Gluten- and casein-free dietary intervention for autism spectrum conditions

Frontiers in Human Neuroscience

Volumn , Issue DEC, 2012, Pages

  Whiteley, Paul ^a   Shattock, Paul ^a   Knivsberg, Ann Mari ^b   Seim, Anders ^c   Reichelt, Karl Ludwig ^d   Todd, Lynda ^a   Carr, Kevin ^a   Hooper, Malcolm ^a  

^a The Robert Luff Laboratory   (United Kingdom)

^b UNIVERSITY OF STAVANGER   (Norway)

^c Department of Pediatric Research University of Oslo Rikshospitalet Medical Centre ^*

^d UNIVERSITY OF OSLO   (Norway)

Author keywords

Autism; Brain; Casein; Diet; Gastrointestinal; Gluten; Intervention; Intestinal permeability

Indexed keywords

FAT; PROTEIN; SUGAR;

AUTISM; CARBOHYDRATE METABOLISM; CASEIN FREE DIET; CLINICAL EFFECTIVENESS; DIET; DIET SUPPLEMENTATION; DIET THERAPY; FOOD AVAILABILITY; GLUTEN FREE DIET; HUMAN; INTESTINAL DYSMOTILITY; LACTOSE INTOLERANCE; NUTRITIONAL PARAMETERS; NUTRITIONAL SUPPORT; NUTRITIONAL VALUE; REVIEW; RISK ASSESSMENT; SAFETY; TREATMENT INDICATION;

EID: 84933672897     PISSN: 16625161     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnhum.2012.00344     Document Type: Review

References (95)

