Self-processing and the default mode network: Interactions with the mirror neuron system

Frontiers in Human Neuroscience

Volumn , Issue SEP, 2013, Pages

  Molnar Szakacs, Istvan ^a,b   Uddin, Lucina Q ^c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d University of Miami   (United States)

Author keywords

Autobiographical memory; Embodiment; Functional connectivity; Medial prefrontal cortex; Mentalizing; Posterior cingulate cortex

Indexed keywords

EID: 84933676748     PISSN: 16625161     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnhum.2013.00571     Document Type: Review

References (150)

1. Addis, D. R., Wong, A. T., and Schacter, D. L. (2007). Remembering the past and imagining the future: common and distinct neural substrates during event construction and elaboration. Neuropsychologia 45, 1363-1377. doi:10.1016/j.neuropsychologia.2006.10.016
2. Andrews-Hanna, J. R., Reidler, J. S., Sepulcre, J., Poulin, R., and Buckner, R. L. (2010). Functional-anatomic fractionation of the brain's default network. Neuron 65, 550-562. doi:10.1016/j.neuron.2010.02.005
3. Arzy, S., Molnar-Szakacs, I., and Blanke, O. (2008). Self in time: imagined self-location influences neural activity related to mental time travel. J. Neurosci. 28, 6502-6507. doi:10.1523/JNEUROSCI.5712-07.2008
4. Arzy, S., Thut, G., Mohr, C., Michel, C. M., and Blanke, O. (2006). Neural basis of embodiment: distinct contributions of temporoparietal junction and extrastriate body area. J. Neurosci. 26, 8074-8081. doi:10.1523/JNEUROSCI.0745-06.2006
5. Barsalou, L. W. (1999). Perceptual symbol systems. Behav. Brain Sci. 22, 577-609; discussion 610-560. doi:10.1017/S0140525X99002149
6. Barsalou, L. W. (2008). Grounded cognition. Annu. Rev. Psychol. 59, 617-645. doi:10.1146/annurev.psych.59.103006.093639
7. Beer, J. S. (2007). The default self: feeling good or being right? Trends Cogn. Sci. (Regul. Ed.) 11, 187-189. doi:10.1016/j.tics.2007.02.004
8. Biswal, B., Yetkin, F. Z., Haughton, V. M., and Hyde, J. S. (1995). Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn. Reson. Med. 34, 537-541. doi:10.1002/mrm.1910340409
9. Blakemore, S. J., Bristow, D., Bird, G., Frith, C., and Ward, J. (2005). Somatosensory activations during the observation of touch and a case of vision-touch synaesthesia. Brain 128(Pt 7), 1571-1583. doi:10.1093/brain/awh500
10. Blanke, O., Mohr, C., Michel, C. M., Pascual-Leone, A., Brugger, P., Seeck, M., et al. (2005). Linking out-of-body experience and self processing to mental own-body imagery at the temporoparietal junction. J. Neurosci. 25, 550-557. doi:10.1523/JNEUROSCI.2612-04.2005
11. Buckner, R. L., Andrews-Hanna, J. R., and Schacter, D. L. (2008). The brain's default network: anatomy, function, and relevance to disease. Ann. N. Y. Acad. Sci. 1124, 1-38. doi:10.1196/annals.1440.011
12. Buckner, R. L., and Carroll, D. C. (2007). Self-projection and the brain. Trends Cogn. Sci. (Regul. Ed.) 11, 49-57. doi:10.1016/j.tics.2006.11.004
13. Carr, L., Iacoboni, M., Dubeau, M. C., Mazziotta, J. C., and Lenzi, G. L. (2003). Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc. Natl. Acad. Sci. U.S.A. 100, 5497-5502. doi:10.1073/pnas.0935845100
14. Cavanna, A. E., and Trimble, M. R. (2006). The precuneus: a review of its functional anatomy and behavioural correlates. Brain 129(Pt 3), 564-583. doi:10.1093/brain/awl004
15. Cherkassky, V. L., Kana, R. K., Keller, T. A., and Just, M. A. (2006). Functional connectivity in a baseline resting-state network in autism. Neuroreport 17, 1687-1690. doi:10.1097/01.wnr.0000239956.45448.4c
16. Cole, D. M., Smith, S. M., and Beckmann, C. F. (2010). Advances and pitfalls in the analysis and interpretation of resting-state FMRI data. Front. Syst. Neurosci. 4:8. doi:10.3389/fnsys.2010.00008
