Different DNA methylation pattern of HPV16, HPV18 and HPV51 genomes in asymptomatic HPV infection as compared to cervical neoplasia

Virology

Volumn 484, Issue , 2015, Pages 227-233

  Simanaviciene, Vaida ^a   Popendikyte, Violeta ^b   Gudleviciene, Zivile ^a,c   Zvirbliene, Aurelija ^a  

^a VILNIUS UNIVERSITY   (Lithuania)

^b Thermo Fischer Scientific Baltic ^*  (Lithuania)

^c National Research Institute   (Lithuania)

Author keywords

Cervical neoplasia; DNA methylation; Human papillomavirus

Indexed keywords

CYTOSINE; TUMOR MARKER; VIRUS DNA;

ADULT; AGED; ARTICLE; ASYMPTOMATIC INFECTION; CANCER GRADING; COMPARATIVE STUDY; CONTROLLED STUDY; CPG ISLAND; DISEASE SEVERITY; DNA METHYLATION; DNA MODIFICATION; DNA SEQUENCE; EPIGENETICS; FEMALE; GENE AMPLIFICATION; GENE TARGETING; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; HUMAN PAPILLOMAVIRUS TYPE 51; HUMAN TISSUE; L1 GENE; LONG CONTROL REGION; MAJOR CLINICAL STUDY; NONHUMAN; PAPILLOMAVIRUS INFECTION; PRIORITY JOURNAL; PROMOTER REGION; UTERINE CERVIX CANCER; VIRUS CARCINOGENESIS; VIRUS DETECTION; VIRUS GENE; VIRUS GENOME; VIRUS MORPHOLOGY; WART VIRUS; ADOLESCENT; ASYMPTOMATIC DISEASE; GENETIC EPIGENESIS; GENETICS; METABOLISM; MIDDLE AGED; PAPILLOMAVIRIDAE; PATHOLOGY; UTERINE CERVIX TUMOR; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

HUMAN PAPILLOMAVIRUS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ASYMPTOMATIC DISEASES; DNA METHYLATION; DNA, VIRAL; EPIGENESIS, GENETIC; FEMALE; GENOME, VIRAL; HUMANS; MIDDLE AGED; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; UTERINE CERVICAL NEOPLASMS; YOUNG ADULT;

EID: 84932641084     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2015.06.008     Document Type: Article

References (38)

