Protective Effect of Spermidine Against Excitotoxic Neuronal Death Induced by Quinolinic Acid in Rats: Possible Neurotransmitters and Neuroinflammatory Mechanism

Neurotoxicity Research

Volumn 28, Issue 2, 2015, Pages 171-184

  Jamwal, Sumit ^a,b   Singh, Shamsher ^a,b   Kaur, Navneet ^a   Kumar, Puneet ^a  

^a ISF COLLEGE OF PHARMACY   (India)

^b I K GUJRAL PUNJAB TECHNICAL UNIVERSITY   (India)

Author keywords

Catecholamines; Huntington s disease; N methyl d Aspartate; Oxidative stress; Quinolinic acid; Spermidine

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 4 AMINOBUTYRIC ACID; 5 HYDROXYINDOLEACETIC ACID; ADENINE; ADENOSINE; CATECHOLAMINE; DOPAMINE; GLUTAMIC ACID; GLUTATHIONE; HOMOVANILLIC ACID; HYPOXANTHINE; INOSINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTRANSMITTER; NITRITE; NORADRENALIN; QUINOLINIC ACID; SCAVENGER; SEROTONIN; SPERMIDINE; TUMOR NECROSIS FACTOR ALPHA; NEUROPROTECTIVE AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY WEIGHT; CHEMICAL ANALYSIS; CONTROLLED STUDY; CORPUS STRIATUM; EXCITOTOXICITY; GRIP STRENGTH; HUNTINGTON DISEASE LIKE SYNDROME; LIPID PEROXIDATION; LOCOMOTION; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; NERVE CELL NECROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL DEATH; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; HUNTINGTON DISEASE; IMMUNOMODULATION; MOTOR ACTIVITY; NERVE CELL; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; WISTAR RAT;

ANIMALIA; RATTUS;

ANIMALS; BODY WEIGHT; CELL DEATH; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUNTINGTON DISEASE; MALE; MOTOR ACTIVITY; NEUROIMMUNOMODULATION; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; QUINOLINIC ACID; RANDOM ALLOCATION; RATS, WISTAR; SPERMIDINE;

EID: 84933675873     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-015-9535-y     Document Type: Article

References (51)

