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1
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0011835203
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note
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(a) This is a transcript of part of a lecture entitled "Continuous Processing Technology Applications in the Fine Chemical Industry" given at the Third International Conference on Organic Process Research and Development, Montreal, July 10-12, 2000.
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3
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0002813232
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Wiley: New York
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For a review of diazomethane, see: Pizey, J. S. Synthetic Reagents; Wiley: New York, 1974; Vol. 2, p 65.
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(1974)
Synthetic Reagents
, vol.2
, pp. 65
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Pizey, J.S.1
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4
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0011839305
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Neeman, M.; Caserio, M. C.; Roberts, J. D.; Johnson, W. S. Tetrahedron 1959, 6, 36.
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(1959)
Tetrahedron
, vol.6
, pp. 36
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Neeman, M.1
Caserio, M.C.2
Roberts, J.D.3
Johnson, W.S.4
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6
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0001690399
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(b) Ogawa, H.; Hagiwara, H.; Chihara, T.; Teratani, S.; Taya, K. Bull. Chem. Soc. Jpn. 1987, 60, 627.
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(1987)
Bull. Chem. Soc. Jpn.
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Ogawa, H.1
Hagiwara, H.2
Chihara, T.3
Teratani, S.4
Taya, K.5
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8
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0028945731
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(a) Kaldor, S. W.; Appelt, K.; Fritz, J. E.; Hammond, M.; Crowell, T. A.; Baxter, A. J.; Hatch, S. D.; Wiskerchen, M.; Muesing, M. A. Bioorg. Med. Chem. Lett. 1995, 5, 715.
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Bioorg. Med. Chem. Lett.
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Kaldor, S.W.1
Appelt, K.2
Fritz, J.E.3
Hammond, M.4
Crowell, T.A.5
Baxter, A.J.6
Hatch, S.D.7
Wiskerchen, M.8
Muesing, M.A.9
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9
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14444281534
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(b) Kaldor, S. W.; Kalish, V. J.; Davies, J. F., II; Shetty, B. W.; Fritz, J. E.; Appelt, K.; Burgess, J. A.; Campanale, K. M.; Chirgadze, N. Y.; Clawson, D. K.; Dressman, B. A.; Hatch, S. D.; Khalil, D. A.; Kosa, M. B.; Lubbehusen, P. P.; Muesing, M. A.; Patick, A. K.; Reich, S. H.; Su, K. S.; Tatlock, J. H. J. Med. Chem. 1997, 40, 3979.
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J. Med. Chem.
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Kaldor, S.W.1
Kalish, V.J.2
Davies J.F. II3
Shetty, B.W.4
Fritz, J.E.5
Appelt, K.6
Burgess, J.A.7
Campanale, K.M.8
Chirgadze, N.Y.9
Clawson, D.K.10
Dressman, B.A.11
Hatch, S.D.12
Khalil, D.A.13
Kosa, M.B.14
Lubbehusen, P.P.15
Muesing, M.A.16
Patick, A.K.17
Reich, S.H.18
Su, K.S.19
Tatlock, J.H.20
more..
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0011870931
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First International Conference on Organic Process Research and Development, San Francisco, November 5-7
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(a) Agouron Pharmaceuticals. Chemical Development of an HIV Protease Inhibitor. First International Conference on Organic Process Research and Development, San Francisco, November 5-7, 1997.
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(1997)
Chemical Development of an HIV Protease Inhibitor
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11
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0036003913
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(b) Ikunaka, M.; Matsumoto, J.; Fujima, Y.; Hirayama, Y. Org. Process Res. Dev. 2002, 6, 49.
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Org. Process Res. Dev.
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, pp. 49
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Ikunaka, M.1
Matsumoto, J.2
Fujima, Y.3
Hirayama, Y.4
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12
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0011870933
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Butterworth-Heinemann: Woburn, MA
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Urben, P. G. Bretherick's Handbook of Reactive Chenical Hazards, 5th Ed.; Butterworth-Heinemann: Woburn, MA, 1995; Vol. 1, p 164.
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(1995)
Bretherick's Handbook of Reactive Chenical Hazards, 5th Ed.
, vol.1
, pp. 164
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Urben, P.G.1
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14
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0011909113
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(Isis Pharmaceuticals). U.S. Patent 549243
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Acevedo, O.; Ross, B.; Andrews, R. S.; Springer, R.; Cook, P. D. Apparatus and Processes for the Large Scale Generation and Transfer of Diazomethane. (Isis Pharmaceuticals). U.S. Patent 549243, 1995.
