Recognition of multiepitope dendrimeric antigens by human immunoglobulin E

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 11, Issue 3, 2015, Pages 579-588

  Montañez, María I ^a,b   Najera, Francisco ^a,c   Mayorga, Cristobalina ^a,b   Ruiz Sanchez, Antonio J ^a,c   Vida, Yolanda ^a,c   Collado, Daniel ^a,c   Blanca, Miguel ^a,b   Torres, María J ^a,b   Perez Inestrosa, Ezequiel ^a,c  

^a Institute of Biomedical Research in Malaga and BIONAND Nanomedicine Platform   (Spain)

^b HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^c UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Allergy; Dendrimer; Immune response; Immunochemistry; In vitro test; Molecular modeling

Indexed keywords

ALLERGIES; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; BIOCHEMISTRY; DENDRIMERS; DIAGNOSIS; MOLECULAR MODELING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANTIGEN RECOGNITION; HUMAN IMMUNOGLOBULIN; IMMUNE RESPONSE; IMMUNOCHEMISTRY; IN-VITRO TESTS; LIMITED SENSITIVITY; PROTEIN CONJUGATES; TRI-DIMENSIONAL STRUCTURE;

EPITOPES;

AMOXICILLIN; ANTIGEN; IMMUNOGLOBULIN E; MULTIEPITOPE DENDRIMERIC ANTIGEN; PENICILLIN G SODIUM; POLYAMIDOAMINE; UNCLASSIFIED DRUG; DENDRIMER; EPITOPE; PAMAM STARBURST; PENICILLIN G;

ANTIGEN RECOGNITION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CONFORMATION; CROSS REACTION; DRUG HYPERSENSITIVITY; ELECTROPHILICITY; HUMAN; IMMUNOCHEMISTRY; MOLECULAR DYNAMICS; NUCLEAR OVERHAUSER EFFECT; NUCLEOPHILICITY; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOALLERGOSORBENT TEST; CHEMISTRY; FEMALE; IMMUNOLOGY; MALE;

AMOXICILLIN; DENDRIMERS; DRUG HYPERSENSITIVITY; EPITOPES; FEMALE; HUMANS; IMMUNOGLOBULIN E; MALE; PENICILLIN G;

EID: 84933518621     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2015.01.006     Document Type: Article

References (42)