17. Craig, A. D. (2003). Interoception: the sense of the physiological condition of the body. Curr. Opin. Neurobiol. 13, 500-505. doi:10.1016/S0959-4388(03)00090-4
18. Craik, F. I. M., Moroz, T. M., Moscovitch, M., Stuss, D. T., Winocur, G., Tulving, E., et al. (1999). In search of the self: a positron emission tomography study. Psychol. Sci. 10, 26-34. doi:10.1111/1467-9280.00102
19. Critchley, H. D., and Harrison, N. A. (2013). Visceral influences on brain and behavior. Neuron 77, 624-638. doi:10.1016/j.neuron.2013.02.008
20. D'Argembeau, A., Collette, F., van der Linden, M., Laureys, S., Del Fiore, G., Degueldre, C., et al. (2005). Self-referential reflective activity and its relationship with rest: a PET study. Neuroimage 25, 616-624. doi:10.1016/j.neuroimage.2004.11.048
21. de Waal, F. B. M. (2008). Putting the altruism back into altruism: the evolution of empathy. Annu. Rev. Psychol. 59, 279-300. doi:10.1146/annurev.psych.59.103006.093625
22. Decety, J., and Jackson, P. L. (2004). The functional architecture of human empathy. Behav. Cogn. Neurosci. Rev. 3, 71-100. doi:10.1177/1534582304267187
23. Denny, B. T., Kober, H., Wager, T. D., and Ochsner, K. N. (2012). A meta-analysis of functional neuroimaging studies of self-and other judgments reveals a spatial gradient for mentalizing in medial prefrontal cortex. J. Cogn. Neurosci. 24, 1742-1752. doi:10.1162/jocn_a_00233
24. Devue, C., and Bredart, S. (2011). The neural correlates of visual self-recognition. Conscious. Cogn. 20, 40-51. doi:10.1016/j.concog.2010.09.007
25. Donaldson, D. I., Petersen, S. E., and Buckner, R. L. (2001). Dissociating memory retrieval processes using fMRI: evidence that priming does not support recognition memory. Neuron 31, 1047-1059. doi:10.1016/S0896-6273(01)00429-9
26. Enticott, P. G., Kennedy, H. A., Rinehart, N. J., Tonge, B. J., Bradshaw, J. L., Taffe, J. R., et al. (2012). Mirror neuron activity associated with social impairments but not age in autism spectrum disorder. Biol. Psychiatry 71, 427-433. doi:10.1016/j.biopsych.2011.09.001
27. Enzi, B., de Greck, M., Prosch, U., Tempelmann, C., and Northoff, G. (2009). Is our self nothing but reward? Neuronal overlap and distinction between reward and personal relevance and its relation to human personality. PLoS ONE 4:e8429. doi:10.1371/journal.pone.0008429
28. Faust, M., Kravetz, S., and Nativ-Safrai, O. (2004). The representation of aspects of the self in the two cerebral hemispheres. Pers. Individ. Dif. 37, 607-619. doi:10.1016/j.paid.2003.09.030
29. Feyers, D., Collette, F., D'Argembeau, A., Majerus, S., and Salmon, E. (2010). Neural networks involved in self-judgement in young and elderly adults. Neuroimage 53, 341-347. doi:10.1016/j.neuroimage.2010.05.071
30. Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., van Essen, D. C., and Raichle, M. E. (2005). The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc. Natl. Acad. Sci. U.S.A. 102, 9673-9678. doi:10.1073/pnas.0504136102
31. Fransson, P. (2006). How default is the default mode of brain function? Further evidence from intrinsic BOLD signal fluctuations. Neuropsychologia 44, 2836-2845. doi:10.1016/j.neuropsychologia.2006.06.017
32. Friston, K. (1994). Functional and effective connectivity in neuroimaging: a synthesis. Hum. Brain Mapp. 2, 56-78. doi:10.1002/hbm.460020107
33. Gallese, V. (2005). ""Being like me": self-other identity, mirror neurons, and empathy, " in Perspectives on Imitation: Mechanisms of Imitation and Imitation in Animals, Vol. 2, eds S. Hurley and N. Chater (Cambridge, MA: MIT Press), 101-118.
34. Gallese, V., and Goldman, A. (1998). Mirror neurons and the simulation theory of mind-reading. Trends Cogn. Sci. (Regul. Ed.) 2, 493-501. doi:10.1016/S1364-6613(98)01262-5
35. Gallotti, M., and Frith, C. D. (2013). Social cognition in the we-mode. Trends Cogn. Sci. (Regul. Ed.) 17, 160-165. doi:10.1016/j.tics.2013.02.002