1. Akula KK, Kaur M, Bishnoi M, Kulkarni SK (2008) Development and validation of an RP-HPLC method for the estimation of adenosine and related purines in brain tissues of rats. J Sep Sci 31(18):3139–3147
2. Aldinio C, Mazzari S, Toffano G, Köhler C, Schwarcz R (1985) Effects of intracerebral injections of quinolinic acid on serotonergic neurons in the rat brain. Brain Res 341(1):57–65
3. Beal MF (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann Neurol 31:119–130
4. Beal MF (1994) Neurochemistry and toxin models in Huntington’s disease. Curr Opin Neurol 7:542–547
5. Belle NAV, Dalmolin GD, Fonini G, Rubin MA, Rocha JBT (2004) Polyamines reduces lipid peroxidation induced by different pro-oxidant agents. Brain Res 1008(2):245–251
6. Belle NA, Dalmolin GD, Fonini G, Gindri Sinhorin VD, Ferreira da Silveira A, Rubin MA et al (2008) Spermine attenuates behavioral and biochemical alterations induced by quinolinic acid in the striatum of rats. Brain Res 1198:107–114
7. Blum D, Gall D, Galas MC, d’Alcantara P, Bantubungi K, Schiffmann SN (2002) The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity. J Neurosci 22:9122–9133
8. Blum D, Hourez R, Galas MC, Popoli P, Schiffmann SN (2003) Adenosine receptors in Huntington’s disease. Lancet Neurol 2:366–374
9. Brouillet E (2014) The 3-NP model of striatal neurodegeneration. Curr Protoc Neurosci. 9(48):1–9
10. Brown P, Dale N (2000) Adenosine A1 receptors modulate high voltage-activated Ca2+ currents and motor pattern generation in the Xenopus embryo. J Physiol 525(3):655–667
11. Caraceni T, Girotti F, Giovannini P, Pederzoli M, Parati E (1979) Effects of DA agonist in Huntington disease hyperkinesia. Ital J Neurol Sci 1(2):155–161
12. Carter C (1994) Neuropharmacology of Polyamines. Academic Press, Londres
13. Carvalho FB, Mello CF, Marisco PC, Tonello R, Girardi BA, Ferreira J et al (2012) Spermidine decreases Na+, K+-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats. Eur J Pharmacol 684(1):79–86
14. Charara A, Heilman C, Levey A, Smith Y (1999) Pre-and postsynaptic localization of GABA B receptors in the basal ganglia in monkeys. Neuroscience 95(1):127–140
15. Chen JY, Wang EA, Cepeda C, Levine MS (2013) Dopamine imbalance in Huntington’s disease: a mechanism for the lack of behavioral flexibility. Front Neurosci. 7:114
16. Coert BA, Anderson RE, Meyer FB (2000) Exogenous spermine reduces ischemic damage in a model of focal cerebral ischemia in the rat. Neurosci Lett 282(1):5–8
17. Dale N, Gilday D (1996) Regulation of rhythmic movements by purinergic neurotransmitters in frog embryos. Nature 383(6597):259–263
18. Donzanti BA, Yamamoto BK (1988) An improved and rapid HPLC-EC method for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusates. Life Sci 43:913–922
19. Drew PD, Chavis JA (2000) Inhibition of microglial cell activation by cortisol. Brain Res Bull 52(5):391–396
20. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82(1):70–77
21. Gallagher MJ, Huang H, Grant ER, Lynch DR (1997) The NR2B-specific interactions of polyamines and protons with the N-methyl-d-aspartate receptor. J Biol Chem 272(40):24971–24979
22. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR (1982) Analysis of nitrate, nitrite, and [15 N] nitrate in biological fluids. Anal Biochem 126(1):131–138
23. Jhamandas K, Boegman R, Beninger R, Miranda A, Lipic K (2000) Excitotoxicity of quinolinic acid: modulation by endogenous antagonists. Neurotox Res 2(2–3):139–155
24. Jongen P, Renier W, Gabreels F (1980) Seven cases of Huntington’s disease in childhood and levodopa induced improvement in the hypokinetic—rigid form. Clin Neurol Neurosurg 82(4):251–261
25. Kalonia H, Mishra J, Kumar A (2012) Targeting neuro-inflammatory cytokines and oxidative stress by minocycline attenuates quinolinic-acid-induced Huntington’s disease-like symptoms in rats. Neurotox Res 22(4):310–320
26. Khan A, Jamwal S, Bijjem KRV, Prakash A, Kumar P (2015) Neuroprotective effect of hemeoxygenase-1/glycogen synthase kinase-3β modulators in 3-nitropropionic acid induced neurotoxicity in rats. Neuroscience 287:66–77
27. Kumar P, Kalonia H, Kumar A (2010) Nitric oxide mechanism in the protective effect of antidepressants against 3-nitropropionic acid induced cognitive deficit, glutathione and mitochondrial alteration in animal model of Huntington’s disease. Behav Pharmacol 21(3):217–230
28. Kumar P, Kalonia H, Kumar A (2011) Novel protective mechanisms of antidepressants against 3-nitroproprionic acid induced Huntington’s-like symptoms: a comparative study. J Psychopharmacol 25(10):1399–1411
29. Kumar P, Kalonia H, Kumar A (2012) Possible GABAergic mechanism in the neuroprotective effect of gabapentin and lamotrigine against 3-nitropropionic acid induced neurotoxicity. Eur J Pharmacol 674(2):265–274
30. Kumar P, Kumar P, Khan A, Deshmukh R, Lal Sharma P (2014) Role of neurosteroids in experimental 3-nitropropionic acid induced neurotoxicity in rats. Eur J Pharmacol 723:38–45
31. Lacey C, Boyes J, Gerlach O, Chen L, Magill P, Bolam J (2005) GABA B receptors at glutamatergic synapses in the rat striatum. Neuroscience 136(4):1083–1095
32. Leegwater-Kim J, Cha J-HJ (2004) The paradigm of Huntington’s disease: therapeutic opportunities in neurodegeneration. NeuroRx. 1(1):128–138
33. Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E et al (2010) Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proc Natl Acad Sci 107(39):16970–16975
34. Lovaas E (1996) Antioxidative and metal-chelating effects of polyaminesI. Antioxid Dis Mech Ther Strateg 38:119
35. Lovaas E, Carlin G (1991) Spermine: an anti-oxidant and anti-inflammatory agent. Free Radic Biol Med 11(5):455–461
36. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265–275
37. Madeo F, Eisenberg T, Büttner S, Ruckenstuhl C, Kroemer G (2010) Spermidine: a novel autophagy inducer and longevity elixir. Autophagy. 6(1):160–162
38. Mehta A, Prabhakar M, Kumar P, Deshmukh R, Sharma P (2013) Excitotoxicity: bridge to various triggers in neurodegenerative disorders. Eur J Pharmacol 698(1):6–18
39. Milnerwood AJ, Gladding CM, Pouladi MA, Kaufman AM, Hines RM, Boyd JD et al (2010) Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington’s disease mice. Neuron 65(2):178–190
40. Minois N, Carmona-Gutierrez D, Madeo F (2011) Polyamines in aging and disease. Aging (Albany NY). 3(8):716
41. Mishra J, Kumar A (2014) Improvement of mitochondrial function by paliperidone attenuates quinolinic acid-induced behavioural and neurochemical alterations in rats: implications in Huntington’s disease. Neurotox Res 26(4):363–381
42. Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates, 6th edn. Academic press, San Diego
43. Pérez-De La Cruz V, Carrillo-Mora P, Santamaría A (2012) Quinolinic acid, an endogenous molecule combining excitotoxicity, oxidative stress and other toxic mechanisms. IJTR. 5:1
44. Ramaswamy S, McBride JL, Kordower JH (2007) Animal models of Huntington’s disease. ILAR J 48(4):356–373
45. Rock DM, Macdonald RL (1995) Polyamine regulation of N-methyl-d-aspartate receptor channels. Annu Rev Pharmacol Toxicol 35(1):463–482
46. Standaert DG, Friberg IK, Landwehrmeyer GB, Young AB, Penney J (1999) Expression of NMDA glutamate receptor subunit mRNAs in neurochemically identified projection and interneurons in the striatum of the rat. Mol Brain Res 64(1):11–23
47. Svenningsson P, Le Moine C, Fisone G, Fredholm BB (1999) Distribution, biochemistry and function of striatal adenosine A 2A receptors. Prog Neurobiol 59:355–396
48. Thakur P, Nehru B (2013) Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson’s disease. Neuroscience 231:420–431
49. Thangarajan S, Deivasigamani A, Natarajan SS, Krishnan P, Mohanan SK (2014) Neuroprotective activity of L-theanine on 3-nitropropionic acid-induced neurotoxicity in rat striatum. Int J Neurosci. 124:673
50. Velloso NA, Dalmolin GD, Fonini G, Gindri Sinhorin VD, Ferreira da Silveira A, Rubin MA, et al (2008) Spermine attenuates behavioral and biochemical alterations induced by quinolinic acid in the striatum of rats. Brain Res 1198:107–114
51. Wills E (1966) Mechanisms of lipid peroxide formation in animal tissues. Biochem J 99:667–676