1. Palm N.W., Rosenstein R.K., Medzhitov R. Allergic host defences. Nature 2012, 484:465-472.
2. Galli S.J., Tsai M. IgE and mast cells in allergic disease. Nat Med 2012, 18:693-704.
3. Mammen M., Choi S.-K., Whitesides G.M. Polyvalent interactions in biological systems: implications for design and use of multivalent ligands and inhibitors. Angew Chem Int Ed 1998, 37:2754-2794.
4. Handlogten M.W., Kiziltepe T., Serezani A.P., Kaplan M.H., Bilgicer B. Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation. Nat Chem Biol 2013, 9:789-795.
5. Uetrecht J. Idiosyncratic drug reactions: past, present, and future. Chem Res Toxicol 2008, 21:84-92.
6. Uetrecht J. Immune-mediated adverse drug reactions. Chem Res Toxicol 2009, 22:24-34.
7. Ebo D.G., Leysen J., Mayorga C., Rozieres A., Knol E.F., Terreehorst I. The in vitro diagnosis of drug allergy: status and perspectives. Allergy 2011, 66:1275-1286.
8. Moggs J.G., Terranova R., Kammüller M.E., Chibout S.-D., Chapman V., Dearman R.J., et al. Regulation of allergic responses to chemicals and drugs: possible roles of epigenetic mechanisms. Toxicol Sci 2012, 130:60-69.
9. Akdis C.A. Allergy and hypersensitivity: mechanisms of allergic disease. Curr Opin Immunol 2006, 18:718-726.
10. Blanca M., Mayorga C., Perez E., Suau R., Juarez C., Vega J.M., et al. Determination of IgE antibodies to the benzyl penicilloyl determinant. A comparison between poly-l-lysine and human serum albumin as carriers. J Immunol Methods 1992, 153:99-105.
11. Torres M.J., Mayorga C., Pamies R., Juarez C., Blanca M., Romano A. Immunologic response to different determinants of benzylpenicillin, amoxicillin, and ampicillin. Comparison between urticaria and anaphylactic shock. Allergy 1999, 54:936-943.
12. Sánchez-Sancho F., Pérez-Inestrosa E., Suau R., Mayorga C., Torres M.J., Blanca M. Dendrimers as carrier protein mimetics for ige antibody recognition. synthesis and characterization of densely penicilloylated dendrimers. Bioconjug Chem 2002, 13:647-653.
13. Montañez M.I., Perez-Inestrosa E., Suau R., Mayorga C., Torres M.J., Blanca M. Dendrimerized cellulose as a scaffold for artificial antigens with applications in drug allergy diagnosis. Biomacromolecules 2008, 9:1461-1466.
14. Montañez M.I., Mayorga C., Torres M.J., Blanca M., Perez-Inestrosa E. Methodologies to anchor dendrimeric nanoconjugates to solid phase: toward an efficient in vitro detection of allergy to β-lactam antibiotics. Nanomedicine Nanotechnol Biol Med 2011, 7:682-685.
15. Montañez M.I., Najera F., Perez-Inestrosa E. NMR studies and molecular dynamic simulation of synthetic dendritic antigens. Polymers 2011, 3:1533-1553.
16. Ruiz-Sanchez A.J., Montanez M.I., Mayorga C., Torres M.J., Kehr N.S., Vida Y., et al. Dendrimer-modified solid supports: nanostructured materials with potential drug allergy diagnostic applications. Curr Med Chem 2012, 19:4942-4954.
17. Vida Y., Montañez M.I., Collado D., Najera F., Ariza A., Blanca M., et al. Dendrimeric antigen-silica particle composites: an innovative approach for IgE quantification. J Mater Chem B 2013, 1:3044-3050.
18. Dendrimers and other dendritic polymers 2001, John Wiley&Sons, West Sussex. 1st ed. J.M.J. Fréchet, D.A. Tomalia (Eds.).
19. Blanca M., Torres M.J., Mayorga C., Perez-Inestrosa E., Suau R., Montanez M.I., et al. Immediate allergic reactions to betalactams: facts and controversies. Curr Opin Allergy Clin Immunol 2004, 4:261-266.
20. Torres M.J., Romano A., Blanca-Lopez N., Doña I., Canto G., Ariza A., et al. Immunoglobulin E-mediated hypersensitivity to amoxicillin: in vivo and in vitro comparative studies between an injectable therapeutic compound and a new commercial compound. Clin Exp Allergy 2011, 41:1595-1601.
21. Antunez C., Martin E., Cornejo-Garcia J., Blanca-Lopez N., R-Pena R., Mayorga C., et al. Immediate hypersensitivity reactions to penicillins and other betalactams. Curr Pharm Des 2006, 12:3327-3333.
22. Novalbos A., Sastre J., Cuesta J., De Las Heras M., Lluch-Bernal M., Bombín C., et al. Lack of allergic cross-reactivity to cephalosporins among patients allergic to penicillins. Clin Exp Allergy 2001, 31:438-443.
