Antagonism effects of cypermethrin on interleukin-6-induced androgen receptor activation

Environmental Toxicology and Pharmacology

Volumn 40, Issue 1, 2015, Pages 172-174

  Wang, Qi ^a   Xu, Li Fang ^a   Zhou, Ji Long ^a   Zhou, Xiao Long ^a   Wang, Hui ^a   Ju, Qiang ^a   Pan, Chen ^a   Zhang, Jin Peng ^a   Zhang, Mei Rong ^a   Yu, Hong Min ^a   Xu, Li Chun ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Androgen receptor; Antiandrogen; Cypermethrin; Interleukin 6; Ligand independent manner

Indexed keywords

ANDROGEN RECEPTOR; CHLORAMPHENICOL TRANSFERASE; CYPERMETHRIN; INTERLEUKIN 6; TRANSFERASE; UNCLASSIFIED DRUG; ANDROSTANOLONE; CATALASE; PYRETHROID;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIGAND BINDING; LNCAP CELL LINE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; REPORTER GENE; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM;

MOUSE MAMMARY TUMOR VIRUS;

ANIMALS; CATALASE; CELL LINE; DIHYDROTESTOSTERONE; GENES, REPORTER; INTERLEUKIN-6; PYRETHRINS; RECEPTORS, ANDROGEN;

EID: 84933046428     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2015.06.008     Document Type: Article

References (25)

1. Cai Z.M., Gui Y.T., Guo X., Yu J., Guo L.D., Zhang L.B., Wang H., Yu J. Low expression of glycoprotein subunit 130 in ejaculated spermatozoa from asthenozoospermic men. J. Androl. 2006, 27:645-652.
2. Chen T., Wang L.H., Farrar W.L. Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells. Cancer Res. 2000, 60:2132-2135.
3. Culig Z., Puhr M. Interleukin-6: a multifunctional targetable cytokine in human prostate cancer. Mol. Cell. Endocrinol. 2012, 360:52-58.
4. Hu J.X., Li Y.F., Li J., Pan C., He Z., Dong H.Y., Xu L.C. Toxic effects of cypermethrin on the male reproductive system: with emphasis on the androgen receptor. J. Appl. Toxicol. 2013, 33:576-585.
5. Hu J.X., Li Y.F., Pan C., Zhang J.P., Wang H.M., Li J., Xu L.C. Anti-androgen effects of cypermethrin on the amino- and carboxyl-terminal interaction of the androgen receptor. Toxicology 2012, 292:99-104.
6. Kim H.J., Lee W.J. Ligand-independent activation of the androgen receptor by insulin-like growth factor-I and the role of the MAPK pathway in skeletal muscle cells. Mol. Cells 2009, 28:589-593.
7. Knez J. Endocrine-disrupting chemicals and male reproductive health. Reprod. Biomed. Online 2013, 26:440-448.
8. Kojima H., Katsura E., Takeuchi S., Niiyama K., Kobayashi K. Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ. Health Perspect. 2004, 112:524-531.
9. Kumar V., Majumdar C., Roy P. Effects of endocrine disrupting chemicals from leather industry effluents on male reproductive system. J. Steroid. Biochem. Mol. Biol. 2008, 111:208-216.
10. Lachance C., Leclerc P. Mediators of the Jak/STAT signaling pathway in human spermatozoa. Biol. Reprod. 2011, 85:1222-1231.
11. Lee S.O., Lou W., Hou M., de Miguel F., Gerber L., Gao A.C. Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells. Clin. Cancer. Res. 2003, 9:370-376.
12. Pan C., Liu Y.P., Li Y.F., Hu J.X., Zhang J.P., Wang H.M., Li J., Xu L.C. Effects of cypermethrin on the ligand-independent interaction between androgen receptor and steroid receptor coactivator-1. Toxicology 2012, 299:160-164.
13. Pan C., Wang Q., Liu Y.P., Xu L.F., Li Y.F., Hu J.X., Jiang M., Zhang J.P., Zhang M.R., Yu H.M., Zhou J.L., Zhou X.L., Xu L.C. Anti-androgen effects of the pyrethroid pesticide cypermethrin on interactions of androgen receptor with corepressors. Toxicology 2013, 311:178-183.
14. Potashnik H., Elhija M.A., Lunenfeld E., Potashnik G., Schlatt S., Nieschlag E., Huleihel M. Interleukin-6 expression during normal maturation of the mouse testis. Eur. Cytokine Netw. 2005, 16:161-165.
15. Rival C., Theas M.S., Guazzone V.A., Lustig L. Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis. J. Reprod. Immunol. 2006, 70:43-58.
16. Sadar M.D., Gleave M.E. Ligand-independent activation of the androgen receptor by the differentiation agent butyrate in human prostate cancer cells. Cancer Res. 2000, 60:5825-5831.
17. Shukla K.K., Agnihotri S., Gupta A., Mahdi A.A., Mohamed E.A., Sankhwar S.N., Sharma P. Significant association of TNFalpha and IL-6 gene with male infertility - an explorative study in Indian populations of Uttar Pradesh. Immunol. Lett. 2013, 156:30-37.
18. Sun H., Xu X.L., Xu L.C., Song L., Hong X., Chen J.F., Cui L.B., Wang X.R. Antiandrogenic activity of pyrethroid pesticides and their metabolite in reporter gene assay. Chemosphere 2007, 66:474-479.
19. Ueda T., Bruchovsky N., Sadar M.D. Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. J. Biol. Chem. 2002, 277:7076-7085.
20. Ueda T., Mawji N.R., Bruchovsky N., Sadar M.D. Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. J. Biol. Chem. 2002, 277:38087-38094.
21. Wang H., Wang Q., Zhao X.F., Liu P., Meng X.H., Yu T., Ji Y.L., Zhang H., Zhang C., Zhang Y., Xu D.X. Cypermethrin exposure during puberty disrupts testosterone synthesis via downregulating StAR in mouse testes. Arch. Toxicol. 2010, 84:53-61.
22. Xu L.C., Liu L., Ren X.M., Zhang M.R., Cong N., Xu A.Q., Shao J.H. Evaluation of androgen receptor transcriptional activities of some pesticides in vitro. Toxicology 2008, 243:59-65.
23. Xu L.C., Sun H., Chen J.F., Bian Q., Qian J., Song L., Wang X.R. Evaluation of androgen receptor transcriptional activities of bisphenol A, octylphenol and nonylphenol in vitro. Toxicology 2005, 216:197-203.
24. Xu L.C., Sun H., Chen J.F., Bian Q., Song L., Wang X.R. Androgen receptor activities of p,p'-DDE, fenvalerate and phoxim detected by androgen receptor reporter gene assay. Toxicol. Lett. 2006, 160:151-157.
25. Yasunaga R., Ikuta J., Murata Y., Inoue K., Koga H., Masaki T., Tamura H. Ligand-independent androgen receptor antagonism caused by the newly developed pesticide pyrifluquinazon (PFQ). Reprod. Toxicol. 2013, 35:1-6.