Genome-wide maps of recombination and chromosome segregation in human oocytes and embryos show selection for maternal recombination rates

Nature Genetics

Volumn 47, Issue 7, 2015, Pages 727-735

  Ottolini, Christian S ^a,b   Newnham, Louise J ^c   Capalbo, Antonio ^d   Natesan, Senthilkumar A ^e   Joshi, Hrishikesh A ^e   Cimadomo, Danilo ^d   Griffin, Darren K ^b   Sage, Karen ^a   Summers, Michael C ^a,b   Thornhill, Alan R ^e   Housworth, Elizabeth ^f   Herbert, Alex D ^c   Rienzi, Laura ^d   Ubaldi, Filippo M ^d   Handyside, Alan H ^a,b,e,g   Hoffmann, Eva R ^c  

^a Bridge Centre   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

^d Clinica Villa Mafalda   (Italy)

^e Illumina Inc ^*  (United Kingdom)

^f INDIANA UNIVERSITY   (United States)

^g UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA;

ADULT; ANEUPLOIDY; ARTICLE; ASYMMETRIC CELL DIVISION; CENTROMERE; CHROMATID; CHROMOSOME ARM; CHROMOSOME NUMBER; CHROMOSOME SEGREGATION; CHROMOSOME SIZE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DNA STRAND; FEMALE; FERTILIZATION IN VITRO; FETUS DEVELOPMENT; FOLLOW UP; GENE AMPLIFICATION; GENE MAPPING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RECOMBINATION; GENETIC SCREENING; GENOTYPE; HAPLOTYPE; HETEROZYGOSITY; HUMAN; HUMAN CELL; HUMAN EMBRYO; INTRACYTOPLASMIC SPERM INJECTION; LIVE BIRTH; MATERNAL AGE; MEIOSIS; OOCYTE; OOCYTE DEVELOPMENT; POLAR BODY; POPULATION STRUCTURE; PREGNANCY DISORDER; PRIORITY JOURNAL; PRONUCLEUS; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SISTER CHROMATID; X CHROMOSOME; CELL CULTURE; CHROMOSOME MAP; CROSSING OVER; DNA SEQUENCE; HUMAN GENOME; PHYSIOLOGY;

CELLS, CULTURED; CHROMOSOME MAPPING; CHROMOSOME SEGREGATION; CROSSING OVER, GENETIC; FEMALE; GENOME, HUMAN; HUMANS; MEIOSIS; OOCYTES; POLAR BODIES; POLYMORPHISM, SINGLE NUCLEOTIDE; RECOMBINATION, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 84933054617     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3306     Document Type: Article

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