Knockdown of NF-κB p65 subunit expression suppsses growth of nude mouse lung tumor cell xenografts by activation of Bax apoptotic pathway

Neoplasma

Volumn 62, Issue 1, 2015, Pages 34-40

  Qu, Y ^a   Zhang, X ^a   Wu, R ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Lung cancer; NF KB; Small interfering RNA; Xenografts

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAX; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARCINOGENICITY; CELL GROWTH; CONTROLLED STUDY; LUNG TUMOR; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT; TUNEL ASSAY; UPREGULATION; WESTERN BLOTTING;

EID: 84933512658     PISSN: 00282685     EISSN: 13384317     Source Type: Journal    
DOI: 10.4149/neo_2015_005     Document Type: Article

References (42)

1. MILLER AV, HICKS MA, NAKAJIMA W, RICHARDSON AC, WINDLE JJ, et al.: Paclitaxel-Induced Apoptosis Is BAK-Dependent, but BAX and BIM-Independent in Breast Tumor. PloS one 2013; 8: e60685. http://dx.doi.org/10.1371/journalpone.0060685
2. BHUJADE A, GUPTA G, TALMALE S, DAS S and Patil M: Induction of apoptosis in A431 skin cancer cells by Cissus quadrangularis Linn stem extract by altering Bax-Bcl-2 ratio, release of cytochrome c from mitochondria and PARP cleavage. Food & function 2013; 4: 338-346.
3. DEYHIMI P AND TAVAKOLI P: Study of apoptosis in oral pemphigus vulgaris using immunohistochemical marker Bax and TUNEL technique. J Oral Pathol Med 2012.
4. SHAPIRO M: The role of adjuvant chemotherapy in early-stage and locally advanced non-small cell lung cancer. Cleveland Clinic Journal of Medicine 2012; 79: e-S42-e-S45.
5. CHEN Y-T, FENG B and Chen L-B: Update of research on drug resistance in small cell lung cancer chemotherapy. Asian Pac J Cancer Prev 2012; 13: 3577-3581. http://dx.doi.org/10.7314/APJCP.2012.13.8.3577.
6. PORE MM, HILTERMANN TJN and Kruyt FA: Targeting apoptosis pathways in lung cancer. Cancer Lett 2013; 332: 359-368. http://dx.doi.org/10.1016/jcanlet.2010.09.012
7. DEAN EJ, RANSON M, BLACKHALL F, HOLT SV and Dive C: Novel therapeutic targets in lung cancer: Inhibitor of apoptosis proteins from laboratory to clinic. Cancer Treat Rev 2007; 33: 203-212. http://dx.doi.org/10.1016/j.crtrv.2006.11.002
8. MALONEY A AND WORKMAN P: HSP90 as a new therapeutic target for cancer therapy: the story unfolds. Expert opinion on biological therapy 2002; 2: 3-24. http://dx.doi.org/10.1517/14712598.2.1.3
9. SIRVENT N, IMBERT V, FRELIN C, GRIESSINGER E AND PEYRON J: Fighting cancer via NF-kappa B inhibition]. Archives de pédiatrie: organe officiel de la Sociéte française de pédiatrie 2003; 10: 632.
10. HAEFNER B: NF-κB: arresting a major culprit in cancer. Drug Discov Today 2002; 7: 653-663. http://dx.doi.org/10.1016/S1359-6446(02)02309-7
11. BARKETT M and GILMORE TD: Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene 1999; 18: 6910-6924. http://dx.doi.org/10.1038/sj.onc.1203238
12. KARIN M, CAO Y, GRETEN FR AND LI Z-W: NF-κB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2002; 2: 301-310. http://dx.doi.org/10.1038/nrc780
13. KARIN M AND LIN A: NF-κB at the crossroads of life and death. Nat Immunol 2002; 3: 221-227. http://dx.doi.org/10.1038/ni0302-221