36. Gandhi, M. K. (1955). My Religion. Ahmedabad: Navajivan Publishing House.
37. Garrity, A. G., Pearlson, G. D., McKiernan, K., Lloyd, D., Kiehl, K. A., and Calhoun, V. D. (2007). Aberrant "default mode" functional connectivity in schizophrenia. Am. J. Psychiatry 164, 450-457. doi:10.1176/appi.ajp.164.3.450
38. Gazzola, V., Aziz-Zadeh, L., and Keysers, C. (2006). Empathy and the somatotopic auditory mirror system in humans. Curr. Biol. 16, 1824-1829. doi:10.1016/j.cub.2006.07.072
39. Gazzola, V., Rizzolatti, G., Wicker, B., and Keysers, C. (2007). The anthropomorphic brain: the mirror neuron system responds to human and robotic actions. Neuroimage 35, 1674-1684. doi:10.1016/j.neuroimage.2007.02.003
40. Gilboa, A. (2004). Autobiographical and episodic memory-one and the same? Evidence from prefrontal activation in neuroimaging studies. Neuropsychologia 42, 1336-1349. doi:10.1016/j.neuropsychologia.2004.02.014
41. Gillihan, S. J., and Farah, M. J. (2005). Is self special? A critical review of evidence from experimental psychology and cognitive neuroscience. Psychol. Bull. 131, 76-97. doi:10.1037/0033-2909.131.1.76
42. Goldberg, I., Ullman, S., and Malach, R. (2008). Neuronal correlates of "free will" are associated with regional specialization in the human intrinsic/default network. Conscious. Cogn. 17, 587-601. doi:10.1016/j.concog.2007.10.003
43. Goldman, A., and de Vignemont, F. (2009). Is social cognition embodied? Trends Cogn. Sci. (Regul. Ed.) 13, 154-159. doi:10.1016/j.tics.2009.01.007
44. Goldman, A. I. (2006). Simulating Minds: The Philosophy, Psychology, and Neuroscience of Mindreading. New York: Oxford University Press.
45. Goleman, D. (2006). Social Intelligence: The New Science of Human Relationships. New York: Random House.
46. Golland, Y., Golland, P., Bentin, S., and Malach, R. (2008). Data-driven clustering reveals a fundamental subdivision of the human cortex into two global systems. Neuropsychologia 46, 540-553. doi:10.1016/j.neuropsychologia.2007.10.003
47. Gopnik, A., and Wellman, H. M. (1992). Why the child's theory of mind really is a theory. Mind Lang. 7, 145-171. doi:10.1111/j.1468-0017.1992.tb00202.x
48. Gordon, R. M. (1986). Folk psychology as simulation. Mind Lang. 1, 158-171. doi:10.1111/j.1468-0017.1986.tb00324.x
49. Gordon, R. M. (1992). The simulation theory: objections and misconceptions. Mind Lang. 7, 11-34. doi:10.1111/j.1468-0017.1992.tb00195.x
50. Greicius, M. D., Krasnow, B., Reiss, A. L., and Menon, V. (2003). Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc. Natl. Acad. Sci. U.S.A. 100, 253-258. doi:10.1073/pnas.0135058100
51. Greicius, M. D., and Menon, V. (2004). Default-mode activity during a passive sensory task: uncoupled from deactivation but impacting activation. J. Cogn. Neurosci. 16, 1484-1492. doi:10.1162/0898929042568532
52. Gusnard, D. A., Akbudak, E., Shulman, G. L., and Raichle, M. E. (2001). Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc. Natl. Acad. Sci. U.S.A. 98, 4259-4264. doi:10.1073/pnas.071043098
53. Gusnard, D. A., and Raichle, M. E. (2001). Searching for a baseline: functional imaging and the resting human brain. Nat. Rev. Neurosci. 2, 685-694. doi:10.1038/35094500
54. Harrison, B. J., Pujol, J., Lopez-Sola, M., Hernandez-Ribas, R., Deus, J., Ortiz, H., et al. (2008). Consistency and functional specialization in the default mode brain network. Proc. Natl. Acad. Sci. U.S.A. 105, 9781-9786. doi:10.1073/pnas.0711791105
55. Hooker, C. I., Verosky, S. C., Germine, L. T., Knight, R. T., and D'Esposito, M. (2008). Mentalizing about emotion and its relationship to empathy. Soc. Cogn. Affect. Neurosci. 3, 204-217. doi:10.1093/scan/nsn019
56. Iacoboni, M. (2009). Imitation, empathy, and mirror neurons. Annu. Rev. Psychol. 60, 653-670. doi:10.1146/annurev.psych.60.110707.163604
57. Iacoboni, M., and Dapretto, M. (2006). The mirror neuron system and the consequences of its dysfunction. Nat. Rev. Neurosci. 7, 942-951. doi:10.1038/nrn2024
58. Iacoboni, M., Koski, L. M., Brass, M., Bekkering, H., Woods, R. P., Dubeau, M. C., et al. (2001). Reafferent copies of imitated actions in the right superior temporal cortex. Proc. Natl. Acad. Sci. U.S.A. 98, 13995-13999. doi:10.1073/pnas.241474598
59. Iacoboni, M., Lieberman, M. D., Knowlton, B. J., Molnar-Szakacs, I., Moritz, M., Throop, C. J., et al. (2004). Watching social interactions produces dorsomedial prefrontal and medial parietal BOLD fMRI signal increases compared to a resting baseline. Neuroimage 21, 1167-1173. doi:10.1016/j.neuroimage.2003.11.013
60. Ingvar, D. H. (1985). "Memory of the future": an essay on the temporal organization of conscious awareness. Hum. Neurobiol. 4, 127-136.
