Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency

Blood

Volumn 125, Issue 26, 2015, Pages 4052-4059

  Prasad, Mahadesh A J ^a   Ungerbäck, Jonas ^a   Åhsberg, Josefine ^a   Somasundaram, Rajesh ^a   Strid, Tobias ^a   Larsson, Malin ^a   Månsson, Robert ^b   De Paepe, Ayla ^a   Lilljebjörn, Henrik ^c   Fioretos, Thoas ^c   Hagman, James ^d   Sigvardsson, Mikael ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d DEPARTMENT OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RAD51 PROTEIN; TRANSCRIPTION FACTOR PAX5; EBF1 PROTEIN, MOUSE; PAX5 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL LEUKEMIA; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; EARLY B CELL FACTOR 1 GENE; GENE; GENE DOSAGE; GENE EXPRESSION; GENE MUTATION; GENETIC PREDISPOSITION; HAPLOINSUFFICIENCY; HETEROZYGOSITY LOSS; LEUKEMIA CELL; LEUKEMOGENESIS; LYMPH NODE; LYMPH NODE CELL; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PAX5 GENE; PRE B LYMPHOCYTE; PRIORITY JOURNAL; RADIATION EXPOSURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRAVIOLET RADIATION; ANIMAL; C57BL MOUSE; CELL TRANSFORMATION; COMET ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; MUTANT MOUSE STRAIN; WESTERN BLOTTING;

ANIMALS; B-CELL-SPECIFIC ACTIVATOR PROTEIN; BLOTTING, WESTERN; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN IMMUNOPRECIPITATION; COMET ASSAY; DNA DAMAGE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HAPLOINSUFFICIENCY; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PRECURSOR CELLS, B-LYMPHOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS;

EID: 84933557673     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-12-617282     Document Type: Article

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