α- and β-Santalols Directly Interact with Tubulin and Cause Mitotic Arrest and Cytotoxicity in Oral Cancer Cells

Journal of Natural Products

Volumn 78, Issue 6, 2015, Pages 1357-1362

  Lee, Brigette ^a   Bohmann, Jonathan ^b   Reeves, Tony ^b   Levenson, Corey ^c   Risinger, April L ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTHWEST RESEARCH INSTITUTE   (United States)

^c Santalis Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SANTALOL; BETA SANTALOL; EAST INDIAN SANDALWOOD OIL; PLANT MEDICINAL PRODUCT; TUBULIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; COLCHICINE; SANTALOL; SESQUITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; MITOSIS SPINDLE; MOUSE; NONHUMAN; SANTALUM ALBUM; SQUAMOUS CELL CARCINOMA CELL LINE; APOPTOSIS; CELL CYCLE; CELL DIVISION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; MICROTUBULE; MITOSIS; MOUTH NEOPLASMS; SANTALUM; STEREOISOMERISM;

SANTALUM;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL DIVISION; COLCHICINE; G2 PHASE; HUMANS; MICROTUBULES; MITOSIS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOUTH NEOPLASMS; SANTALUM; SESQUITERPENES; STEREOISOMERISM; TUBULIN;

EID: 84933056389     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/acs.jnatprod.5b00207     Document Type: Article

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