-
1
-
-
0023211986
-
Isolation and characterization of DNA from the plasma of cancer-patients
-
Stroun, M., Anker, P., Lyautey, J., Lederrey, C. & Maurice, P. A. Isolation and characterization of DNA from the plasma of cancer-patients. Eur. J. Cancer Clin. Oncol. 23, 707-712 (1987).
-
(1987)
Eur. J. Cancer Clin. Oncol.
, vol.23
, pp. 707-712
-
-
Stroun, M.1
Anker, P.2
Lyautey, J.3
Lederrey, C.4
Maurice, P.A.5
-
2
-
-
77949395254
-
Keeping tabs on tumor DNA
-
Kaiser, J. Keeping tabs on tumor DNA. Science 327, 1074 (2010).
-
(2010)
Science
, vol.327
, pp. 1074
-
-
Kaiser, J.1
-
3
-
-
84903218109
-
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
-
Newman, A. M. et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nature Med. 20, 548-556 (2014).
-
(2014)
Nature Med.
, vol.20
, pp. 548-556
-
-
Newman, A.M.1
-
4
-
-
79957458567
-
Cell-free nucleic acids as biomarkers in cancer patients
-
Schwarzenbach, H., Hoon, D. S. B. & Pantel, K. Cell-free nucleic acids as biomarkers in cancer patients. Nature Rev. Cancer 11, 426-437 (2011).
-
(2011)
Nature Rev. Cancer
, vol.11
, pp. 426-437
-
-
Schwarzenbach, H.1
Hoon, D.S.B.2
Pantel, K.3
-
5
-
-
84898476658
-
Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA
-
Thierry, A. R. et al. Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA. Nature Med. 20, 430-436 (2014).
-
(2014)
Nature Med.
, vol.20
, pp. 430-436
-
-
Thierry, A.R.1
-
6
-
-
84873558500
-
Direct detection of a BRAF mutation in total RNA from melanoma cells using cantilever arrays
-
Huber, F., Lang, H. P., Backmann, N., Rimoldi, D. & Gerber, C. Direct detection of a BRAF mutation in total RNA from melanoma cells using cantilever arrays. Nature Nanotechnol. 8, 125-129 (2013).
-
(2013)
Nature Nanotechnol.
, vol.8
, pp. 125-129
-
-
Huber, F.1
Lang, H.P.2
Backmann, N.3
Rimoldi, D.4
Gerber, C.5
-
7
-
-
51349141191
-
Circulating mutant DNA to assess tumor dynamics
-
Diehl, F. et al. Circulating mutant DNA to assess tumor dynamics. Nature Med. 14, 985-990 (2008).
-
(2008)
Nature Med.
, vol.14
, pp. 985-990
-
-
Diehl, F.1
-
8
-
-
84896371874
-
Detection of circulating tumor DNA in early- and late-stage human malignancies
-
Bettegowda, C. et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci. Transl. Med. 6, 224ra24 (2014).
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 224ra24
-
-
Bettegowda, C.1
-
9
-
-
84877579861
-
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
-
Murtaza, M. et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 497, 108-113 (2013).
-
(2013)
Nature
, vol.497
, pp. 108-113
-
-
Murtaza, M.1
-
10
-
-
0027485066
-
Single base pair mutation analysis by PNA directed PCR clamping
-
Ørum, H. et al. Single base pair mutation analysis by PNA directed PCR clamping. Nucleic Acids Res. 21, 5332-5336 (1993).
-
(1993)
Nucleic Acids Res.
, vol.21
, pp. 5332-5336
-
-
Ørum, H.1
-
11
-
-
3242882243
-
Peptide nucleic acid clamp PCR: A novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes
-
Taback, A. et al. Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes. Int. J. Cancer 111, 409-414 (2004).
-
(2004)
Int. J. Cancer
, vol.111
, pp. 409-414
-
-
Taback, A.1
-
12
-
-
34548843880
-
Single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe for the detection of rare mutations
-
Chiou, C-C., Luo, J-D. & Chen, T-L. Single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe for the detection of rare mutations. Nature Protocols 1, 2604-2612 (2007).
-
(2007)
Nature Protocols
, vol.1
, pp. 2604-2612
-
-
Chiou, C.-C.1
Luo, J.-D.2
Chen, T.-L.3
-
13
-
-
76549132066
-
Colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells
-
García-Olmo, D. C. et al. Colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells. Cancer Res. 70, 560-567 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 560-567
-
-
García-Olmo, D.C.1
-
14
-
-
84959852078
-
Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering
-
Kelley, S. O. et al. Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering. Nature Nanotechnol. 9, 969-980 (2014).
-
(2014)
Nature Nanotechnol.