1. World Health Organisation (WHO). Tenth revision of the International Classification of Diseases and related health problems. Clinical descriptions and diagnostic guidelines. Geneva. WHO; 1992.
2. Mattila ML, Kielinen M, Linna SL, et al. Autism spectrum disorders according to DSM-IV-TR and comparison with DSM-5 draft criteria: an epidemiological study. J Am Acad Child Adolesc Psychiatry. 2011 Jun; 50: 583-592.e11.
3. Tomchek SD, Dunn W. Sensory processing in children with and without autism: a comparative study using the short sensory profile. Am J Occup Ther. 2007; 61: 190-200.
4. Whyatt CP, Craig CM. Motor skills in children aged 7-10 years, diagnosed with autism spectrum disorder. J Autism Dev Disord. 2012; 42: 1799-1809.
5. Grafodatskaya D, Chung B, Szatmari P, et al. Autism spectrum disorders and epigenetics. J Am Acad Child Adolesc Psychiatry. 2010;49:794-809.
6. Klei L, Sanders SJ, Murtha MT, et al. Common genetic variants, acting additively, are a major source of risk for autism. Mol Autism. 2012; 3: 9.
7. Novarino G, El-Fishawy P, Kayserili H, et al. Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy. Science. 2012; 338: 394-397.
8. Nordahl CW, Lange N, Li DD, et al. Brain enlargement is associated with regression in preschool-age boys with autism spectrum disorders. Proc Natl Acad Sci U S A. 2011; 108: 20195-20200.
9. Fountain C, Winter AS, Bearman PS. Six developmental trajectories characterize children with autism. Pediatrics. 2012; 129: e1112-1120.
10. Whiteley P, Todd L, Carr K, et al. Gender ratios in autism, Asperger syndrome and autism spectrum disorder. Autism Insights. 2010;2:1-8.
11. Centers for Disease Control and Prevention (CDC). Increasing prevalence of parent-reported attention-deficit/hyperactivity disorder among children - -- United States, 2003 and 2007. MMWR Morb Mortal Wkly Rep. 2010; 59: 1439-1443.
12. Autism and Developmental Disabilities Monitoring Network Surveillance Year 2008 Principal Investigators; Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders--Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2008. MMWR Surveill Summ. 2012; 61: 1-19.
13. Rutter M. Incidence of autism spectrum disorders: changes over time and their meaning. Acta Paediatr. 2005;94:2-15.
14. Weintraub K. The prevalence puzzle: Autism counts. Nature. 2011; 479:22-24.
15. Steffenburg S, Steffenburg U, Gillberg C. Autism spectrum disorders in children with active epilepsy and learning disability: comorbidity, pre- and perinatal background, and seizure characteristics. Dev Med Child Neurol. 2003;45:724-730.
16. Barcia G, Posar A, Santucci M, et al. Autism and coeliac disease. J Autism Dev Disord. 2008;38:407-408.
17. Genuis SJ, Bouchard TP. Celiac disease presenting as autism. J Child Neurol. 2010;25:114-119.
18. Ashwood P, Anthony A, Pellicer AA, et al. Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology. J Clin Immunol. 2003;23:504-517.
19. Latif A, Heinz P, Cook R. Iron deficiency in autism and Asperger syndrome. Autism. 2002;6:103-114.
20. Buie T, Campbell DB, Fuchs GJ 3rd, et al. Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics. 2010; 125 Suppl 1:S1-18.
21. Volkmar FR, Lord C, Bailey A, et al. Autism and pervasive developmental disorders. J Child Psychol Psychiatry. 2004;45:135-170.
22. Dawson G, Jones EJ, Merkle K, et al. Early behavioral intervention is associated with normalized brain activity in young children with autism. J Am Acad Child Adolesc Psychiatry. 2012;51:1150-1159.
23. Francis K. Autism interventions: a critical update. Dev Med Child Neurol. 2005;47:493-499.
24. Oberman LM. mGluR antagonists and GABA agonists as novel pharmacological agents for the treatment of autism spectrum disorders. Expert Opin Investig Drugs. 2012 Sep 26.
25. Kalyva E. Comparison of eating attitudes between adolescent girls with and without Asperger syndrome: daughters' and mothers' reports. J Autism Dev Disord. 2009;39:480-486.
26. Martins Y, Young RL, Robson DC. Feeding and eating behaviors in children with autism and typically developing children. J Autism Dev Disord. 2008;38:1878-1887.
27. Whiteley P, Dodou K, Todd L, et al. Body mass index of UK children diagnosed with pervasive developmental disorders. Pediatr Int. 2004;46:531-533.
28. Curtin C, Anderson SE, Must A, et al. The prevalence of obesity in children with autism: a secondary data analysis using nationally representative data from the National Survey of Children's Health. BMC Pediatrics. 2010;10:11.
29. Adams JB, Audhya T, McDonough-Means S, et al. Effect of a vitamin/mineral supplement on children and adults with autism. BMC Pediatr. 2011;11:111.
30. Dohan FC, Grassberger JC, Lowell FM, et al. Relapsed schizophrenics: more rapid improvement on a milk and cereal free diet. Br J Psychiatry 1969;115:595-596.
31. Kanner L. Autistic disturbances of affective contact. Nervous Children. 1943;2:217-250.
32. Asperger H. [Psychopathology of children with celiac disease.] Ann Paediatr. 1961;197:346-351.