61. Jackson, P. L., Brunet, E., Meltzoff, A. N., and Decety, J. (2006). Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain. Neuropsychologia 44, 752-761. doi:10.1016/j.neuropsychologia.2005.07.015
62. Johnson, S. C., Baxter, L. C., Wilder, L. S., Pipe, J. G., Heiserman, J. E., and Prigatano, G. P. (2002). Neural correlates of self-reflection. Brain 125(Pt 8), 1808-1814. doi:10.1093/brain/awf181
63. Kaplan, J. T., Aziz-Zadeh, L., Uddin, L. Q., and Iacoboni, M. (2008). The self across the senses: an fMRI study of self-face and self-voice recognition. Soc. Cogn. Affect. Neurosci. 3, 218-223. doi:10.1093/scan/nsn014
64. Keenan, J. P., Freund, S., Hamilton, R. H., Ganis, G., and Pascual-Leone, A. (2000). Hand response differences in a self-face identification task. Neuropsychologia 38, 1047-1053. doi:10.1016/S0028-3932(99)00145-1
65. Keenan, J. P., Nelson, A., O'Connor, M., and Pascual-Leone, A. (2001). Self-recognition and the right hemisphere. Nature 409, 305. doi:10.1038/35053167
66. Kelley, W. M., Macrae, C. N., Wyland, C. L., Caglar, S., Inati, S., and Heatherton, T. F. (2002). Finding the self? An event-related fMRI study. J. Cogn. Neurosci. 14, 785-794. doi:10.1162/08989290260138672
67. Keysers, C., and Gazzola, V. (2007). Integrating simulation and theory of mind: from self to social cognition. Trends Cogn. Sci. (Regul. Ed.) 11, 194-196. doi:10.1016/j.tics.2007.02.002
68. Keysers, C., Wicker, B., Gazzola, V., Anton, J. L., Fogassi, L., and Gallese, V. (2004). A touching sight: SII/PV activation during the observation and experience of touch. Neuron 42, 335-346. doi:10.1016/S0896-6273(04)00156-4
69. Kim, H. (2012). A dual-subsystem model of the brain's default network: self-referential processing, memory retrieval processes, and autobiographical memory retrieval. Neuroimage 61, 966-977. doi:10.1016/j.neuroimage.2012.03.025
70. Kircher, T. T., Senior, C., Phillips, M. L., Rabe-Hesketh, S., Benson, P. J., Bullmore, E. T., et al. (2001). Recognizing one's own face. Cognition 78, B1-B15. doi:10.1016/S0010-0277(00)00104-9
71. Kjaer, T. W., Nowak, M., and Lou, H. C. (2002). Reflective self-awareness and conscious states: PET evidence for a common midline parietofrontal core. Neuroimage 17, 1080-1086. doi:10.1006/nimg.2002.1230
72. Klein, S. B., Cosmides, L., Costabile, K. A., and Mei, L. (2002). Is there something special about the self? A neuropsychological case study. J. Res. Pers. 36, 490-506. doi:10.1016/S0092-6566(02)00001-6
73. Leech, R., Kamourieh, S., Beckmann, C. F., and Sharp, D. J. (2011). Fractionating the default mode network: distinct contributions of the ventral and dorsal posterior cingulate cortex to cognitive control. J. Neurosci. 31, 3217-3224. doi:10.1523/JNEUROSCI.5626-10.2011
74. Legrand, D., and Ruby, P. (2009). What is self-specific? Theoretical investigation and critical review of neuroimaging results. Psychol. Rev. 116, 252-282. doi:10.1037/a0014172
75. Lieberman, M. D. (2007). Social cognitive neuroscience: a review of core processes. Annu. Rev. Psychol. 58, 259-289. doi:10.1146/annurev.psych.58.110405.085654
76. Lombardo, M. V., Chakrabarti, B., Bullmore, E. T., Wheelwright, S. J., Sadek, S. A., Suckling, J., et al. (2010). Shared neural circuits for mentalizing about the self and others. J. Cogn. Neurosci. 22, 1623-1635. doi:10.1162/jocn.2009.21287
77. Lou, H. C., Luber, B., Crupain, M., Keenan, J. P., Nowak, M., Kjaer, T. W., et al. (2004). Parietal cortex and representation of the mental self. Proc. Natl. Acad. Sci. U.S.A. 101, 6827-6832. doi:10.1073/pnas.0400049101
78. Macrae, C. N., Moran, J. M., Heatherton, T. F., Banfield, J. F., and Kelley, W. M. (2004). Medial prefrontal activity predicts memory for self. Cereb. Cortex 14, 647-654. doi:10.1093/cercor/bhh025