, vol.9
, pp. 969-980
-
-
Kelley, S.O.1
-
15
-
-
33745247792
-
Electrochemical sensors
-
Bakker, E. & Qin, Y. Electrochemical sensors. Anal. Chem. 78, 3965-3983 (2006).
-
(2006)
Anal. Chem.
, vol.78
, pp. 3965-3983
-
-
Bakker, E.1
Qin, Y.2
-
16
-
-
79951615475
-
Protein detection using arrayed microsensor chips: Tuning sensor footprint to achieve ultrasensitive readout of CA-125 in serum and whole blood
-
Das, J. & Kelley, S. O. Protein detection using arrayed microsensor chips: tuning sensor footprint to achieve ultrasensitive readout of CA-125 in serum and whole blood. Anal. Chem. 83, 1167-1172 (2011).
-
(2011)
Anal. Chem.
, vol.83
, pp. 1167-1172
-
-
Das, J.1
Kelley, S.O.2
-
17
-
-
84870791797
-
DNA nanostructure-based interfacial engineering for PCR-free ultrasensitive electrochemical analysis of microRNA
-
Wen, Y. et al. DNA nanostructure-based interfacial engineering for PCR-free ultrasensitive electrochemical analysis of microRNA. Sci. Rep. 2, 867 (2012).
-
(2012)
Sci. Rep.
, vol.2
, pp. 867
-
-
Wen, Y.1
-
18
-
-
84858429109
-
Ultrasensitive electrochemical detection of prostate-specific antigen (PSA) using gold-coated magnetic nanoparticles as 'dispersible electrodes'
-
Chuah, K. et al. Ultrasensitive electrochemical detection of prostate-specific antigen (PSA) using gold-coated magnetic nanoparticles as 'dispersible electrodes'. Chem. Commun. 48, 3503-3505 (2012).
-
(2012)
Chem. Commun.
, vol.48
, pp. 3503-3505
-
-
Chuah, K.1
-
19
-
-
84910656633
-
Ultrasensitive electroanalysis of low-level free microRNAs in blood by maximum signal amplification of catalytic silver deposition using alkaline phosphatase-incorporated gold nanoclusters
-
Si, Y. et al. Ultrasensitive electroanalysis of low-level free microRNAs in blood by maximum signal amplification of catalytic silver deposition using alkaline phosphatase-incorporated gold nanoclusters. Anal. Chem. 86, 10406-10414 (2014).
-
(2014)
Anal. Chem.
, vol.86
, pp. 10406-10414
-
-
Si, Y.1
-
20
-
-
84878631925
-
Multiplexed electrochemical protein detection and translation to personalized cancer diagnostics
-
Rusling, J. F. Multiplexed electrochemical protein detection and translation to personalized cancer diagnostics. Anal. Chem. 85, 5304-5310 (2013).
-
(2013)
Anal. Chem.
, vol.85
, pp. 5304-5310
-
-
Rusling, J.F.1
-
21
-
-
70350627563
-
Direct profiling of cancer biomarkers in tumour tissue using a multiplexed nanostructured microelectrode integrated circuit
-
Fang, Z. et al. Direct profiling of cancer biomarkers in tumour tissue using a multiplexed nanostructured microelectrode integrated circuit. ACS Nano 3, 3207-3213 (2009).
-
(2009)
ACS Nano
, vol.3
, pp. 3207-3213
-
-
Fang, Z.1
-
22
-
-
79955374281
-
Hierarchical nanotextured microelectrodes overcome the molecular transport barrier to achieve rapid, direct bacterial detection
-
Soleymani, L. et al. Hierarchical nanotextured microelectrodes overcome the molecular transport barrier to achieve rapid, direct bacterial detection. ACS Nano 5, 3360-3366 (2011).
-
(2011)
ACS Nano
, vol.5
, pp. 3360-3366
-
-
Soleymani, L.1
-
23
-
-
79958785745
-
Genetic analysis of H1N1 influenza virus from throat swab samples in a microfluidic system for point-of-care diagnostics
-
Ferguson, B. S. et al. Genetic analysis of H1N1 influenza virus from throat swab samples in a microfluidic system for point-of-care diagnostics. J. Am. Chem. Soc. 133, 9129-9135 (2011).
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 9129-9135
-
-
Ferguson, B.S.1
-
24
-
-
84860842832
-
Rapid, sensitive, and quantitative detection of pathogenic DNA at the point of care through microfluidic electrochemical quantitative loop-mediated isothermal amplification
-
Hsieh, K., Patterson, A. S., Ferguson, B. S., Plaxco, K. W. & Soh, H. T. Rapid, sensitive, and quantitative detection of pathogenic DNA at the point of care through microfluidic electrochemical quantitative loop-mediated isothermal amplification. Angew. Chem. Int. Ed. 51, 4896-4900 (2012).
