A retrospective cohort study examining the association between body mass index and mortality in severe sepsis

Internal and Emergency Medicine

Volumn 10, Issue 4, 2015, Pages 471-479

  Gaulton, Timothy Glen ^a   Marshall MacNabb, C ^b   Mikkelsen, Mark Evin ^b,c   Agarwal, Anish Kumar ^b,c   Cham Sante, S ^d   Shah, Chirag Vinay ^e   Gaieski, David Foster ^b,c,f  

^a HARVARD UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^d Janet Weis Children s Hospital   (United States)

^e MORRISTOWN MEDICAL CENTER   (United States)

^f THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Body mass index; Obesity; Organ dysfunction; Resuscitation; Sepsis

Indexed keywords

ADULT; AGED; BODY MASS; BODY WEIGHT; COMPLICATION; FEMALE; HOSPITAL EMERGENCY SERVICE; HUMAN; LENGTH OF STAY; MALE; MIDDLE AGED; MORBID OBESITY; MORTALITY; RETROSPECTIVE STUDY; SEPSIS; STATISTICAL MODEL;

ADULT; AGED; BODY MASS INDEX; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; LENGTH OF STAY; LOGISTIC MODELS; MALE; MIDDLE AGED; OBESITY, MORBID; RETROSPECTIVE STUDIES; SEPSIS; THINNESS;

EID: 84933180726     PISSN: 18280447     EISSN: 19709366     Source Type: Journal    
DOI: 10.1007/s11739-015-1200-1     Document Type: Article

References (34)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303–1310
2. Gaieski DF, Edwards JM, Kallan M, Carr BG (2013) Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med 41:1167–1174
3. Nguyen HB, Rivers EP, Abrahamian FM et al (2006) Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med 48:28–54
4. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM (2006) Prevalence of overweight and obesity in the United States, 1999–2004. JAMA 295:1549–1555
5. Troiano RP, Frongillo EA Jr, Sobal J, Levitsky DA (1996) The relationship between body weight and mortality: a quantitative analysis of combined information from existing studies. Int J Obes Relat Metab Disord 20:63–75
6. Garrouste-Orgeas M, Troche G, Azoulay E et al (2004) Body mass index. An additional prognostic factor in ICU patients. Intensive Care Med 30:437–443
7. Tremblay A, Bandi V (2003) Impact of body mass index on outcomes following critical care. Chest 123:1202–1207
8. El-Solh A, Sikka P, Bozkanat E, Jaafar W, Davies J (2001) Morbid obesity in the medical ICU. Chest 120:1989–1997
9. Goulenok C, Monchi M, Chiche J-D, Mira JP, Dhainaut JFo, Cariou A (2004) Influence of overweight on ICU mortality. Chest 125:1441–1445
10. Akinnusi ME, Pineda LA, El Solh AA (2008) Effect of obesity on intensive care morbidity and mortality: a meta-analysis. Crit Care Med 36:151–158
11. Frat JP, Gissot V, Ragot S et al (2008) Impact of obesity in mechanically ventilated patients: a prospective study. Intensive Care Med 34:1991–1998
12. Ray DE, Matchett SC, Baker K, Wasser T, Young MJ (2005) The effect of body mass index on patient outcomes in a medical ICU. Chest 127:2125–2131
13. Sakr Y, Madl C, Filipescu D et al (2008) Obesity is associated with increased morbidity but not mortality in critically ill patients. Intensive Care Med 34:1999–2009
14. Prescott HC, Chang VW, O’Brien JR, JM, Langa KM, Iwashyna T (2014) Obesity and 1-year outcomes in older americans with severe sepsis. Crit Care Med (Epub ahead of print)
15. Shor-Posner G, Campa A, Zhang G et al (2000) When obesity is desirable: a longitudinal study of the Miami HIV-1-infected drug abusers (MIDAS) cohort. J Acquir Immune Defic Syndr 23:81–88
16. Fleischmann E, Teal N, Dudley J, May W, Bower JD, Salahudeen AK (1999) Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. Kidney Int 55:1560–1567
17. Grady KL, White-Williams C, Naftel D et al (1999) Are preoperative obesity and cachexia risk factors for post heart transplant morbidity and mortality: a multi-institutional study of preoperative weight-height indices. Cardiac Transplant Research Database (CTRD) Group. J Heart Lung Transplant 18:750–763
18. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr (1999) Body-mass index and mortality in a prospective cohort of US adults. N Engl J Med 341:1097–1105
19. Hoit BD, Gilpin EA, Maisel AA, Henning H, Carlisle J, Ross J Jr (1987) Influence of obesity on morbidity and mortality after acute myocardial infarction. Am Heart J 114:1334–1341
20. Choban PS, Weireter LJ Jr, Maynes C (1991) Obesity and increased mortality in blunt trauma. J Trauma 31:1253–1257
21. Hedlund J, Hansson LO, Ortqvist A (1995) Short- and long-term prognosis for middle-aged and elderly patients hospitalized with community-acquired pneumonia: impact of nutritional and inflammatory factors. Scand J Infect Dis 27:32–37
22. Morris AE, Stapleton RD, Rubenfeld GD, Hudson LD, Caldwell E, Steinberg KP (2007) The association between body mass index and clinical outcomes in acute lung injury*. Chest 131:342–348
23. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G (2003) SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 31(4):1250–1256
24. Mikkelsen M, Miltiades A, Gaieski D et al (2009) Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med 37(5):1670–1677
25. Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) APACHE II: a severity of disease classification system. Crit Care Med 13:818–829
26. Clinical Guidelines on the Identification (1998) Evaluation, and treatment of overweight and obesity in adults-the evidence report. National Institutes of Health. Obes Res 6(Suppl 2):51S–209S
27. Maldonado G, Greenland S (1993) Simulation study of confounder-selection strategies. Am J Epidemiol 138:923–936
28. Desquilbet L, Mariotti F (2010) Dose-response analyses using restricted cubic spline functions in public health research. Statist Med 29:1037–1057
29. Sakr Y, Elia C, Mascia L, Barberis B et al (2012) Being overweight or obese is associated with decreased mortality in critically ill patients: a retrospective analysis of a large regional Italian multicenter cohort. J Crit Care 27:414–721
30. Sack MN, Murphy E (2011) The role of comorbidities in cardioprotection. J Cardiovasc Pharmacol Ther 16:267–272
31. Shah R, Hinkle CC, Haris L et al (2012) Adipose genes down-regulated during experimental endotoxemia are also suppressed in obesity. J Clin Endocrinol Metab 97:E2152–E2159
32. Stapleton RD, Dixon AE, Parsons PE et al (2010) The association between body mass index and plasma cytokine levels in patients with acute lung injury. Chest 138:568–577
33. Padwal RS, Pajewski NM, Allison DB, Sharma AM (2011) Using the Edmonton obesity staging system to predict mortality in a population-representative cohort of people with overweight and obesity. CMAJ 183(14):E1059–E1066
34. Wang HE, Griffin R, Judd S et al (2013) Obesity and risk of sepsis: A population-based cohort study. Obesity (Silver Spring) (Epub ahead of print)