79. Margulies, D. S., Vincent, J. L., Kelly, C., Lohmann, G., Uddin, L. Q., Biswal, B. B., et al. (2009). Precuneus shares intrinsic functional architecture in humans and monkeys. Proc. Natl. Acad. Sci. U.S.A. 106, 20069-20074. doi:10.1073/pnas.0905314106
80. Markus, H. (1977). Self-schemata and processing information about the self. J. Pers. Soc. Psychol. 35, 63-78. doi:10.1037/0022-3514.35.2.63
81. Mason, M. F., Norton, M. I., van Horn, J. D., Wegner, D. M., Grafton, S. T., and Macrae, C. N. (2007). Wandering minds: the default network and stimulus-independent thought. Science 315, 393-395. doi:10.1126/science.1131295
82. McKiernan, K. A., D'Angelo, B. R., Kaufman, J. N., and Binder, J. R. (2006). Interrupting the "stream of consciousness": an fMRI investigation. Neuroimage 29, 1185-1191. doi:10.1016/j.neuroimage.2005.09.030
83. McKiernan, K. A., Kaufman, J. N., Kucera-Thompson, J., and Binder, J. R. (2003). A parametric manipulation of factors affecting task-induced deactivation in functional neuroimaging. J. Cogn. Neurosci. 15, 394-408. doi:10.1162/089892903321593117
84. Mehta, U. M., Basavaraju, R., Thirthalli, J., and Gangadhar, B. N. (2012). Mirror neuron dysfunction-a neuro-marker for social cognition deficits in drug naive schizophrenia. Schizophr. Res. 141, 281-283. doi:10.1016/j.schres.2012.07.005
85. Meltzoff, A., and Brooks, R. (2001). ""Like me" as a building block for understanding other minds: bodily acts, attention and intention, " in Intentions and Intentionality: Foundations of Social Cognition, eds B. Malle, L. Moses, and D. Baldwin (Cambridge: MIT Press), 171-191.
86. Menon, V., and Uddin, L. Q. (2010). Saliency, switching, attention and control: a network model of insula function. Brain Struct. Funct. 214, 655-667. doi:10.1007/s00429-010-0262-0
87. Miall, R. C., and Robertson, E. M. (2006). Functional imaging: is the resting brain resting? Curr. Biol. 16, R998-R1000. doi:10.1016/j.cub.2006.10.041
88. Mitchell, J. P., Macrae, C. N., and Banaji, M. R. (2006). Dissociable medial prefrontal contributions to judgments of similar and dissimilar others. Neuron 50, 655-663. doi:10.1016/j.neuron.2006.03.040
89. Modinos, G., Ormel, J., and Aleman, A. (2009). Activation of anterior insula during self-reflection. PLoS ONE 4:e4618. doi:10.1371/journal.pone.0004618
90. Molnar-Szakacs, I. (2011). From actions to empathy and morality-a neural perspective. J. Econ. Behav. Organ. 77, 76-85. doi:10.1016/j.jebo.2010.02.019
91. Molnar-Szakacs, I., and Arzy, S. (2009). Searching for an integrated self-representation. Commun. Integr. Biol. 2, 365-367. doi:10.4161/cib.2.4.8290
92. Molnar-Szakacs, I., Iacoboni, M., Koski, L., and Mazziotta, J. C. (2005a). Functional segregation within pars opercularis of the inferior frontal gyrus: evidence from fMRI studies of imitation and action observation. Cereb. Cortex 15, 986-994. doi:10.1093/cercor/bhh199
93. Molnar-Szakacs, I., Uddin, L. Q., and Iacoboni, M. (2005b). Right-hemisphere motor facilitation by self-descriptive personality-trait words. Eur. J. Neurosci. 21, 2000-2006. doi:10.1111/j.1460-9568.2005.04019.x
94. Molnar-Szakacs, I., Kaplan, J., Greenfield, P. M., and Iacoboni, M. (2006). Observing complex action sequences: the role of the fronto-parietal mirror neuron system. Neuroimage 33, 923-935. doi:10.1016/j.neuroimage.2006.07.035
95. Molnar-Szakacs, I., and Uddin, L. Q. (2012). "The emergent self: how distributed neural networks support self-representation, " in Handbook of Neurosociology, Handbooks of Sociology and Social Research, eds D. D. Franks and J. H. Turner (New York: Springer), 167-182.
