Effect of novel quercetin pivaloyl ester on functions of adult rat microglia

Biologia (Poland)

Volumn 70, Issue 5, 2015, Pages 690-702

  Kuniaková, Marcela ^a   Mrvová, Nataša ^b   Knezl, Vladimír ^b   Račková, Lucia ^b  

^a Faculty of Medicine of Comenius University and University Hospital Bratislava   (Slovakia)

^b INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

Author keywords

activation; ageing; flavonoids; microglia; neurodegeneration; senescence

Indexed keywords

RATTUS;

EID: 84934277943     PISSN: 00063088     EISSN: 13369563     Source Type: Journal    
DOI: 10.1515/biolog-2015-0082     Document Type: Article

References (37)

1. Acarin L., González B., Castellano B. & Castro A.J. 1997. Quantitative analysis of microglial reaction to a cortical excitotoxic lesion in the early postnatal brain. Exp. Neurol. 147: 410-417.
2. Alliot F., Lecain E., Grima B. & Pessac B. 1991. Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain. Proc. Natl. Acad. Sci. USA 88: 1541-1545.
3. Bournival J., Plouffe M., Renaud J., Provencher C. & Martinoli M.-G. 2012. Quercetin and sesamin protect dopaminergic cells from MPP+-induced neuroinflammation in a microglial (N9)-neuronal (PC12) coculture system. Oxid. Med. Cell. Longev. 2012: 921941.
4. Carson M.J., Reilly C.R., Sutcliffe J.G. & Lo D. 1998. Mature microglia resemble immature antigen-presenting cells. Glia 22: 72-85.
5. Chakraborty J., Singh R., Dutta D., Naskar A., Rajamma U. & Mohanakumar K.P. 2014. Quercetin improves behavioral deficiencies, restores astrocytes and microglia, and reduces serotonin metabolism in 3-nitropropionic acid-induced rat model of Huntington's disease. CNS Neurosci. Ther. 20: 10-19.
6. de Freitas V., da Silva Porto P., Assuncao M., Cadete-Leite A., Andrade J.P. & Paula-Barbosa M.M. 2004. Flavonoids from grape seeds prevent increased alcohol-induced neuronal lipofuscin formation. Alcohol Alcohol. 39: 303-311.
7. Flanary B.E. & StreitW.J. 2004. Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes. Glia 45: 75-88.
8. Gieche J., Mehlhase J., Licht A., Zacke T., Sitte N. & Grune T. 2001. Protein oxidation and proteolysis in RAW264.7 macrophages: effects of PMA activation. Biochim. Biophys. Acta 1538: 321-328.
9. Giulian D. & Baker T.J. 1986. Characterisation of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6: 2163-2178.
10. Jang S. & Johnson R.W. 2010. Can consuming flavonoids restore old microglia to their youthful state? Nutr. Rev. 68: 719-728.
11. Kang C.H., Choi Y.H., Moon S.K., Kim W.J. & Kim G.Y. 2013. Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-?B pathway and activating the Nrf2-dependent HO-1 pathway. Int. Immunopharmacol. 17: 808-813.
12. Kao T.K., Ou Y.C., Raung S.L., Lai C.Y., Liao S.L. & Chen C.J. 2010. Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia. Life Sci. 86: 315-321.
13. Karuppagounder S.S., Madathil S.K., Pandey M., Haobam R., Rajamma U. & Mohanakumar K.P. 2013. Quercetin upregulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats. Neuroscience 236: 136-148.
14. Kelsey N.A.,Wilkins H.M. & Linseman D.A. 2010. Nutraceutical antioxidants as novel neuroprotective agents. Molecules 15: 7792-7814.
15. Kumar S. & Pandey A.K. 2013. Chemistry and biological activities of flavonoids: an overview. ScientificWorld Journal 2013: 162750.
16. Lovelace M.D. & Cahill D.M. 2007. A rapid cell counting method utilising acridine orange as a novel discriminating marker for both cultured astrocytes and microglia. J. Neurosci. Methods 165: 223-229.
17. Luo X.G., Ding J.Q. & Chen S.D. 2010. Microglia in the aging brain: relevance to neurodegeneration. Mol. Neurodegener. 5: 12.