14. LI Z-W, CHU W, HU Y, DELHASE M, DEERINCK T, et al.: The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor kB activation and prevention ot apoptosis. J Exp Med 1999; 189: 1839-1845. http://dx.doi.org/10.1084/jem.189.11.1839
15. WANG X, CHEN Y, REN I AND QU X: Small interfering RNA for effective cancer therapies. Mini reviews in medicinal chemistry 2011; 11: 114-124. http://dx.doi.org/10.2174/138955711794519528
16. VERSTREPEN L, CARPENTIER I, VERHELST K AND BEYAERT R: ABINS: A20 binding inhibitors of NF-κB and apoptosis signaling. Biochem Pharmacol 2009; 78: 105-114. http://dx.doi.org/10.1016/j.bcp.2009.02.009
17. ZHAO M, GAO Y, WANG L, LIU S, HAN B, et al.: Overexpression of Integrin-linked Kinase Promotes Lung Cancer Cell Migration and Invasion via NF-κB-mediated Upregulation of Matrix Metalloproteinase-9. Int J Med Sci 2013; 10:995. http://dx.doi.org/10.7150/ijms.5963
18. CHEN P-M, WU T-C, WANG Y-C, CHENG Y-W, SHEU G.T, et al.: Activation of NF-κB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKβ expression. Carcinogenesis 2013, 34: 2655-2663. http://dx.doi.org/10.1093/carcin/bgt220
19. TANG Z-P, DONG Q-Z, CUI Q-Z, PAPAVASSILIOU P, WANG E-D, et al.: Ataxia-Telangiectasia Group D Complementing Gene (ATDC) Promotes Lung Cancer Cell Proliferation by Activating NF-κB Pathway. PloS one 2013; 8: e63676. http://dx.doi.org/10.1371/journal.pone.0063676
20. YOUN H, JEONG J-C, JEONG YS, KIM E-J AND UM S-J: Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells. Biological & pharmaceutical bulletin 2012; 36: 944-951. http://dx.doi.org/10.1248/bpb.b12-01004
21. MI J, ZHANG X, RABBANI ZN, LIU Y, REDDY SK, et al.: RNA aptamer-targeted inhibition of NF-κB suppresses nonsmall cell lung cancer resistance to doxorubicin. Mol Ther 2007; 16: 66-73. http://dx.doi.org/10.1038/sj.mt.6300320
22. MA J, ZHANG Z AND ZHANG L: Expression of NF-kappa B and AP-1 in non-small cell lung cancer. Zhongguo fei ai za zhi=Chinese journal of lung cancer 2005; 8: 440.
23. TABATA M AND GANAPATHI R: NF-κB Activation in Topoisomerase I Inhibitor-Induced Apoptotic Cell Death in Human Non-Small Cell Lung Cancer. Ann N Y Acad Sci 2000; 922: 343-344. http://dx.doi.org/10.1111/j.1749-6632.2000.tb07060.x
24. YU M AND LIU X: [Recent progress in the study of HIV-1 transcription factor NF-kappaB and its inhibitors], Yao xue xue bao= Acta pharmaceutica Sinica 2007; 42: 1007-1012.
25. MAYO MW, NORRIS JL AND BALDWIN AS: Ras regulation of NF-kB and apoptosis. Methods in enzymology 2001; 333:73-87. http://dx.doi.org/10.1016/S0076-6879(01)33046-X
26. FARROW S: Death receptors, NF-kappa B activation and apoptosis: the potential for therapeutic intervention. Biochem Soc Trans 1999; 27: 812.
27. VAN ANTWERP DJ, MARTIN SJ, VERMA IM and GREEN DR: INHIBITION OF TNFTNDUCED APOPTOSIS BY NF-κB. Trends Cell Biol 1998; 8: 107-111. http://dx.doi.org/10.1016/S0962-8924(97)01215-4
28. RUSHWORTH SA, BOWLES KM, RANINGA P and MACEWAN DJ: NF-κB-inhibited acute myeloid leukemia cells are rescued from apoptosis by heme oxygenase-1 induction. Cancer Res 2010; 70: 2973-2983. http://dx.doi.org/10.1158/0008-5472.CAN-09-3407