96. Molnar-Szakacs, I., Wang, M. J., Laugeson, E. A., Overy, K., Wu, W. L., and Piggot, J. (2009). Autism, emotion recognition and the mirror neuron system: the case of music. Mcgill J. Med. 12, 87.
97. Moran, J. M., Heatherton, T. F., and Kelley, W. M. (2009). Modulation of cortical midline structures by implicit and explicit self-relevance evaluation. Soc. Neurosci. 4, 197-211. doi:10.1080/17470910802250519
98. Moran, J. M., Kelley, W. M., and Heatherton, T. F. (2013). What can the organization of the brain's default mode network tell us about self-knowledge? Front. Hum. Neurosci. 7:391. doi:10.3389/fnhum.2013.00391
99. Moran, J. M., Macrae, C. N., Heatherton, T. F., Wyland, C. L., and Kelley, W. M. (2006). Neuroanatomical evidence for distinct cognitive and affective components of self. J. Cogn. Neurosci. 18, 1586-1594. doi:10.1162/jocn.2006.18.9.1586
100. Nanetti, L., Cerliani, L., Gazzola, V., Renken, R., and Keysers, C. (2009). Group analyses of connectivity-based cortical parcellation using repeated k-means clustering. Neuroimage 47, 1666-1677. doi:10.1016/j.neuroimage.2009.06.014
101. Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., and Panksepp, J. (2006). Self-referential processing in our brain-a meta-analysis of imaging studies on the self. Neuroimage 31, 440-457. doi:10.1016/j.neuroimage.2005.12.002
102. Paulus, F. M., Muller-Pinzler, L., Westermann, S., and Krach, S. (2013). On the distinction of empathic and vicarious emotions. Front. Hum. Neurosci. 7:196. doi:10.3389/fnhum.2013.00196
103. Pfeifer, J. H., Lieberman, M. D., and Dapretto, M. (2007). "I know you are but what am I?!": neural bases of self-and social knowledge retrieval in children and adults. J. Cogn. Neurosci. 19, 1323-1337. doi:10.1162/jocn.2007.19.8.1323
104. Platek, S. M., Keenan, J. P., Gallup, G. G. Jr., and Mohamed, F. B. (2004). Where am I? The neurological correlates of self and other. Brain Res. Cogn. Brain Res. 19, 114-122. doi:10.1016/j.cogbrainres.2003.11.014
105. Platek, S. M., and Kemp, S. M. (2009). Is family special to the brain? An event-related fMRI study of familiar, familial, and self-face recognition. Neuropsychologia 47, 849-858. doi:10.1016/j.neuropsychologia.2008.12.027
106. Platek, S. M., Loughead, J. W., Gur, R. C., Busch, S., Ruparel, K., Phend, N., et al. (2006). Neural substrates for functionally discriminating self-face from personally familiar faces. Hum. Brain Mapp. 27, 91-98. doi:10.1002/hbm.20168
107. Platek, S. M., Wathne, K., Tierney, N. G., and Thomson, J. W. (2008). Neural correlates of self-face recognition: an effect-location meta-analysis. Brain Res. 1232, 173-184. doi:10.1016/j.brainres.2008.07.010
108. Preston, S. D., and de Waal, F. B. (2002). Empathy: its ultimate and proximate bases. Behav. Brain Sci. 25, 1-20; discussion 20-71.
109. Qin, P., and Northoff, G. (2011). How is our self related to midline regions and the default-mode network? Neuroimage 57, 1221-1233. doi:10.1016/j.neuroimage.2011.05.028
110. Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., and Shulman, G. L. (2001). A default mode of brain function. Proc. Natl. Acad. Sci. U.S.A. 98, 676-682. doi:10.1073/pnas.98.2.676
111. Rizzolatti, G., Fadiga, L., Gallese, V., and Fogassi, L. (1996). Premotor cortex and the recognition of motor actions. Brain Res. Cogn. Brain Res. 3, 131-141. doi:10.1016/0926-6410(95)00038-0
112. Rizzolatti, G., and Sinigaglia, C. (2010). The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations. Nat. Rev. Neurosci. 11, 264-274. doi:10.1038/nrn2805
113. Rogers, T. B., Kuiper, N. A., and Kirker, W. S. (1977). Self-reference and the encoding of personal information. J. Pers. Soc. Psychol. 35, 677-688. doi:10.1037/0022-3514.35.9.677
114. Ruby, P., and Decety, J. (2001). Effect of subjective perspective taking during simulation of action: a PET investigation of agency. Nat. Neurosci. 4, 546-550.