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(1995)
Apparatus and Processes for the Large Scale Generation and Transfer of Diazomethane
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Acevedo, O.1
Ross, B.2
Andrews, R.S.3
Springer, R.4
Cook, P.D.5
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15
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0002049842
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(Aerojet-General Corporation). U.S. Patent 5,817,778
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Archibald, T. G.; Huang, D.-S.; Pratton, M. H.; Barnard, J. C. Large Scale batch process for Diazomethane. (Aerojet-General Corporation). U.S. Patent 5,817,778, 1998.
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(1998)
Large Scale batch process for Diazomethane
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Archibald, T.G.1
Huang, D.-S.2
Pratton, M.H.3
Barnard, J.C.4
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16
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0011900621
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(Aerojet-General Corporation). U.S. Pataent 5,854,405
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Archibald, T. G.; Barnard, J. C.; Harlan, R. F. Continuous Process for Diazomethane from an N-Methyl-N-nitrosoamine and from Methylurea through N-Methyl-N-nitrosourea. (Aerojet-General Corporation). U.S. Pataent 5,854,405, 1998.
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(1998)
Continuous Process for Diazomethane from an N-Methyl-N-nitrosoamine and from Methylurea through N-Methyl-N-nitrosourea
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Archibald, T.G.1
Barnard, J.C.2
Harlan, R.F.3
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0000452649
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Wiley: New York
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Arndt, F. Organic Syntheses; Wiley: New York, 1943; Collect. Vol. II, p 461.
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(1943)
Organic Syntheses
, vol.2
, pp. 461
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Arndt, F.1
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0031575858
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(a) Golding, B. T.; Bleasdale, C.; McGinnis, J.; Muller, S.; Rees, H. T.; Rees, N. H.; Farmer, P. B.; Watson, W. P. Tetrahedron 1997, 53, 4063.
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(1997)
Tetrahedron
, vol.53
, pp. 4063
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Golding, B.T.1
Bleasdale, C.2
McGinnis, J.3
Muller, S.4
Rees, H.T.5
Rees, N.H.6
Farmer, P.B.7
Watson, W.P.8
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22
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0011900622
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note
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(b) All the Diazald studies were carded out in collaboration with Chilworth Technology, Southampton, UK.
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23
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0011909115
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note
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UN Transportation of Dangerous Goods Regulations, Test Series C, Test C.2 (TNO Deflagration test).
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24
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0011874610
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note
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UN Transportation of Dangerous Goods Regulations, Test Series E, Test E.2 (DPV test).
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0011867876
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note
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UN Transportation of Dangerous Goods Regulations, Test Series H, Test H.4.
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0011874433
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note
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Diazald should be classified for packaging and transportation as follows: N-methyl-N-nitroso-p-toluene sulphonamide wetted with not less than 15% water (DIAZALD (85%w/w with water)). Self-Reactive Solid, Type D, Temperature-Controlled, UN Number 3236, UN Class 4.1, temperature control conditions: SADT = 40 °C, control temperature = 30 °C, emergency temperature = 35 °C, packing group II (packing instruction 520), packing method OP7 (limits package size to 50 kg net mass).
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0011874434
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note
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Testing carried out by Imperial Dynamite Co. Ltd., Neston, UK.
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0011836541
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First International Conference on Organic Process Research and Development, San Francisco, November 5-7
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Archibald, T. A. Diazomethane: Commercialization of a Highly Hazardous Material; First International Conference on Organic Process Research and Development, San Francisco, November 5-7, 1997.
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(1997)
Diazomethane: Commercialization of a Highly Hazardous Material
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Archibald, T.A.1
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0011834936
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Butterworth-Heinemann: Woburn, MA
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Urben, P. G. Bretherick's Handbook of Reactive Chenical Hazards, 5th Ed.; Butterworth-Heinemann: Woburn, MA, 1995; Vol. 1, p 1498.
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(1995)
Bretherick's Handbook of Reactive Chenical Hazards, 5th Ed.
, vol.1
, pp. 1498
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Urben, P.G.1
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0011835416
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note
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Diazomethane explosion studies were carried out in collaboration with the Centre for Explosion Studies, Aberystwyth, UK.
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35
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0011911937
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note
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The details of the subsequent diazomethane chemistry will be covered in a separate publication.
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