Study on the Distribution and Elimination of the New Hormone Irisin in Vivo: New Discoveries Regarding Irisin

Hormone and Metabolic Research

Volumn 47, Issue 8, 2015, Pages 591-595

  Lv, J ^a   Pan, Y ^a   Li, X ^b   Cheng, D ^b   Ju, H ^a   Tian, J ^a   Shi, H ^b   Zhang, Y ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

hepatobiliary clearance; iodine 125 radionuclide; renal clearance; small animal SPECT CT

Indexed keywords

IODINE 125; IRISIN; FIBRONECTIN; FNDC5 PROTEIN, MOUSE; RADIOACTIVE IODINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY CLEARANCE; CONTROLLED STUDY; HORMONAL REGULATION; IN VIVO STUDY; KIDNEY CLEARANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ANIMAL; C57BL MOUSE; GALLBLADDER; KIDNEY; LIVER; METABOLISM; SCINTISCANNING;

ANIMALIA; MUS;

ANIMALS; FIBRONECTINS; GALLBLADDER; IODINE RADIOISOTOPES; KIDNEY; LIVER; MICE; MICE, INBRED C57BL; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84933519893     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0035-1547261     Document Type: Article

References (12)

1. Flegal K. M., Kit B. K., Orpana H., Graubard B. I. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA: 2013; 309 71 82
2. Novelle M. G., Contreras C., Romero-Pico A., Lopez M., Dieguez C. Irisin, two years later. Int J Endocrinol: 2013; 2013 1 8
3. Bostrom P., Wu J., Jedrychowski M. P., Korde A., Ye L., Lo J. C., Rasbach K. A., Bostrom E. A., Choi J. H., Long J. Z., Kajimura S., Zingaretti M. C., Vind B. F., Tu H., Cinti S., Hojlund K., Gygi S. P., Spiegelman B. M. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature: 2012; 481 463 468
4. Castillo-Quan J. I. From white to brown fat through the PGC-1alpha-dependent myokine irisin: implications for diabetes and obesity. Dis Model Mech: 2012; 5 293 295
5. Charos A. E., Reed B. D., Raha D., Szekely A. M., Weissman S. M., Snyder M. A highly integrated and complex PPARGC1A transcription factor binding network in HepG2 cells. Genome Res: 2012; 22 1668 1679
6. Wu J., Bostrom P., Sparks L. M., Ye L., Choi J. H., Giang A. H., Khandekar M., Virtanen K. A., Nuutila P., Schaart G., Huang K., Tu H., van Marken Lichtenbelt W. D., Hoeks J., Enerback S., Schrauwen P., Spiegelman B. M. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell: 2012; 150 366 376
7. Cousin B., Cinti S., Morroni M., Raimbault S., Ricquier D., Penicaud L., Casteilla L. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci: 1992; 103 931 942
8. Cunha A. Basic research: Irisin - behind the benefits of exercise. Nat Rev Endocrinol: 2012; 8 195
9. Diao L., Meibohm B. Pharmacokinetics and pharmacokinetic-pharmacodynamic correlations of therapeutic peptides. Clin Pharmacokinet: 2013; 52 855 868
10. Carone F. A., Peterson D. R. Hydrolysis and transport of small peptides by the proximal tubule. Am J Physiol: 1980; 238 151 158
11. Tolmachev V., Orlova A., Lundqvist H. Approaches to improve cellular retention of radiohalogen labels delivered by internalising tumour-targeting proteins and peptides. Curr Med Chem: 2003; 10 2447 2460
12. Zhang H. J., Zhang X. F., Ma Z. M., Pan L. L., Chen Z., Han H. W., Han C. K., Zhuang X. J., Lu Y., Li X. J., Yang S. Y., Li X. Y. Irisin is inversely associated with intrahepatic triglyceride contents in obese adults. J Hepatol: 2013; 59 557 562