115. Sajonz, B., Kahnt, T., Margulies, D. S., Park, S. Q., Wittmann, A., Stoy, M., et al. (2010). Delineating self-referential processing from episodic memory retrieval: common and dissociable networks. Neuroimage 50, 1606-1617. doi:10.1016/j.neuroimage.2010.01.087
116. Salomon, R., Levy, D. R., and Malach, R. (2013). Deconstructing the default: cortical subdivision of the default mode/intrinsic system during self-related processing. Hum. Brain Mapp. doi:10.1002/hbm.22268
117. Sandrone, S. (2013). Self through the mirror (neurons) and default mode network: what neuroscientists found and what can still be found there. Front. Hum. Neurosci. 7:383. doi:10.3389/fnhum.2013.00383
118. Saxe, R. (2006). Uniquely human social cognition. Curr. Opin. Neurobiol. 16, 235-239. doi:10.1016/j.conb.2006.03.001
119. Saxe, R., Moran, J. M., Scholz, J., and Gabrieli, J. (2006). Overlapping and non-overlapping brain regions for theory of mind and self reflection in individual subjects. Soc. Cogn. Affect. Neurosci. 1, 229-234. doi:10.1093/scan/nsl034
120. Schacter, D. L., Addis, D. R., and Buckner, R. L. (2007). Remembering the past to imagine the future: the prospective brain. Nat. Rev. Neurosci. 8, 657-661. doi:10.1038/nrn2213
121. Schacter, D. L., Addis, D. R., and Buckner, R. L. (2008). Episodic simulation of future events: concepts, data, and applications. Ann. N. Y. Acad. Sci. 1124, 39-60. doi:10.1196/annals.1440.001
122. Schippers, M. B., and Keysers, C. (2011). Mapping the flow of information within the putative mirror neuron system during gesture observation. Neuroimage 57, 37-44. doi:10.1016/j.neuroimage.2011.02.018
123. Schippers, M. B., Roebroeck, A., Renken, R., Nanetti, L., and Keysers, C. (2010). Mapping the information flow from one brain to another during gestural communication. Proc. Natl. Acad. Sci. U.S.A. 107, 9388-9393. doi:10.1073/pnas.1001791107
124. Schneider, F., Bermpohl, F., Heinzel, A., Rotte, M., Walter, M., Tempelmann, C., et al. (2008). The resting brain and our self: self-relatedness modulates resting state neural activity in cortical midline structures. Neuroscience 157, 120-131. doi:10.1016/j.neuroscience.2008.08.014
125. Sestieri, C., Corbetta, M., Romani, G. L., and Shulman, G. L. (2011). Episodic memory retrieval, parietal cortex, and the default mode network: functional and topographic analyses. J. Neurosci. 31, 4407-4420. doi:10.1523/JNEUROSCI.3335-10.2011
126. Shamay-Tsoory, S. G., Tomer, R., Goldsher, D., Berger, B. D., and Aharon-Peretz, J. (2004). Impairment in cognitive and affective empathy in patients with brain lesions: anatomical and cognitive correlates. J. Clin. Exp. Neuropsychol. 26, 1113-1127. doi:10.1080/13803390490515531
127. Shulman, G. L., Corbetta, M., Fiez, J. A., Buckner, R. L., Miezin, F. M., Raichle, M. E., et al. (1997). Searching for activations that generalize over tasks. Hum. Brain Mapp. 5, 317-322. doi:10.1002/(SICI)1097-0193(1997)5:4
128. Singer, T. (2006). The neuronal basis and ontogeny of empathy and mind reading: review of literature and implications for future research. Neurosci. Biobehav. Rev. 30, 855-863. doi:10.1016/j.neubiorev.2006.06.011
129. Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., and Frith, C. D. (2004). Empathy for pain involves the affective but not sensory components of pain. Science 303, 1157-1162. doi:10.1126/science.1093535
130. Spreng, R. N., and Grady, C. L. (2009). Patterns of brain activity supporting autobiographical memory, prospection, and theory-of-mind and their relationship to the default mode network. J. Cogn. Neurosci. 22, 1112-1123. doi:10.1162/jocn.2009.21282
131. Spreng, R. N., Mar, R. A., and Kim, A. S. (2009). The common neural basis of autobiographical memory, prospection, navigation, theory of mind, and the default mode: a quantitative meta-analysis. J. Cogn. Neurosci. 21, 489-510. doi:10.1162/jocn.2008.21029