-
(2012)
Angew. Chem. Int. Ed.
, vol.51
, pp. 4896-4900
-
-
Hsieh, K.1
Patterson, A.S.2
Ferguson, B.S.3
Plaxco, K.W.4
Soh, H.T.5
-
25
-
-
70350335850
-
Direct, electronic microRNA detection for the rapid determination of differential expression profiles
-
Yang, H. et al. Direct, electronic microRNA detection for the rapid determination of differential expression profiles. Angew. Chem. Int. Ed. 48, 8461-8464 (2009).
-
(2009)
Angew. Chem. Int. Ed.
, vol.48
, pp. 8461-8464
-
-
Yang, H.1
-
26
-
-
84876521026
-
Development of a 'signal-on' electrochemical DNA sensor with an oligo-thymine spacer for point mutation detection
-
Wu, Y. & Lai, R. Y. Development of a 'signal-on' electrochemical DNA sensor with an oligo-thymine spacer for point mutation detection. Chem. Commun. 49, 3422-3424 (2013).
-
(2013)
Chem. Commun.
, vol.49
, pp. 3422-3424
-
-
Wu, Y.1
Lai, R.Y.2
-
27
-
-
84869994112
-
ELCR: Electrochemical detection of single DNA base changes via ligase chain reaction
-
Wee, E. J. H., Shiddiky, M. J. A., Brown, M. A. & Trau, M. ELCR: electrochemical detection of single DNA base changes via ligase chain reaction. Chem. Commun. 48, 12014-12016 (2012).
-
(2012)
Chem. Commun.
, vol.48
, pp. 12014-12016
-
-
Wee, E.J.H.1
Shiddiky, M.J.A.2
Brown, M.A.3
Trau, M.4
-
28
-
-
80052129556
-
Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets
-
Xiang, Y. & Lu, Y. Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets. Nature Chem. 3, 697-703 (2011).
-
(2011)
Nature Chem.
, vol.3
, pp. 697-703
-
-
Xiang, Y.1
Lu, Y.2
-
29
-
-
0141765878
-
Electrochemical DNA sensors
-
Drummond, T. G., Hill, M. G. & Barton, J. K. Electrochemical DNA sensors. Nature Biotechnol. 21, 1192-1199 (2003).
-
(2003)
Nature Biotechnol.
, vol.21
, pp. 1192-1199
-
-
Drummond, T.G.1
Hill, M.G.2
Barton, J.K.3
-
30
-
-
84894231307
-
Hybridization chain reaction amplification of microRNA detection with a tetrahedral DNA nanostructure-based electrochemical biosensor
-
Ge, Z. et al. Hybridization chain reaction amplification of microRNA detection with a tetrahedral DNA nanostructure-based electrochemical biosensor. Anal. Chem. 86, 2124-2130 (2014).
-
(2014)
Anal. Chem.
, vol.86
, pp. 2124-2130
-
-
Ge, Z.1
-
31
-
-
84886946085
-
Rapid, sensitive, and quantitative detection of pathogenic DNA at the point of care via microfluidic electrochemical quantitative loop-mediated isothermal amplification (MEQ-LAMP)
-
Hsieh, K., Patterson, A. S., Ferguson, B. S., Plaxco, K. W. & Soh, H. T. Rapid, sensitive, and quantitative detection of pathogenic DNA at the point of care via microfluidic electrochemical quantitative loop-mediated isothermal amplification (MEQ-LAMP). Angew. Chem. Int. Ed. 124, 4980-4984 (2012).
-
(2012)
Angew. Chem. Int. Ed.
, vol.124
, pp. 4980-4984
-
-
Hsieh, K.1
Patterson, A.S.2
Ferguson, B.S.3
Plaxco, K.W.4
Soh, H.T.5
-
32
-
-
84932610917
-
The effect of interfacial design on the electrochemical detection of DNA and microRNA using methylene blue at low-density DNA films
-
Tavallaie, R., Darwish, N., Gebala, M., Hibbert, D. B. & Gooding, J. J. The effect of interfacial design on the electrochemical detection of DNA and microRNA using methylene blue at low-density DNA films. Chem Electro Chem 1, 165-171 (2014).
-
(2014)
Chem Electro Chem
, vol.1
, pp. 165-171
-
-
Tavallaie, R.1
Darwish, N.2
Gebala, M.3
Hibbert, D.B.4
Gooding, J.J.5
-
33
-
-
34547183500
-
Origin and prognostic value of circulating KRAS mutations in lung cancer patients
-
Gautschi, O. et al. Origin and prognostic value of circulating KRAS mutations in lung cancer patients. Cancer Lett. 254, 265-273 (2007).