29. KIM D-S, PARK S-S, NAM B-H, KIM I-H AND KIM S-Y: Reversal of drug resistance in breast cancer cells by transglutaminase 2 inhibition and nuclear factor-κB inactivation. Cancer Res 2006; 66: 10936-10943. http://dx.doi.org/10.1158/0008-5472.CAN-06-1521
30. MEYLAN E, DOOLEY AL, FELDSER DM, SHEN L, TURK E, et al.: Requirement for NF-&kgr; B signalling in a mouse model of lung adenocarcinoma. Nature 2009; 462: 104-107. http://dx.doi.org/10.1038/nature08462
31. CONNELLY L, BARHAM W, ONISHKO HM, SHERRILL T, CHODOSH LA, et al.: Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden. Oncogene 2010; 30:1402-1412. http://dx.doi.org/10.1038/onc.2010.521
32. ENARI M, SAKAHIRA H, YOKOYAMA H, OKAWA K, IWAMATSU A, et al.: A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1998; 391: 43-50. http://dx.doi.org/10.1038/34112
33. TIAN F, FAN T, JIANG Y, ZHANG X AND WANG X: A small interfering RNA targeting NF-κB p65 alone or combined with 5-FU inhibits growth of esophageal squamous cell carcinoma in nude mice. Pathology-Research and Practice 2012; 208; 32-38. http://dx.doi.Org/10.1016/j.prp.2011.10.011
34. INOUE M, MATSUMOTO S, SAITO H, TSUJITANIS AND IKEGUCHI M: Intraperitoneal administration of a small interfering RNA targeting nuclear factor-kappa B with paclitaxel successfully prolongs the survival of xenograft model mice with peritoneal metastasis of gastric cancer. Int J Cancer 2008; 123: 2696-2701. http://dx.doi.org/10.1002/ijc.23867
35. ZHU A, ZHOU H, XIA J, JIN H, WANG K, et al.: Ziyuglycoside II-induced apoptosis in human gastric carcinoma BGC-823 cells by regulating Bax/Bcl-2 expression and activating caspase-3 pathway. Braz J Med Biol Res 2013; 46:670-675. http://dx.doi.org/10.1590/1414-431X20133050
36. MURPHY K, RANGANATHAN V, FARNSWORTH M, KAVALLARIS M and LOCK R: Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells. Cell Death Differ 2000; 7: 102-111. http://dx.doi.org/10.1038/sj.cdd.4400597
37. NOMURA M, SHIMIZU S, ITO T, NARITA M, MATSUDA H, et al.: Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2. Cancer Res 1999; 59: 5542-5548.
38. FINUCANE DM, BOSSY-WETZEL E, WATERHOUSE NJ, COTTER TG AND GREEN DR: Bax-induced caspase activation and apoptosis via cytochromec release from mitochondria is inhibitable by Bcl-xL. J Biol Chem 1999; 274: 2225-2233. http://dx.doi.org/10.1074/jbc.274.4.2225
39. WALENSKY LD AND GAVATHIOTIS E: BAX UNLEASHED: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore. Trends Biochem Sci 2011; 36: 642-652. http://dx.doi.org/10.1016/j.tibs.2011.08.009
40. BASA-EZ G, SOANE L AND HARDWICK JM: A New View of the Lethal Apoptotic Pore. PLoS biology 2012; 10:el001399. http://dx.doi.org/10.1371/journal.pbio.1001399
41. ROSSÉ T, OLIVIER R, MONNEY L, RAGER M, CONUS S, et al.: Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature 1998; 391: 496-499. http://dx.doi,org/10.1038/35160
42. JURGENSMEIER JM, XIE Z, DEVERAUX Q, ELLERBY L, BREDESEN D, et al.: Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A 1998; 95: 4997-5002. http://dx.doi.org/10.1073/.pnas.95.9.4997