132. Sridharan, D., Levitin, D. J., and Menon, V. (2008). A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. Proc. Natl. Acad. Sci. U.S.A. 105, 12569-12574. doi:10.1073/pnas.0800005105
133. Sugiura, M., Watanabe, J., Maeda, Y., Matsue, Y., Fukuda, H., and Kawashima, R. (2005). Cortical mechanisms of visual self-recognition. Neuroimage 24, 143-149. doi:10.1016/j.neuroimage.2004.07.063
134. Svoboda, E., McKinnon, M. C., and Levine, B. (2006). The functional neuroanatomy of autobiographical memory: a meta-analysis. Neuropsychologia 44, 2189-2208. doi:10.1016/j.neuropsychologia.2006.05.023
135. Symons, C. S., and Johnson, B. T. (1997). The self-reference effect in memory: a meta-analysis. Psychol. Bull. 121, 371-394. doi:10.1037/0033-2909.121.3.371
136. Szpunar, K. K., Watson, J. M., and McDermott, K. B. (2007). Neural substrates of envisioning the future. Proc. Natl. Acad. Sci. U.S.A. 104, 642-647. doi:10.1073/pnas.0610082104
137. Uddin, L. Q. (2011). Brain connectivity and the self: the case of cerebral disconnection. Conscious. Cogn. 20, 94-98. doi:10.1016/j.concog.2010.09.009
138. Uddin, L. Q., Iacoboni, M., Lange, C., and Keenan, J. P. (2007). The self and social cognition: the role of cortical midline structures and mirror neurons. Trends Cogn. Sci. (Regul. Ed.) 11, 153-157. doi:10.1016/j.tics.2007.01.001
139. Uddin, L. Q., Kaplan, J. T., Molnar-Szakacs, I., Zaidel, E., and Iacoboni, M. (2005). Self-face recognition activates a frontoparietal "mirror" network in the right hemisphere: an event-related fMRI study. Neuroimage 25, 926-935. doi:10.1016/j.neuroimage.2004.12.018
140. Uddin, L. Q., Kelly, A. M., Biswal, B. B., Castellanos, F. X., and Milham, M. P. (2009). Functional connectivity of default mode network components: correlation, anticorrelation, and causality. Hum. Brain Mapp. 30, 625-637. doi:10.1002/hbm.20531
141. Uddin, L. Q., Molnar-Szakacs, I., Zaidel, E., and Iacoboni, M. (2006). rTMS to the right inferior parietal lobule disrupts self-other discrimination. Soc. Cogn. Affect. Neurosci. 1, 65-71. doi:10.1093/scan/nsl003
142. van den Heuvel, M. P., and Sporns, O. (2011). Rich-club organization of the human connectome. J. Neurosci. 31, 15775-15786. doi:10.1523/JNEUROSCI.3539-11.2011
143. Vinogradov, S., Luks, T. L., Schulman, B. J., and Simpson, G. V. (2008). Deficit in a neural correlate of reality monitoring in schizophrenia patients. Cereb. Cortex 18, 2532-2539. doi:10.1093/cercor/bhn028
144. Vogeley, K., and Fink, G. R. (2003). Neural correlates of the first-person-perspective. Trends Cogn. Sci. (Regul. Ed.) 7, 38-42. doi:10.1016/S1364-6613(02)00003-7
145. Vollm, B. A., Taylor, A. N., Richardson, P., Corcoran, R., Stirling, J., McKie, S., et al. (2006). Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task. Neuroimage 29, 90-98. doi:10.1016/j.neuroimage.2005.07.022
146. Wagner, D. D., Haxby, J. V., and Heatherton, T. F. (2012). The representation of self and person knowledge in the medial prefrontal cortex. Wiley Interdiscip. Rev. Cogn. Sci. 3, 451-470. doi:10.1002/wcs.1183
147. Weissman, D. H., Roberts, K. C., Visscher, K. M., and Woldorff, M. G. (2006). The neural bases of momentary lapses in attention. Nat. Neurosci. 9, 971-978. doi:10.1038/nn1727
148. Wicker, B., Keysers, C., Plailly, J., Royet, J. P., Gallese, V., and Rizzolatti, G. (2003a). Both of us disgusted in my insula: the common neural basis of seeing and feeling disgust. Neuron 40, 655-664. doi:10.1016/S0896-6273(03)00679-2
149. Wicker, B., Ruby, P., Royet, J. P., and Fonlupt, P. (2003b). A relation between rest and the self in the brain? Brain Res. Brain Res. Rev. 43, 224-230. doi:10.1016/j.brainresrev.2003.08.003
150. Zysset, S., Huber, O., Ferstl, E., and von Cramon, D. Y. (2002). The anterior frontomedian cortex and evaluative judgment: an fMRI study. Neuroimage 15, 983-991. doi:10.1006/nimg.2001.1008