-
(2007)
Cancer Lett.
, vol.254
, pp. 265-273
-
-
Gautschi, O.1
-
34
-
-
76749151984
-
Potential clinical significance of a plasma-based KRAS mutation analysis in patients with advanced non-small cell lung cancer
-
Wang, S. et al. Potential clinical significance of a plasma-based KRAS mutation analysis in patients with advanced non-small cell lung cancer. Clin. Cancer Res. 16, 1324-1330 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 1324-1330
-
-
Wang, S.1
-
35
-
-
72549094483
-
Programming the detection limits of biosensors through controlled nanostructuring
-
Soleymani, L., Fang, Z., Sargent, E. H. & Kelley, S. O. Programming the detection limits of biosensors through controlled nanostructuring. Nature Nanotechnol. 4, 844-848 (2009).
-
(2009)
Nature Nanotechnol.
, vol.4
, pp. 844-848
-
-
Soleymani, L.1
Fang, Z.2
Sargent, E.H.3
Kelley, S.O.4
-
36
-
-
70350341085
-
Nanostructuring of patterned microelectrodes to enhance the sensitivity of electrochemical nucleic acids detection
-
Soleymani, L. et al. Nanostructuring of patterned microelectrodes to enhance the sensitivity of electrochemical nucleic acids detection. Angew. Chem. Int. Ed. 48, 8457-8460 (2009).
-
(2009)
Angew. Chem. Int. Ed.
, vol.48
, pp. 8457-8460
-
-
Soleymani, L.1
-
37
-
-
84864350042
-
An ultrasensitive universal detector based on neutralizer displacement
-
Das, J. et al. An ultrasensitive universal detector based on neutralizer displacement. Nature Chem. 4, 642-648 (2012).
-
(2012)
Nature Chem.
, vol.4
, pp. 642-648
-
-
Das, J.1
-
38
-
-
84881357649
-
Tuning the bacterial detection sensitivity of nanostructured microelectrodes
-
Das, J. & Kelley, S. O. Tuning the bacterial detection sensitivity of nanostructured microelectrodes. Anal. Chem. 85, 7333-7338 (2013).
-
(2013)
Anal. Chem.
, vol.85
, pp. 7333-7338
-
-
Das, J.1
Kelley, S.O.2
-
39
-
-
84879672467
-
Solution-based circuits enable rapid and multiplexed pathogen detection
-
Lam, B. et al. Solution-based circuits enable rapid and multiplexed pathogen detection. Nature Commun. 4, 2001 (2013).
-
(2013)
Nature Commun.
, vol.4
, pp. 2001
-
-
Lam, B.1
-
40
-
-
84884956292
-
Proximal bacterial lysis and detection in nanoliter wells using electrochemistry
-
Besant, J. D., Das, J., Sargent, E. H. & Kelley, S. O. Proximal bacterial lysis and detection in nanoliter wells using electrochemistry. ACS Nano 7, 8183-8189 (2013).
-
(2013)
ACS Nano
, vol.7
, pp. 8183-8189
-
-
Besant, J.D.1
Das, J.2
Sargent, E.H.3
Kelley, S.O.4
-
41
-
-
77954629827
-
Nanostructuring of sensors determines the efficiency of biomolecular capture
-
Bin, X., Sargent, E. H. & Kelley, S. O. Nanostructuring of sensors determines the efficiency of biomolecular capture. Anal. Chem. 82, 5928-5931 (2010).
-
(2010)
Anal. Chem.
, vol.82
, pp. 5928-5931
-
-
Bin, X.1
Sargent, E.H.2
Kelley, S.O.3
-
42
-
-
0242653693
-
Electrocatalytic detection of pathogenic DNA sequences and antibiotic resistance markers
-
Lapierre, M. A., O'Keefe, M. M., Taft, B. J. & Kelley, S. O. Electrocatalytic detection of pathogenic DNA sequences and antibiotic resistance markers. Anal. Chem. 75, 6327-6333 (2003).
-
(2003)
Anal. Chem.
, vol.75
, pp. 6327-6333
-
-
Lapierre, M.A.1
O'Keefe, M.M.2
Taft, B.J.3
Kelley, S.O.4
-
46
-
-
84914165881
-
Effect of microelectrode structure on electrocatalysis at nucleic acid-modified sensors
-
Zhou, Y., Wan, Y., Sage, A., Poudineh, M. & Kelley, S. O. Effect of microelectrode structure on electrocatalysis at nucleic acid-modified sensors. Langmuir 30, 14322-14328 (2014).
-
(2014)
Langmuir
, vol.30
, pp. 14322-14328
-
-
Zhou, Y.1
Wan, Y.2
Sage, A.3
Poudineh, M.4
Kelley, S.O.5
|