18. Maeba R., Shimasaki H., Ueta N. & Inoue K. 1990. Accumulation of ceroid-like pigments in macrophages cultured with phosphatidylcholine liposomes in vitro. Biochim. Biophys. Acta 1042: 287-293.
19. Milackova I., Rackova L., Majekova M., Mrvova N. & Stefek M. 2015. Protection or cytotoxicity mediated by a novel quinonoid-polyphenol compound? Gen. Physiol. Biophys. 34: 51-64.
20. Moussaud S. & Draheim H.J. 2010. A new method to isolate microglia from adult mice and culture them for an extended period of time. J. Neurosci. Methods 187: 243-253.
21. Oda K., Ogata S., Koriyama Y., Yamada E., Mifune K. & Ikehara Y. 1988. Tris inhibits both proteolytic and oligosaccharide processing occurring in the Golgi complex in primary cultured rat hepatocytes. J. Biol. Chem. 263: 12576-12583.
22. Persson H.L., Yu Z., Tirosh O., Eaton J.W. & Brunk U.T. 2003. Prevention of oxidant-induced cell death by lysosomotropic iron chelators. Free Radic. Biol. Med. 34: 1295-1305.
23. Pietsch K., Saul N., Chakrabarti S., Sturzenbaum S.R., Menzel R. & Steinberg C.E. 2011. Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid-and rosmarinic acid-mediated life extension in C. elegans. Biogerontology 12: 329-347.
24. Poole C.A., Reilly H.C. & Flint M.H. 1982. The adverse effects of HEPES, TES, and BES zwitterion buffers on the ultrastructure of cultured chick embryo epiphyseal chondrocytes. In Vitro 18: 755-765.
25. Rook G.A., Steele J., Umar S. & Dockrell H.M. 1985. A simple method for the solubilisation of reduced NBT, and its use as a colorimetric assay for activation of human macrophages by gamma-interferon. J. Immunol. Methods 82: 161-167.
26. Santambrogio L., Belyanskaya S.L., Fischer F.R., Cipriani B., Brosnan C.F., Ricciardi-Castagnoli P., Stern L.J., Strominger J.L. & Riese R. 2001. Developmental plasticity of CNS microglia. Proc. Natl. Acad. Sci. USA 98: 6295-6300.
27. Stolzing A., Widmer R., Jung T., Voss P. & Grune T. 2006. Tocopherol-mediated modulation of age-related changes in microglial cells: turnover of extracellular oxidized protein material. Free Radic. Biol. Med. 40: 2126-2135.
28. Streit W.J. 1990. An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4). J. Histochem. Cytochem. 38: 1683-1686.
29. Streit W.J. & Xue Q.S. 2010. The brain's aging immune system. Aging Dis. 1: 254-261.
30. Sundelin S.P. & Terman A. 2002. Different effects of chloroquine and hydroxychloroquine on lysosomal function in cultured retinal pigment epithelial cells. APMIS 110: 481-489.
31. Tsikas D. 2007. Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the L-arginine/nitric oxide area of research. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 851: 51-70.
32. Ulker S., McKeown P.P. & Bayraktutan U. 2003. Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities. Hypertension 41: 534-539.
33. Veverka M., Gallovic J., Svajdlenka E., Veverkova E., Pronayova N., Milackova I. & Stefek M. 2013. Novel quercetin derivatives: synthesis and screening for antioxidant activity and aldose reductase inhibition. Chem. Papers 67: 76-83.
34. von Bernhardi R., Ramírez G., Toro R. & Eugenín J. 2007. Proinflammatory conditions promote neuronal damage mediated by amyloid precursor protein and decrease its phagocytosis and degradation by microglial cells in culture. Neurobiol. Dis. 26: 153-164.
35. von Bernhardi R., Tichauer J. & Eugenín-von Bernhardi L. 2011. Proliferating culture of aged microglia for the study of neurodegenerative diseases. J. Neurosci. Methods 202: 65-69.
36. Wong W.T. 2013. Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation. Front. Cell Neurosci. 7: 22.
37. Zizková P., Bla͉kovi? D., Májeková M., ͈vorc L., Ra?ková L., Ratkovská L., Veverka M. & Horáková L. 2014. Novel quercetin derivatives in treatment of peroxynitrite-oxidized SERCA1. Mol. Cell. Biochem. 386: 1-14.