1. Badal S, Badal V, Calleja-Macias IE, Kalantari M, Chuang LSH, Li BFL, et al. The human papillomavirus-18 genome is efficiently targeted by cellular DNA methylation. Virology 2004, 324:483-492.
2. Badal V, Chuang LS, Tan EH, Badal S, Villa LL, Wheeler CM, et al. CpG methylation of human papillomavirus type 16 DNA in cervical cancer cell lines and in clinical specimens: genomic hypomethylation correlates with carcinogenic progression. J. Virol. 2003, 77:6227-6234.
3. Bhattacharjee B, Sengupta S. CpG methylation of HPV16 LCR at E2 binding site proximal to P97 is associated with cervical cancer in presence of intact E2. Virology 2006, 354:280-285.
4. Brandsma JL, Sun Y, Lizardi PM, Tuck DP, Zelterman D, Haines GK, et al. Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy. Virology 2009, 389:100-107.
5. Bryant D, Onions T, Raybould R, Jones S, Tristram A, Hibbitts S, et al. Increased methylation of Human papillomavirus type 16 DNA correlates with viral integration in vulval intraepithelial neoplasia. J. Clin. Virol. 2014, 61:393-399.
6. Burd EM. Human papillomavirus and cervical cancer. Clin. Microbiol. Rev. 2003, 16:1-17.
7. Cogliano V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F. Carcinogenicity of human papillomaviruses. Lancet Oncol. 2005, 6:204.
8. Daniel B, Mukherjee G, Seshadri L, Vallikad E, Krishna S. Changes in the physical state and expression of human papillomavirus type 16 in the progression of cervical intraepithelial neoplasia lesions analysed by PCR. J. Gen. Virol. 1995, 76:2589-2593.
9. Ding DC, Chiang MH, Lai HC, Hsiung CA, Hsieh CY, Chu TY. Methylation of the long control region of HPV16 is related to the severity of cervicalneoplasia. Eur. J. Obstet. Gynecol. Reprod. Biol. 2009, 147:215-220.
10. Doerfler W, Remus R, Müller K, Heller H, Hohlweg U, Schubbert R. The fate of foreign DNA in mammalian cells and organisms. Dev. Biol. 2001, 106:89-97.
11. Fernandez AF, Rosales C, Lopez-Nieva P, Grana O, Ballestar E, Ropero S, et al. The dynamicDNA methylomes of double-stranded DNA viruses associated with human cancer. Genome Res. 2009, 19:438-451.
12. Gall T, Kis A, Feher E, Gergely L, Szarka K. Virological failure of intralesional cidofovir therapy in recurrent respiratory papillomatosis is not associated with genetic or epigenetic changes of HPV11: complete genome comparison of sequential isolates. Antiviral Res. 2011, 92:356-358.
13. Hong D, Ye F, Lu W, HuY, Wan X, Chen Y, et al. Methylation status of the longcontrol region of HPV16 in clinical cervical specimens. Mol. Med. Rep. 2008, 1:555-560.
14. Hoory T, Monie A, Gravitt P, Wu TC. Molecular epidemiology of human papillomavirus. J. Formos. Med. Assoc. 2008, 107:198-217.
15. Kalantari M, Calleja-Macias IE, Tewari D, Hagmar B, Lie K, Barrera-Saldana HA, et al. Conserved methylation patterns of human papillomavirus type 16 DNA in asymptomatic infection and cervical neoplasia. J. Virol. 2004, 78:12762-12772.
16. Kalantari M, Chase DM, Tewari KS, Bernard HU. Recombination of human papillomavirus-16 and host DNA in exfoliated cervical cells: a pilot study of L1 gene methylation and chromosomal integration as biomarkers of carcinogenic progression. J. Med. Virol. 2010, 82:311-320.
17. Kalantari M, Garcia-Carranca A, Morales-Vazquez CD, Zuna R, Montiel DP, Calleja-Macias IE, et al. Laser capture microdissection of cervical human papillomavirus infections: copy number of the virus in cancerous and normal tissue and heterogeneous DNA methylation. Virology 2009, 390:261-267.
18. Kalantari M, Villa LL, Calleja-Macias IE, Bernard HU. Human papillomavirus-16 and 18 in penile carcinomas: DNA methylation, chromosomal recombination, and genomic variation. Int. J. Cancer 2008, 123:1832-1840.
19. Kulis M, Esteller M. DNA methylation and cancer. Adv. Genet. 2010, 70:27-56.
20. Lazo PA. The molecular genetics of cervical carcinoma. Br. J. Cancer 1999, 80:2008-2018.
21. Longworth MS, Laimins LA. Pathogenesis of human papillomaviruses in differentiating epithelia. Microbiol. Mol. Biol. Rev. 2004, 68:362-372.
22. Mazumder ID, Singh RK, Mitra S, Dutta S, Chakraborty C, Basu PS, et al. Genetic and epigenetic changes of HPV16 in cervical cancer differentially regulate E6/E7 expression and associate with disease progression. Gynecol. Oncol. 2011, 123:597-604.
23. Mirabello L, Schiffman M, Ghosh A, Rodriguez AC, Vasiljevic N, Wentzensen N, et al. Elevated methylation of HPV16 DNA is associated with the development of high grade cervical intraepithelial neoplasia. Int. J. Cancer 2012, 132:1412-1422.
24. Murakami I, Fujii T, Dan K, Saito M, Ohno A, Iwata T, et al. Methylation of human papillomavirus-52 and -58 is a candidate biomarker in cervical neoplasia. J. Clin. Virol. 2013, 58:149-154.
25. Piyathilake CJ, Macaluso M, Alvarez RD, Chen M, Badiga S, Edberg JC, et al. A higher degree of methylation of the HPV16 E6 gene is associated with a lower likelihood of being diagnosed with cervical intraepithelial neoplasia. Cancer 2011, 117:957-963.
26. Simanaviciene V, Gudleviciene Z, Popendikyte V, Dekaminaviciute D, Stumbryte A, Rubinaite V, Zvirbliene A. Studies on the prevalence of oncogenic HPV types among Lithuanian women with cervical pathology. J .Med. Virol. 2015, 87:461-471.
27. Snellenberg S, Schutze DM, Claassen-Kramer D, Meijer CJ, Snijders PJ, Steenbergen RD. Methylation status of the E2 binding sites of HPV16 in cervical lesions determined with the Luminex® xMAP system. Virology 2012, 422:357-365.
28. Sun C, Reimers LL, Burk RD. Methylation of HPV16 genome CpG sites is associated with cervix precancer and cancer. Gynecol. Oncol. 2011, 121:59-63.
29. Sutter D, Doerfler W. Methylation of integrated adenovirus type 12 DNA sequences in transformed cells is inversely correlated with viral gene expression. Proc. Natl. Acad. Sci. USA 1980, 77:253-256.
30. Thain A, Jenkins O, Clarke AR, Gaston K. CpG methylation directly inhibits binding of the human papillomavirus type 16 E2 protein to specific DNA sequences. J. Virol. 1996, 70:7233-7235.
31. Turan T, Kalantari M, Calleja-Macias IE, Cubie HA, Cuschieri K, Villa LL, et al. Methylation of the human papillomavirus-18 L1 gene: a biomarker of neoplastic progression?. Virology 2006, 349:175-183.
32. Ure AE, Forslund O. Lack of methylation in the upstream region of human papillomavirus type 6 from aerodigestive tract papillomas. J. Virol. 2012, 86:13790-13794.
33. Van Tine BA, Kappes JC, Banerjee NS, Knops J, Lai L, Steenbergen RD, et al. Clonal selection for transcriptionally active viral oncogenes during progression to cancer. J. Virol. 2004, 78:11172-11186.
34. Vasiljevic N, Scibior-Bentkowska D, Brentnall A, Cuzick J, Lorincz A. A comparison of methylation levels in HPV18, HPV31 and HPV33 genomes reveals similar associations with cervical precancers. J. Clin. Virol. 2014, 59:161-166.
35. Vinokurova S, von Knebel DM. Differential methylation of the HPV16 upstream regulatory region during epithelial differentiation and neoplastic transformation. PLoS One 2011, 6:e24451.
36. Wentzensen N, Sun C, Ghosh A, Kinney W, Mirabello L, Wacholder S, et al. Methylation of HPV18, HPV31, and HPV45 genomes and cervical intraepithelial neoplasia grade 3. J. Natl. Cancer Inst. 2012, 104:1738-1749.
37. World Health Organisation, 2014. Human papillomavirus (HPV) and cervical cancer. Available from: (accessed November, 2014). http://www.who.int/mediacentre/factsheets/fs380/en/.
38. Xi LF, Jiang M, Shen Z, Hulbert A, Zhou XH, Lin YY, et al. Inverse association between methylation of human papillomavirus type 16 DNA and risk of cervical intraepithelial neoplasia grades 2 or 3. PLoS One 2011, 6:e23897.