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(e) Jiménez-González, C., Poechlauer, P., Broxterman, Q. B., et al. "Key green engineering research areas for sustainable manufacturing: a perspective from pharmaceutical and fine chemicals manufacturers" Org. Process Res. Dev. 15, 900-911, (2011).
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Use of continuous flow technology to harness hazardous chemistries and process conditions - A tool for the manufacturing of active pharmaceutical ingredients
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(a) Mastronardi, F., Gutmann, B., Kappe, C. O. "Continuous flow generation and reactions of anhydrous diazomethane using a Teflon AF-2400 tube-in-tube reactor", Org. Lett. 15, 5590-5593, (2013);
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(b) Pinho, V. D., Gutmann, B., Miranda, L. S. M., et al. "Continuous flow synthesis of α-haloketones - essential building blocks of antiretroviral agents", J. Org. Chem. 79, 1555-1562, (2014);
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(e) Maurya, R. A., Park, C. P., Lee, J. H. et al. "Continuous in situ generation, separation, and reaction of diazomethane in a dual-channel microreactor", Angew. Chem. Int. Ed., 50, 5952-5955, (2011).
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(a) Deadman, B. J., Collins, S. G., Maguire, A. R. "Taming hazardous chemistry in flow: the continuous processing of diazo and diazonium compounds", Chem. Eur. J., 21, 2298-2308 (2015);
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