Genome-wide association analysis identified splicing single nucleotide polymorphism in CFLAR predictive of triptolide chemo-sensitivity

BMC Genomics

Volumn 16, Issue 1, 2015, Pages

  Chauhan, Lata ^a   Jenkins, Gregory D ^b   Bhise, Neha ^c   Feldberg, Tanya ^c   Mitra Ghosh, Taraswi ^c   Fridley, Brooke L ^d   Lamba, Jatinder K ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

CFLAR; Genome wide association studies; Hap map; Single nucleotide polymorphisms; Triptolide

Indexed keywords

CASPASE 10; CASPASE 8; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE 1; STAT6 PROTEIN; TRIPTOLIDE; CFLAR PROTEIN, HUMAN; DITERPENE; EPOXIDE; HERBACEOUS AGENT; JAK1 PROTEIN, HUMAN; PHENANTHRENE DERIVATIVE; SMALL INTERFERING RNA;

ALTERNATIVE RNA SPLICING; ARTICLE; CASPASE 10 GENE; CASPASE 8 GENE; CAUCASIAN; CFLAR GENE; CHEMOSENSITIVITY; CHROMOSOME 2; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG RESPONSE; GENE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC TRANSFECTION; HAPLOTYPE MAP; HUMAN; HUMAN CELL; IC50; LYMPHOBLASTOID CELL LINE; NUCLEAR FACTOR KAPPA B GENE; PHARMACOGENETICS; PPIL3 GENE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; STAT6 GENE; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HUMAN GENOME; METABOLISM; QUANTITATIVE TRAIT LOCUS; RNA INTERFERENCE; RNA SPLICING; TRIPTERYGIUM; TUMOR CELL LINE;

TRIPTERYGIUM WILFORDII;

CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES; DRUGS, CHINESE HERBAL; EPOXY COMPOUNDS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HUMANS; JANUS KINASE 1; PHENANTHRENES; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RNA INTERFERENCE; RNA SPLICING; RNA, SMALL INTERFERING; TRIPTERYGIUM;

EID: 84933043798     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/s12864-015-1614-1     Document Type: Article

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