Biopharm. 79 2011 241 249
22. A. Bernardi, R.L. Frozza, A. Meneghetti, J.B. Hoppe, A.M. Battastini, A.R. Pohlmann, S.S. Guterres, and C.G. Salbego Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Abeta1-42 in Alzheimer's disease models Int. J. Nanomed. 7 2012 4927 4942
23. R.L. Frozza, A. Bernardi, J.B. Hoppe, A.B. Meneghetti, A. Matte, A.M. Battastini, A.R. Pohlmann, S.S. Guterres, and C. Salbego Neuroprotective effects of resveratrol against Abeta administration in rats are improved by lipid-core nanocapsules Mol. Neurobiol. 47 2013 1066 1080
24. A. Zanotto-Filho, K. Coradini, E. Braganhol, R. Schröder, C.M. de Oliveira, A. Simões-Pires, A.M.O. Battastini, A.R. Pohlmann, S.S. Guterres, C.M. Forcelini, R.C.R. Beck, and J.C.F. Moreira Curcumin-loaded lipid-core nanocapsules as a strategy to improve pharmacological efficacy of curcumin in glioma treatment Eur. J. Pharm. Biopharm. 83 2013 156 167
25. R.L. Frozza, A. Bernardi, K. Paese, J.B. Hoppe, T. da Silva, A.M. Battastini, A.R. Pohlmann, S.S. Guterres, and C. Salbego Characterization of trans-resveratrol-loaded lipid-core nanocapsules and tissue distribution studies in rats J. Biomed. Nanotechnol. 6 2010 694 703
26. J.S. Almeida, F. Lima, S.D. Ros, L.O. Bulhoes, L.M. de Carvalho, and R.C. Beck Nanostructured systems containing rutin: in vitro antioxidant activity and photostability studies Nanoscale Res. Lett. 5 2010 1603 1610
27. I.C. Külkamp, B.D. Rabelo, S.J. Berlitz, M. Isoppo, M.D. Bianchin, S.R. Schaffazick, A.R. Pohlmann, and S.S. Guterres Nanoencapsulation improves the in vitro antioxidant activity of lipoic acid J. Biomed. Nanotechnol. 7 2011 598 607
28. C.B. Detoni, G.D. Souto, A.L.M. da Silva, A.R. Pohlmann, and S.S. Guterres Photostability and skin penetration of different E-resveratrol-loaded supramolecular structures Photochem. Photobiol. 88 2012 913 921
29. F. Figueiro, A. Bernardi, R.L. Frozza, T. Terroso, A. Zanotto-Filho, E.H. Jandrey, J.C. Moreira, C.G. Salbego, M.I. Edelweiss, A.R. Pohlmann, S.S. Guterres, and A.M. Battastini Resveratrol-loaded lipid-core nanocapsules treatment reduces in vitro and in vivo glioma growth J. Biomed. Nanotechnol. 9 2013 516 526
30. L.M. de Carvalho, J.M. Monserrat, F. Scholz, F.O. Lima, M.B. da Rosa, M. Hilgemann, L.S. Muller, H. Faccin, P.B. Ramos, and C. Viana Substrate-free determination of the radical scavenging activity of phenolic compounds by photochemical generation of hydroxyl radicals and HPLC-UV detection Sep. Sci. Technol. 48 2013 1123 1131
31. E. Jager, C.G. Venturini, F.S. Poletto, L.M. Colome, J.P. Pohlmann, A. Bernardi, A.M. Battastini, S.S. Guterres, and A.R. Pohlmann Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area J. Biomed. Nanotechnol. 5 2009 130 140
32. C.G. Venturini, E. Jager, C.P. Oliveira, A. Bernardi, A.M.O. Battastini, S.S. Guterres, and A.R. Pohlmann Formulation of lipid core nanocapsules Colloids Surf., A: Physicochem. Eng. Aspects 375 2011 200 208
33. C. Caddeo, K. Teskac, C. Sinico, and J. Kristl Effect of resveratrol incorporated in liposomes on proliferation and UV-B protection of cells Int. J. Pharm. 363 2008 183 191
34. X. Lu, C. Ji, H. Xu, X. Li, H. Ding, M. Ye, Z. Zhu, D. Ding, X. Jiang, X. Ding, and X. Guo Resveratrol-loaded polymeric micelles protect cells from Abeta-induced oxidative stress Int. J. Pharm. 375 2009 89 96
35. K. Teskač, and J. Kristl The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol Int. J. Pharm. 390 2010 61 69
36. M. Sessa, M.L. Balestrieri, G. Ferrari, L. Servillo, D. Castaldo, N. D'Onofrio, F. Donsi, and R. Tsao Bioavailability of encapsulated resveratrol into nanoemulsion-based delivery systems Food Chem. 147 2014 42 50
37. V. Kakkar, and I.P. Kaur Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain Food Chem. Toxicol. 49 2011 2906 2913
38. X. Gao, F. Zheng, G. Guo, X. Liu, R. Fan, Z.-Y. Qian, N. Huang, and Y.-Q. Wei Improving the anti-colon cancer activity of curcumin with biodegradable nano-micelles J. Mater. Chem. B 1 2013 5778 5790
39. L. Wu, J. Zhang, and W. Watanabe Physical and chemical stability of drug nanoparticles Adv. Drug Deliv. Rev. 63 2011 456 469
40. V. Filipe, A. Hawe, and W. Jiskoot Critical evaluation of nanoparticle tracking analysis (NTA) by nanosight for the measurement of nanoparticles and protein aggregates Pharm. Res. 27 2010 796 810
41. S. Reuter, S.C. Gupta, M.M. Chaturvedi, and B.B. Aggarwal Oxidative stress, inflammation, and cancer: how are they linked? Free Radic. Biol. Med. 49 2010 1603 1616
42. A.K. Jain, K. Thanki, and S. Jain Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity Mol. Pharm. 10 2013 3459 3474
43. R. Misra, and S.K. Sahoo Coformulation of doxorubicin and curcumin in poly(D,L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells Mol. Pharm. 8 2011 852 866
44. B. Al-Lazikani, U. Banerji, and P. Workman Combinatorial drug therapy for cancer in the post-genomic era Nat. Biotechnol. 30 2012 679 692
45. C.P. Oliveira, C.G. Venturini, B. Donida, F.S. Poletto, I.S. Guterres, and A.R. Pohlmann An algorithm to determine the mechanism of drug distribution in lipid-core nanocapsule formulations Soft Matter 9 2013 1141 1150
46. Y. He, J.C. Li, H. Uyama, S. Kobayashi, and Y. Inoue Hydrogen-bonding interaction and miscibility between poly(epsilon-caprolactone) and enzymatically polymerized novel polyphenols J. Polym. Sci. Part B - Polym. Phys. 39 2001 2898 2905
47. K.C. Yen, T.K. Mandal, and E.M. Woo Enhancement of bio-compatibility via specific interactions in polyesters modified with a bio-resourceful macromolecular ester containing polyphenol groups J. Biomed. Mater. Res. A 86 2008 701 712
48. J. Araújo, S. Nikolic, M.A. Egea, E.B. Souto, and M.L. Garcia Nanostructured lipid carriers for triamcinolone acetonide delivery to the posterior segment of the eye Colloids Surf., B 88 2011 150 157