33. Pavone L, Fiumara A, Bottaro G, et al. Autism and celiac disease: failure to validate the hypothesis that a link might exist. Biol Psychiatry. 1997;42:72-75.
34. Knivsberg A-M, Reichelt KL, Nødland M. Reports on dietary intervention in autistic disorders. Nutr Neurosci. 2001;4:25-37.
35. Mulloy A, Lang R, O'Reilly M, et al. Gluten-free and casein-free diets in the treatment of autism spectrum disorders: A systematic review. Res Autism Spectr Disord. 2010;4:328-339.
36. Mulloy A, Lang R, O'Reilly M, et al. Addendum to "gluten-free and casein-free diets in treatment of autism spectrum disorders: A systematic review. Res Autism Spectr Disord. 2011;5:86-88.
37. Millward C, Ferriter M, Calver S, et al. Gluten- and casein-free diets for autistic spectrum disorder. Cochrane Database Syst Rev. 2008;2:CD003498.
38. Knivsberg A-M, Wiig K, Lind G, et al. Dietary intervention in autistic syndromes. Brain Dysfunct. 1990; 3: 315-317.
39. Knivsberg A-M, Reichelt KL, Nødland M, et al. Autistic syndromes and diet: A follow-up study. Scan J Educ Res. 1995; 39: 223-236.
40. Knivsberg A-M, Reichelt KL, Høien T, et al. A randomised, controlled study of dietary intervention in autistic syndromes. Nutr Neurosci. 2002;5:251-261.
41. Whiteley P, Haracopos D, Knivsberg A-M, et al. The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders. Nutr Neurosci. 2010;13:87-100.
42. Johnson CR, Handen BL, Zimmer M, et al. Effects of a gluten free/casein free diet in young children with autism: a pilot study. J Dev Phys Disabil. 2011;23:213-225.
43. Whiteley P, Rodgers J, Savery D, et al. A gluten-free diet as an intervention for autism and associated spectrum disorders: preliminary findings. Autism. 1999;3:45-65.
44. Elder JH, Shankar M, Shuster J, et al. The gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trial. J Autism Dev Disord. 2006;36:413-20.
45. Lucarelli S, Frediani T, Zingoni A, et al. Food allergy and infantile autism. Panminerva Med. 1995;37:137-141.
46. Diet and behaviour in young children with autism (NCT00090428) (ClinicalTrials.gov). Accessed on October 25, 2012.
47. Pennesi CM, Klein LC. Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder: based on parental report. Nutr Neurosci. 2012;15:85-91.
48. Pratesi R, Modelli IC, Martins RC, et al. Celiac disease and epilepsy: favorable outcome in a child with difficult to control seizures. Acta Neurol Scand. 2003;108:290-293.
49. Lee PR, Kossoff EH. Dietary treatments for epilepsy: management guidelines for the general practitioner. Epilepsy Behav. 2011;21:115-121.
50. Evangeliou A, Vlachonikolis I, Mihailidou H, et al. Application of a ketogenic diet in children with autistic behavior: pilot study. J Child Neurol. 2003;18:113-118.
51. Charman T, Taylor E, Drew A, et al. Outcome at 7 years of children diagnosed with autism at age 2: predictive validity of assessments conducted at 2 and 3 years of age and pattern of symptom change over time. J Child Psychol Psychiatry. 2005;46:500-513.
52. Afzal N, Murch S, Thirrupathy K, et al. Constipation with acquired megarectum in children with autism. Pediatrics. 2003;112: 939-942
53. A study to assess the role of a gluten free-dairy free (GFCF) diet in the dietary management of autism associated gastrointestinal disorders (NCT01116388) (ClinicalTrials.gov). Accessed on October 25, 2012.
54. Arnold GL, Hyman SL, Mooney RA, et al. Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies. J Autism Dev Disord. 2003;33:449-454.
55. Cornish E. Gluten and casein free diets in autism: a study of the effects on food choice and nutrition. J Human Nutr Diet. 2002;15:261-269.
56. Adams S, Burton N, Cutress A, et al. Development of double blind gluten and casein free test foods for use in an autism dietary trial. J Human Nutr Diet. 2008;21: 374.
57. Mariani P, Viti MG, Montuori M, et al. The gluten-free diet: a nutritional risk factor for adolescents with celiac disease? J Pediatr Gastroenterol Nutr. 1998;27:519-523.
58. Hsu CL, Lin CY, Chen CL, et al. The effects of a gluten and casein-free diet in children with autism: a case report. Chang Gung Med J. 2009;32:459-465.
59. Hediger ML, England LJ, Molloy CA, et al. Reduced bone cortical thickness in boys with autism or autism spectrum disorder. J Autism Dev Disord. 2008;38:848-856.
60. Clark JH, Rhoden DK, Turner DS. Symptomatic vitamin A and D deficiencies in an eight-year-old with autism. JPEN J Parenter Enteral Nutr. 1993;17:284-286.
61. Stewart C, Latif A. Symptomatic nutritional rickets in a teenager with autistic spectrum disorder. Child Care Health Dev. 2008;34:276-278.
62. Herndon AC, DiGuiseppi C, Johnson SL, et al. Does nutritional intake differ between children with autism spectrum disorders and children with typical development? J Autism Dev Disord. 2009;39:212-222.
63. Neumeyer AM, Gates A, Ferrone C, et al. Bone density in peripubertal boys with autism spectrum disorders. J Autism Dev Disord. 2012 Nov 4.