23. Miranda A., Blanca M., Vega J.M., Moreno F., Carmona M.J., García J.J., et al. Cross-reactivity between a penicillin and a cephalosporin with the same side chain. J Allergy Clin Immunol 1996, 98:671-677.
24. Moreno F., Blanca M., Mayorga C., Terrados S., Moya M., Perez E., et al. Studies of the specificities of IgE antibodies found in sera from subjects with allergic reactions to penicillins. Int Arch Allergy Immunol 1995, 108:74-81.
25. Audicana M., Bernaola G., Urrutia I., Echechipia S., Gastaminza G., Muñoz D., et al. Allergic reactions to betalactams: studies in a group of patients allergic to penicillin and evaluation of cross-reactivity with cephalosporin. Allergy 1994, 49:108-113.
26. Blanca M., Mayorga C., Sanchez F., Vega J.M., Fernandez J., Juarez C., et al. Differences in serum IgE antibody activity to benzylpenicillin and amoxicillin measured by RAST in a group of penicillin allergic patients. Allergy 1991, 46:632-638.
27. Ariza A., Barrionuevo E., Mayorga C., Montañez M.I., Perez-Inestrosa E., Ruiz-Sánchez A., et al. IgE to penicillins with different specificities can be identified by a multiepitope macromolecule: bihaptenic penicillin structures and IgE specificities. J Immunol Methods 2014, 406:43-50.
28. Kalé L., Skeel R., Bhandarkar M., Brunner R., Gursoy A., Krawetz N., et al. NAMD2: greater scalability for parallel molecular dynamics. J Comput Phys 1999, 151:283-312.
29. Tanis I., Karatasos K. Association of a weakly acidic anti-inflammatory drug (ibuprofen) with a poly(amidoamine) dendrimer as studied by molecular dynamics simulations. J Phys Chem B 2009, 113:10984-10993.
30. Díaz N., Suárez D., Merz K.M. Molecular dynamics simulations of the mononuclear zinc-β-lactamase from Bacillus cereus complexed with benzylpenicillin and a quantum chemical study of the reaction mechanism. J Am Chem Soc 2001, 123:9867-9879.
31. Roberts B.P., Scanlon M.J., Krippner G.Y., Chalmers D.K. Molecular dynamics of poly(l-lysine) dendrimers with naphthalene disulfonate caps. Macromolecules 2009, 42:2775-2783.
32. Humphrey W., Dalke A., Schulten K. VMD: visual molecular dynamics. J Mol Graph 1996, 14:33-38.
33. Blanca M., Romano A., Torres M.J., Férnandez J., Mayorga C., Rodriguez J., et al. Update on the evaluation of hypersensitivity reactions to betalactams. Allergy 2009, 64:183-193.
34. Chai M., Niu Y., Youngs W.J., Rinaldi P.L. Structure and conformation of DAB dendrimers in solution via multidimensional NMR techniques. J Am Chem Soc 2001, 123:4670-4678.
35. Naylor A.M., Goddard W.A., Kiefer G.E., Tomalia D.A. Starburst dendrimers. 5. Molecular shape control. J Am Chem Soc 1989, 111:2339-2341.
36. Liu Y., Bryantsev V.S., Diallo M.S., Goddard W.A. PAMAM dendrimers undergo pH responsive conformational changes without swelling. J Am Chem Soc 2009, 131:2798-2799.
37. Wu P., Malkoch M., Hunt J.N., Vestberg R., Kaltgrad E., Finn M.G., et al. Multivalent, bifunctional dendrimers prepared by click chemistry. Chem Commun 2005, 5775-5777.
38. Zong H., Thomas T.P., Lee K.-H., Desai A.M., Li M., Kotlyar A., et al. Bifunctional PAMAM dendrimer conjugates of folic acid and methotrexate with defined ratio. Biomacromolecules 2012, 13:982-991.
39. Montañez M.I., Hed Y., Utsel S., Ropponen J., Malmström E., Wågberg L., et al. Bifunctional dendronized cellulose surfaces as biosensors. Biomacromolecules 2011, 12:2114-2125.
40. Antoni P., Hed Y., Nordberg A., Nyström D., von Holst H., Hult A., et al. Bifunctional dendrimers: from robust synthesis and accelerated one-pot postfunctionalization strategy to potential applications. Angew Chem Int Ed 2009, 48:2126-2130.
41. Goodwin A.P., Lam S.S., Fréchet J.M.J. Rapid, efficient synthesis of heterobifunctional biodegradable dendrimers. J Am Chem Soc 2007, 129:6994-6995.
42. Blanca M., Mayorga C., Torres M.J., Warrington R., Romano A., Demoly P., et al. Side-chain-specific reactions to betalactams: 14years later. Clin Exp Allergy 2002, 32:192-197.