64. Perrin JM, Coury DL, Hyman SL, et al. Complementary and alternative medicine use in a large pediatric autism sample. Pediatrics. 2012; 130: Suppl. 2. S77-S82.
65. Cook JD, Dassenko SA, Whittaker P. Calcium supplementation: effect on iron absorption. Am J Clin Nutr. 1991;53:106-111.
66. Whiteley P, Shattock P, Carr K, et al. How could a gluten- and casein-free diet ameliorate symptoms associated with autism spectrum conditions? Autism Insights. 2010;2:39-53.
67. Baieli S, Pavone L, Meli C, et al. Autism and phenylketonuria. J Autism Dev Disord. 2003;3:201-204.
68. Seim AR, Reichelt KL. An enzyme/brain-barrier theory of psychiatric pathogenesis: unifying observations on phenylketonuria, autism, schizophrenia and postpartum psychosis. Med Hypotheses. 1995;45:498-502.
69. Shattock P, Whiteley P. Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical intervention. Expert Opin Ther Targets. 2002;6:175-183.
70. Reichelt KL, Tveiten D, Knivsberg A-M, et al. Peptide's role in autism with emphasis on exorphins. Microbial Ecol Health Dis. 2012; 23: 18958.
71. Vojdani A, O'Bryan T, Green JA, et al. Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutr Neurosci. 2004;7:151-161.
72. Sun Z, Cade JR. A peptide found in schizophrenia and autism causes behavioral changes in rats. Autism. 1999; 3: 85-95.
73. Sun Z, Cade JR, Fregley MJ, et al. β-Casomorphin induces Fos-like immunoreactivity in discrete brain regions relevant to schizophrenia and autism. Autism. 1999; 3: 67-83.
74. Kost NV, Sokolov OY, Kurasova OB, et al. Beta-casomorphins-7 in infants on different type of feeding and different levels of psychomotor development. Peptides. 2009; 30: 1854-1860.
75. D'Eufemia P, Celli M, Finocchiaro R, et al. Abnormal intestinal permeability in children with autism. Acta Paediatr. 1996;85:1076-1079.
76. de Magistris L, Familiari V, Pascotto A, et al. Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives. J Pediatr Gastroenterol Nutr. 2010;51:418-424.
77. Boukthir S, Matoussi N, Belhadj A, et al. [Abnormal intestinal permeability in children with autism]. Tunis Med. 2010;88:685-686.
78. Robertson MA, Sigalet DL, Holst JJ, et al. Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study. J Autism Dev Disord. 2008;38:1066-1071.
79. Cummins AG, Penttila IA, Labrooy JT, et al. Recovery of the small intestine in coeliac disease on a gluten-free diet: changes in intestinal permeability, small bowel morphology and T-cell activity. J Gastroenterol Hepatol. 1991;6:53-57.
80. Severance EG, Alaedini A, Yang S, et al. Gastrointestinal inflammation and associated immune activation in schizophrenia. Schizophr Res. 2012; 138: 48-53.
81. Bowling FG, Heussler HS, McWhinney A, et al. Plasma and urinary sulfate determination in a cohort with autism. Biochem Genet. 2012 Oct 27.
82. Fasano A. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin Gastroenterol Hepatol. 2012; 10: 1096-1100.
83. Severance EG, Kannan G, Gressitt KL. et al. Anti-gluten immune response following Toxoplasma gondii infection in mice. PLoS ONE. 2012; 7(11): e50991.
84. Cass H, Gringras P, March J, et al. Absence of urinary opioid peptides in children with autism. Arch Dis Child. 2008;93:745-750.
85. Wang L, Angley MT, Gerber JP, et al. Is urinary indolyl-3-acryloylglycine a biomarker for autism with gastrointestinal symptoms? Biomarkers. 2009;14:596-603.
86. Williams BL, Hornig M, Buie T, et al. Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PLoS One. 2011;6:e24585.
87. Kushak RI, Lauwers GY, Winter HS, et al. Intestinal disaccharidase activity in patients with autism: effect of age, gender, and intestinal inflammation. Autism. 2011;15:285-294.
88. Parracho HM, Bingham MO, Gibson GR, et al. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. J Med Microbiol. 2005;54:987-991.
89. Williams BL, Hornig M, Parekh T, et al. Application of novel PCR-based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances. MBio. 2012;3. pii: e00261-11.
90. Clayton TA. Metabolic differences underlying two distinct rat urinary phenotypes, a suggested role for gut microbial metabolism of phenylalanine and a possible connection to autism. FEBS Lett. 2012;586:956-961.
91. De Santis A, Addolorato G, Romito A, et al. Schizophrenic symptoms and SPECT abnormalities in a coeliac patient: regression after a gluten-free diet. J Intern Med. 1997; 242: 421-423.
92. Jyonouchi H, Sun S, Itokazu N. Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology. 2002;46:76-84.
93. Pelsser LM, Frankena K, Toorman J, et al. Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trial. Lancet. 2011;377:494-503.
94. Niederhofer H. Association of attention-deficit/hyperactivity disorder and celiac disease: a brief report. Prim Care Companion CNS Disord. 2011;13: pii: PCC.10br01104.
95. Biesiekierski JR, Newnham ED, Irving PM, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double- blind randomized placebo-controlled trial. Am J Gastroenterol. 2011;106:508-514.